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  3. Hydreo-500 Capsule 10's

Hydreo-500 Capsule 10's, Pack of 10 CapsuleS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Hydreo-500 Capsule 10's is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). It works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs accept a normal shape, restores the flow of blood, and protects against problems like painful sickle cell attacks. It may cause side effects such as loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting.

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Synonym :

HYDROXYCARBAMIDE

Composition :

HYDROXYUREA-500MG

Manufacturer/Marketer :

Knoll Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Hydreo-500 Capsule 10's

Hydreo-500 Capsule 10's is an anticancer medicine used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). Head and neck cancer is a disease including abnormal growth of the tissues of the neck and head that may also have the ability to attack or spread to other portions of the body.

In cancer, Hydreo-500 Capsule 10's works by blocking an enzyme that is required for growing cells. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs).

You may experience loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Hydreo-500 Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Take Hydreo-500 Capsule 10's as prescribed by your doctor. You are advised to take Hydreo-500 Capsule 10's for as long as your doctor has prescribed it for you, depending on your medical conditions. Do not chew, break, or crush the medicine. Swallow the medicine as a whole with a glass of water.

Before starting Hydreo-500 Capsule 10's, please inform your doctor if you have any allergies, kidney disease, liver disease, injury to your legs, HIV or AIDS, high levels of uric acid in your blood, or treatment with chemotherapy or radiation. Hydreo-500 Capsule 10's may increase the chances of other cancer. Inform your doctor about this risk. Immediately contact your doctor if you are pregnant because this Hydreo-500 Capsule 10's can cause harmful effects on the unborn baby.

Uses of Hydreo-500 Capsule 10's

Hydreo-500 Capsule 10's is used in the treatment of head and neck cancer, blood cancer, and sickle cell anaemia. The detailed uses of Hydreo-500 Capsule 10's are as follows:

  • Treats Head and Neck Cancer:Hydreo-500 Capsule 10's is used alone or in combination with radiotherapy to treat squamous cell carcinoma (skin cancer) of the head and neck by preventing the cancer cells from growing and multiplying.
  • Treats Blood Cancer: Hydreo-500 Capsule 10's helps slow the progression of chronic myeloid leukaemia by reducing the number of abnormal white blood cells in the bone marrow and blood.
  • Manages Ovarian Cancer: Hydreo-500 Capsule 10's is used as part of a chemotherapy treatment to help control the growth and spread of ovarian cancer cells.
  • Manages Sickle Cell Anaemia: Hydreo-500 Capsule 10's increases the level of fetal haemoglobin, which helps reduce the frequency of painful sickle cell attacks, the need for blood transfusion, and complications such as acute chest syndrome.

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Directions for Use

  • Take Hydreo-500 Capsule 10's with or without food as advised by your doctor.
  • Hydreo-500 Capsule 10's is generally taken once a day or as directed by the doctor.
  • Swallow Hydreo-500 Capsule 10's as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Hydreo-500 Capsule 10's belongs to a group of the class known as an antimetabolite.
  • It is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).
  • In cancer, Hydreo-500 Capsule 10's works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing.
  • In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs).
  • This helps the RBCs assume a normal shape, restores blood flow, and protects against problems like painful sickle cell attacks.

How Hydreo-500 Capsule 10's Works

Hydreo-500 Capsule 10's works by blocking an enzyme required for cell growth. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs assume a normal shape, restores blood flow, and protects against problems like painful sickle cell attacks.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Hydreo-500 Capsule 10's

Do not take more than the prescribed dose of Hydreo-500 Capsule 10's as it may cause an overdose. The symptoms of overdose include darkening of the skin, sores in the mouth and throat and pain, redness, swelling, and scaling on the hands and feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Before taking Hydreo-500 Capsule 10's inform your doctor if you have any kind of infection because Hydreo-500 Capsule 10's may worsen the infections.
  • Consult your doctor if you experience any allergy symptoms.
  • Inform your doctor if you have any history of kidney disease, liver disease, injury to your legs, HIV or AIDS, high levels of uric acid in your blood, or treatment with chemotherapy or radiation.
  • Hydreo-500 Capsule 10's may increase the chances of other cancers. Inform your doctor about this risk.
  • Immediately contact your doctor if you are pregnant because this Hydreo-500 Capsule 10's can cause harmful effects on the unborn baby.
  • Both women and men using this Hydreo-500 Capsule 10's should use birth control to avoid pregnancy. 
  • The use of this Hydreo-500 Capsule 10's by either parent may result in birth defects.
  • You should not take this Hydreo-500 Capsule 10's during breastfeeding; inform your doctor if you take Hydreo-500 Capsule 10's.
  • If any powder from a damaged pill is leaked, wash it up immediately with a wet paper towel and dispose of the towel in a closed plastic bag out of reach of children.

Drug-Drug Interactions

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HydroxycarbamideEtanercept
Severe
HydroxycarbamideTetracaine
Severe

Drug-Drug Interactions

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HydroxycarbamideEtanercept
Severe
How does the drug interact with Hydreo-500 Capsule:
Hydreo-500 Capsule when used in conjunction with etanercept may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Hydreo-500 Capsule with etanercept, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideTetracaine
Severe
How does the drug interact with Hydreo-500 Capsule:
Tetracaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Hydreo-500 Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Hydreo-500 Capsule and tetracaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideClozapine
Severe
How does the drug interact with Hydreo-500 Capsule:
Taking Hydreo-500 Capsule and Clozapine can increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Hydreo-500 Capsule, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor.
HydroxycarbamideThalidomide
Severe
How does the drug interact with Hydreo-500 Capsule:
Taking thalidomide with Hydreo-500 Capsule may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Hydreo-500 Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideBacitracin
Severe
How does the drug interact with Hydreo-500 Capsule:
Hydreo-500 Capsule when used in conjunction with bacitracin may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Hydreo-500 Capsule with bacitracin, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideMepivacaine
Severe
How does the drug interact with Hydreo-500 Capsule:
Mepivacaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Hydreo-500 Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Hydreo-500 Capsule and mepivacaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideProcaine
Severe
How does the drug interact with Hydreo-500 Capsule:
Procaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Hydreo-500 Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Hydreo-500 Capsule and procaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideFingolimod
Severe
How does the drug interact with Hydreo-500 Capsule:
Hydreo-500 Capsule when used with fingolimod may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Hydreo-500 Capsule with fingolimod, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideEtidocaine
Severe
How does the drug interact with Hydreo-500 Capsule:
Etidocaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Hydreo-500 Capsule, which may also lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficit may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Hydreo-500 Capsule and Etidocaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideTeriflunomide
Severe
How does the drug interact with Hydreo-500 Capsule:
Hydreo-500 Capsule when used in conjunction with teriflunomide may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Hydreo-500 Capsule with teriflunomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take Hydreo-500 Capsule 10's at the same time daily, either with or without a meal.
  • It is recommended to remain hydrated and drink a lot of fluids while taking Hydreo-500 Capsule 10's.
  • Do not miss any dose and finish the course as recommended by your doctor.
  • Use an efficient method of birth control to prevent pregnancy while taking this Hydreo-500 Capsule 10's.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

Hydreo-500 Capsule 10's Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Hydreo-500 Capsule 10's. Taking alcohol in larger amounts causes dizziness.

bannner image

Pregnancy

Unsafe

Hydreo-500 Capsule 10's is not safe during pregnancy because it may cause harmful effects to the baby.

bannner image

Breast Feeding

Consult your doctor

It is unknown whether Hydreo-500 Capsule 10's is excreted in human milk. Please consult a doctor before using Hydreo-500 Capsule 10's while breastfeeding.

bannner image

Driving

Caution

Hydreo-500 Capsule 10's may cause dizziness or a severe headache. Therefore, drive only if you are alert after taking Hydreo-500 Capsule 10's.

bannner image

Liver

Consult your doctor

If you have any concerns regarding the use of Hydreo-500 Capsule 10's in patients with liver problems, please consult a doctor.

bannner image

Kidney

Consult your doctor

If you have any concerns regarding the use of Hydreo-500 Capsule 10's in patients with kidney problems, please consult a doctor.

bannner image

Children

Unsafe

The safety and efficacy of Hydreo-500 Capsule 10's have not been established in children. Therefore, it is not recommended for children.

FAQs

Hydreo-500 Capsule 10's is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).

Take the Hydreo-500 Capsule 10's as soon as you can, but avoid the missed dose if it is nearly time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of Hydreo-500 Capsule 10's entirely.

Immediately go to the emergency department of your nearest hospital. Be ready to tell or show what was taken, how much, and when it happened.

Hydreo-500 Capsule 10's may cause a risk of skin cancer. Avoid contact with sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outside. Do not handle Hydreo-500 Capsule 10's without the protection of skin.

Hydreo-500 Capsule 10's can cause dizziness and drowsiness during the first limited hours after you take it. These side effects are more expected to happen when you start taking Hydreo-500 Capsule 10's or when your doctor increases your dose.

Do not stop taking Hydreo-500 Capsule 10's without discussing it with your doctor. Your doctor will most likely tell you to take another medicine, folic acid (a vitamin), to reduce some of the side effects of this Hydreo-500 Capsule 10's. Take this Hydreo-500 Capsule 10's exactly as instructed.

Hydreo-500 Capsule 10's is a medication that requires careful monitoring and dosing based on your individual medical condition, weight, and other factors. Please consult your healthcare provider if you have any questions about your hydroxyurea dosage. They can provide personal guidance and ensure you're taking the correct amount.

Hydreo-500 Capsule 10's can cause diarrhoea as a side effect. If you have watery or bloody diarrhoea, call your doctor. Do not use anti-diarrhea medicine unless your paediatrician tells you to.

Yes, it is recommended that you avoid certain foods and drinks while taking Hydreo-500 Capsule 10's. Some substances can interact with the medication, potentially affecting its effectiveness or increasing the risk of side effects. Here are some things to avoid: alcohol, grapefruit, grapefruit juice, Foods high in tyramine (aged cheeses, cured meats, fermented foods, and certain types of beans), and excessive caffeine.

If you're feeling tired and weak while taking hydroxyurea, try these tips: rest when needed, eat healthy foods, drink plenty of water, and get enough sleep. Gentle exercise can also help. Discuss with your healthcare provider if you're experiencing severe fatigue or weakness that interferes with your daily activities. They may be able to adjust your treatment or recommend additional strategies.

Hydreo-500 Capsule 10's is not safe during pregnancy because it may cause harmful effects to the baby.

Hydreo-500 Capsule 10's can make your hair thin or fall out. This is a common side effect, but how much hair you lose can change from person to person. Sometimes, hair loss is temporary, but in rare cases, it can be permanent. If you're worried about hair loss, talk to your doctor. They can help you manage it.

If you notice any changes in your skin while taking Hydreo-500 Capsule 10's, talk to your doctor. It's common to have darker skin or a rash. To protect your skin, use sunscreen, moisturize, and avoid things that might irritate it. If your skin problems are severe, see a dermatologist.

If you are having trouble with constipation while taking Hydreo-500 Capsule 10's, try these tips: eat more fibre, drink plenty of water, exercise regularly, and consider using over-the-counter laxatives after talking to your doctor. Avoid food that can worsen constipation, and try to go to the bathroom at the same time each day. If your constipation is severe, talk to your doctor.

To reduce the risk of infection while taking Hydreo-500 Capsule 10's, wash your hands often, avoid sick people, keep your home clean, get vaccinated, watch for signs of infection, and follow your doctor's instructions.

Common side effects of Hydreo-500 Capsule 10's may include loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Hydreo-500 Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Country of origin

India

Manufacturer/Marketer address

M-17, Pharma Tower, Basement & Ground Floor, Badli Industrial Area, New Delhi 110 042
Other Info - HYD0227

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 23, 2025 | 10:40 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/hydroxyurea.html
  2. https://www.medicines.org.uk/emc/product/271/pil#gref
  3. https://www.webmd.com/drugs/2/drug-7818/hydroxyurea-oral/details

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