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compositionComposition:HYDROXYUREA-500MG
prescription
Prescription Medicine
info
Readrox 500mg Capsule

Readrox 500mg Capsule is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). It works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs accept a normal shape, restores the flow of blood, and protects against problems like painful sickle cell attacks. It may cause side effects such as loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROXYUREA-500MG

Manufacturer/Marketer :

Miracalus Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Readrox 500mg Capsule

Readrox 500mg Capsule is an oral prescription medication used to reduce the frequency of painful crises and the need for blood transfusions in people with sickle cell anaemia. It is also prescribed to treat certain types of blood cancers, such as chronic myeloid leukaemia, and other blood disorders like polycythaemia vera. This medication works by helping the body produce healthier red blood cells or by slowing down the growth of abnormal cells.

To get the best results, you must take Readrox 500mg Capsule consistently at the same time every day as directed by your doctor. You can take this medicine with or without food, but taking it with a full glass of water is generally recommended. Along with taking this medication, staying well-hydrated by drinking plenty of fluids is a crucial lifestyle step that supports your body during treatment.

While taking Readrox 500mg Capsule, you may experience mild side effects like nausea, mild stomach upset, or temporary hair thinning. However, you must contact your doctor immediately if you notice signs of serious issues, such as unusual bruising, fever, sore throat, or sores on your legs.

Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as this medication can cause severe harm to an unborn baby. Before starting, talk to your doctor if you have a history of kidney disease, liver damage, or a weakened immune system.

This medicine can interact with certain vaccines, gout medications, and antiviral drugs, which may increase the risk of severe side effects or reduce how well your treatments work. Elderly individuals and those with reduced kidney function should consult their doctor closely, as they may require special monitoring while taking Readrox 500mg Capsule.

Uses of Readrox 500mg Capsule

Readrox 500mg Capsule is used to manage and treat sickle cell anaemia, chronic myeloid leukaemia and polycythaemia vera. The detailed uses of Readrox 500mg Capsule are as follows:

  • Sickle cell anaemia: Readrox 500mg Capsule helps by increasing the amount of foetal haemoglobin in the blood, which prevents red blood cells from changing into a crescent shape, thereby reducing painful crises and the need for blood transfusions.
  • Chronic myeloid leukaemia: Readrox 500mg Capsule works by slowing down the overproduction of abnormal white blood cells in the bone marrow, helping to manage blood cell counts.
  • Polycythaemia vera: Readrox 500mg Capsule helps control the excess production of red blood cells, which lowers the risk of blood clots and improves blood flow throughout the body.
     

Key Benefits

Readrox 500mg Capsule helps manage certain blood disorders by improving blood cell function and reducing disease-related complications. By supporting healthier blood cell levels and circulation, it helps improve quality of life and long-term health outcomes.

  • Helps Reduce Painful Sickle Cell Crises: For individuals with sickle cell disease, Readrox 500mg Capsule helps reduce the frequency and severity of painful vaso-occlusive episodes, supporting greater comfort and reducing the need for hospitalisation.
  • Supports Healthy Blood Cell Function: By improving blood cell production and reducing complications associated with blood disorders, Readrox 500mg Capsule helps lessen symptoms such as fatigue and weakness related to anaemia, supporting better daily functioning.
  • Helps Protect Against Long-Term Complications: Regular use of Readrox 500mg Capsule helps reduce the risk of complications caused by abnormal blood cells or impaired blood flow, supporting the health of vital organs and improving long-term disease management.
     

Directions for Use

  • Take Readrox 500mg Capsule with or without food as advised by your doctor.
  • Readrox 500mg Capsule is generally taken once a day or as directed by the doctor.
  • Swallow Readrox 500mg Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Readrox 500mg Capsule Works

Readrox 500mg Capsule contains hydroxyurea. It works by targeting the way certain cells in your body grow and divide. It acts as an inhibitor of an enzyme called ribonucleotide reductase, which is essential for making DNA. By temporarily blocking this enzyme, the medicine slows down or stops the rapid division of abnormal or overactive cells, such as those found in leukaemia or polycythaemia vera. In patients with sickle cell anaemia, Readrox 500mg Capsule helps by prompting the bone marrow to produce foetal haemoglobin. This specific type of haemoglobin prevents red blood cells from stiffening and bending into the sickle shape. As a result, the cells remain round and flexible, allowing them to flow smoothly through small blood vessels without causing blockages or pain.
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Alcohol

Consult your doctor

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Readrox 500mg Capsule. Taking alcohol in larger amounts causes dizziness.

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Pregnancy

Unsafe

Readrox 500mg Capsule is not safe during pregnancy because it may cause harmful effects to the baby.

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Breast Feeding

Consult your doctor

It is unknown whether Readrox 500mg Capsule is excreted in human milk. Please consult a doctor before using Readrox 500mg Capsule while breastfeeding.

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Driving

Caution

Readrox 500mg Capsule may cause dizziness or a severe headache. Therefore, drive only if you are alert after taking Readrox 500mg Capsule.

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Liver

Consult your doctor

If you have any concerns regarding the use of Readrox 500mg Capsule in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Readrox 500mg Capsule in patients with kidney problems, please consult a doctor.

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Children

Unsafe

The safety and efficacy of Readrox 500mg Capsule have not been established in children. Therefore, it is not recommended for children.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Readrox 500mg Capsule in elderly patients. Please consult your doctor.

What if I have taken an overdose of Readrox 500mg Capsule

If you suspect an overdose or have taken more than your prescribed amount, seek immediate medical attention right away. Symptoms of an overdose may include severe skin changes, swelling, or extreme fatigue.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water throughout the day. Staying hydrated is particularly crucial for sickle cell patients to help prevent blood flow blockages.
  • Protect your skin: This medication can make your skin more sensitive to the sun and increase the risk of skin damage. Wear protective clothing and apply a broad-spectrum sunscreen daily when outdoors.
  • Practice strict hand hygiene: Because this medicine can lower your white blood cell count and weaken your immune system, wash your hands frequently and avoid close contact with individuals who are sick.
  • Avoid live vaccines: Talk to your healthcare provider before receiving any immunisations, as live vaccines should be avoided during treatment.
     

Have a query?

How Soon It Starts Working

  • The time required for Readrox 500mg Capsule to start working: The time required for Readrox 500mg Capsule to start working is 1 to 4 hours after administration.
  • The time for which the effects of Readrox 500mg Capsule last: The effect of Readrox 500mg Capsule lasts for 24 hours.

What if you forget to take Readrox 500mg Capsule

If you miss a dose of Readrox 500mg Capsule, take it as soon as you remember on the same day. If you do not remember until the next day, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Readrox 500mg Capsule at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the container tightly closed and protect it from excessive heat, moisture, and direct sunlight.

Drug Warnings

  • Wear gloves when handling: Caregivers handling the capsules should wear disposable gloves to prevent direct skin contact with the medication.
  • Keep up with blood tests: You will need regular blood tests while taking this medication so your doctor can monitor your blood cell counts and ensure your kidneys and liver are functioning safely.
  • Use reliable birth control: Both men and women must use highly effective, reliable birth control during treatment and for several months after stopping the medication to prevent pregnancy.
  • Monitor for skin ulcers: Inspect your skin, especially your legs and ankles, regularly for any red spots, sores, or painful ulcers, and report them to your doctor immediately.
  • Avoid touching broken capsules: If a capsule accidentally breaks or spills, clean the area with a damp paper towel immediately, place it in a sealed bag, and throw it away, making sure not to inhale the powder.
     

verifiedApollotooltip
  • Certain antiretroviral medicines (e.g., didanosine, stavudine): Taking Readrox 500mg Capsule with certain medicines used to treat HIV may increase the risk of serious side effects, including liver damage and pancreatitis. Your doctor may recommend alternative treatment or closer monitoring if these medicines are used together.
  • Medicines that suppress the immune system or bone marrow: Combining Readrox 500mg Capsule with other medicines that reduce bone marrow function may increase the risk of low white blood cell, red blood cell, or platelet counts. Regular blood tests may be needed during treatment.
     

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verifiedApollotooltip

No clinically significant food interactions are known with Readrox 500mg Capsule when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIMETABOLITES]

FAQs

Readrox 500mg Capsule is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).
Take the Readrox 500mg Capsule as soon as you can, but avoid the missed dose if it is nearly time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of Readrox 500mg Capsule entirely.
Immediately go to the emergency department of your nearest hospital. Be ready to tell or show what was taken, how much, and when it happened.
Readrox 500mg Capsule may cause a risk of skin cancer. Avoid contact with sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outside. Do not handle Readrox 500mg Capsule without the protection of skin.
Readrox 500mg Capsule can cause dizziness and drowsiness during the first limited hours after you take it. These side effects are more expected to happen when you start taking Readrox 500mg Capsule or when your doctor increases your dose.
Do not stop taking Readrox 500mg Capsule without discussing it with your doctor. Your doctor will most likely tell you to take another medicine, folic acid (a vitamin), to reduce some of the side effects of this Readrox 500mg Capsule. Take this Readrox 500mg Capsule exactly as instructed.
Readrox 500mg Capsule is a medication that requires careful monitoring and dosing based on your individual medical condition, weight, and other factors. Please consult your healthcare provider if you have any questions about your hydroxyurea dosage. They can provide personal guidance and ensure you're taking the correct amount.
Readrox 500mg Capsule can cause diarrhoea as a side effect. If you have watery or bloody diarrhoea, call your doctor. Do not use anti-diarrhea medicine unless your paediatrician tells you to.
Yes, it is recommended that you avoid certain foods and drinks while taking Readrox 500mg Capsule. Some substances can interact with the medication, potentially affecting its effectiveness or increasing the risk of side effects. Here are some things to avoid: alcohol, grapefruit, grapefruit juice, Foods high in tyramine (aged cheeses, cured meats, fermented foods, and certain types of beans), and excessive caffeine.
If you're feeling tired and weak while taking hydroxyurea, try these tips: rest when needed, eat healthy foods, drink plenty of water, and get enough sleep. Gentle exercise can also help. Discuss with your healthcare provider if you're experiencing severe fatigue or weakness that interferes with your daily activities. They may be able to adjust your treatment or recommend additional strategies.
Readrox 500mg Capsule is not safe during pregnancy because it may cause harmful effects to the baby.
Readrox 500mg Capsule can make your hair thin or fall out. This is a common side effect, but how much hair you lose can change from person to person. Sometimes, hair loss is temporary, but in rare cases, it can be permanent. If you're worried about hair loss, talk to your doctor. They can help you manage it.
If you notice any changes in your skin while taking Readrox 500mg Capsule, talk to your doctor. It's common to have darker skin or a rash. To protect your skin, use sunscreen, moisturize, and avoid things that might irritate it. If your skin problems are severe, see a dermatologist.
If you are having trouble with constipation while taking Readrox 500mg Capsule, try these tips: eat more fibre, drink plenty of water, exercise regularly, and consider using over-the-counter laxatives after talking to your doctor. Avoid food that can worsen constipation, and try to go to the bathroom at the same time each day. If your constipation is severe, talk to your doctor.
To reduce the risk of infection while taking Readrox 500mg Capsule, wash your hands often, avoid sick people, keep your home clean, get vaccinated, watch for signs of infection, and follow your doctor's instructions.
Common side effects of Readrox 500mg Capsule may include loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Readrox 500mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
No, you should not open, break, or chew Readrox 500mg Capsule capsules. The powder inside can be harmful if it touches your skin or is inhaled. If you have trouble swallowing capsules, talk to your doctor or pharmacist for safe alternative options.
No, Readrox 500mg Capsule can cause severe birth defects. Both men and women should use effective contraception while taking this medicine and for a specific period after stopping. If you are planning a family, talk to your doctor to discuss safer alternatives.
You should avoid receiving live vaccines (such as the yellow fever or MMR vaccine) while taking Readrox 500mg Capsule, as your weakened immune system may not react safely. Always check with your doctor or pharmacist before getting any vaccine.
Mild skin darkening or nail changes are common side effects of Readrox 500mg Capsule. However, you should still mention any skin changes to your doctor to rule out other issues, especially if you notice painful sores or ulcers.
Yes, regular blood tests are absolutely essential. Your doctor needs to monitor your red blood cells, white blood cells, and platelets to make sure your dose is safe. Talk to your doctor to set up your blood test schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Hydroxyurea Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Product Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026] Check here
  4. Hydroxyurea solution [Prescribing Information]. 2025. [Accessed on 23 May 2025] Check here
  5. Central Drugs Standard Control Organisation: New Drug Approval List from SND Division (From 01/01/2024 to 30/04/2024). 2024. [Accessed on 23 May 2025] Check here
  6. Hydroxyurea [Prescribing Information]. 2024. [Accessed on 23 May 2025] Check here
  7. EMC, Hydroxyurea. [Accessed on 14 Sep, 2019]Check here
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