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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Imojac-XR Tablet 10's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Canixa Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Imojac-XR Tablet 10's

Imojac-XR Tablet 10's is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Imojac-XR Tablet 10's contains Tofacitinib, which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Imojac-XR Tablet 10's will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Imojac-XR Tablet 10's with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Imojac-XR Tablet 10's if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Imojac-XR Tablet 10's if you are pregnant or breastfeeding. Imojac-XR Tablet 10's is not recommended for use in children below 18 years as safety and effectiveness have not been established. 

Uses of Imojac-XR Tablet 10's

Imojac-XR Tablet 10's is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Imojac-XR Tablet 10's are as follows:

  • Treatment of Rheumatoid Arthritis: Imojac-XR Tablet 10's helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.
  • Management of Psoriatic Arthritis: Imojac-XR Tablet 10's treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.
  • Treatment of Ulcerative Colitis: Imojac-XR Tablet 10's helps to induce and maintain remission in moderate to severe ulcerative colitis.

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Directions for Use

  • Imojac-XR Tablet 10's can be taken with or without food.
  • It is recommended to take Imojac-XR Tablet 10's 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
  • Swallow Imojac-XR Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Key Benefits

  • Imojac-XR Tablet 10's belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
  • Imojac-XR Tablet 10's is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).
  • This medicine helps lower inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

How Imojac-XR Tablet 10's Works

Imojac-XR Tablet 10's contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Imojac-XR Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Imojac-XR Tablet 10's

Take Imojac-XR Tablet 10's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause unwanted side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Imojac-XR Tablet 10's if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. 
  • Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. 
  • If your white blood cell count or red blood cell count is low, avoid taking Imojac-XR Tablet 10's.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Imojac-XR Tablet 10's, which helps the physician decide the best treatment plan.

Drug-Drug Interactions

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TofacitinibNelfinavir
Severe

Drug-Drug Interactions

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TofacitinibNelfinavir
Severe
How does the drug interact with Imojac-XR Tablet:
When Imojac-XR Tablet is taken with Nelfinavir, that may increase the risk of side effects.

How to manage the interaction:
Although taking Imojac-XR Tablet and Nelfinavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Imojac-XR Tablet:
Taking Imojac-XR Tablet with Paclitaxel may increase the risk of infection.

How to manage the interaction:
Although taking Paclitaxel and Imojac-XR Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Imojac-XR Tablet:
Taking Imojac-XR Tablet with Topotecan may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Imojac-XR Tablet and Topotecan, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Imojac-XR Tablet:
Taking Carfilzomib with Imojac-XR Tablet may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Imojac-XR Tablet with Carfilzomib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Imojac-XR Tablet:
When Imojac-XR Tablet is taken with Daunorubicin, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Imojac-XR Tablet and Daunorubicin, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Imojac-XR Tablet:
Taking Imojac-XR Tablet with phenobarbital, may decrease Imojac-XR Tablet blood levels and effects.

How to manage the interaction:
Although taking phenobarbital and Imojac-XR Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Imojac-XR Tablet:
Taking Imojac-XR Tablet with atazanavir may increase the blood levels of Imojac-XR Tablet. This may lead to cause severe infections.

How to manage the interaction:
Co-administration of Imojac-XR Tablet with Atazanavir can possibly result in an interaction, but it can be taken if your doctor has advised it. However consult your doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to your doctor.
How does the drug interact with Imojac-XR Tablet:
When Imojac-XR Tablet and levamisole are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
Although taking Levamisole and Imojac-XR Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Imojac-XR Tablet:
Combining Infliximab with Imojac-XR Tablet can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Imojac-XR Tablet and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Imojac-XR Tablet:
Using Imojac-XR Tablet together with dasatinib may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Imojac-XR Tablet with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Imojac-XR Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Imojac-XR Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

[ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)]

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Alcohol

Safe if prescribed

It is not known if alcohol interacts with Imojac-XR Tablet 10's, so please consult a doctor.

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Pregnancy

Consult your doctor

Imojac-XR Tablet 10's must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Imojac-XR Tablet 10's and for 4 weeks after discontinuation.

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Breast Feeding

Consult your doctor

Avoid breastfeeding while taking Imojac-XR Tablet 10's. Please consult a doctor if you have any concerns.

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Driving

Safe if prescribed

Imojac-XR Tablet 10's generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Imojac-XR Tablet 10's is not recommended for patients with severe liver problems.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Imojac-XR Tablet 10's is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.

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Geriatrics

Consult your doctor

No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.

FAQs

Imojac-XR Tablet 10's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Imojac-XR Tablet 10's works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Imojac-XR Tablet 10's. Consult your doctor before taking Imojac-XR Tablet 10's if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Imojac-XR Tablet 10's. Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Imojac-XR Tablet 10's might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Imojac-XR Tablet 10's if you are trying to become pregnant or if you have any concerns regarding this.

Imojac-XR Tablet 10's affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Imojac-XR Tablet 10's is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Imojac-XR Tablet 10's may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Imojac-XR Tablet 10's may begin working within 2-8 weeks after starting the treatment.

Imojac-XR Tablet 10's should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Imojac-XR Tablet 10's, inform the doctor if you are taking tocilizumab.

Prior to starting Imojac-XR Tablet 10's, active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

Lg Floor, Block No. 2, , Attalika Warehouse (South), , 12 Km Mysore Road, R.V.C.E. Post, , Bangalore 560059.
Other Info - IMO0045

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