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Inflitza 25 Softgel Capsule belongs to the group of medicines called protein kinase inhibitors used to treat acute myeloid leukaemia (AML). It is sometimes, also used to treat aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL).
Inflitza 25 Softgel Capsule contains Midostaurin, which works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.
Inflitza 25 Softgel Capsule may cause certain side effects such as nausea, vomiting, headache, fever, musculoskeletal pain, and upper abdominal pain. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen. Take Inflitza 25 Softgel Capsule as prescribed by your doctor.
Discontinue taking Inflitza 25 Softgel Capsule and inform your physician if you observe any allergic reactions. Inform the doctor about your health condition and medications to rule out any side effects. Do not take Inflitza 25 Softgel Capsule if you are pregnant or breastfeeding. This medicine is not recommended for children as safety and effectiveness have not been established.
Inflitza 25 Softgel Capsule is used in the treatment of Acute myeloid leukaemia (AML), aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), and mast cell leukaemia (MCL). The detailed uses of Inflitza 25 Softgel Capsule are as follows:
Inflitza 25 Softgel Capsule belongs to the group of medicines called protein kinase inhibitors used to treat acute myeloid leukaemia (AML) in patients who are FLT3 mutation-positive. It is also used to treat aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL). Inflitza 25 Softgel Capsule contains Midostaurin, which works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.
Consult your doctor
It is not known if alcohol affects Inflitza 25 Softgel Capsule. Please consult your doctor.
Unsafe
Inflitza 25 Softgel Capsule is not recommended during pregnancy as it may harm your unborn baby. Therefore, if you are pregnant or planning for pregnancy, talk to the doctor for advice.
Unsafe
Inflitza 25 Softgel Capsule may harm the baby. Avoid breastfeeding during treatment with Inflitza 25 Softgel Capsule and for at least 4 months after stopping the treatment.
Caution
Inflitza 25 Softgel Capsule may cause dizziness and vertigo. Be cautious while driving or operating machinery.
Consult your doctor
If you have a pre-existing or a history of liver disease, inform your doctor before receiving Inflitza 25 Softgel Capsule. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Consult your doctor
If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Inflitza 25 Softgel Capsule. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Caution
The safety and effectiveness of Inflitza 25 Softgel Capsule in children below 18 years have not been established.
Caution
Inflitza 25 Softgel Capsule may cause QT prolongation, a heart rhythm condition that can lead to serious complications like fainting or irregular heartbeat. If you have heart problems such as heart failure or a history of arrhythmias, your doctor will need to evaluate the risks and may monitor your heart closely during treatment.
Caution
Geriatric patients can take Inflitza 25 Softgel Capsule, but doctors usually proceed with caution due to age-related changes in metabolism and organ function. Studies suggest it can be effective and safe in older adults with AML, especially when combined with low-intensity therapies.

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Do not take Inflitza 25 Softgel Capsule if you are allergic to any of its components, if you are taking medicines used to treat tuberculosis (rifampicin), epilepsy (carbamazepine or phenytoin), prostate cancer (enzalutamide), or herbal products (St. John’s Wort) or if you are pregnant or breastfeeding. Inform the doctor if you have any infections, heart disorders, lung, kidney or liver diseases. Seek immediate medical attention if you experience symptoms of low white blood cell count (fever, sore throat, mouth ulcers), lung problems (fever, chest pain, cough with or without mucous, trouble breathing or shortness of breath), or heart problems (chest pain or discomfort, fainting, dizziness, light-headedness, shortness of breath, blue discolouration of your lips, hands or feet, or swelling of your lower limbs).
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Inflitza 25 Softgel Capsule is used to treat Acute myeloid leukaemia (AML), aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), and mast cell leukaemia (MCL).
Inflitza 25 Softgel Capsule works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.
If you miss a dose of Inflitza 25 Softgel Capsule, take your next dose at the scheduled time. Avoid taking an extra dose to make up for the missed dose.
Inflitza 25 Softgel Capsule may reduce fertility in men and women. Before starting the treatment, discuss with the doctor if you have any concerns regarding fertility.
Continue taking Inflitza 25 Softgel Capsule even if you feel well. Do not stop taking Inflitza 25 Softgel Capsule without talking to the doctor.
If you vomit after taking Inflitza 25 Softgel Capsule, do take another dose. Continue with your regular dosing schedule and take the next dose at your scheduled time. If nausea or vomiting persists or worsens, consult the doctor.
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