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Written By Santoshini Reddy G , M Pharmacy

Mistaurin Capsule is also used to treat aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL). It contains Midostaurin, which works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells. This medicine is not recommended for children as safety and effectiveness have not been established.

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Composition :

MIDOSTAURIN-25MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mistaurin Capsule

Mistaurin Capsule belongs to the group of medicines called protein kinase inhibitors used to treat acute myeloid leukaemia (AML). It is sometimes, also used to treat aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL).

Mistaurin Capsule contains Midostaurin, which works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.

Mistaurin Capsule may cause certain side effects such as nausea, vomiting, headache, fever, musculoskeletal pain, and upper abdominal pain. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen. Take Mistaurin Capsule as prescribed by your doctor.

Discontinue taking Mistaurin Capsule and inform your physician if you observe any allergic reactions. Inform the doctor about your health condition and medications to rule out any side effects. Do not take Mistaurin Capsule if you are pregnant or breastfeeding. This medicine is not recommended for children as safety and effectiveness have not been established.

Uses of Mistaurin Capsule

Treatment of Acute myeloid leukaemia (AML), aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), and mast cell leukaemia (MCL)

Directions for Use

Take Mistaurin Capsule with food. Swallow the medicine as a whole with water; do not crush or chew it. Take this medicine exactly as advised by the doctor.

Medicinal Benefits

Mistaurin Capsule belongs to the group of medicines called protein kinase inhibitors used to treat acute myeloid leukaemia (AML) in patients who are FLT3 mutation-positive. It is also used to treat aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL). Mistaurin Capsule contains Midostaurin, which works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.

How Mistaurin Capsule Works

Mistaurin Capsule contains Midostaurin, which works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Mistaurin Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Mistaurin Capsule may include feeling cold, goosebumps, increased blood pressure (headache, flushing, blurred vision, pounding heartbeat) and trouble urinating. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Mistaurin Capsule if you are allergic to any of its components, if you are taking medicines used to treat tuberculosis (rifampicin), epilepsy (carbamazepine or phenytoin), prostate cancer (enzalutamide), or herbal products (St. John’s Wort) or if you are pregnant or breastfeeding. Inform the doctor if you have any infections, heart disorders, lung, kidney or liver diseases. Seek immediate medical attention if you experience symptoms of low white blood cell count (fever, sore throat, mouth ulcers), lung problems (fever, chest pain, cough with or without mucous, trouble breathing or shortness of breath), or heart problems (chest pain or discomfort, fainting, dizziness, light-headedness, shortness of breath, blue discolouration of your lips, hands or feet, or swelling of your lower limbs).

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Mistaurin Capsule:
Coadministration of Ziprasidone and Mistaurin Capsule increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Mistaurin Capsule is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mistaurin Capsule:
Using chloroquine together with Mistaurin Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Chloroquine with Mistaurin Capsule can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mistaurin Capsule:
When Mistaurin Capsule is taken with Ketoconazole, it may significantly increase the blood levels of Mistaurin Capsule. It can lead to side effects.

How to manage the interaction:
Although taking Ketoconazole and Mistaurin Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain and burning during urination, consult the doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Mistaurin Capsule:
Mistaurin Capsule blood levels may be significantly raised by combining itraconazole and Mistaurin Capsule.

How to manage the interaction:
Although there is a possible interaction between Mistaurin Capsule and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
How does the drug interact with Mistaurin Capsule:
The combined use of Mistaurin Capsule and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Mistaurin Capsule and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Mistaurin Capsule:
Coadministration of baricitinib and Mistaurin Capsule can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Mistaurin Capsule if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Mistaurin Capsule:
Using Moxifloxacin together with Mistaurin Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Moxifloxacin and Mistaurin Capsule, but it can be taken if prescribed by a doctor. If you experience fast or irregular heartbeat, dizziness, trouble breathing, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water to stay hydrated.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS
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Alcohol

Consult your doctor

It is not known if alcohol affects Mistaurin Capsule. Please consult your doctor.

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Pregnancy

Unsafe

Mistaurin Capsule is not recommended during pregnancy as it may harm your unborn baby. Therefore, if you are pregnant or planning for pregnancy, talk to the doctor for advice.

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Breast Feeding

Unsafe

Mistaurin Capsule may harm the baby. Avoid breastfeeding during treatment with Mistaurin Capsule and for at least 4 months after stopping the treatment.

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Driving

Caution

Mistaurin Capsule may cause dizziness and vertigo. Be cautious while driving or operating machinery.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Mistaurin Capsule. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Mistaurin Capsule. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Caution

The safety and effectiveness of Mistaurin Capsule in children below 18 years have not been established.

Have a query?

FAQs

Mistaurin Capsule is used to treat Acute myeloid leukaemia (AML), aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), and mast cell leukaemia (MCL).

Mistaurin Capsule works by blocking the action of kinase enzymes in abnormal cells and stops their division and growth. Thereby, it helps prevent the spread of cancer and mast cells.

If you miss a dose of Mistaurin Capsule, take your next dose at the scheduled time. Avoid taking an extra dose to make up for the missed dose.

Mistaurin Capsule may reduce fertility in men and women. Before starting the treatment, discuss with the doctor if you have any concerns regarding fertility.

Continue taking Mistaurin Capsule even if you feel well. Do not stop taking Mistaurin Capsule without talking to the doctor.

If you vomit after taking Mistaurin Capsule, do take another dose. Continue with your regular dosing schedule and take the next dose at your scheduled time. If nausea or vomiting persists or worsens, consult the doctor.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - MIS0119

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