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  3. INLYTA 5MG TABLETLET 14'S

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INLYTA 5MG TABLETLET 14'S, Pack of 1 TABLET
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

INLYTA 5MG TABLETLET is used to treat Renal Cell Carcinoma. It contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, INLYTA 5MG TABLETLET stops the production, spread and growth of cancerous cells.

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Composition :

AXITINIB-5MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About INLYTA 5MG TABLETLET

INLYTA 5MG TABLETLET is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

INLYTA 5MG TABLETLET contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

INLYTA 5MG TABLETLET may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. INLYTA 5MG TABLETLET should be taken as advised by your doctor.

Avoid taking INLYTA 5MG TABLETLET if you are allergic to it or any other components of it. Before taking INLYTA 5MG TABLETLET , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of INLYTA 5MG TABLETLET

INLYTA 5MG TABLETLET is used in the treatment of Renal Cell Carcinoma. The detailed use of INLYTA 5MG TABLETLET is as follows:<br/>• Advanced Renal Cell Carcinoma (RCC): INLYTA 5MG TABLETLET is commonly prescribed for RCC, especially in patients who have not responded to previous treatments.<br/>

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Directions for Use

• INLYTA 5MG TABLETLET can be taken with or without food as prescribed by your doctor.• It is recommended to take twice daily; however, follow your doctor's advice regarding the dosage and duration.• Swallow the medicine as a whole with a glass of water.• Do not break, chew or crush INLYTA 5MG TABLETLET .

Medicinal Benefits

INLYTA 5MG TABLETLET contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, INLYTA 5MG TABLETLET stops the body's production, spread and growth of cancerous cells.

How INLYTA 5MG TABLETLET Works

INLYTA 5MG TABLETLET contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep INLYTA 5MG TABLETLET out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Inlyta 5mg Tabletlet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of INLYTA 5MG TABLETLET

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of INLYTA 5MG TABLETLET may include dizziness, coughing up blood, and seizures. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

To treat your condition effectually, continue taking INLYTA 5MG TABLETLET for the period that your doctor has prescribed. Avoid taking INLYTA 5MG TABLETLET if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. INLYTA 5MG TABLETLET may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking INLYTA 5MG TABLETLET .

Drug-Drug Interactions

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AxitinibPosaconazole
Severe
AxitinibCobicistat
Severe

Drug-Drug Interactions

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AxitinibPosaconazole
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
Taking Inlyta 5mg Tabletlet with posaconazole can increase the blood levels of Inlyta 5mg Tabletlet. This may raise the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole and Inlyta 5mg Tabletlet, they can be taken together if prescribed by a doctor. However, if you experience diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
AxitinibCobicistat
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
When Inlyta 5mg Tabletlet is taken with Cobicistat, the body's ability to break down Inlyta 5mg Tabletlet is reduced.

How to manage the interaction:
There may be a possibility of interaction between Cobicistat and Inlyta 5mg Tabletlet, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AxitinibEtravirine
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
Etravirine may decrease the blood levels of Inlyta 5mg Tabletlet, which may make Inlyta 5mg Tabletlet less effective in treating the condition.

How to manage the interaction:
Taking Inlyta 5mg Tabletlet with Etravirine together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AxitinibItraconazole
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
Coadministration of Itraconazole and Inlyta 5mg Tabletlet may significantly increase the blood levels of Inlyta 5mg Tabletlet.

How to manage the interaction:
Inlyta 5mg Tabletlet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Any of the following symptoms should be reported: high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling skin on the hands and feet, chest pain, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, fits, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood. Do not stop any medications without consulting a doctor.
AxitinibCarbamazepine
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
Taking carbamazepine and Inlyta 5mg Tabletlet together can reduce the effects of Inlyta 5mg Tabletlet, which may make medication less effective in treating your condition.

How to manage the interaction:
Taking carbamazepine and Inlyta 5mg Tabletlet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibBosentan
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
Taking Inlyta 5mg Tabletlet with bosentan may significantly reduce the blood levels of Inlyta 5mg Tabletlet, making the medication less effective in treating the condition.

How to manage the interaction:
Although using Bosentan and Inlyta 5mg Tabletlet together can result in an interaction, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
AxitinibClotrimazole
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
Taking Inlyta 5mg Tabletlet with clotrimazole can increase the effect of Inlyta 5mg Tabletlet.

How to manage the interaction:
Although taking Clotrimazole with Inlyta 5mg Tabletlet may result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibBoceprevir
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
When Inlyta 5mg Tabletlet and boceprevir are taken together it may considerably raise Inlyta 5mg Tabletlet levels in the blood. This may eventually result in increased side effects.

How to manage the interaction:
Co-administration of Inlyta 5mg Tabletlet with Boceprevir can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain or pressure; pain in the arms, back, neck, or jaw; swelling; shortness of breath; numbness or weakness on one side of the body; headache; vision changes; seizures, unusual bleeding or bruising; red or black stools; coughing up or vomiting blood or blood clots; and severe stomach or abdominal pain, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AxitinibLeflunomide
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
When Inlyta 5mg Tabletlet is taken with Leflunomide, the risk of liver problems increases.

How to manage the interaction:
Although there is an interaction between leflunomide and Inlyta 5mg Tabletlet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AxitinibSaquinavir
Severe
How does the drug interact with Inlyta 5mg Tabletlet:
When Inlyta 5mg Tabletlet is taken with Saquinavir, the body's ability to break down Inlyta 5mg Tabletlet may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Inlyta 5mg Tabletlet and Saquinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Inlyta 5mg Tabletlet.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

INLYTA 5MG TABLETLET Substitute

Substitutes safety advice
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Alcohol

Caution

Limit alcohol consumption while taking INLYTA 5MG TABLETLET .

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Pregnancy

Unsafe

INLYTA 5MG TABLETLET is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking INLYTA 5MG TABLETLET . You should not become pregnant while you are taking INLYTA 5MG TABLETLET . Using effective birth control methods while on treatment with INLYTA 5MG TABLETLET is suggested.

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Breast Feeding

Caution

It is not known whether INLYTA 5MG TABLETLET passes into breastmilk. Hence, if you are breastfeeding, inform your doctor before taking INLYTA 5MG TABLETLET . Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Driving

Unsafe

INLYTA 5MG TABLETLET may cause dizziness and visual disturbances in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with INLYTA 5MG TABLETLET .

bannner image

Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. INLYTA 5MG TABLETLET is known to cause elevated liver enzymes, which may be fatal. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking INLYTA 5MG TABLETLET . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

INLYTA 5MG TABLETLET is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

FAQs

INLYTA 5MG TABLETLET is used to treat Renal Cell Carcinoma.

INLYTA 5MG TABLETLET contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

INLYTA 5MG TABLETLET is safe to be taken by a diabetic person. However, take INLYTA 5MG TABLETLET only after consulting with a doctor, as they may adjust the dosing according to your condition.

INLYTA 5MG TABLETLET may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

The possible signs and symptoms of kidney cancer are haematuria (blood in urine), low back pain on one side, fever, fatigue, weight loss, loss of appetite, anaemia (low blood count), and a lump on the side or lower back.

INLYTA 5MG TABLETLET should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.

Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Your doctor may suggest blood tests, and liver & kidney function tests before starting INLYTA 5MG TABLETLET . If you are female, you will have to take a pregnancy test before starting treatment.

People who are allergic to any of the components in INLYTA 5MG TABLETLET should not take this medicine. It is also not recommended during pregnancy and breastfeeding.

Yes, INLYTA 5MG TABLETLET might decrease fertility in men and women. Talk to the doctor if you have any concerns regarding fertility during treatment with INLYTA 5MG TABLETLET .

Fatigue could be a side effect of INLYTA 5MG TABLETLET . To cope with fatigue rest properly, eat healthy food, limit alcohol/caffeine, and manage stress. However, consult the doctor if you have excessive tiredness as it could be a sign of heart failure.

Consult your doctor if you get tired more easily, generally feel colder than other people, or your voice deepens whilst taking this medicine as these could be signs of the thyroid problem. The doctor will recommend thyroid function tests before and during treatment with INLYTA 5MG TABLETLET .

Posterior Reversible Leukoencephalopathy Syndrome is a neurological condition characterised by headache, seizures (fits), confusion, and changes in vision with or without high blood pressure. Consult the doctor immediately if you notice these symptoms.

Swelling of the abdomen, legs or ankles, protruding neck veins, excessive tiredness, and shortness of breath could be an indication of heart failure. Consult the doctor if you experience these symptoms.

Store INLYTA 5MG TABLETLET at room temperature, in a dry place. Keep out of sight and reach of children.

INLYTA 5MG TABLETLET may cause side effects such as diarrhoea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you.

Country of origin

INDIA

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051
Other Info - INL0072

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:05 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202324lbl.pdf
  2. https://www.drugs.com/mtm/axitinib.html
  3. https://medlineplus.gov/druginfo/meds/a612017.html
  4. https://reference.medscape.com/drug/inlyta-axitinib-999715
  5. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/axitinib

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