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  3. Intensic 100 mg Injection 5 ml

Intensic 100 mg Injection 5 ml, Pack of 1 INJECTION
Intensic 100 mg Injection 5 ml, Pack of 1 INJECTION
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Intensic 100 mg Injection 5 ml is used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). It contains Irinotecan, which works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells cannot divide. As a result, Irinotecan inhibits cancer cell division and growth.

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Synonym :

IRINOTECAN HYDROCHLORIDE

Composition :

IRINOTECAN-100MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Intensic 100 mg Injection 5 ml

Intensic 100 mg Injection 5 ml belongs to a class of antineoplastic medications or chemotherapy drugs primarily used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). Colorectal cancer is a disease in which cells in the colon or rectum grow out of control.

Intensic 100 mg Injection 5 ml contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can not divide. As a result, Irinotecan inhibits cancer cell division and growth.

Intensic 100 mg Injection 5 ml should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), Neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). You should talk to your doctor if you persistently experience these side effects.

Avoid using Intensic 100 mg Injection 5 ml if you are allergic to it. Intensic 100 mg Injection 5 ml can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on treatment with Intensic 100 mg Injection 5 ml. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Intensic 100 mg Injection 5 ml

Treatment of Colorectal cancer

Directions for Use

Intensic 100 mg Injection 5 ml should be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Medicinal Benefits

Intensic 100 mg Injection 5 ml is an antineoplastic medicine or chemotherapeutic treatment used to control or treat colorectal cancer (colon or rectal cancer). Intensic 100 mg Injection 5 ml contains Irinotecan acts by inhibiting an enzyme known as topoisomerase I. This enzyme is required for all cells to divide and flourish. Irinotecan inhibits this enzyme, preventing cancer cells from dividing. As a result, Irinotecan inhibits cancer cell division and growth.

How Intensic 100 mg Injection 5 ml Works

Intensic 100 mg Injection 5 ml contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can not divide. As a result, Irinotecan inhibits cancer cell division and growth.

Storage

Store in a cool and dry place away from sunlight
Side effects of Intensic 100 mg Injection 5 ml
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Maintaining adequate hydration will help you control your magnesium levels and improve your general health.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
  • If you notice symptoms like redness, rash, itching, nausea, chills, fever, chest pain, or trouble breathing, after your infusion, contact your healthcare provider right away to stop the medication.
  • Your doctor may treat you with medications like antihistamines, corticosteroids, fever reducers, anti-nausea drugs, and oxygen therapy; they may also administer epinephrine if you have a severe, life-threatening allergic reaction.
  • Your vital signs will be checked regularly, and depending on how severe the reaction is, your infusion may be slowed down or stopped for good.
  • Drink lots of fluids before, during, and after your infusion to help your body clear out any substances causing a reaction.
  • Try to rest and relax before and after your infusion to reduce stress and help your body recover.
  • Eat a balanced diet to support your immune system and overall well-being.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Intensic 100 mg Injection 5 ml

Since Intensic 100 mg Injection 5 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Intensic 100 mg Injection 5 ml may cause severe neutropenia and severe diarrhoea.

Drug Warnings

Before taking the Intensic 100 mg Injection 5 ml, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Before and during your therapy, your doctor will prescribe laboratory testing on a regular basis. You may also suffer severe diarrhoea (known as ''late diarrhoea'') more than 24 hours after receiving Irinotecan. Your doctor would advise you to take antidiarrheal drugs at regular intervals throughout the day and night. When taking antidiarrheal drugs, always follow your doctor's instructions. During your therapy, your doctor will also inform you which foods to take and which to avoid to reduce diarrhoea. Drink plenty of fluids and strictly adhere to this diet.

Drug-Drug Interactions

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IrinotecanKetoconazole
Critical
IrinotecanClarithromycin
Severe

Drug-Drug Interactions

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IrinotecanKetoconazole
Critical
How does the drug interact with Intensic 100 mg Injection 5 ml:
Using Intensic 100 mg Injection 5 ml together with ketoconazole can increase the risk of side effects.

How to manage the interaction:
Taking Ketoconazole with Intensic 100 mg Injection 5 ml is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
IrinotecanClarithromycin
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
When Clarithromycin is taken with Intensic 100 mg Injection 5 ml, it can interfere with the normal clearance of Intensic 100 mg Injection 5 ml from the body. This may increase side effects.

How to manage the interaction:
Although taking Intensic 100 mg Injection 5 ml and Clarithromycin together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - feeling sick, throwing up, stomach pain, diarrhea, not enough water in your body sores in your mouth, not enough red blood cells, bleeding problems, looking pale, feeling tired, feeling dizzy or passing out, having a fever or chills, a sore throat, muscle pain, trouble breathing, losing weight, feeling pain, or bleeding or bruising - make sure to call your doctor right away. Do not stop using any medications without a doctor's advice.
IrinotecanRifampicin
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
Taking Intensic 100 mg Injection 5 ml with rifampicin can decrease the blood levels of Intensic 100 mg Injection 5 ml, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Intensic 100 mg Injection 5 ml and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
IrinotecanRitonavir
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
Taking Ritonavir with Intensic 100 mg Injection 5 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Intensic 100 mg Injection 5 ml and Ritonavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination contact a doctor. Do not discontinue any medications without consulting a doctor.
IrinotecanMifepristone
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
Co-administration of Intensic 100 mg Injection 5 ml with mifepristone may significantly increase the effect of Intensic 100 mg Injection 5 ml.

How to manage the interaction:
Taking Intensic 100 mg Injection 5 ml with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience symptoms such as nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid heartbeat, or chest pain. Do not discontinue any medications without consulting a doctor.
IrinotecanRifabutin
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
Taking Rifabutin and Intensic 100 mg Injection 5 ml may significantly reduce the blood levels of Intensic 100 mg Injection 5 ml, which may make the medication less effective.

How to manage the interaction:
Although taking Intensic 100 mg Injection 5 ml and Rifabutin together can evidently cause an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms consult the doctor immediately. Do not discontinue any medications without first consulting your doctor.
IrinotecanGemfibrozil
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
Co-administration of Gemfibrozil with Intensic 100 mg Injection 5 ml can increase the risk or severity of side effects like dehydration, lung or breathing problems, or bleeding problems.

How to manage the interaction:
Although taking Gemfibrozil and Intensic 100 mg Injection 5 ml together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like diarrhea, feeling weak, blood clots, lung problems, feeling sick, throwing up, stomach pain, mouth sores, shortness of breath, looking pale, feeling tired, dizziness, fatigue, fever or chills, a sore throat, muscle pain, bleeding, bruises, losing weight, pain or burning urination consult a doctor right away. Do not discontinue any medications without consulting a doctor.
IrinotecanTofacitinib
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
Taking Tofacitinib with Intensic 100 mg Injection 5 ml may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Tofacitinib with Intensic 100 mg Injection 5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
IrinotecanEnzalutamide
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
When Enzalutamide is taken with Intensic 100 mg Injection 5 ml, the blood levels of Intensic 100 mg Injection 5 ml may be greatly decreased, which might diminish the effectiveness of Intensic 100 mg Injection 5 ml in curing your cancer.

How to manage the interaction:
Co-administration of Intensic 100 mg Injection 5 ml with Enzalutamide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
IrinotecanEtanercept
Severe
How does the drug interact with Intensic 100 mg Injection 5 ml:
When Etanercept is used with Intensic 100 mg Injection 5 ml, the risk or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Etanercept and Intensic 100 mg Injection 5 ml, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Intensic 100 mg Injection 5 ml Substitute

Substitutes safety advice

  • CAMPTO INJECTION 100MG

    by Others

    ₹4754.20per tablet

  • Inotad 100 Injection 1's

    by Others

    ₹2970.00per tablet

  • Irnotop 100mg Injection

    by Others

    ₹1620.00per tablet

  • Iretrol-Taj 100mg Injection

    by Others

    ₹688.80per tablet

  • Irinores 100mg Injection

    by Others

    ₹2870.00per tablet

Product Substitutes

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Intensic 100 mg Injection 5 ml.

bannner image

Pregnancy

Unsafe

Intensic 100 mg Injection 5 ml should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

bannner image

Breast Feeding

Unsafe

Intensic 100 mg Injection 5 ml should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

bannner image

Driving

Caution

Intensic 100 mg Injection 5 ml can make you dizzy or impair your vision, especially in the first 24 hours after taking it. Do not drive or operate machinery until you know how this drug affects you.

bannner image

Liver

Caution

Intensic 100 mg Injection 5 ml should be used with caution if you have liver disease. Inform your doctor before receiving the Intensic 100 mg Injection 5 ml if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Caution

It is not recommended for use in patients on dialysis. Inform your doctor before receiving the Intensic 100 mg Injection 5 ml if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

Safety and effectiveness in children have not been established. Hence, use is not recommended.

Have a query?

FAQs

Intensic 100 mg Injection 5 ml is used to treat Colorectal cancer.

Intensic 100 mg Injection 5 ml contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can't divide. As a result, Irinotecan inhibits cancer cell division and growth.

Intensic 100 mg Injection 5 ml should not be used in patients with pulmonary diseases. So, inform your doctor if you have pulmonary disorders (lung problems).

While taking Intensic 100 mg Injection 5 ml, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Intensic 100 mg Injection 5 ml.

The live vaccine may not work while on treatment with Intensic 100 mg Injection 5 ml. Only have immunizations/vaccinations after talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Irinotecan therapy may lead to Neutropenia (an unusually low number of neutrophil cells). Your doctor will order laboratory testing on a regular basis before and during your treatment.

You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.

You are recommended to take the advice of your doctor before taking Intensic 100 mg Injection 5 ml. As Intensic 100 mg Injection 5 ml is not used during pregnancy.

The common side effects of Intensic 100 mg Injection 5 ml are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - INT0476

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:44 PM IST

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Reference

  1. https://www.cancer.gov/about-cancer/treatment/drugs/irinotecanhydrochloride
  2. https://medlineplus.gov/druginfo/meds/a608043.html
  3. https://www.ncbi.nlm.nih.gov/books/NBK554441/
  4. https://reference.medscape.com/drug/camptosar-irinotecan-342252
  5. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/irinotecan
  6. https://chemocare.com/druginfo/irinotecan
  7. https://www.hopkinsmedicine.org/health/conditions-and-diseases/cancer/cancer-diet-foods-to-add-and-avoid-during-cancer-treatment
  8. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020571s048lbl.pdf
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