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compositionComposition:IRINOTECAN-100MG
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Prescription Medicine
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Irrvitop Injection 5ml is used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). It contains Irinotecan, which works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells cannot divide. As a result, Irinotecan inhibits cancer cell division and growth.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IRINOTECAN-100MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Irrvitop Injection 5ml

Irrvitop Injection 5ml is a prescription medication used to treat advanced cancer of the colon or rectum. It is typically prescribed when other treatments have not produced the desired results or as part of a primary treatment plan. This medicine is designed to help slow or stop the growth of cancer cells in the body.

This medicine is typically injected as an intravenous infusion once every two to three weeks, depending on your treatment plan. Consistency is vital, as keeping your scheduled appointments ensures the medication works continuously to target cancer cells. Since it is injected directly into a vein by a healthcare provider, food intake does not affect how the medication is absorbed, but eating light meals on treatment days and staying well-hydrated can improve your comfort. Making simple lifestyle adjustments, like drinking extra fluids and eating smaller, more frequent meals, can support your body during therapy.

While this medicine is highly effective, it can cause common side effects such as nausea, hair loss, and temporary tiredness. However, you must seek immediate medical attention if you experience severe, watery diarrhoea or signs of a serious infection, such as a high fever or chills.

Talk to your doctor before starting this treatment if you have a history of liver damage, asthma, or kidney disease. Do not take this if you have severe bone marrow failure, severe inflammatory bowel disease, or high levels of bilirubin in your blood.

This medication can interact with certain other medicines, herbal supplements like St. John's Wort, and alcohol, which may increase the risk of severe side effects or make the treatment less effective. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you must consult your healthcare provider to discuss the specific risks and protective measures needed.

Uses of Irrvitop Injection 5ml

Your doctor may prescribe Irrvitop Injection 5ml to treat the following conditions:

  • Colorectal cancer (cancer of the colon or rectum): Irrvitop Injection 5ml helps by targeting and slowing the growth of cancer cells in the large intestine or rectum, often used when other treatments have not worked or in combination with other chemotherapy drugs.
  • Advanced pancreatic cancer: In certain combination regimens, Irrvitop Injection 5ml helps stop cancer cells from multiplying and spreading in pancreatic tissues.
  • Small cell lung cancer: In some clinical cases, it is used to help manage and treat advanced lung cancer by disrupting the replication of fast-growing cancer cells.

Key Benefits

Irrvitop Injection 5ml helps slow the growth and spread of advanced cancer cells, supporting better disease control and helping relieve symptoms caused by tumour growth. It is often used as part of combination chemotherapy to improve treatment outcomes.

  • Helps slow cancer progression: Inhibits the growth and spread of cancer cells, helping control advanced disease and delay tumour progression.
  • Relieves cancer-related symptoms: By reducing tumour growth, it may help ease symptoms such as pain, abdominal discomfort, bowel obstruction, or pressure caused by the tumour.
  • Enhances combination therapy: Works alongside other chemotherapy medicines to improve the overall effectiveness of cancer treatment in appropriate patients.
  • Supports quality of life: Better disease control may help reduce cancer-related symptoms, maintain physical function, and improve overall well-being during treatment.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Irrvitop Injection 5ml will be administered by a trained healthcare professional.
  • Do not self-administer.

How Irrvitop Injection 5ml Works

Irrvitop Injection 5ml contains irinotecan, which works by blocking a specific protein in the body called topoisomerase I. This protein is essential for cancer cells to copy their DNA and multiply. By blocking this protein, the medicine causes damage to the DNA of the cancer cells, preventing them from dividing and ultimately causing them to die. Because cancer cells divide much faster than normal cells, they are highly sensitive to this blockage, which helps shrink tumours and control the spread of the disease.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Irrvitop Injection 5ml.

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Pregnancy

Unsafe

Irrvitop Injection 5ml should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Irrvitop Injection 5ml should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Irrvitop Injection 5ml can make you dizzy or impair your vision, especially in the first 24 hours after taking it. Do not drive or operate machinery until you know how this drug affects you.

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Liver

Caution

Irrvitop Injection 5ml should be used with caution if you have liver disease. Inform your doctor before receiving the Irrvitop Injection 5ml if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

It is not recommended for use in patients on dialysis. Inform your doctor before receiving the Irrvitop Injection 5ml if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Safety and effectiveness in children have not been established. Hence, use is not recommended.

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Heart

Caution

Irrvitop Injection 5ml may be used in patients with heart problems, but it requires close monitoring due to risks like bradycardia and dehydration-related cardiac complications. Medical supervision is essential to ensure safe administration.

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Geriatrics

Caution

Geriatric patients can receive irinotecan injections, but they may be more prone to severe side effects like diarrhea. Dose adjustments and close medical supervision are often necessary to ensure safe treatment.

What if I have taken an overdose of Irrvitop Injection 5ml

Since this medication is prepared and given by trained medical staff, an overdose is highly unlikely. However, if you suspect an error or experience severe symptoms immediately after your infusion, notify your medical team right away.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink plenty of clear fluids, such as water, oral rehydration solutions, or clear broths, to replace lost fluids, especially if you develop diarrhoea during treatment.
  • Eat small, easy-to-digest meals: Choose bland, low-fibre foods such as bananas, white rice, applesauce, plain toast, or crackers if you experience nausea or diarrhoea. Gradually return to your normal diet as your symptoms improve.
  • Avoid foods that worsen stomach upset: Limit dairy products (if they aggravate symptoms), caffeine, alcohol, and spicy, greasy, or highly seasoned foods, as these may increase nausea or diarrhoea.
  • Reduce your risk of infections: Wash your hands frequently, maintain good personal hygiene, and avoid close contact with people who have contagious illnesses, as this medicine may temporarily lower your white blood cell count and increase your risk of infections.
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How Soon It Starts Working

The time required for Irrvitop Injection 5ml to start to work: The exact onset time of Irrvitop Injection 5ml has not been clinically established. The time for which the effects of Irrvitop Injection 5ml last: The duration of Irrvitop Injection 5ml effect is unknown.

What if you forget to take Irrvitop Injection 5ml

Because this medicine is given in a clinical setting by healthcare professionals, missing a dose is rare. If you miss or have to cancel an appointment for your infusion, contact your clinic or doctor immediately to reschedule your treatment and keep your therapy on track.

Storage

•Unopened vials of Irrvitop Injection 5ml should be stored at room temperature, between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Manage diarrhoea promptly: Monitor your bowel movements closely. Your doctor may prescribe an anti-diarrhoeal medicine, such as loperamide, to keep at home. Start taking it at the first sign of loose stools and contact your healthcare team if diarrhoea is severe or persistent.
  • Report injection site problems immediately: During or after the infusion, tell your nurse immediately if you experience burning, pain, swelling, redness, or a cold sensation at the injection site, as leakage of the medicine outside the vein can damage surrounding tissues.
  • Avoid medicines that increase bleeding risk: Do not take aspirin, NSAIDs (such as ibuprofen), or other blood-thinning medicines unless your oncologist specifically advises you to, as Irrvitop Injection 5ml may lower your platelet count and increase the risk of bleeding.
  • Avoid live vaccines: Do not receive live vaccines during treatment unless your doctor specifically recommends them, as your immune system may be weakened and unable to respond safely.
  • Use effective contraception: Use reliable birth control during treatment and for the period recommended by your doctor after your final dose, as Irrvitop Injection 5ml can harm an unborn baby. Inform your doctor immediately if you or your partner become pregnant during treatment.

verifiedApollotooltip
  • Strong liver enzyme inducers (such as carbamazepine, phenytoin, or phenobarbital): May decrease the level of Irrvitop Injection 5ml in your body, making the treatment less effective.
  • Strong liver enzyme inhibitors (such as ketoconazole, clarithromycin, or atazanavir): May significantly increase the level of Irrvitop Injection 5ml in your body, increasing the risk of severe side effects like low blood counts and severe diarrhea.
  • St. John's Wort: Can lower the effectiveness of this medication and should be avoided during treatment.

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verifiedApollotooltip
  • Grapefruit and grapefruit juice: May interfere with how your liver breaks down this medicine, potentially increasing toxic side effects.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Irrvitop Injection 5ml is used to treat Colorectal cancer.
Irrvitop Injection 5ml contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can't divide. As a result, Irinotecan inhibits cancer cell division and growth.
Irrvitop Injection 5ml should not be used in patients with pulmonary diseases. So, inform your doctor if you have pulmonary disorders (lung problems).
While taking Irrvitop Injection 5ml, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Irrvitop Injection 5ml.
The live vaccine may not work while on treatment with Irrvitop Injection 5ml. Only have immunizations/vaccinations after talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Irinotecan therapy may lead to Neutropenia (an unusually low number of neutrophil cells). Your doctor will order laboratory testing on a regular basis before and during your treatment.
You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.
You are recommended to take the advice of your doctor before taking Irrvitop Injection 5ml. As Irrvitop Injection 5ml is not used during pregnancy.
The common side effects of Irrvitop Injection 5ml are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). If any of these side effects persist or worsen, please consult your doctor.
This medicine can irritate the digestive tract and affect the nerves that control bowel movements. This can cause early diarrhoea (during the infusion) or late diarrhoea (days after). Talk to your doctor about how to manage this with anti-diarrhoea medications.
This medicine can cause dizziness, sleepiness, or temporary vision problems shortly after administration. It is safest to have someone else drive you home after your appointment. Talk to your doctor if you experience these symptoms.
Yes, temporary hair thinning or hair loss is a common side effect of this treatment. Your hair will typically start to grow back after your chemotherapy cycles are complete. Talk to your doctor if you have concerns about managing hair loss.
It is highly recommended to avoid alcohol during treatment. Alcohol can worsen nausea, increase dehydration, and put extra strain on your liver, which is already processing the medication. Talk to your doctor or pharmacist for guidance.
A fever (especially 38°C/100.4°F or higher) is a medical emergency during this treatment because your immune system may be weak. Contact your doctor or go to the nearest emergency room immediately. Talk to your doctor about monitoring your temperature.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A608043 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Nbk554441 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 020571S048Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Irinotecan hydrochloride trihydrate. 1995Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here
  6. Hikma Pharmaceuticals USA Inc. Irinotecan hydrochloride Injection. Dailymed. [Revised in June 2020]. [Accessed on 22nd March 2023]Check here
  7. Hospira UK Limited. Irinotecan Hydrochloride 20 mg/mL concentrate for solution for infusion. European Medicines Compendium. [Revised in December 2022]. [Accessed on 22nd March 2023]Check here

Country of origin

INDIA

Manufacturer/Marketer address

PO Bag No. : 1014, Banjara Hills, Hyderabad ? 500034.
Other Info - IRR0014
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