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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Pistis Healthcare

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About ISN Pist Tablet 15's

ISN Pist Tablet 15's is an oral prescription medicine used to treat heart failure. It is typically prescribed alongside other standard heart failure medications to help manage symptoms and improve survival. This combination may be particularly useful in certain patients who cannot tolerate ACE inhibitors or angiotensin receptor blockers (ARBs), or when additional symptom control is needed as part of a comprehensive heart failure treatment plan. By helping blood vessels relax and improving blood flow, this medicine reduces the workload on the heart and supports long-term heart health.

For this medicine to work effectively, it must be taken consistently every day exactly as your doctor directs. You can take this medicine with or without food, but choosing one way and sticking to it with every dose helps keep medication levels steady in your body. Making healthy changes, such as eating a low-salt diet and staying moderately active, will also help you get the best results from your treatment.

Like all medications, ISN Pist Tablet 15's can cause some side effects, with headaches and dizziness being the most common, especially when you first start taking it. While these mild issues often improve over time, you should contact your doctor immediately if you experience serious symptoms such as severe lightheadedness, fainting, or a fast heartbeat.

Talk to your doctor before starting ISN Pist Tablet 15's if you have a history of low blood pressure, lupus, or severe kidney or liver problems. Do not take this medicine if you are currently taking certain medications for erectile dysfunction or high blood pressure in the lungs, as this combination can cause a dangerous, sudden drop in blood pressure.

This medicine can interact with alcohol, which may increase your risk of dizziness and low blood pressure. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss whether this treatment is safe and appropriate for your specific situation.

Uses of ISN Pist Tablet 15's

ISN Pist Tablet 15's is used in the treatment of heart failure. The detailed uses of ISN Pist Tablet 15's are as follows:

  • Heart Failure Management: Helps reduce the workload on the heart by relaxing blood vessels, improving blood flow, and reducing symptoms such as shortness of breath and fatigue.
  • Adjunctive Therapy in Chronic Heart Failure: May be prescribed alongside other heart failure medicines to improve symptom control, support physical activity, and reduce the risk of hospitalisation.
  • Alternative Treatment Option for Certain Patients: May be used in patients who cannot tolerate ACE inhibitors or ARBs, or when additional treatment is needed as determined by a healthcare provider.

Key Benefits

ISN Pist Tablet 15's helps improve heart function in people with heart failure by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body. This helps reduce symptoms and supports better day-to-day functioning. Benefits may include:

  • Reduces the workload and strain on the heart.
  • Improves blood flow and oxygen delivery to body tissues.
  • Helps reduce shortness of breath and fatigue associated with heart failure.
  • Improves the ability to perform daily activities and physical tasks.
  • May reduce the risk of hospitalisation due to worsening heart failure symptoms.
  • Supports better long-term management of heart failure and overall quality of life.
Side effects of ISN Pist Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

Follow these steps to take your medicine safely and effectively:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can change how the medicine is absorbed into your body.
  • Take this medicine at the same times every day to keep a steady amount of the drug in your system.
  • You may take this medication with or without food, but be consistent with how you take it.

Always follow your doctor's exact instructions regarding how and when to take ISN Pist Tablet 15's. Do not stop taking this medication suddenly without consulting your healthcare provider, even if you feel better.

How ISN Pist Tablet 15's Works

ISN Pist Tablet 15's contains Isosorbide Dinitrate and Hydralazine. • Isosorbide Dinitrate: It helps relax and widen the blood vessels, especially the veins. This reduces the amount of blood returning to the heart, lowering the strain on the heart and helping it work more efficiently. • Hydralazine: It helps relax and widen the arteries, allowing blood to flow more easily through the body. This reduces the workload on the heart and improves blood circulation.
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Alcohol

Unsafe

Consuming alcohol with the ISN Pist Tablet 15's is not advisable as it may cause unpleasant side effects, or you may become more sensitive to the effects of alcohol.

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Pregnancy

Consult your doctor

ISN Pist Tablet 15's is not recommended during pregnancy. Please discuss with the doctor if you have any concerns.

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Breast Feeding

Consult your doctor

ISN Pist Tablet 15's is not recommended during nursing. Please discuss with the doctor if you have any concerns.

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Driving

Unsafe

ISN Pist Tablet 15's may cause dizziness in some people, so it may affect your ability to drive.

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Liver

Caution

ISN Pist Tablet 15's to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

ISN Pist Tablet 15's to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

The safety and effectiveness of ISN Pist Tablet 15's in children have not been established.

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Heart

Caution

ISN Pist Tablet 15's can be used in heart patients if prescribed by the physician in heart failure patients. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Exercise caution while giving ISN Pist Tablet 15's in geriatric patients. Close monitoring of the individual is required.

What if I have taken an overdose of ISN Pist Tablet 15's

In case of an accidental overdose, seek emergency medical help or contact a poison control centre immediately. Symptoms of an overdose may include severe dizziness, fainting, a very fast heartbeat, confusion, or cold, sweaty skin.

Diet & Lifestyle Advise

  • Limit your sodium intake: Eat a low-salt diet as recommended by your doctor, as excess salt causes your body to hold onto fluid, putting extra stress on your heart.
  • Monitor your weight daily: Weigh yourself every morning after using the bathroom but before eating. Report any sudden weight gain (such as 2 to 3 pounds in a day or 5 pounds in a week) to your doctor, as this can be a sign of fluid buildup.
  • Avoid alcohol: Limit or avoid alcoholic beverages, as alcohol can interact with this medicine to cause severe dizziness or dangerously low blood pressure.
  • Stay active safely: Engage in light, doctor-approved physical activity, such as walking, to help strengthen your cardiovascular system.

Have a query?

How Soon It Starts Working

  • The time required for ISN Pist Tablet 15's to start to work: ISN Pist Tablet 15's ideally shows its action within 1 hour after administration.
  • The time for which the effects of ISN Pist Tablet 15's last: The effect of ISN Pist Tablet 15's lasts for 4 to 6 hours.

What if you forget to take ISN Pist Tablet 15's

If you miss a dose of ISN Pist Tablet 15's, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Change positions slowly: Stand up gradually from a sitting or lying position to help prevent dizziness and reduce the risk of falls.
  • Avoid certain medicines without medical advice: Do not take medicines used for erectile dysfunction while using ISN Pist Tablet 15's, as this combination may cause a severe drop in blood pressure.
  • Monitor your blood pressure regularly: Check your blood pressure and heart rate at home as advised by your doctor and report any unusual changes.
  • Protect your skin from sunlight: This medicine may increase your sensitivity to the sun. Wear protective clothing and apply sunscreen when spending time outdoors.
  • Inform healthcare providers before procedures: Tell your surgeon, dentist, or healthcare provider that you are taking ISN Pist Tablet 15's before undergoing any medical or dental procedure.
  • Do not take ISN Pist Tablet 15's: Unless specifically advised by your doctor, if you are allergic to its ingredients, have severe low blood pressure, are taking erectile dysfunction medicines, have certain serious heart conditions, or have had a serious reaction to nitrate medicines. Inform your doctor about your complete medical history before starting treatment.
  • Watch for worsening heart failure symptoms: Contact your doctor if you notice increasing shortness of breath, swelling of the feet or ankles, sudden weight gain, unusual fatigue, or reduced ability to perform normal activities.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Erectile dysfunction medications (e.g., sildenafil, tadalafil, or vardenafil): Taking these with ISN Pist Tablet 15's can cause an extremely dangerous, rapid drop in blood pressure.
  • Other blood pressure medicines (e.g., diuretics or beta-blockers): Combining these can increase the risk of excessively low blood pressure and dizziness.
  • Certain migraine medications: May interact with this medicine and alter its blood-vessel-relaxing effects.

Drug-Food Interactions

  • Alcohol: Drinking alcohol while taking this medicine can increase the risk of severe dizziness, lightheadedness, and fainting by further lowering your blood pressure.

Drug-Disease Interactions

  • Low blood pressure (hypotension): This medicine can make existing low blood pressure worse.
  • Severe kidney or liver damage: May affect how your body processes and clears this medication, requiring closer monitoring by your doctor.
  • Systemic lupus erythematosus: This medicine can trigger or worsen symptoms of lupus, such as joint pain and rashes.

Drug-Drug Interactions

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How does the drug interact with ISN Pist Tablet:
Taking avanafil with isosorbide dinitrate can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, or fast heartbeats. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Taking riociguat with isosorbide dinitrate can cause a significant decrease in blood pressure.

How to manage the interaction:
Taking isosorbide dinitrate with riociguat can lead to interactions, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headaches, flushing, or fast heartbeats. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Taking tadalafil with isosorbide dinitrate can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, or fast heartbeats. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Coadministration of isosorbide dinitrate and sildenafil can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate and Sildenafil together can lead to an interaction, it can be taken only if advised by a doctor. However, if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Coadministration of bupivacaine with isosorbide dinitrate may cause methemoglobinemia (a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Although there is an interaction between bupivacaine and isosorbide dinitrate, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, or rapid or shallow breathing. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Taking isosorbide dinitrate with chloroprocaine may cause methemoglobinemia (a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Although there is an interaction between isosorbide dinitrate and chloroprocaine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, or rapid or shallow breathing. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Co-administration of Tizanidine with ISN Pist Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Although there is an interaction between tizanidine and hydralazine, they can be taken together if prescribed by a doctor. However, if you experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with ISN Pist Tablet:
Taking isosorbide dinitrate with ropivacaine may cause methemoglobinemia (a blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although there is an interaction between isosorbide dinitrate and ropivacaine, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, or fast heartbeats. Do not stop using any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Taking isosorbide dinitrate with levobupivacaine may cause methemoglobinemia (a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Although there is an interaction between isosorbide dinitrate and levobupivacaine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, or rapid or shallow breathing. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ISN Pist Tablet:
Taking isosorbide dinitrate with sodium nitrite may cause methemoglobinemia (a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Although there is an interaction between isosorbide dinitrate and sodium nitrite, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, fast breathing, fast heartbeat, or confusion. Do not stop using any medications without consulting the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[VASODILATORS]

FAQs

ISN Pist Tablet 15's is used to treat heart failure, a condition that occurs when the heart does not pump enough blood for the body's needs.

ISN Pist Tablet 15's relaxes the heart's muscles and widens the heart's veins and arteries for easy flow of blood to every part of our body. It helps lower raised blood pressure by relaxing and widening the heart's muscles.

Yes, the use of ISN Pist Tablet 15's can make you feel dizzy. This may often occur when you suddenly rise from a sitting or lying position. To lower the chance of feeling dizzy (faint) or passing out, rise slowly if you have been lying down or sitting.

Keep this medicine tightly closed in the container or the original packaging. Store it according to the instructions mentioned on the pack or label. Dispose of unused medicine. Make sure pets, children, and other people do not consume it.

Take ISN Pist Tablet 15's with or without food, accompanied by a glass of water. Swallow the medicine whole, without chewing, breaking, or crushing it. Follow your doctor's instructions for dose and duration, and complete the entire prescribed course.

The common side effects of the ISN Pist Tablet 15's that may occur in some individuals are headache, nausea, dizziness, and lightheadedness (a fainting sensation). Most of these side effects of ISN Pist Tablet 15's do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

No, it is advisable not to drink alcohol while taking ISN Pist Tablet 15's. Drinking alcohol during treatment may cause increased dizziness and drowsiness, or it may cause unpleasant side effects.

Yes, there are some precautions or warnings associated with ISN Pist Tablet 15's. Exercise caution while using this medication and it is not advisable for individuals with low blood pressure. Pregnant or breastfeeding women should consult their doctor before use. Additionally, it may cause dizziness, so driving after taking this medication is not recommended.

If you miss a dose of ISN Pist Tablet 15's, take it as soon as you remember. However, if it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for a missed one.

No, you must not take ISN Pist Tablet 15's with erectile dysfunction medications like sildenafil, tadalafil, or vardenafil. Combining these medicines can cause a sudden, severe, and dangerous drop in blood pressure. Talk to your doctor if you have concerns about this interaction.

Mild headaches are a very common side effect when starting ISN Pist Tablet 15's as your body adjusts to the relaxed blood vessels. These headaches often lessen over time. Do not take any over-the-counter pain relievers without checking with your healthcare provider first. Talk to your doctor if your headaches are severe or do not go away.

This medicine starts working in your body shortly after you take it, but it may take several weeks of consistent use before you notice an improvement in your overall heart failure symptoms, such as having more energy or easier breathing. Talk to your doctor if you do not feel any improvement over time.

No, you should never stop taking this medication suddenly, even if you feel completely healthy. Stopping it abruptly can cause your heart failure symptoms to worsen rapidly. Any changes to your treatment plan must be guided by your healthcare provider. Talk to your doctor before making any adjustments.

The safety of this medicine during pregnancy or breastfeeding is not fully established. It should only be used if the potential benefit justifies the potential risk to the baby. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Yes, your doctor may recommend regular blood tests to check your kidney function, blood cell counts, and to monitor for any signs of an autoimmune or lupus-like reaction. It is important to keep all of your scheduled laboratory and doctor appointments. Talk to your doctor for more information.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

VAIKUNTH COMPLEX-2, Ghodasar, Ahmedabad, Gujarat 380050
Other Info - ISN0001
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