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compositionComposition:GLIMEPIRIDE-1MG+METFORMIN-500MG+VOGLIBOSE-0.2MG
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Prescription Medicine
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ISTAPHASE MG 1 TABLET 1 is used to treat type 2 diabetes mellitus. It acts by increasing the amount of insulin released by the pancreas. Thus, prevent the blood glucose levels from rising to very high levels and keeps your diabetes under control. It may cause certain common side effects such as hypoglycaemia (low blood glucose levels), taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-1MG+METFORMIN-500MG+VOGLIBOSE-0.2MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ISTAPHASE MG 1 TABLET 1

ISTAPHASE MG 1 TABLET 1 is a prescription tablet designed to help manage blood sugar levels in adults with type 2 diabetes. It is used when a single or double medication therapy, along with diet and exercise, is not enough to keep blood sugar within a safe range. By keeping glucose levels controlled, this medication helps prevent long-term health complications associated with diabetes. To get the best results, you must take ISTAPHASE MG 1 TABLET 1 consistently every day exactly as your doctor prescribes. It is typically taken shortly before or with your first main meal of the day to help control the rise in blood sugar that occurs after eating.

Combining this medication with a balanced, low-sugar diet and regular physical activity is essential for achieving optimal blood sugar control. While taking ISTAPHASE MG 1 TABLET 1, some people may experience mild side effects like an upset stomach, mild diarrhea, or temporary low blood sugar. If you experience serious symptoms such as severe confusion, shakiness, extreme sleepiness, or yellowing of your skin or eyes, you must contact your doctor immediately. These symptoms can be signs of more serious complications that require medical attention.

Before starting ISTAPHASE MG 1 TABLET 1, tell your doctor about your complete medical history, especially if you have heart problems or a history of low blood sugar. Do not take this if you have severe kidney disease, advanced liver damage, or if you are experiencing diabetic ketoacidosis.

Your doctor will evaluate your overall organ function to make sure this medicine is safe for you. This medication can interact with other substances, such as alcohol, which significantly increases your risk of dangerous blood sugar drops or a rare but severe metabolic condition. If you are pregnant, planning to become pregnant, breastfeeding, or are over the age of 65, talk to your doctor or pharmacist to determine if this is the right option for you.

Uses of ISTAPHASE MG 1 TABLET 1

ISTAPHASE MG 1 TABLET 1 is used to treat Type 2 diabetes mellitus. The detailed uses of ISTAPHASE MG 1 TABLET 1 are as follows:

  • Type 2 Diabetes Mellitus: ISTAPHASE MG 1 TABLET 1 is prescribed to help lower high blood sugar levels in adults whose diabetes cannot be controlled by diet, exercise, and single-agent medications alone.

Key Benefits

ISTAPHASE MG 1 TABLET 1 provides reliable, daily support to help you manage your health and avoid the physical toll of fluctuating blood sugar levels. By keeping your blood sugar stable, this medicine brings several key health benefits:

  • Helps maintain healthy blood sugar control (glycemic control) throughout the day.
  • Reduces blood sugar spikes after meals.
  • Improves the body's ability to use insulin effectively.
  • Helps lower excess glucose production by the liver.
  • Reduces the risk of long-term diabetes-related complications, including nerve damage, kidney disease, vision problems, and cardiovascular complications when used as part of a comprehensive diabetes management plan.
Side effects of Istaphase MG 1 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

These are the following ways one can use ISTAPHASE MG 1 TABLET 1:

  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can interfere with how the medication is released into your body.
  • Take this medication exactly as prescribed by your doctor, usually right before or with your first main meal of the day.
  • Never adjust your dose or stop taking this medication without consulting your doctor first, even if your blood sugar readings improve.

How ISTAPHASE MG 1 TABLET 1 Works

ISTAPHASE MG 1 TABLET 1 combines three distinct active medicines that work together in your body to lower blood sugar levels. Glimepiride (sulfonylurea, stimulates insulin secretion), Voglibose (alpha-glucosidase inhibitor, delays carbohydrate absorption), and Metformin (biguanide, reduces hepatic glucose output and improves insulin sensitivity). The insulin-stimulating component is part of the medicine that prompts your pancreas to release more insulin, which is the natural hormone your body uses to clear sugar out of the bloodstream and into your cells for energy. The slower carbohydrate absorption is the component that works directly in your digestive system to slow down the breakdown of complex carbohydrates from your food into simple sugars. This delays sugar absorption, preventing sharp blood sugar spikes after your meals. The liver and insulin-sensitivity helper part work in two ways, as it reduces the amount of excess sugar your liver makes and releases into your body, and it helps your muscles use your body's existing insulin much more efficiently.
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Alcohol

Unsafe

Taking ISTAPHASE MG 1 TABLET 1 with alcohol can cause hypoglycaemia and can also lead to a rare but life-threatening condition known as lactic acidosis. So, keep your doctor informed if you drink alcohol.

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Pregnancy

Consult your doctor

As the data around the use of ISTAPHASE MG 1 TABLET 1 in pregnant women is limited, the use of ISTAPHASE MG 1 TABLET 1 in pregnancy is unknown. Please consult your doctor for advice before using ISTAPHASE MG 1 TABLET 1.

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Breast Feeding

Consult your doctor

The name is not recommended during breastfeeding. However, your doctor may prescribe it for you during breastfeeding if he/she feels that the benefit to you outweighs the risk. You should not take ISTAPHASE MG 1 TABLET 1 without a doctor's advice.

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Driving

Unsafe

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

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Liver

Caution

ISTAPHASE MG 1 TABLET 1 to be taken with caution, especially if you have a history of liver disease.

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Kidney

Caution

ISTAPHASE MG 1 TABLET 1 to be taken with caution, especially if you have a history of Kidney disease

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Children

Unsafe

ISTAPHASE MG 1 TABLET 1 is not recommended for children below the age of 18 years as the safety and effectiveness of ISTAPHASE MG 1 TABLET 1 has not been established in children due to limited evidence.

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Heart

Consult your doctor

ISTAPHASE MG 1 TABLET 1 should be used with caution if you have any cardiac problems. This medicine is contraindicated in patients with severe heart failure.

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Geriatrics

Caution

Caution should be exercised in geriatric patients while taking ISTAPHASE MG 1 TABLET 1.

What if I have taken an overdose of ISTAPHASE MG 1 TABLET 1

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. An overdose can cause dangerously low blood sugar or lactic acidosis, both of which require urgent medical treatment.

Diet & Lifestyle Advise

  • Count your carbohydrates: Learn to track your daily carbohydrate intake to maintain stable blood sugar levels and avoid sudden spikes or drops.
  • Eat consistent meals: Do not skip meals while taking this medication, as missing a meal can cause your blood sugar to drop dangerously low.
  • Carry fast-acting sugar: Always keep a source of fast-acting sugar with you, such as glucose tablets, fruit juice, or hard candy, to quickly treat sudden symptoms of low blood sugar.
  • Exercise regularly: Engage in moderate physical activity, like walking or cycling, for at least 150 minutes per week, as exercise helps your body use insulin more effectively.
health query

Have a query?

How Soon It Starts Working

The time required for ISTAPHASE MG 1 TABLET 1 to start to work: The time required for ISTAPHASE MG 1 TABLET 1 to show its action is not clinically established. The time for which the effects of ISTAPHASE MG 1 TABLET 1 last: The duration of action for ISTAPHASE MG 1 TABLET 1 is not clinically established.

What if you forget to take ISTAPHASE MG 1 TABLET 1

If you miss a dose, take it with your next main meal if that meal is coming up soon. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store ISTAPHASE MG 1 TABLET 1 at room temperature, ideally below 30°C (86°F), in a dry place. • Keep the tablets in their original blister packaging to protect them from direct sunlight, heat, and moisture.

Drug Warnings

  • Monitor your blood sugar levels regularly as advised by your doctor to ensure the medication is working safely and effectively.
  • Check your skin and feet daily for any cuts, sores, or infections, as diabetes can slow down your body's natural healing process.
  • Inform any surgeon, dentist, or medical specialist that you are taking ISTAPHASE MG 1 TABLET 1, especially if you need to undergo surgery or a medical scan involving contrast dye.
  • Avoid drinking alcohol, as it can interfere with blood sugar control and significantly increase your risk of severe low blood sugar and lactic acidosis.
  • ISTAPHASE MG 1 TABLET 1 is not intended for use in children and adolescents unless specifically prescribed by a specialist. Its safety and effectiveness in pediatric patients have not been well established.
  • If you suspect an overdose, seek emergency medical attention immediately. Call or go to the nearest hospital emergency department. Symptoms may include severe low blood sugar, extreme weakness, confusion, loss of consciousness, or signs of lactic acidosis.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Beta-blockers: May mask the warning signs of low blood sugar, such as a rapid heart rate.
  • Water pills (diuretics) and steroids: May raise your blood sugar levels, reducing the effectiveness of ISTAPHASE MG 1 TABLET 1.
  • Pain relievers (NSAIDs) and certain blood pressure medications (ACE inhibitors): May increase the risk of low blood sugar or affect kidney function when taken together.
Glimepiride + Metformin + VogliboseIopromide
Critical
Glimepiride + Metformin + VogliboseGatifloxacin
Critical

Drug-Drug Interactions

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Glimepiride + Metformin + VogliboseIopromide
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseGatifloxacin
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Taking Glimepiride with Gatifloxacin may affect both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Glimepiride + Metformin + VogliboseIomeprol
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseIodamide
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseMetrizamide
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Glimepiride + Metformin + VogliboseIopamidol
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseIodixanol
Critical
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseGrepafloxacin
Severe
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Glimepiride with Grepafloxacin can cause both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Although there is a possible interaction between Glimepiride and Grepafloxacin, you can take these medicines together if prescribed by a doctor. If you experience headache, dizziness, sleepiness, confusion, shaking, feeling hungry, weak, heart racing, high blood sugar, low blood sugar, serious infections, bleeding, feeling anxious, feeling sick or very thirsty - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
Glimepiride + Metformin + VogliboseOfloxacin
Severe
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Ofloxacin and Glimepiride can cause both hyperglycemia (high blood glucose) and, hypoglycemia (low blood glucose).

How to manage the interaction:
Although combining Ofloxacin and Glimepiride can lead to an interaction, they can be taken on a doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), consult a doctor. Keep an eye on your blood glucose level. Do not discontinue any medications without consulting a doctor.
Glimepiride + Metformin + VogliboseVoriconazole
Severe
How does the drug interact with Istaphase MG 1 Tablet:
Co-administration of Glimepiride with Voriconazole may increase the blood levels and effects of Glimepiride.

How to manage the interaction:
Although there is a possible interaction, glimepiride can be taken with voriconazole if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Increases the risk of dangerous low blood sugar and a serious metabolic condition called lactic acidosis.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

ISTAPHASE MG 1 TABLET 1 is a combination of anti-diabetic drugs used to treat type 2 diabetes mellitus.
If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing and frequent infections, contact doctor as it can be a condition of type 2 diabetes.
Hypoglycaemia refers to low blood sugar levels. The symptoms of hypoglycaemia include nausea, headache, irritability, hunger, sweating, dizziness. ISTAPHASE MG 1 TABLET 1 can cause hypoglycaemia. Hypoglycaemia can occur if you miss or delay your food, drink alcohol, over-exercise or take other anti-diabetic medicine along with ISTAPHASE MG 1 TABLET 1. Diabetics are advised to keep a quick source of sugar like glucose tablets, honey or fruit juice with them.
ISTAPHASE MG 1 TABLET 1 should be avoided in patients who are allergic to any of the components or excipients of this medicine. It should be avoided in patients suffering from moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
If you feel thirsty after taking ISTAPHASE MG 1 TABLET 1, it may be because of dehydration as ISTAPHASE MG 1 TABLET 1 can lead to loss of fluids. Increase intake of fluids, if even then you feel thirsty please consult your doctor.
If you have been affected with diabetes, you should have a test of HbA1c once in three months.
Yes, long-term usage of ISTAPHASE MG 1 TABLET 1 can cause vitamin B12 deficiency as it interferes with the absorption of vitamin B12 in the stomach. The symptoms can be managed by taking Vitamin B12 supplements as advised by your doctor.
No. Till date there is no clinical evidence that states that ISTAPHASE MG 1 TABLET 1 affects fertility in either men or women.
Lactic acidosis is rare but life threatening condition when, there is too much of lactic acid build up in the bloodstream. Long term intake of ISTAPHASE MG 1 TABLET 1 may lead to lactic acidosis when cells get deprived of the oxygen levels. Symptoms of lactic acidoisis includes burning sensation of muscle, muscle ache, fast breathing, nausea and stomach pain. Immediately contact doctor if you experience any of these symptoms when on ISTAPHASE MG 1 TABLET 1.
If you feel shaky, sweaty, or dizzy, immediately consume 15 to 20 grams of fast-acting sugar, such as a half-cup of fruit juice, glucose tablets or plain sugar. Check your sugar again in 15 minutes, and if it is still low, repeat the treatment. Talk to your doctor if this happens frequently.
Follow a diet rich in fibre, low in fat with sufficient carbohydrates, protein, vitamins and minerals. Maintain the regular meal timings and try to have 2-3 healthy snacks between meals such as salads and soups. Use edible oils moderately and drink at least 8-10 glasses of water every day.
You are recommended to avoid white bread, maida, poori, naan, noodles, biryani, fried rice, carrot juice, soups, deep-fried vegetables, creams and vegetable curries with excess oil. Also, avoid mango, seetaphal, jack fruit, fruit salads with ice cream, and fruit-based desserts. Avoid overeating. Avoid shopping when you are hungry. You could be tempted to purchase oil and fried food.
ISTAPHASE MG 1 TABLET 1 acts by encouraging insulin secretion from the β-cells of the pancreas and increase the amount of insulin released by the pancreas. Also, it helps to restore the body's proper response to the insulin it naturally produces.
Store ISTAPHASE MG 1 TABLET 1 at room temperature. Protect from light and moisture. Keep it out of reach of children.
ISTAPHASE MG 1 TABLET 1 may cause side effects such as hypoglycemia (low blood sugar level), taste change, stomach pain, nausea, diarrhea, and headache. If these side effects persist or worsen, please consult your doctor.
No, you should avoid alcohol. Drinking alcohol while taking this medicine significantly increases your risk of severe low blood sugar and a rare but dangerous condition called lactic acidosis. Talk to your doctor for more information.
It is usually best to take this medication right before your first main meal of the day, or exactly as your doctor has instructed. Taking it with your meal helps prevent post-meal blood sugar spikes and reduces stomach upset.
Some components of this medicine are generally weight-neutral or may support mild weight loss, while others can occasionally cause slight weight gain due to increased insulin action. Talk to your doctor or pharmacist about what to expect.
No, you should never stop taking your medication without consulting your doctor. Normal blood sugar readings mean the medication is working as intended, and stopping it suddenly can cause your blood sugar to rise rapidly again.
This medication is generally not recommended during pregnancy or breastfeeding. Insulin is typically preferred to manage blood sugar during these times. Talk to your doctor for safe alternatives.
This medication is cleared from your body through your kidneys. While it does not directly damage healthy kidneys, patients with significantly reduced kidney function (eGFR below 45 or 30) may need dose adjustments or discontinuation, as per standard guidelines. Metformin should be used with caution between eGFR 30–45 and is contraindicated below eGFR 30; and glimepiride also requires caution in renal impairment due to hypoglycemia risk. Your doctor will perform routine blood tests to monitor your kidney function and ensure it remains safe for you to take.
No, you must swallow the tablet whole. Crushing, chewing, or breaking the tablet can cause too much of the medication to release into your body at once, which increases the risk of side effects and low blood sugar. Talk to your doctor if you have trouble swallowing.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Center for Biotechnology Information (NCBI). Pmc3919386 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.594 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.6048 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Metformin Hydrochloride (Prolonged Release), Voglibose & Glimepiride [Patient Information Sheet]. 2015. [Accessed on 28th Sept. 2023]Check here
  5. Central Drugs Standard Control Organisation [Internet]. Cdscoonline.gov.in. 2024 [Accessed on 17 July 2025]Check here
  6. Glimepiride+Metformin+Voglibose [Product Monograph]. 2018. [Accessed on 25 Oct. 2021]Check here

Country of origin

INDIA

Manufacturer/Marketer address

7-2-A2, Hetero Corporate, Industrial Estates, Sanath Nagar, Hyderabad – 500 018. Telangana, INDIA
Other Info - IST0025
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