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  3. Jakavi 20 mg Tablet 14's

Jakavi 20 mg Tablet 14's, Pack of 14 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Jakavi 20 mg Tablet is used in the treatment of myelofibrosis (cancer of bone marrow), polycythaemia vera (cancer of the blood), and graft-versus-host disease (GVHD, a complication of hematopoietic stem-cell transplant). It contains Ruxolitinib, which works by blocking the signals that cause cancer cells to multiply. Thereby, it helps treat myelofibrosis and polycythaemia vera. It also helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

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Composition :

RUXOLITINIB-20MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Jakavi 20 mg Tablet

Jakavi 20 mg Tablet belongs to the group of medicines called kinase inhibitors indicated in the treatment of myelofibrosis (cancer of bone marrow), polycythaemia vera (cancer of the blood), and graft-versus-host disease (GVHD, a complication of hematopoietic stem-cell transplant).

Jakavi 20 mg Tablet contains Ruxolitinib, which works by blocking the signals that cause cancer cells to multiply. Thereby, it helps treat myelofibrosis and polycythaemia vera. Jakavi 20 mg Tablet helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

In some cases, Jakavi 20 mg Tablet may cause side effects such as dizziness, headache, weight gain, fever, and constipation. Most of these side effects may not require medical attention and resolve over time. Talk with your doctor if any of the side effects persist or worsen.

Let the doctor know if you are allergic to any components in Jakavi 20 mg Tablet . This medicine is not recommended during pregnancy and breastfeeding. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Jakavi 20 mg Tablet

Jakavi 20 mg Tablet is used in the treatment of Myelofibrosis, polycythaemia vera (PV), and graft-versus-host disease (GVHD). The detailed uses of Jakavi 20 mg Tablet are as follows:<br/>• Treat myelofibrosis (MF): Jakavi 20 mg Tablet is used for intermediate or high-risk primary myelofibrosis, post-polycythemia vera MF, and post-essential thrombocythemia MF. It helps reduce spleen size and alleviate symptoms like fatigue and bone pain.<br/>• Manage polycythemia vera (PV): Jakavi 20 mg Tablet is used for patients who are intolerant to or have an inadequate response to hydroxyurea. It controls elevated red blood cell counts and reduces thrombotic risk.<br/>• Treat graft-versus-host disease (GVHD): Jakavi 20 mg Tablet is used in steroid-refractory acute and chronic GVHD in patients aged 12 years and older. It suppresses immune overactivity and reduces inflammation.<br/>

Directions for Use

• Take Jakavi 20 mg Tablet with or without food or as advised by a doctor.• Recommended to take twice daily or as advised by your doctor.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Jakavi 20 mg Tablet belongs to the group of medicines called kinase inhibitors indicated in the treatment of myelofibrosis and polycythaemia vera in adults. It is also used to treat graft-versus-host disease in adults and children above 12 years of age. Jakavi 20 mg Tablet contains Ruxolitinib, which works by blocking the action of Janus-associated kinase enzymes, reduces the size of the spleen in patients with myelofibrosis and relieves symptoms like fever, bone pain, night sweats, and weight loss. Jakavi 20 mg Tablet selectively blocks enzymes called Janus Associated Kinases (JAK1 and JAK2); this helps relieve the symptoms, reduce spleen size and the volume of red blood cells produced in patients with polycythaemia vera, thus potentially reducing the risk of serious blood or vascular complications. Jakavi 20 mg Tablet reduces signs and symptoms of the acute and chronic forms of graft-versus-host disease, leading to disease improvement and survival of the transplanted cells.

How Jakavi 20 mg Tablet Works

Jakavi 20 mg Tablet contains Ruxolitinib, which works by blocking the signals that cause cancer cells to multiply. Thereby, it helps treat myelofibrosis and polycythaemia vera. Jakavi 20 mg Tablet helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Jakavi 20 mg Tablet out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Jakavi 20 mg Tablet
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Jakavi 20 mg Tablet

Do not take more than prescribed dose. Using more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you may have overdosed of Jakavi 20 mg Tablet , please go to the emergency department of the closest hospital or nursing home.

Drug Warnings

Do not take Jakavi 20 mg Tablet if you are allergic to any of its components or if you are pregnant/breastfeeding. Inform the doctor if you have/had infections, tuberculosis, hepatitis B, kidney or liver problems, skin cancer, HIV or AIDS, anaemia, blood clots, heart attack or stroke, shingles, heart problems, high cholesterol, low blood count, if you smoke or if you are on dialysis. Seek medical attention if you experience symptoms of blood disorder (unexpected bleeding/bruising, shortness of breath, frequent infections, unusual tiredness or pale skin), infections (fever and chills), tuberculosis (chronic cough with blood-tinged sputum, night sweats, fever, and weight loss), serious brain infection (confusion or difficulty thinking, difficulty walking or loss of balance, difficulty speaking, weakness, blurred vision or loss of vision), shingles (painful skin rash with blisters), or skin cancer (any changes in skin). Let the doctor know if you are taking any other medicines, including supplements or herbal products.

Drug-Drug Interactions

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RuxolitinibClarithromycin
Severe
RuxolitinibPonatinib
Severe

Drug-Drug Interactions

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RuxolitinibClarithromycin
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Clarithromycin may boost the blood levels and effects of Jakavi 20 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Jakavi 20 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body pains. Do not stop using any medications without a doctor's advice.
RuxolitinibPonatinib
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Jakavi 20 mg Tablet and Ponatinib together may increase the risk of bleeding.

How to manage the interaction:
Although taking Jakavi 20 mg Tablet and Ponatinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without consulting doctor.
RuxolitinibBaricitinib
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Coadministration of baricitinib and Jakavi 20 mg Tablet can increase the risk of developing infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Jakavi 20 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
RuxolitinibClozapine
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Co-administration of clozapine with Jakavi 20 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Clozapine and Jakavi 20 mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, sore throat, or muscle aches, pain while urinating, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
RuxolitinibEdoxaban
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Jakavi 20 mg Tablet and edoxaban together with Jakavi 20 mg Tablet may increase the risk of bleeding.

How to manage the interaction:
Although taking Jakavi 20 mg Tablet and Edoxaban together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without consulting doctor.
RuxolitinibPosaconazole
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Jakavi 20 mg Tablet and Posaconazole may increase the blood levels and effects of Jakavi 20 mg Tablet.

How to manage the interaction:
Co-administration of Jakavi 20 mg Tablet with Posaconazole can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body aches. Do not stop using any medications without a doctor's advice.
RuxolitinibEnoxaparin
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking enoxaparin with Jakavi 20 mg Tablet can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Enoxaparin with Jakavi 20 mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like bleeding, bruising, dizziness, severe headaches, black or tarry stools, weakness, and vomiting other symptoms to watch out for include black or tarry stools, weakness, and vomiting. Do not discontinue any medications without consulting a doctor.
RuxolitinibCobicistat
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Jakavi 20 mg Tablet and Cobicistat may increase the blood levels of Jakavi 20 mg Tablet.

How to manage the interaction:
Although taking Jakavi 20 mg Tablet and Cobicistat together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body pains. Do not stop using any medications without consulting a doctor.
RuxolitinibLeflunomide
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Jakavi 20 mg Tablet together with Leflunomide may increase the risk of infections.

How to manage the interaction:
Although taking Leflunomide and Jakavi 20 mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RuxolitinibVoclosporin
Severe
How does the drug interact with Jakavi 20 mg Tablet:
Taking Jakavi 20 mg Tablet together with Voclosporin may increase the risk of infections.

How to manage the interaction:
Although taking Jakavi 20 mg Tablet and Voclosporin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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RUXOLITINIB-20MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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RUXOLITINIB-20MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Grape fruit or grapefruit juice with Jakavi 20 mg Tablet may increase the blood levels of Jakavi 20 mg Tablet. Although there is a possible interaction, Jakavi 20 mg Tablet can be taken if prescribed by a doctor. Contact a doctor if you have any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bleeding or bruises, fever, chills, sore throat, body pains, or other flu-like symptoms. Do not stop taking the medication without consulting a doctor.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables, whole grains and fruits in your diet.
  • Get optimal sleep; rest well.
  • Limit fast food, processed meat, salty snacks, highly processed foods and beverages.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Jakavi 20 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol interacts with Jakavi 20 mg Tablet . Please consult the doctor.

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Pregnancy

Unsafe

Ruxolitinib belongs to pregnancy category C. Do not take Jakavi 20 mg Tablet if you are pregnant. Consult the doctor if you are pregnant, planning for pregnancy or if you think you are pregnant.

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Breast Feeding

Unsafe

It is not known if Ruxolitinib passes into breast milk. Avoid breastfeeding while on treatment with Jakavi 20 mg Tablet and for 2 weeks after the last dose.

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Driving

Caution

If you experience dizziness after taking Jakavi 20 mg Tablet , avoid driving or operating heavy machinery.

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Liver

Caution

Dose adjustment may be needed in patients with hepatic impairment. If you have a history of liver problems, inform the doctor before taking Jakavi 20 mg Tablet .

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Kidney

Caution

Dose adjustment may be needed in patients with moderate or severe renal impairment. It may not be recommended for patients with end-stage renal disease not requiring dialysis. If you have a history of kidney problems, inform the doctor before taking Jakavi 20 mg Tablet .

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Children

Unsafe

Jakavi 20 mg Tablet is not intended for use by children below 18 years for the treatment of myelofibrosis or polycythaemia vera. For graft-versus-host disease, this medicine is not recommended for children below 12 years as the safety and effectiveness have not been established.

Have a query?

FAQs

Jakavi 20 mg Tablet is used to treat Myelofibrosis, polycythaemia vera (PV), and graft-versus-host disease (GVHD).

Jakavi 20 mg Tablet helps treat myelofibrosis and polycythaemia vera by blocking the signals that cause cancer cells to multiply. It helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

Jakavi 20 mg Tablet may decrease your ability to fight infections and increase the risk of serious infection. Consult the doctor if you develop signs of infection such as fever, chills, sweats, sore throat, cough, sore, or frequent/urgent/painful urination.

Do not start a new medicine, including prescription medicines, non-prescription medicines and herbal or supplement medicines, whilst on treatment with Jakavi 20 mg Tablet without consulting your doctor.

Jakavi 20 mg Tablet may increase the risk of developing tuberculosis (TB), particularly if you are already infected with TB but do not have any symptoms. Inform the doctor if you have had TB or if you experience symptoms of TB like cough, cough with blood or mucus, weight loss, weakness or tiredness, loss of appetite, chills, fever, or night sweats.

Country of origin

Switzerland

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - JAK0008

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.7786.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202192lbl.pdf
  3. https://www.novartis.com/sg-en/sites/novartis_sg/files/Jakavi-Oct.SIN2020v1-app070622-pdf.pdf
  4. https://medlineplus.gov/druginfo/meds/a612006.html
  5. https://www.drugs.com/mtm/ruxolitinib.html

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