Jakavi 20 mg Tablet belongs to the group of medicines called kinase inhibitors indicated in the treatment of myelofibrosis (cancer of bone marrow), polycythaemia vera (cancer of the blood), and graft-versus-host disease (GVHD, a complication of hematopoietic stem-cell transplant).

Jakavi 20 mg Tablet contains Ruxolitinib, which works by blocking the signals that cause cancer cells to multiply. Thereby, it helps treat myelofibrosis and polycythaemia vera. Jakavi 20 mg Tablet helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

In some cases, Jakavi 20 mg Tablet may cause side effects such as dizziness, headache, weight gain, fever, and constipation. Most of these side effects may not require medical attention and resolve over time. Talk with your doctor if any of the side effects persist or worsen.

Let the doctor know if you are allergic to any components in Jakavi 20 mg Tablet . This medicine is not recommended during pregnancy and breastfeeding. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Jakavi 20 mg Tablet is used in the treatment of Myelofibrosis, polycythaemia vera (PV), and graft-versus-host disease (GVHD). The detailed uses of Jakavi 20 mg Tablet are as follows:

• Treat myelofibrosis (MF): Jakavi 20 mg Tablet is used for intermediate or high-risk primary myelofibrosis, post-polycythemia vera MF, and post-essential thrombocythemia MF. It helps reduce spleen size and alleviate symptoms like fatigue and bone pain.
• Manage polycythemia vera (PV): Jakavi 20 mg Tablet is used for patients who are intolerant to or have an inadequate response to hydroxyurea. It controls elevated red blood cell counts and reduces thrombotic risk.
• Treat graft-versus-host disease (GVHD): Jakavi 20 mg Tablet is used in steroid-refractory acute and chronic GVHD in patients aged 12 years and older. It suppresses immune overactivity and reduces inflammation.

• Take Jakavi 20 mg Tablet with or without food or as advised by a doctor.
• Recommended to take twice daily or as advised by your doctor.
• Swallow the medicine as a whole with a glass of water.
• Do not crush, break, or chew it.

Jakavi 20 mg Tablet belongs to the group of medicines called kinase inhibitors indicated in the treatment of myelofibrosis and polycythaemia vera in adults. It is also used to treat graft-versus-host disease in adults and children above 12 years of age. Jakavi 20 mg Tablet contains Ruxolitinib, which works by blocking the action of Janus-associated kinase enzymes, reduces the size of the spleen in patients with myelofibrosis and relieves symptoms like fever, bone pain, night sweats, and weight loss. Jakavi 20 mg Tablet selectively blocks enzymes called Janus Associated Kinases (JAK1 and JAK2); this helps relieve the symptoms, reduce spleen size and the volume of red blood cells produced in patients with polycythaemia vera, thus potentially reducing the risk of serious blood or vascular complications. Jakavi 20 mg Tablet reduces signs and symptoms of the acute and chronic forms of graft-versus-host disease, leading to disease improvement and survival of the transplanted cells.

Do not take Jakavi 20 mg Tablet if you are allergic to any of its components or if you are pregnant/breastfeeding. Inform the doctor if you have/had infections, tuberculosis, hepatitis B, kidney or liver problems, skin cancer, HIV or AIDS, anaemia, blood clots, heart attack or stroke, shingles, heart problems, high cholesterol, low blood count, if you smoke or if you are on dialysis. Seek medical attention if you experience symptoms of blood disorder (unexpected bleeding/bruising, shortness of breath, frequent infections, unusual tiredness or pale skin), infections (fever and chills), tuberculosis (chronic cough with blood-tinged sputum, night sweats, fever, and weight loss), serious brain infection (confusion or difficulty thinking, difficulty walking or loss of balance, difficulty speaking, weakness, blurred vision or loss of vision), shingles (painful skin rash with blisters), or skin cancer (any changes in skin). Let the doctor know if you are taking any other medicines, including supplements or herbal products.