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compositionComposition:RUXOLITINIB-5MG
prescription
Prescription Medicine
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Jakavi 5 mg Tablet is used in the treatment of myelofibrosis (cancer of bone marrow), polycythaemia vera (cancer of the blood), and graft-versus-host disease (GVHD, a complication of hematopoietic stem-cell transplant). It contains Ruxolitinib, which works by blocking the signals that cause cancer cells to multiply. Thereby, it helps treat myelofibrosis and polycythaemia vera. It also helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RUXOLITINIB-5MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Jakavi 5 mg Tablet

Jakavi 5 mg Tablet is a prescription medicine used to treat specific bone marrow disorders and immune system complications. It is primarily prescribed for myelofibrosis, polycythaemia vera when other treatments have failed, and certain types of graft-versus-host disease. This medicine targets specific proteins in the body to help control the abnormal production of blood cells and calm severe inflammation.

To get the best results, you must take Jakavi 5 mg Tablet consistently every day, typically twice a day as directed by your healthcare provider. You can take this medicine with or without food, which makes it easy to fit into your daily routine. Adopting simple lifestyle changes, such as eating a balanced diet, staying well-hydrated, and taking steps to avoid exposure to germs, can further support your health while on this treatment.

While taking Jakavi 5 mg Tablet , you may experience common side effects like bruising, dizziness, headaches, or low blood cell counts. However, it is vital to contact your doctor immediately if you develop any signs of serious complications. These include severe or unusual bleeding, persistent fevers, or a painful, blistering skin rash.

Before you begin this treatment, tell your doctor if you have a history of tuberculosis, hepatitis B, liver damage, or kidney disease. Do not take this if you are allergic to any of its ingredients or have a severe, active infection. Your healthcare team will evaluate your medical history to ensure this medication is safe for you.

This medicine can interact with certain substances, such as grapefruit juice, and other prescription medications that alter how your liver breaks down drugs. Pregnant or breastfeeding women should consult their doctor before starting this medicine, as it can cause harm to a developing baby. Elderly individuals should also talk to their healthcare provider to see if any special monitoring is necessary.

Uses of Jakavi 5 mg Tablet

Jakavi 5 mg Tablet is used to treat specific bone marrow disorders and immune system complications. The detailed uses of Jakavi 5 mg Tablet are as follows:

  • Myelofibrosis: This is a serious bone marrow disorder where scar tissue replaces normal bone marrow, leading to an enlarged spleen, severe fatigue, and low blood cell counts. Jakavi 5 mg Tablet helps by shrinking the spleen and relieving constitutional symptoms like night sweats, bone pain, and itching.
  • Polycythaemia Vera: In this condition, the bone marrow produces too many red blood cells, which thickens the blood and increases the risk of clots. Jakavi 5 mg Tablet is prescribed for patients who do not respond to or cannot tolerate standard therapies, helping to regulate blood cell production and reduce spleen size.
  • Graft-versus-Host Disease (GvHD): This complication occurs after a stem cell or bone marrow transplant when the donor's immune cells attack the recipient's organs. Jakavi 5 mg Tablet helps by calming the overactive donor immune cells, reducing damage to the skin, liver, and digestive system in both acute and chronic forms of the condition.

Key Benefits

Jakavi 5 mg Tablet helps treat certain bone marrow and immune-related disorders by targeting abnormal signalling that drives disease activity. By reducing disease burden and controlling inflammation, it can improve both physical symptoms and overall quality of life.

  • Helps Reduce Enlarged Spleen: In conditions such as myelofibrosis and polycythaemia vera, Jakavi 5 mg Tablet can help shrink an enlarged spleen, relieving abdominal pressure, pain, early fullness after meals, and discomfort during movement.
  • Relieves Systemic Symptoms: By controlling disease activity, Jakavi 5 mg Tablet may help reduce symptoms such as fatigue, night sweats, itching, bone pain, and other symptoms that commonly interfere with daily life.
  • Supports Immune Control After Transplant: In appropriate transplant settings, Jakavi 5 mg Tablet helps calm excessive immune activity, reducing the risk of immune-related tissue damage and supporting a more stable recovery.
Side effects of Jakavi 5 mg Tablet
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.

Directions for Use

  • Take Jakavi 5 mg Tablet with or without food or as advised by a doctor.
  • Recommended to take twice daily or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Jakavi 5 mg Tablet Works

Jakavi 5 mg Tablet contains ruxolitinib, which belongs to a class of medicines called JAK inhibitors. It works by blocking the activity of specific enzymes in the body known as Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2). These enzymes act like communication switches, sending signals that tell the bone marrow to produce blood cells and trigger inflammatory responses. In conditions like myelofibrosis and polycythaemia vera, these JAK pathways become overactive, causing the body to produce too many abnormal blood cells and trigger severe, widespread inflammation. By blocking these signals, Jakavi 5 mg Tablet calms this overactivity. This process helps normalise blood cell production, shrinks an enlarged spleen, and reduces the inflammatory signals that cause debilitating symptoms.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Jakavi 5 mg Tablet . Please consult the doctor.

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Pregnancy

Unsafe

Ruxolitinib belongs to pregnancy category C. Do not take Jakavi 5 mg Tablet if you are pregnant. Consult the doctor if you are pregnant, planning for pregnancy or if you think you are pregnant.

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Breast Feeding

Unsafe

It is not known if Ruxolitinib passes into breast milk. Avoid breastfeeding while on treatment with Jakavi 5 mg Tablet and for 2 weeks after the last dose.

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Driving

Caution

If you experience dizziness after taking Jakavi 5 mg Tablet , avoid driving or operating heavy machinery.

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Liver

Caution

Dose adjustment may be needed in patients with hepatic impairment. If you have a history of liver problems, inform the doctor before taking Jakavi 5 mg Tablet .

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Kidney

Caution

Dose adjustment may be needed in patients with moderate or severe renal impairment. It may not be recommended for patients with end-stage renal disease not requiring dialysis. If you have a history of kidney problems, inform the doctor before taking Jakavi 5 mg Tablet .

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Children

Unsafe

Jakavi 5 mg Tablet is not intended for use by children below 18 years for the treatment of myelofibrosis or polycythaemia vera. For graft-versus-host disease, this medicine is not recommended for children below 12 years as the safety and effectiveness have not been established.

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Heart

Caution

Jakavi 5 mg Tablet may be used in heart patients, but only with close monitoring due to risks like blood clots and changes in blood pressure. Your doctor will evaluate your condition and adjust treatment to minimize complications.

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Geriatrics

Caution

Geriatric patients can take Jakavi 5 mg Tablet , but with careful monitoring. While age alone isn’t a barrier, older adults may face higher risks of anemia, low platelet counts, and infections, so doctors typically adjust the dose and track blood levels regularly.

What if I have taken an overdose of Jakavi 5 mg Tablet

If you suspect an overdose or if someone else has taken too much of this medicine, seek emergency medical care immediately. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid grapefruit, grapefruit juice, and Seville oranges while taking this medicine, as they can raise the levels of the drug in your body to unsafe levels.
  • Wash your hands frequently and stay away from crowds or individuals who are sick, as this medicine can lower your immune system and make you more prone to catching infections.
  • Protect your skin from sun exposure by wearing long sleeves, a wide-brimmed hat and applying a high SPF broad-spectrum sunscreen daily, as this treatment can increase your risk of certain skin cancers.
  • Keep all your scheduled medical appointments and blood tests so your healthcare team can monitor your blood counts and general health closely.
health query

Have a query?

How Soon It Starts Working

The time required for Jakavi 5 mg Tablet to start to work: Jakavi 5 mg Tablet ideally shows its action within 1 to 2 hours minutes after administration. The time for which the effects of Jakavi 5 mg Tablet last: The duration of action for Jakavi 5 mg Tablet is unknown.

What if you forget to take Jakavi 5 mg Tablet

If you miss a dose, skip the missed dose entirely and take your next dose at your regularly scheduled time. Do not take an extra tablet or double your dose to make up for the one you missed.

Storage

•Store Jakavi 5 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Do not stop taking Jakavi 5 mg Tablet abruptly, as your spleen may enlarge rapidly and your symptoms could return with severe intensity.
  • Always tell any healthcare professional treating you, including dentists and surgeons, that you are taking this medicine.
  • Monitor your body for any new, changing, or unusual skin marks, moles, or growths, and report them to your doctor right away.
  • Check your skin regularly for any painful rashes, tingling, or blisters on one side of your body, which could indicate a shingles infection.
  • Ensure your doctor knows if you have ever had tuberculosis or hepatitis B, as this medicine can cause these dormant infections to become active again.

Drug-Drug Interactions

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  • Strong CYP3A4 inhibitors: Medicines such as ketoconazole, clarithromycin, and ritonavir can slow down how your body breaks down Jakavi 5 mg Tablet , leading to higher levels in your blood and increasing the risk of severe side effects.
  • Strong CYP3A4 inducers: Medicines like rifampin, phenytoin, and carbamazepine can make your body break down Jakavi 5 mg Tablet too quickly, reducing its effectiveness.
RuxolitinibVoclosporin
Severe
RuxolitinibClarithromycin
Severe

Drug-Drug Interactions

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RuxolitinibVoclosporin
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet together with Voclosporin may increase the risk of infections.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Voclosporin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RuxolitinibClarithromycin
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Clarithromycin may boost the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Jakavi 5 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body pains. Do not stop using any medications without a doctor's advice.
RuxolitinibKetoconazole
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet with ketoconazole may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Ketoconazole and Jakavi 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience paleness, tiredness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body pains, or other flu-like symptoms, consult with a doctor immediately. Do not stop using any medications without a doctor's advice.
RuxolitinibRivaroxaban
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Co-administration of Jakavi 5 mg Tablet and Rivaroxaban can increase the risk or severity of bleeding problems.

How to manage the interaction:
Co-administration of Jakavi 5 mg Tablet and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
RuxolitinibFosamprenavir
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet with Fosamprenavir may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Fosamprenavir together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Do not stop using any medications without consulting doctor.
RuxolitinibPonatinib
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and Ponatinib together may increase the risk of bleeding.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Ponatinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without consulting doctor.
RuxolitinibFluconazole
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Co-administration of Jakavi 5 mg Tablet with Fluconazole may increase the blood levels of Jakavi 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Fluconazole can be taken with Jakavi 5 mg Tablet if prescribed by the doctor. Consult the doctor if you experience signs and symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms. Do not discontinue the medications without consulting a doctor.
RuxolitinibCertolizumab
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet together with Certolizumab may increase the risk of infections.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Certolizumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loos stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
RuxolitinibEdoxaban
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and edoxaban together with Jakavi 5 mg Tablet may increase the risk of bleeding.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Edoxaban together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without consulting doctor.
RuxolitinibBoceprevir
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and Boceprevir may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Boceprevir together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Do not stop taking any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Seville Oranges: Eating these fruits or drinking their juice can interfere with the enzymes that break down Jakavi 5 mg Tablet , significantly increasing the drug's levels in your bloodstream.
RUXOLITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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RUXOLITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Grape fruit or grapefruit juice with Jakavi 5 mg Tablet may increase the blood levels of Jakavi 5 mg Tablet. Although there is a possible interaction, Jakavi 5 mg Tablet can be taken if prescribed by a doctor. Contact a doctor if you have any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bleeding or bruises, fever, chills, sore throat, body pains, or other flu-like symptoms. Do not stop taking the medication without consulting a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

FAQs

Jakavi 5 mg Tablet is used to treat Myelofibrosis, polycythaemia vera (PV), and graft-versus-host disease (GVHD).
Jakavi 5 mg Tablet helps treat myelofibrosis and polycythaemia vera by blocking the signals that cause cancer cells to multiply. It helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.
Jakavi 5 mg Tablet may decrease your ability to fight infections and increase the risk of serious infection. Consult the doctor if you develop signs of infection such as fever, chills, sweats, sore throat, cough, sore, or frequent/urgent/painful urination.
Do not start a new medicine, including prescription medicines, non-prescription medicines and herbal or supplement medicines, whilst on treatment with Jakavi 5 mg Tablet without consulting your doctor.
Jakavi 5 mg Tablet may increase the risk of developing tuberculosis (TB), particularly if you are already infected with TB but do not have any symptoms. Inform the doctor if you have had TB or if you experience symptoms of TB like cough, cough with blood or mucus, weight loss, weakness or tiredness, loss of appetite, chills, fever, or night sweats.
It is best to avoid or limit alcohol while on this medicine, especially if you have a history of liver damage. Alcohol can strain your liver, which is responsible for processing this medication. Talk to your doctor or pharmacist about what is safe for you.
No, this medicine is not a cure. It is designed to manage and control the symptoms, shrink an enlarged spleen, and improve your daily quality of life. Talk to your doctor to understand your overall treatment plan.
You should avoid "live" vaccines (such as those for yellow fever, shingles, or certain measles vaccines) while taking this medicine. Because your immune system may be weakened, live vaccines could cause a serious infection. Talk to your doctor or pharmacist before scheduling any vaccinations.
A fever can be an early sign of a serious infection, and because this medicine lowers your body's defence system, you should treat this seriously. Contact your doctor or seek medical care immediately. Talk to your doctor about other warning signs of infection to watch for.
No, this medicine is not recommended during pregnancy because it can harm an unborn baby. You should also avoid breastfeeding while taking this medicine and for a period after your last dose. Talk to your doctor or pharmacist to discuss safe alternative treatments and reliable birth control options.
Mild hair thinning or hair loss is a less common side effect, but it has been reported by some patients. If you notice significant hair changes that worry you, talk to your doctor or pharmacist for reassurance and guidance.
This medicine can reduce the number of red blood cells, white blood cells, and platelets in your blood. Regular blood tests allow your healthcare provider to monitor these levels and adjust your dose safely if your counts drop too low. Talk to your doctor if you have concerns about your test results.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.7786 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 202192Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A612006 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Ruxolitinib Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Ruxolitinib [Prescribing Information]. 2011. [Accessed on 27 Mar. 2019]Check here
  6. Ruxolitinib [Prescribing Information]. 2018. [Accessed on 27Mar. 2019]Check here
  7. Jakavi Oct.Sin2020V1 App070622 Pdf. [Accessed on 02 Jun. 2026]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - JAK0015
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