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compositionComposition:DEFERIPRONE-250MG
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Kelfer-250Mg Capsule is used to treat iron overload caused by frequent blood transfusions in patients with thalassemia syndromes (inherited blood disorders) when current chelation therapy is inadequate.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DEFERIPRONE-250MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Kelfer-250Mg Capsule

Kelfer-250Mg Capsule is a medicine used to reduce excess iron in the body. Iron overload can develop in people who receive frequent blood transfusions, including people with thalassaemia and certain other blood disorders. Too much iron can gradually damage organs such as the heart and liver, so controlling iron levels is an important part of long-term treatment.

Take this medicine exactly as prescribed by your doctor. It can generally be taken with or without food. Taking it with food may help if you experience nausea or stomach discomfort.

Some people may experience nausea, stomach discomfort, joint pain, or reddish-brown urine. One of the most important risks is a severe reduction in neutrophils, which are white blood cells that help fight infection. Consult your doctor right away if you develop fever, sore throat, chills, mouth sores, or other signs of infection.

Before starting treatment, tell your doctor if you have previously had low white blood cell counts, frequent infections, or liver or kidney problems. Regular blood tests are important during treatment to monitor your white blood cell count, iron levels, and other health measures.

Tell your doctor about all medicines, antacids, vitamins, minerals, and supplements you take. Also tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as this medicine may harm an unborn baby and may not be suitable during breastfeeding.

Uses of Kelfer-250Mg Capsule

Your doctor may prescribe Kelfer-250Mg Capsule to help manage the following condition:

  • Iron overload: Helps remove excess iron that can build up in the body after repeated blood transfusions, particularly when iron-removing treatment is needed to prevent or reduce iron-related organ damage.

Key Benefits

Kelfer-250Mg Capsule helps lower excess iron levels and reduces the harmful effects of long-term iron accumulation.

  • Protects organs from excess iron: Lowering iron levels helps reduce iron-related damage to organs such as the heart and liver.
  • Supports long-term iron control: The treatment can help keep iron levels within the target range set by your healthcare team.
Side effects of Kelfer-250Mg Capsule
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Take Kelfer-250Mg Capsule with food to prevent stomach upset.
  • Recommended to take two or three times daily or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Kelfer-250Mg Capsule Works

Kelfer-250Mg Capsule contains deferiprone, a type of medicine called an iron chelator, meaning a medicine that binds to excess iron. After deferiprone enters the body, it attaches to excess iron and forms a compound that the body can remove. Most of this bound iron is then passed out in the urine. This process gradually reduces excess iron stored in the body and helps lower the risk of damage caused by iron overload.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Kelfer-250Mg Capsule as it may make the side effects worse.

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Pregnancy

Unsafe

Deferiprone belongs to pregnancy category D. Do not take Kelfer-250Mg Capsule if you are pregnant as it may cause foetal harm.

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Breast Feeding

Unsafe

It is not known if Deferiprone passes into breast milk. Avoid breastfeeding during treatment with Kelfer-250Mg Capsule and for two weeks after the last dose.

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Driving

Safe if prescribed

Kelfer-250Mg Capsule is unlikely to affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

The safety and efficacy of Kelfer-250Mg Capsule in patients with severe liver problems have not been established. Please consult the doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult the doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

The safety and effectiveness of Kelfer-250Mg Capsule in children have not been established.

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Heart

Consult your doctor

Kelfer-250Mg Capsule should be avoided in heart patients due to risks of low white blood cells, liver stress, and potential cardiac complications. Safer iron chelation therapies are preferred under medical guidance.

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Geriatrics

Caution

Kelfer-250Mg Capsule may be used in geriatric patients, as studies have not shown age-specific limitations to its effectiveness. However, older adults may be more vulnerable to side effects like neutropenia and liver stress, so regular monitoring and cautious dosing are essential.

What if I have taken an overdose of Kelfer-250Mg Capsule

If you take more than the prescribed amount, seek medical advice promptly. Take the medicine packaging with you so healthcare professionals know what medicine and strength you have taken.

Diet & Lifestyle Advise

  • Avoid unnecessary iron supplements: Do not take iron-containing supplements or multivitamins unless your doctor recommends them.
  • Check supplements before using them: Ask your doctor before taking vitamin C or mineral supplements because they may affect iron management or interact with your treatment.
  • Eat a balanced diet: Do not severely restrict iron-containing foods unless your doctor or dietitian specifically advises you to do so.
  • Stay adequately hydrated: Drink enough fluids unless your doctor has advised you to limit your fluid intake.
  • Attend regular monitoring: Keep appointments for blood tests and iron assessments so your doctor can check how well treatment is working.
health query

Have a query?

How Soon It Starts Working

  • The time required for Kelfer-250Mg Capsule to start to work: The time required for Kelfer-250Mg Capsule to show its action is unknown.
  • The time for which the effects of Kelfer-250Mg Capsule last: The duration of action for Kelfer-250Mg Capsule is unknown.

What if you forget to take Kelfer-250Mg Capsule

If you miss a dose, take it when you remember unless it is nearly time for your next scheduled dose. If it is almost time for the next dose, skip the missed dose and continue with your usual schedule. Do not take two doses together to make up for a missed dose.

Storage

•Store Kelfer-250Mg Capsule according to the instructions on the product label or packaging, typically between 20°C and 25°C.

Drug Warnings

  • Attend blood tests regularly: Your white blood cell count must be monitored during treatment because deferiprone can cause severe neutropenia or agranulocytosis, meaning a dangerously low level of infection-fighting white blood cells.
  • Watch for signs of infection: Stop taking the medicine and contact your doctor immediately if you develop fever, sore throat, chills, mouth sores, or other signs of infection. Your blood cell count should be checked promptly.
  • Monitor your iron levels: Regular iron assessments help your doctor determine whether treatment is working and whether your dose needs to be changed.
  • Check antacids and mineral supplements: Products containing aluminium, iron, zinc, or other minerals may interact with deferiprone. Follow your doctor's instructions about how much time to leave between these products and your medicine.
  • Expect possible urine colour changes: Reddish-brown urine can occur because iron bound to deferiprone is removed through the urine. Tell your doctor if the colour change is accompanied by pain, burning, or other urinary symptoms.
  • Tell your doctor about liver problems: Liver function may need to be monitored during treatment.
  • Avoid pregnancy during treatment: This medicine may harm an unborn baby. Use effective contraception as advised by your doctor during treatment and for the recommended period after your final dose.
  • Discuss breastfeeding: Breastfeeding is generally not recommended during deferiprone treatment. Ask your doctor when it is safe to breastfeed after treatment has ended.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that can lower white blood cell counts (e.g. clozapine, carbimazole, certain chemotherapy medicines): Taking these with deferiprone may increase the risk of a serious reduction in white blood cells. Your doctor will decide whether the combination is appropriate and what monitoring is required.
  • Aluminium-containing antacids: Aluminium can bind to deferiprone and interfere with treatment. Take these products separately according to your doctor or pharmacist's instructions.
  • Mineral supplements (e.g. iron or zinc): Deferiprone can bind to certain metals. These supplements should be separated from your dose according to the instructions provided by your doctor or pharmacist.
DeferiproneValganciclovir
Severe
DeferiproneGemcitabine
Severe

Drug-Drug Interactions

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DeferiproneValganciclovir
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Taking Valganciclovir and Kelfer-250Mg Capsule may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Valganciclovir and Kelfer-250Mg Capsule, but it can be taken if prescribed by a doctor. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, trouble breathing, losing weight, or pain while peeing - contact your doctor right away. Do not stop using any medications without a doctor's advice.
DeferiproneGemcitabine
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Gemcitabine can cause higher levels of Kelfer-250Mg Capsule in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Gemcitabine and Kelfer-250Mg Capsule, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain while urinating contact a doctor right away. Do not stop using any medications without a doctor's advice.
DeferiproneMitomycin
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Kelfer-250Mg Capsule can lower white blood cell count and combining it with mitomycin which can also affect white blood cells or bone marrow function may increase the risk.

How to manage the interaction:
Although taking Mitomycin and Kelfer-250Mg Capsule together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, call a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeferipronePropylthiouracil
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Coadministration of Kelfer-250Mg Capsule with Clozapine can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Propylthiouracil and Kelfer-250Mg Capsule, you can take these medicines together if prescribed by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, or burning during urination. Do not discontinue any medications without first consulting your doctor.
DeferiproneDapsone
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Using Kelfer-250Mg Capsule together with dapsone may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Dapsone and Kelfer-250Mg Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience fever, muscle aches, shortness of breath, and pain or burning during urination, contact a doctor. Do not stop using any medications without consulting a doctor.
DeferiproneInfliximab
Severe
How does the drug interact with Kelfer-250Mg Capsule:
taking Infliximab and Kelfer-250Mg Capsule can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Infliximab and Kelfer-250Mg Capsule together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fever, chills, or muscle aches, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DeferiproneMethimazole
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Taking Methimazole with Kelfer-250Mg Capsule may increase the risk of severe infections.

How to manage the interaction:
Taking Methimazole with Kelfer-250Mg Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms - like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination - contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeferiproneBortezomib
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Coadministration of Kelfer-250Mg Capsule and bortezomib may increase the risk of infections.

How to manage the interaction:
Although using Bortezomib and Kelfer-250Mg Capsule together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, body sores, or burning during urination. Do not stop taking any medications without consulting a doctor.
DeferiproneAzacitidine
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Taking Azacitidine with Kelfer-250Mg Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Azacitidine with Kelfer-250Mg Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without talking to a doctor.
DeferiproneGanciclovir
Severe
How does the drug interact with Kelfer-250Mg Capsule:
Ganciclovir can cause higher levels of Kelfer-250Mg Capsule in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Ganciclovir and Kelfer-250Mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms - like a sore throat, fever, or muscle aches - it's important to let a doctor know right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Kelfer-250Mg Capsule when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IRON-CHELATING AGENTS]

FAQs

Kelfer-250Mg Capsule is used to remove excess iron from the body. It is used to treat iron overload caused by frequent blood transfusions in patients with thalassemia syndromes when current chelation therapy is inadequate.
Kelfer-250Mg Capsule works by attaching to iron in the body and facilitating its removal.
Kelfer-250Mg Capsule may cause reddish/brown discolouration of urine. Do not worry, as this is a very common side effect and is not harmful. However, if you have any concerns, talk to your doctor.
Maintain a gap of 4 hours between Kelfer-250Mg Capsule and mineral/vitamin supplements and antacids containing polyvalent cations like iron, aluminium, and zinc.
The common side effects of the Kelfer-250Mg Capsule are nausea, vomiting, abdominal pain, reddish/brown discoloration of urine, headache, diarrhoea. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
Deferiprone binds to excess iron, and much of this bound iron leaves your body through the urine. This can make your urine appear reddish-brown. Tell your doctor if you also have pain, burning, blood in the urine, or other unusual symptoms.
Stop taking this medicine and contact your doctor immediately. Fever, sore throat, chills, or mouth sores may indicate a serious reduction in infection-fighting white blood cells and require prompt blood testing.
Deferiprone may harm an unborn baby and should generally be avoided during pregnancy. Tell your doctor immediately if you are pregnant, think you may be pregnant, or are planning a pregnancy.
There is no universal alcohol rule that applies to everyone taking deferiprone. However, alcohol can affect the liver, and liver function may need monitoring during treatment. Ask your doctor whether alcohol is appropriate for you, particularly if you have liver problems.
Do not severely restrict iron-containing foods unless your doctor or dietitian recommends it. The main concern is avoiding unnecessary iron supplements. A balanced diet is generally appropriate.
Yes. Deferiprone can generally be taken with or without food. Taking it with food may help if it causes nausea or stomach discomfort.

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Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - KEL0149

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