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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Kelfer-500mg Capsule is used to treat iron overload caused by frequent blood transfusions in patients with thalassemia syndromes when current chelation therapy is inadequate. It contains Deferiprone, which works by attaching to iron and helps your body pass the extra iron out in the urine. Thus, it helps treat iron overload. In some cases, Kelfer-500mg Capsule may cause side effects such as nausea, vomiting, abdominal pain, and reddish/brown discolouration of the urine.

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Composition :

DEFERIPRONE-500MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Kelfer-500mg Capsule

Kelfer-500mg Capsule is indicated to remove excess iron from the body. It is used to treat iron overload caused by frequent blood transfusions in patients with thalassemia syndromes when current chelation therapy is inadequate.

Kelfer-500mg Capsule contains Deferiprone, which works by attaching to iron and helps your body pass the extra iron out in the urine. Thus, it helps treat iron overload.

In some cases, Kelfer-500mg Capsule may cause side effects such as nausea, vomiting, abdominal pain, and reddish/brown discolouration of the urine. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

If you are allergic to any components in Kelfer-500mg Capsule , please inform your doctor. Do not take Kelfer-500mg Capsule if you are pregnant or breastfeeding. The safety and effectiveness have not been established in children. Keep the doctor informed about your health condition and medications to rule out any side effects.

Uses of Kelfer-500mg Capsule

Treatment of iron overload

Directions for Use

Take Kelfer-500mg Capsule with or without food. Take Kelfer-500mg Capsule with food if you experience nausea, vomiting, or stomach upset. Swallow the medicine as a whole with water; do not crush or chew it.

Medicinal Benefits

Kelfer-500mg Capsule belongs to the group of medicines called iron chelators used to remove excess iron from the body. It is used to treat iron overload caused by frequent blood transfusions in patients with thalassemia syndromes when current chelation therapy is inadequate. Kelfer-500mg Capsule contains Deferiprone, which works by attaching to iron in the body so that it can be removed from the body. Thus, it helps treat iron overload.

How Kelfer-500mg Capsule Works

Kelfer-500mg Capsule contains Deferiprone, which works by attaching to iron and helps your body pass the extra iron out in the urine. Thus, it helps treat iron overload.

Storage

Store in a cool and dry place away from sunlight
Side effects of Kelfer-500 Capsule
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Kelfer-500mg Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Kelfer-500mg Capsule may include uncontrollable eye movements, double vision and unusual, slowed, or uncontrollable movements of any part of the body. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Kelfer-500mg Capsule if you are allergic to any of its components, if you have a very low/low blood cell count, or if you are pregnant or breastfeeding. Consult the doctor if you become pregnant during treatment with Kelfer-500mg Capsule . Stop using Kelfer-500mg Capsule and consult the doctor immediately if you experience signs of infection like fever, chills, body pain, skin sores, or sore throat. Inform the doctor if you have a weak immune system or liver or kidney disease. Let the doctor know if you are taking any prescription/non-prescription medicines, mineral/vitamin supplements or herbal products.

Drug-Drug Interactions

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DeferiproneValganciclovir
Severe
DeferiproneAzathioprine
Severe

Drug-Drug Interactions

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DeferiproneValganciclovir
Severe
How does the drug interact with Kelfer-500 Capsule:
Taking Valganciclovir and Kelfer-500 Capsule may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Valganciclovir and Kelfer-500 Capsule, but it can be taken if prescribed by a doctor. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, trouble breathing, losing weight, or pain while peeing - contact your doctor right away. Do not stop using any medications without a doctor's advice.
DeferiproneAzathioprine
Severe
How does the drug interact with Kelfer-500 Capsule:
Taking Azathioprine with Kelfer-500 Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Azathioprine and Kelfer-500 Capsule, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
DeferiproneMercaptopurine
Severe
How does the drug interact with Kelfer-500 Capsule:
Co-administration of Kelfer-500 Capsule and Mercaptopurine together can increase the risk of neutropenia.

How to manage the interaction:
Although taking Mercaptopurine and Kelfer-500 Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, contact a doctor immediately, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination. Do not discontinue any medications without consulting a doctor.
DeferiproneCarboplatin
Severe
How does the drug interact with Kelfer-500 Capsule:
Using Carboplatin with Kelfer-500 Capsule, can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Carboplatin and Kelfer-500 Capsule, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DeferiproneDasatinib
Severe
How does the drug interact with Kelfer-500 Capsule:
Using Kelfer-500 Capsule together with Dasatinib may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Dasatinib and Kelfer-500 Capsule, you can take these medicines together if prescribed by a doctor. If you're having any of these symptoms like fever, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DeferiproneLevetiracetam
Severe
How does the drug interact with Kelfer-500 Capsule:
Coadministration of Kelfer-500 Capsule with levetiracetam can increase the toxicity of the other.

How to manage the interaction:
Taking Levetiracetam with Kelfer-500 Capsule together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
DeferiproneMitomycin
Severe
How does the drug interact with Kelfer-500 Capsule:
Kelfer-500 Capsule can lower white blood cell count and combining it with mitomycin which can also affect white blood cells or bone marrow function may increase the risk.

How to manage the interaction:
Although taking Mitomycin and Kelfer-500 Capsule together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, call a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeferipronePropylthiouracil
Severe
How does the drug interact with Kelfer-500 Capsule:
Coadministration of Kelfer-500 Capsule with Clozapine can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Propylthiouracil and Kelfer-500 Capsule, you can take these medicines together if prescribed by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, or burning during urination. Do not discontinue any medications without first consulting your doctor.
DeferiproneChloramphenicol
Severe
How does the drug interact with Kelfer-500 Capsule:
Taking Chloramphenicol and Kelfer-500 Capsule may increase the risk of infections.

How to manage the interaction:
Taking Chloramphenicol with Kelfer-500 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
DeferiproneRituximab
Severe
How does the drug interact with Kelfer-500 Capsule:
Taking Rituximab with Kelfer-500 Capsule may increase the risk of infections.

How to manage the interaction:
Taking Rituximab with Kelfer-500 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Follow a well-balanced diet.
  • Reduce the intake of iron-rich foods like red meat.
  • Donate blood regularly.
  • Avoid using iron cookware.
  • Do not take vitamin C foods that are rich in iron.

Habit Forming

No

Therapeutic Class

IRON-CHELATING AGENTS
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Alcohol

Unsafe

Avoid alcohol consumption while taking Kelfer-500mg Capsule as it may make the side effects worse.

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Pregnancy

Unsafe

Deferiprone belongs to pregnancy category D. Do not take Kelfer-500mg Capsule if you are pregnant as it may cause foetal harm.

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Breast Feeding

Unsafe

It is not known if Deferiprone passes into breast milk. Avoid breastfeeding during treatment with Kelfer-500mg Capsule and for two weeks after the last dose.

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Driving

Safe if prescribed

Kelfer-500mg Capsule is unlikely to affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

The safety and efficacy of Kelfer-500mg Capsule in patients with severe liver problems have not been established. Please consult the doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult the doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and effectiveness of Kelfer-500mg Capsule in children have not been established.

FAQs

Kelfer-500mg Capsule is used to remove excess iron from the body. It is used to treat iron overload caused by frequent blood transfusions in patients with thalassemia syndromes when current chelation therapy is inadequate.

Kelfer-500mg Capsule works by attaching to iron in the body and facilitating its removal.

Kelfer-500mg Capsule may cause reddish/brown discolouration of urine. Do not worry, as this is a very common side effect and is not harmful. However, if you have any concerns, talk to your doctor.

Maintain a gap of 4 hours between Kelfer-500mg Capsule and mineral/vitamin supplements and antacids containing polyvalent cations like iron, aluminium, and zinc.

The common side effects of the Kelfer-500mg Capsule are nausea, vomiting, abdominal pain, reddish/brown discoloration of urine, headache, diarrhoea. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - KEL0142

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