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compositionComposition:ALPHA KETOANALOGUE
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Prescription Medicine
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Ketodel Tablet is used to treat chronic kidney disease. It contains Alpha Ketoanalogue, which works by lowering urea levels in the blood and improving kidney function. In some cases, this medicine may cause side effects such as increased calcium levels, nausea, vomiting, diarrhoea, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ALPHA KETOANALOGUE

Manufacturer/Marketer :

Oriva Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ketodel Tablet

Ketodel Tablet is a specialised medical nutrition therapy used to manage chronic kidney disease in patients with renal impairment. It is prescribed to prevent and treat damage caused by faulty protein metabolism when kidney function is reduced. By providing essential nutrients without overloading the kidneys with toxic waste, it helps maintain overall body function.

This medication must be taken consistently every day, exactly as prescribed, to be effective in managing kidney health. You should take Ketodel Tablet during your meals to help your body process and utilise the nutrients correctly. For the best results, it is crucial to combine this treatment with a strict, low-protein diet and regular physical activity recommended by your healthcare team.

While taking Ketodel Tablet , some people may experience mild side effects, such as a slight increase in calcium levels or mild stomach upset. If you notice signs of severe calcium buildup, such as extreme muscle weakness, confusion, or severe nausea, you must consult your doctor immediately.

Before starting Ketodel Tablet , talk to your doctor if you have any existing metabolic conditions or mineral imbalances. Do not take this medicine if you already have abnormally high calcium levels in your blood or if you have a hereditary disorder that affects how your body processes amino acids.

Avoid taking this medicine at the same time as certain antibiotics or iron supplements. The calcium salts present in the tablets can bind to these medicines in the gastrointestinal tract, reducing their absorption and effectiveness. Your doctor or pharmacist may recommend spacing these medicines by at least 2 hours. If you are pregnant, breastfeeding, or an elderly individual, consult your healthcare provider to ensure this treatment is safe for your specific needs.

Uses of Ketodel Tablet

Ketodel Tablet is used to manage chronic kidney disease in patients with renal impairment. The detailed uses of Ketodel Tablet are as follows:

  • Chronic Kidney Disease (CKD): Helps delay the progression of kidney damage in patients with moderate to severe kidney disease by reducing the accumulation of toxic waste products in the blood.
  • Uremia Prevention: Helps manage and prevent symptoms caused by the buildup of nitrogen-containing waste products in the blood, which happens when kidneys cannot filter properly.

Key Benefits

Ketodel Tablet helps support nutrition in people with chronic kidney disease who are following a low-protein diet. It provides essential amino acid precursors without adding a significant nitrogen load, helping reduce the build-up of waste products in the blood.

  • Supports Nutrition on a Low-Protein Diet: Ketodel Tablet helps provide the building blocks needed for protein synthesis while helping limit the burden on the kidneys.
  • Helps Reduce Uremic Waste: By improving the use of dietary protein and reducing nitrogen waste production, Ketodel Tablet may help lower the accumulation of toxic waste products associated with kidney disease.
  • May Help Preserve Kidney Function: Better metabolic control may help support remaining kidney function and may delay the need for dialysis in appropriate patients when used as part of a prescribed kidney care plan.
  • Improves Daily Wellbeing: By supporting nutritional status, Ketodel Tablet may help reduce fatigue, muscle cramps, poor appetite, nausea, and other symptoms related to advanced kidney disease, improving overall comfort and quality of life.
Side effects of Ketodel Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Ketodel Tablet can be taken with meals to increase absorption.
  • It is advised to take this medication three times daily or as prescribed by your doctor.
  • Swallow Ketodel Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Ketodel Tablet Works

Ketodel Tablet contains alpha-ketoanalogues, which are nitrogen-free precursors of essential amino acids. After absorption, these alpha-ketoacids undergo transamination, a process in which they accept an amino (nitrogen) group from non-essential amino acids or other nitrogen-containing compounds in the body, converting into essential amino acids. This allows the body to maintain protein synthesis without introducing additional dietary nitrogen, helping reduce the production and accumulation of nitrogenous waste while supporting nutritional status and limiting the workload on the kidneys in people following a low-protein diet.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Ketodel Tablet to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

Ketodel Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult the doctor; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Caution should be exercised, and it is advisable to consult a doctor before using it. The doctor will prescribe if the doctor thinks the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focused. If you experience drowsiness after taking this medication, you should not drive or operate machinery or vehicles.

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Liver

Consult your doctor

Inform your doctor before taking Ketodel Tablet if you have a liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Safe if prescribed

Ketodel Tablet can be taken safely if prescribed. Usually, it does not affect the kidney.

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Children

Unsafe

The safety and efficacy of Ketodel Tablet in children have not been established. Ketodel Tablet is not recommended in children.

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Heart

Caution

Ketodel Tablet is generally safe for heart patients, but they should be taken under medical supervision.

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Geriatrics

Caution

Geriatric patients may take Ketodel Tablet with caution, as age-related kidney or calcium metabolism changes require medical supervision. Always consult your doctor to ensure it's suitable for your health status and other medications.

What if I have taken an overdose of Ketodel Tablet

If you take more than the prescribed amount, seek immediate medical attention. Symptoms of an overdose may include severe nausea, vomiting, extreme thirst, or signs of high blood calcium levels.

Diet & Lifestyle Advise

  • Follow a strict low-protein or very low-protein diet under the close supervision of a clinical dietitian or your doctor to ensure the medication works as intended.
  • Ensure you consume enough daily calories from non-protein sources, such as healthy fats and carbohydrates, to prevent your body from breaking down its own muscle tissue for energy.
  • Keep all laboratory appointments to monitor your blood calcium, phosphate, and kidney function levels regularly.
  • Stay adequately hydrated, but strictly follow any fluid restriction guidelines provided by your kidney specialist.
health query

Have a query?

How Soon It Starts Working

The time required for Ketodel Tablet to start to work: The time required for Ketodel Tablet to show its action is not clinically established. 

The time for which the effects of Ketodel Tablet last: The duration of action for Ketodel Tablet is not clinically established.

What if you forget to take Ketodel Tablet

Take the missed dose as soon as you remember, provided it is during or immediately after a meal. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Ketodel Tablet at room temperature below 30°C, unless otherwise specified on the product label.

Drug Warnings

  • Always inspect the blister packaging before use; do not take the medication if the foil is broken or damaged.
  • Ensure you have your blood calcium levels checked regularly, as this medicine can cause calcium buildup.
  • Do not take calcium supplements, antacids containing calcium, or vitamin D preparations without talking to your doctor first.
  • Always take this medicine during meals to maximise its nutritional effectiveness and prevent stomach upset.

Drug-Drug Interactions

verifiedApollotooltip
  • Antibiotics and Iron: May reduce the absorption of certain antibiotics (such as tetracyclines and quinolones) and iron supplements. Space these medications at least two hours apart from Ketodel Tablet .
  • Calcium and Vitamin D: Taking this medicine alongside calcium supplements or vitamin D analogues can significantly increase the risk of high blood calcium levels.
KetoconazolePimozide
Critical
KetoconazoleEliglustat
Critical

Drug-Drug Interactions

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KetoconazolePimozide
Critical
How does the drug interact with Ketodel Tablet:
When Pimozide is taken with Ketodel Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketodel Tablet with Pimozide is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleEliglustat
Critical
How does the drug interact with Ketodel Tablet:
When Eliglustat is taken with Ketodel Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketodel Tablet with Eliglustat is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or slow heart rate, weak pulse, or heart palpitations, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleZiprasidone
Critical
How does the drug interact with Ketodel Tablet:
Taking Ketodel Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Ketodel Tablet is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, breathing difficult. Do not discontinue any medications without consulting a doctor.
KetoconazoleAlprazolam
Critical
How does the drug interact with Ketodel Tablet:
Co-administration of Alprazolam with Ketodel Tablet may considerably increase the blood levels of Alprazolam, which may result in side effects.

How to manage the interaction:
Although there is an interaction between Alprazolam and Ketodel Tablet, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
KetoconazoleAlfuzosin
Critical
How does the drug interact with Ketodel Tablet:
Using alfuzosin together with Ketodel Tablet may significantly increase the blood levels of alfuzosin, which may result in side effects.

How to manage the interaction:
Taking Alfuzosin with Ketodel Tablet is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fainting, headache, flushing, nasal congestion, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
KetoconazoleMidazolam
Critical
How does the drug interact with Ketodel Tablet:
Co-administration of Ketodel Tablet and Midazolam may increase the risk of side effects.

How to manage the interaction:
Although taking Ketodel Tablet and Midazolam together is not recommended as it may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
KetoconazoleVenetoclax
Critical
How does the drug interact with Ketodel Tablet:
When Venetoclax is taken with Ketodel Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Ketodel Tablet with Venetoclax is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. if you experience nausea, vomiting, diarrhea, fatigue, bleeding problems, and infections, consult a doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleDronedarone
Critical
How does the drug interact with Ketodel Tablet:
When Dronedarone is taken with Ketodel Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketodel Tablet with Dronedarone is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleVoclosporin
Critical
How does the drug interact with Ketodel Tablet:
When Voclosporin is taken with Ketodel Tablet, it can increase the risk of serious side effects.

How to manage the interaction:
Taking Ketodel Tablet with Voclosporin is not recommended, it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor immediately.
KetoconazoleNimodipine
Critical
How does the drug interact with Ketodel Tablet:
When Nimodipine is taken with Ketodel Tablet, it can increase the blood levels of Nimodipine which may lead to serious side effects .

How to manage the interaction:
Taking Ketodel Tablet with Nimodipine is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience -irregular heart rhythm, swelling, and low blood pressure, consult the doctor. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • High-Calcium Foods: Consuming excessive amounts of dairy products or calcium-fortified foods may increase the risk of calcium buildup in the blood.
ALPHA KETOANALOGUEGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ALPHA KETOANALOGUEGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Ketodel Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Ketodel Tablet.

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Habit Forming

No

Therapeutic Class

[NUTRITIONAL SUPPLEMENT]

FAQs

Ketodel Tablet is used in the treatment of chronic kidney disease.
Ketodel Tablet mimics the same catabolic pathways as amino acids and works by improving the body's metabolism, thereby improving renal function.
CKD is usually caused by various conditions such as high blood pressure, diabetes, high cholesterol, kidney infections, kidney inflammation, kidney stones that keep coming back, an enlarged prostate, and long-term or regular use of certain medicines such as lithium and non-steroidal anti-inflammatory drugs (NSAIDs).
CKD can be diagnosed using blood and urine tests. These tests look for high levels of certain substances in the blood and urine that show your kidneys are malfunctioning. The results of these tests can be used to determine the stage of your kidney disease.
There are usually no symptoms of kidney disease in the early stages. At a more advanced stage, symptoms can include tiredness, swollen ankles, feet or hands, shortness of breath, feeling sick, and blood in your pee (urine). It may only be diagnosed if you have a blood or urine test for another reason and the results show a possible problem with your kidneys.
No, Ketodel Tablet is not same as arginine alpha-ketoglutarate. Ketodel Tablet contains alpha ketoanalogue which is a combination of different amino acids, whereas arginine alpha-ketoglutarate is a combination of alpha-ketoglutaric acid &essential amino acid arginine.
Ketodel Tablet should be swallowed as a whole with water; do not crush or chew it.
Side effects of Ketodel Tablet include increased calcium levels, nausea, vomiting, diarrhoea, and abdominal pain. Talk to your doctor if you experience these side effects persistently.
This medicine works best when combined with a low-protein diet prescribed by your doctor. Taking it without dietary restrictions may reduce its benefits. Talk to your doctor or pharmacist about a customised diet plan.
Taking this medicine during meals helps your body absorb and use the nutrients properly to convert waste products into essential proteins. It also helps prevent stomach discomfort.
No, it cannot cure chronic kidney disease, but it helps delay the progression of the disease and reduces the accumulation of toxic waste in your blood. Talk to your doctor to understand how this fits into your overall treatment plan.
If blood tests show high calcium levels, your doctor may reduce your dose, recommend a lower-calcium diet, or temporarily stop the medication. Always follow your doctor's guidance.
There is limited safety data regarding its use during pregnancy. Talk to your doctor or pharmacist to weigh the potential benefits against any risks before starting this medicine.
Yes. The calcium salts present in this medicine can bind to iron in the gastrointestinal tract, reducing its absorption. To minimise this interaction, take iron supplements at least 2 hours before or after Ketodel Tablet or follow the schedule recommended by your doctor or pharmacist.
While there is no direct interaction, alcohol can put extra strain on your kidneys and affect your overall hydration status. It is best to consult your doctor about safe alcohol consumption.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

306, V.I.P Plaza, Plot No. 1, I.P Ext., Delhi - 110092 (India)
Other Info - KET0206

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