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compositionComposition:PEMBROLIZUMAB-100MG
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Keytruda 100 mg Injection 4 ml is an anti-cancer medicine used in the treatment of various types of cancers in both adult and paediatric populations. It contains Pembrolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death receptor-1 (PD-1), thereby stopping the abnormal growth of cancer cells. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PEMBROLIZUMAB-100MG

Manufacturer/Marketer :

Msd Pharmaceutical Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Keytruda 100 mg Injection 4 ml

Keytruda 100 mg Injection 4 ml is an advanced immunotherapy injection used to treat several types of serious or advanced cancers, including skin cancer, lung cancer, and bladder cancer. It works by helping your body's own immune system recognise and destroy cancer cells. This treatment is prescribed when other standard therapies have not worked or as a primary option to manage cancer growth.

Because this medication is given as an intravenous infusion, it is scheduled at regular intervals, typically every 3 or 6 weeks. You do not need to make any changes to your diet on the day of your infusion, and it can be received with or without food. Staying well-hydrated and consuming small, balanced meals before your appointment can help you feel more comfortable during the process.

Common side effects of this treatment include severe tiredness, mild skin rashes, itching, and nausea. Because this medicine stimulates your immune system, it can occasionally cause your body to attack normal tissues, leading to serious liver damage, lung inflammation, or severe bowel irritation. You must contact your medical team immediately if you develop a new cough, shortness of breath, severe stomach pain, or yellowing of your skin or eyes.

Before starting this treatment, discuss your medical history thoroughly with your oncologist. Do not take this if you have had a life-threatening allergic reaction to this medication in the past. It is especially important to tell your doctor if you have an active autoimmune disease, a history of lung inflammation, or have received an organ or stem cell transplant.

This medicine can interact with other treatments, particularly high-dose corticosteroids, which may lower its effectiveness by suppressing the immune system. If you are pregnant, planning to become pregnant, or breastfeeding, you must consult your doctor immediately, as this treatment can cause serious harm to an unborn baby.

Uses of Keytruda 100 mg Injection 4 ml

Your doctor may recommend this medicine to help manage the following conditions:

  • Advanced Melanoma: It helps the immune system identify and destroy skin cancer cells that have spread to other parts of the body or cannot be removed by surgery.
  • Non-Small Cell Lung Cancer (NSCLC): It assists in shrinking or slowing the growth of lung tumours, working either alone or alongside chemotherapy.
  • Urothelial Carcinoma: It targets advanced bladder and urinary tract cancers by boosting your body's natural defences to fight tumour progression.
  • Head and Neck Squamous Cell Carcinoma: It is used to manage recurrent or spreading head and neck cancers by enabling immune cells to control the spread of the disease.
  • Classical Hodgkin Lymphoma: It helps treat this specific blood cancer in adults and children when the disease has returned or failed to respond to other treatments.

Key Benefits

When taken consistently as directed, this medicine may provide the following health benefits:

  • Supports targeted cancer treatment: This medicine helps your immune system recognise and attack cancer cells more effectively. By targeting cancer cells rather than directly damaging healthy cells like traditional chemotherapy, it may help control tumour growth while reducing damage to normal tissues.
  • Helps improve quality of life: By slowing tumour growth or reducing the spread of cancer, this treatment may help relieve symptoms such as pain, breathing difficulties, or persistent cough. This can improve comfort, daily functioning, and overall well-being during treatment.
Side effects of Keytruda 100 mg Injection 4 ml
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.

Directions for Use

  • It is advised to follow your doctor's instructions on the dosage and timing of Keytruda 100 mg Injection 4 ml for effective use.
  • Keytruda 100 mg Injection 4 ml will be administered by the doctor or nurse.
  • Do not self-administer.

How Keytruda 100 mg Injection 4 ml Works

This injection contains Keytruda 100 mg Injection 4 ml. Cancer cells are highly skilled at hiding from your body's natural defence system. They often use a specific pathway called the PD-1 pathway to transmit a do not attack signal to your immune cells. This signal effectively blinds your immune system, allowing the tumour to grow unchecked. It acts as a checkpoint blocker. It binds to the PD-1 receptors on your immune cells, cutting off the cancer's ability to send the do not attack signal. By removing this biological brake, the medicine reactivates your body's own immune cells, allowing them to detect, target, and destroy the cancer cells throughout your body.
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Alcohol

Consult your doctor

It is unknown whether Keytruda 100 mg Injection 4 ml interacts with alcohol. Consult your doctor.

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Pregnancy

Unsafe

Keytruda 100 mg Injection 4 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Keytruda 100 mg Injection 4 ml. You should not become pregnant while you are taking Keytruda 100 mg Injection 4 ml for at least 4 months from the last dose of Keytruda 100 mg Injection 4 ml. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Keytruda 100 mg Injection 4 ml should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and at least for 4 months from the last dose of medicine.

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Driving

Caution

Keytruda 100 mg Injection 4 ml will be administered in the hospital setting. Driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Keytruda 100 mg Injection 4 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Keytruda 100 mg Injection 4 ml is safe for use in children above two years of age when recommended by the physician. It will be administered only if the benefits outweigh risks.

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Heart

Caution

Keytruda 100 mg Injection 4 ml may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Keytruda 100 mg Injection 4 ml.

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Geriatrics

Safe if prescribed

Keytruda 100 mg Injection 4 ml is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Keytruda 100 mg Injection 4 ml

Since this medicine is prepared and given by trained healthcare professionals in a controlled clinical environment, an accidental overdose is highly unlikely. However, if you experience sudden, severe side effects or suspect an issue with your infusion, notify the clinic staff.

Diet & Lifestyle Advise

  • Prioritise hydration: Drink plenty of water and clear fluids in the days surrounding your infusion. This helps protect your kidney function and keeps you hydrated if you experience diarrhoea.
  • Protect your skin: This treatment can make your skin more sensitive. Apply a gentle, fragrance-free moisturiser daily and use a broad-spectrum sunscreen with SPF 30 or higher when outdoors.
  • Eat small, nutrient-dense meals: If you experience nausea or a low appetite, eat 5 to 6 small meals throughout the day instead of 3 large ones. Focus on bland, high-protein foods to support your energy.
  • Practice infection safety: Wash your hands frequently, avoid crowded areas, and stay away from individuals who are sick, as your body's immune system is highly active and adjusting.
  • Balance rest with light activity: Fatigue is common. Listen to your body and rest when needed, but try to incorporate short, gentle walks into your daily routine to help maintain your strength.

Health Queries

If someone is diagnosed with melanoma, is it certain that they will die within 5 to 10 years, or can advanced treatments and medications improve their survival rate?

Veda Maddala

Veda Maddala

M Pharmacy

No, a melanoma diagnosis is absolutely not a certain death sentence. If caught early, it is highly treatable, with a 5-year survival rate over 99%. Even for advanced or metastatic melanoma, the outlook has dramatically improved. Modern treatments like immunotherapy (using generics like pembrolizumab or nivolumab) and targeted therapies (like dabrafenib) train your immune system or target specific gene mutations to fight the cancer. Many patients with advanced stages are now living long, high-quality lives, often achieving long-term remission. Your prognosis depends heavily on the tumor's specific characteristics, so discussing these advanced options with an oncologist is highly recommended.

What immunotherapy medicines are available for the treatment of food pipe (esophageal) cancer?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

For esophageal (food pipe) cancer, immunotherapy is an advanced treatment option that helps your own immune system recognize and destroy cancer cells. The main generic immunotherapy medicines used are pembrolizumab and nivolumab. In some cases, ipilimumab may also be used in combination. These medicines are typically prescribed for advanced stages of the disease, often alongside chemotherapy, or as additional therapy after surgery to help prevent the cancer from returning. They have significantly improved outcomes and offer great hope. Your oncology team will perform specific biomarker tests on your tumor to see if these treatments are the best and safest fit for you.

What are the common symptoms of cancer, and what medications or treatments are used to manage it?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Common symptoms of cancer can include unexplained weight loss, persistent fatigue, unusual lumps, or changes in the skin. However, these are often caused by common, non-cancerous conditions. Treatments depend on the cancer type and stage. They primarily include surgery, radiation, and medications. Medical treatments include chemotherapy (like cisplatin), targeted therapy, immunotherapy (like pembrolizumab), and hormone therapy (like tamoxifen). Many cancers are highly treatable today, especially when detected early. If you have any unusual or persistent symptoms, please consult your doctor for a proper evaluation.

Is chest cancer a condition that is fetal?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Although it is not always fatal, breast cancer can be extremely dangerous. When cancer is detected early and treated appropriately with surgery, medication, radiation, or other therapy, many patients make a full recovery. The cancer's stage, general health, and the speed at which therapy starts all affect the result. A breast lump, nipple alterations, skin abnormalities, or inexplicable soreness are examples of warning symptoms. The likelihood of a successful course of treatment is significantly increased by early medical evaluation and routine follow-up.
health query

Have a query?

How Soon It Starts Working

The time required for Keytruda 100 mg Injection 4 ml to start to work: The time required for Keytruda 100 mg Injection 4 ml to show its action is not clinically established. The time for which the effects of Keytruda 100 mg Injection 4 ml last: The duration of action for Keytruda 100 mg Injection 4 ml is not clinically established.

What if you forget to take Keytruda 100 mg Injection 4 ml

Because this medication is given at a clinic under a strict schedule, missing an appointment can affect your treatment. If you miss an appointment or need to reschedule, call your doctor's office immediately. The medical team will arrange the safest and quickest way to get your treatment schedule back on track.

Storage

•It is stored under strict clinical conditions before it is prepared for you.

Drug Warnings

  • Verify the solution clarity: Ensure the medical staff inspects the vial before preparation; the liquid should be clear to slightly pearly, colourless to pale yellow, and free of visible particles.
  • Report symptoms immediately: Do not wait for your next scheduled appointment to report new symptoms. Early treatment of immune-mediated side effects with steroids is vital.
  • Carry an immunotherapy alert card: Always keep a medical alert card in your wallet stating that you are receiving it so that emergency medical staff are aware of your treatment.
  • Avoid live vaccines: Do not receive any live vaccines (such as yellow fever or oral typhoid vaccines) while using this medicine, as they can cause serious complications.
  • Check your blood sugar: If you have diabetes, monitor your blood sugar levels more frequently, as this medicine can affect your endocrine system and cause sudden glucose changes.

Drug-Drug Interactions

verifiedApollotooltip
  • Systemic corticosteroids (like prednisone or dexamethasone): Taking these immune-suppressing drugs before starting it can make your cancer treatment less effective. However, they may be prescribed after you start treatment to manage immune-related side effects.
  • Immunosuppressive medications: Any drug that lowers your body's immune response can counteract the therapeutic action of this medicine.
PembrolizumabPomalidomide
Severe
PembrolizumabThalidomide
Severe

Drug-Drug Interactions

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PembrolizumabPomalidomide
Severe
How does the drug interact with Keytruda 100 mg Injection 4 ml:
Taking Keytruda 100 mg Injection 4 ml with Pomalidomide together may increase the risk of serious side effects.

How to manage the interaction:
Taking Keytruda 100 mg Injection 4 ml with Pomalidomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.
PembrolizumabThalidomide
Severe
How does the drug interact with Keytruda 100 mg Injection 4 ml:
Taking Keytruda 100 mg Injection 4 ml with thalidomide may increase the risk of serious side effects.

How to manage the interaction:
Although taking thalidomide and Keytruda 100 mg Injection 4 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
PembrolizumabBetamethasone
Severe
How does the drug interact with Keytruda 100 mg Injection 4 ml:
Taking Keytruda 100 mg Injection 4 ml with betamethasone may decrease the effects of Keytruda 100 mg Injection 4 ml, which may make the medication less effective.

How to manage the interaction:
Although there is a possibility of interaction, it can be taken if prescribed by doctor. Do not stop using any medications without consulting a doctor.
PembrolizumabLenalidomide
Severe
How does the drug interact with Keytruda 100 mg Injection 4 ml:
Using lenalidomide and Keytruda 100 mg Injection 4 ml together can increase the risk of adverse effects.

How to manage the interaction:
Taking Lenalidomide with Keytruda 100 mg Injection 4 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Keytruda 100 mg Injection 4 ml when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Keytruda 100 mg Injection 4 ml is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Metastatic Melanoma, non-small cell lung cancer, Malignant pleural mesothelioma, Stomach Cancer, Squamous cell carcinoma of the head and neck, Cervical cancer, and Urothelial carcinoma.
Keytruda 100 mg Injection 4 ml contains Pembrolizumab, which works by inhibiting the action of a PD-1 that causes the multiplication of cancerous cells.
It is given as an intravenous (IV) infusion into a vein by a trained healthcare provider in a clinic or hospital setting. The infusion typically takes about 30 minutes to complete. Talk to your doctor or pharmacist about your specific infusion schedule.
You should avoid receiving live vaccines during your treatment, as they can cause severe reactions. Inactivated vaccines are usually safe, but you must consult your healthcare provider before getting any vaccination. Talk to your doctor or pharmacist for personalised advice.
Early signs of lung inflammation include a new or worsening cough, shortness of breath, and chest pain. If you notice any of these changes, contact your medical team immediately. Talk to your doctor or pharmacist if you notice changes in your breathing.
No, it does not typically cause the widespread hair loss associated with traditional chemotherapy. Some patients may experience mild hair thinning, but complete hair loss is very rare. Talk to your doctor or pharmacist if you have concerns about skin or hair changes.
There is no direct chemical interaction between alcohol and this medicine. However, alcohol can contribute to dehydration, fatigue, and liver strain, which are important to avoid during cancer therapy. Talk to your doctor or pharmacist about safe lifestyle choices.
You should report any skin rash or itching to your healthcare team. Mild rashes can often be managed with gentle moisturisers or topical creams, but a severe or peeling rash requires urgent medical attention. Talk to your doctor or pharmacist about how to manage skin irritation.
Your doctor may test your tumour sample for markers such as PD-L1 expression, tumour mutational burden (TMB), or MSI-H/dMMR status. These tests help determine whether it is likely to work for your type of cancer and help your doctor choose the most appropriate treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 125514S066Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A614048 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Pembrolizumab Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Pembrolizumab Pembrolizumab. 2014. [Accessed on 26 Mar. 2019]Check here
  5. KEYTRUDA® (pembrolizumab) & KEYTRUDA QLEX™ (pembrolizumab and berahyaluronidase alfa. [Accessed on 02 Jun. 2026]Check here
  6. Medscape Clinical Reference. Keytruda Pembrolizumab 999962 Dosage & Guidelines. New York, NY: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  7. Pembrolizumab (Keytruda). [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Platina, 8Th Floor, C.59, G Block, Bandra Kurla Complex, Bandra (East) , Mumbai - 400098,
Other Info - KEY0037
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