For esophageal (food pipe) cancer, immunotherapy is an advanced treatment option that helps your own immune system recognize and destroy cancer cells. The main generic immunotherapy medicines used are pembrolizumab and nivolumab. In some cases, ipilimumab may also be used in combination. These medicines are typically prescribed for advanced stages of the disease, often alongside chemotherapy, or as additional therapy after surgery to help prevent the cancer from returning. They have significantly improved outcomes and offer great hope. Your oncology team will perform specific biomarker tests on your tumor to see if these treatments are the best and safest fit for you.