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  3. Lefno-20 Tablet 10's

Lefno-20 Tablet 10's, Pack of 10 TABLETS
Lefno-20 Tablet 10's, Pack of 10 TABLETS
Lefno-20 Tablet 10's, Pack of 10 TABLETS
Lefno-20 Tablet 10's, Pack of 10 TABLETS
Lefno-20 Tablet 10's, Pack of 10 TABLETS
Lefno-20 Tablet 10's, Pack of 10 TABLETS
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axis icici
bhim UPI
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefno-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefno-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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20% OFF, applicable on orders > INR 5499
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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lefno-20 Tablet

Lefno-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefno-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefno-20 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefno-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefno-20 Tablet if you are pregnant or planning for pregnancy, as Lefno-20 Tablet may cause serious congenital disabilities. Lefno-20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefno-20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefno-20 Tablet as it could lead to increased dizziness and liver damage. Lefno-20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefno-20 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefno-20 Tablet with or without food. Swallow Lefno-20 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefno-20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefno-20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefno-20 Tablet Works

Lefno-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight
Side effects of Lefno-20 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

What if I have taken an overdose of Lefno-20 Tablet

Do not take more than the prescribed dose of Lefno-20 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefno-20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefno-20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefno-20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefno-20 Tablet may cause dizziness, so drive with caution. Lefno-20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideEnalapril
Severe
LeflunomideTenofovir alafenamide
Severe

Drug-Drug Interactions

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LeflunomideEnalapril
Severe
How does the drug interact with Lefno-20 Tablet:
Enalapril has the potential to cause liver damage; this effect can be increased by the coadministration of medications that affect the liver, such as Lefno-20 Tablet. This effect can be seen even long after discontinuing Lefno-20 Tablet as it stays in your blood longer.

How to manage the interaction:
Although taking Enalapril together with Lefno-20 Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of liver damage like fever, chills, unusual bleeding, dark-coloured urine, light colour stools, yellowish discolouration of skin and eyes, and abdominal pain. It is advised not to consume alcohol while using these medications as it may increase the damage o the liver. Do not discontinue any medications without consulting your doctor.
LeflunomideTenofovir alafenamide
Severe
How does the drug interact with Lefno-20 Tablet:
Taking Lefno-20 Tablet with tenofovir alafenamide can increase the risk of liver problems.

How to manage the interaction:
Taking Lefno-20 Tablet and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomidePenicillamine
Severe
How does the drug interact with Lefno-20 Tablet:
Using penicillamine with Lefno-20 Tablet can increase the risk of low blood levels.

How to manage the interaction:
There may be a possibility of interaction between Lefno-20 Tablet and Penicillamine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideRuxolitinib
Severe
How does the drug interact with Lefno-20 Tablet:
Taking Ruxolitinib together with Lefno-20 Tablet may increase the risk of infections.

How to manage the interaction:
Although taking Lefno-20 Tablet and Ruxolitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
LeflunomideBrentuximab
Severe
How does the drug interact with Lefno-20 Tablet:
Combining Brentuximab vedotin with Lefno-20 Tablet can increase the risk of negative side effects.

How to manage the interaction:
There may be a possibility of interaction between Lefno-20 Tablet and Brentuximab, but it can be taken if prescribed by a doctor. If you notice any of these symptoms - liver problems, infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding - contact your doctor right away." Do not discontinue any medications without consulting your doctor.
LeflunomideRituximab
Severe
How does the drug interact with Lefno-20 Tablet:
Taking Rituximab with Lefno-20 Tablet can increase the risk of infections.

How to manage the interaction:
Taking Rituximab with Lefno-20 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
LeflunomideDeflazacort
Severe
How does the drug interact with Lefno-20 Tablet:
Co-administration of Deflazacort with Lefno-20 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Deflazacort and Lefno-20 Tablet, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomidePazopanib
Severe
How does the drug interact with Lefno-20 Tablet:
Taking Pazopanib with Lefno-20 Tablet can increase the risk of serious infections.

How to manage the interaction:
Although taking Lefno-20 Tablet and Pazopanib together can cause an interaction, it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideBrigatinib
Severe
How does the drug interact with Lefno-20 Tablet:
Brigatinib can cause higher levels of Lefno-20 Tablet in the blood by reducing its excretion.

How to manage the interaction:
There may be a possibility of interaction between Lefno-20 Tablet and Brigatinib, but it can be taken if prescribed by a doctor. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideParacetamol
Severe
How does the drug interact with Lefno-20 Tablet:
Co-administration of Paracetamol and Lefno-20 Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Paracetamol and Lefno-20 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefno-20 Tablet Substitute

Substitutes safety advice

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Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefno-20 Tablet . Alcohol intake, along with Lefno-20 Tablet , may cause liver disease.

bannner image

Pregnancy

Unsafe

It is not recommended to take Lefno-20 Tablet while you are pregnant. Lefno-20 Tablet may cause serious birth defects.

bannner image

Breast Feeding

Unsafe

It is not recommended to take Lefno-20 Tablet while you are breastfeeding. Lefno-20 Tablet passes into breast milk.

bannner image

Driving

Caution

Lefno-20 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefno-20 Tablet .

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefno-20 Tablet .

bannner image

Children

Unsafe

Lefno-20 Tablet is not approved for children under the age of 18 years.

Have a query?

FAQs

Lefno-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Lefno-20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Lefno-20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefno-20 Tablet . Take Lefno-20 Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - LEF0005

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_4276_003_FinalPL.pdf
  2. https://www.drugs.com/uk/leflunomide-10-mg-tablets-leaflet.html
  3. https://www.drugs.com/cdi/leflunomide.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
  5. https://www.gwh.nhs.uk/media/190756/leflunomide2.pdf
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