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compositionComposition:LITHIUM CARBONATE-400MG
prescription
Prescription Medicine
info
Lithosyn Sr 450 Tab 10'S
Lithosyn Sr 450 Tab belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

LITHIUM CARBONATE-400MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lithosyn Sr 450 Tab

Lithosyn Sr 450 Tab belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Lithosyn Sr 450 Tab contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lithosyn Sr 450 Tab as prescribed. Your doctor will advise you on how often you need to take Lithosyn Sr 450 Tab based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lithosyn Sr 450 Tab do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lithosyn Sr 450 Tab or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lithosyn Sr 450 Tab . Regular blood tests are recommended while taking Lithosyn Sr 450 Tab to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Lithosyn Sr 450 Tab .

Uses of Lithosyn Sr 450 Tab

Lithosyn Sr 450 Tab is used to manage and prevent mood disorders by stabilizing emotional fluctuations. The detailed uses of Lithosyn Sr 450 Tab are as follows:

  • Treatment of mania: Lithosyn Sr 450 Tab is used to control abnormal hyperactivity and unstable mood associated with manic episodes.
  • Management of bipolar depression: Lithosyn Sr 450 Tab stabilizes mood swings in individuals with bipolar disorder, reducing episodes of depression and mania.
  • Prevention of recurrent affective disorders: Lithosyn Sr 450 Tab is indicated to reduce the frequency and severity of recurrent depression.

Key Benefits

Lithosyn Sr 450 Tab is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lithosyn Sr 450 Tab contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lithosyn Sr 450 Tab relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

Directions for Use

  • Take Lithosyn Sr 450 Tab with food for better absorption, or take it as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Lithosyn Sr 450 Tab Works

Lithosyn Sr 450 Tab contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lithosyn Sr 450 Tab as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Lithosyn Sr 450 Tab is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Lithosyn Sr 450 Tab as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

Lithosyn Sr 450 Tab may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lithosyn Sr 450 Tab .

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Liver

Safe if prescribed

Lithosyn Sr 450 Tab is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Lithosyn Sr 450 Tab with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lithosyn Sr 450 Tab is not recommended for patients with severe kidney problems.

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Children

Caution

Lithosyn Sr 450 Tab is generally not recommended for children below 12 years. However, Lithosyn Sr 450 Tab may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

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Heart

Unsafe

Lithosyn Sr 450 Tab should not be used in patients with severe heart disease. It should be taken only after seeking advice from your doctor, especially if you have or have had any heart problems.

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Geriatrics

Caution

Lithosyn Sr 450 Tab should be given with caution in elderly patients due to an increased risk of side effects. Please inform your doctor before use.

What if I have taken an overdose of Lithosyn Sr 450 Tab

Take Lithosyn Sr 450 Tab only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Lithosyn Sr 450 Tab .
  • Do regular exercise and maintain a stable weight as Lithosyn Sr 450 Tab may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Have a query?

How Soon It Starts Working

The time required for Lithosyn Sr 450 Tab to start to work: The time required for Lithosyn Sr 450 Tab to show its action is unknown. The time for which the effects of Lithosyn Sr 450 Tab last: The duration of action for Lithosyn Sr 450 Tab is unknown.

What if you forget to take Lithosyn Sr 450 Tab

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue back to your regular dosage routine. Avoid taking two doses at once.

Storage

• Store in a cool and dry place away from sunlight. • Keep Lithosyn Sr 450 Tab out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Regular blood tests are recommended while taking Lithosyn Sr 450 Tab to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lithosyn Sr 450 Tab . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lithosyn Sr 450 Tab as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

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Drug-Drug Interaction: Lithosyn Sr 450 Tab may have interaction with high blood pressure-lowering medicines (ramipril, lisinopril, methyldopa, amlodipine, diltiazem), pain killers (ibuprofen, diclofenac, celecoxib, indomethacin), asthma drugs (theophylline), antipsychotics (olanzapine, haloperidol, clozapine, sertindole), fits related drugs (phenytoin, clonazepam, carbamazepine), heart-related medicines (quinidine, amiodarone, propafenone, ranolazine, procainamide, disopyramide, hydroquinidine, ibutilide, sotalol, dofetilide), antidepressants (paroxetine, amitriptyline, fluoxetine), antibiotics (trimethoprim, spectinomycin, metronidazole, tetracycline).

Drug-Food Interaction: Lithosyn Sr 450 Tab may interact with caffeine. Therefore, reduce the intake of caffeine including coffee, tea, or herbal medicines as it may decrease the effect of Lithosyn Sr 450 Tab . Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness, or difficulty in concentrating. Intake of sodium may also alter lithium levels. Hence, maintain a constant dietary intake of salt.

Drug-Disease Interaction: If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, Brugada syndrome (a hereditary syndrome affecting the heart), hypothyroidism (low thyroid levels), and low sodium levels, inform your doctor before taking Lithosyn Sr 450 Tab .

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Lithosyn Sr 450 Tab belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.
Lithosyn Sr 450 Tab helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.
Lithosyn Sr 450 Tab is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lithosyn Sr 450 Tab .
Lithosyn Sr 450 Tab may cause weight gain but it is not necessary for everyone taking Lithosyn Sr 450 Tab to experience this side effect. However, in order to avoid gaining weight while taking Lithosyn Sr 450 Tab , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.
It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.
Lithosyn Sr 450 Tab may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Lithosyn Sr 450 Tab to avoid dehydration.
You are not recommended to stop taking Lithosyn Sr 450 Tab without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lithosyn Sr 450 Tab for as long as your doctor has prescribed it and if you experience any difficulty while taking Lithosyn Sr 450 Tab , please consult your doctor so that the dose may be gradually reduced.
You are not recommended to take Lithosyn Sr 450 Tab with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Lithosyn Sr 450 Tab with any other medicines, you are advised to contact your doctor.
The effects of Lithosyn Sr 450 Tab can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Lithosyn Sr 450 Tab regularly as prescribed by your doctor to maintain its effectiveness.
It's important to inform your doctor about your hypertension and the medications you're taking for it as Lithosyn Sr 450 Tab can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.
No, you should not increase the dose of Lithosyn Sr 450 Tab on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.
Yes, Lithosyn Sr 450 Tab can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
Yes, Lithosyn Sr 450 Tab can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Lithosyn Sr 450 Tab .
Lithosyn Sr 450 Tab should only be started if adequate facilities for assessing Lithosyn Sr 450 Tab levels are available. Because elevated levels of Lithosyn Sr 450 Tab are linked to Lithosyn Sr 450 Tab toxicity. Lithosyn Sr 450 Tab toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lithosyn Sr 450 Tab levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Lithosyn Sr 450 Tab should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Lithosyn Sr 450 Tab may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.
Certain medications which decrease the levels of Lithosyn Sr 450 Tab in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Lithosyn Sr 450 Tab , inform your doctor about all the medicines you are taking.
The common side effects of Lithosyn Sr 450 Tab are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.10828 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 017812S033,018421S032,018558S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Lithium Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. National Health Service (NHS). Lithium - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020] Check here
  6. Krutika Chokhawala, Sarah Lee, Abdolreza Saadabadi. Lithium. National Library of Medicine. National Center for Biotechnology Information. PubMed Central. May 2022. [Accessed on 13th February 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12Th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - LIT0052

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