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Reviewed By Santoshini Reddy G , M Pharmacy

Mabthera 100 mg Injection is used to treat Non-Hodgkin's disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris. It contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, It works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

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Composition :

RITUXIMAB-100MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Mabthera 100 mg Injection

Mabthera 100 mg Injection belongs to a class of medicines called monoclonal antibodies used in the treatment of non-Hodgkin’s disease and chronic lymphocytic leukaemia. This medicine is also used in treating rheumatoid arthritis in combination with methotrexate and granulomatosis in combination with glucocorticoids. It is also used to treat Pemphigus Vulgaris (PV) and mature B-cell acute leukaemia (B-AL).

Mabthera 100 mg Injection contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Mabthera 100 mg Injection works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time

Mabthera 100 mg Injection may cause certain side effects, such as pale skin, painful urination, night sweats, flushing, back pain, nausea, vomiting, diarrhoea, stomach pain, mouth sores, peeling of skin, injection site reactions and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Mabthera 100 mg Injection is a parenteral preparation. A trained healthcare professional will administer it. Hence, do not self-administer.

Mabthera 100 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Also, inform your doctor if you have liver/kidney disease, hepatitis B virus infection, cardiac disorders, any active infections, or gastrointestinal disorders before receiving this injection. Mabthera 100 mg Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome, and angina in some patients. Hence, careful monitoring should be done during the entire treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of Mabthera 100 mg Injection

Treatment of Non-Hodgkin's disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris

Directions for Use

Mabthera 100 mg Injection will be administered by a trained healthcare professional. Hence, do not self-administer. 

Medicinal Benefits

Mabthera 100 mg Injection contains Rituximab, which belongs to the class of monoclonal antibodies. It works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Mabthera 100 mg Injection works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

How Mabthera 100 mg Injection Works

Mabthera 100 mg Injection contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Mabthera 100 mg Injection works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mabthera 100 mg Injection

  • Pale skin
  • Diarrhoea
  • Painful urination
  • Night sweats
  • Flushing
  • Back pain
  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Mouth sores
  • Peeling of skin
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection

What if I have taken an overdose of Mabthera 100 mg Injection

Since Mabthera 100 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Mabthera 100 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, hepatitis B Virus infection, cardiac disorders, any active infections, or gastrointestinal disorders. Mabthera 100 mg Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome (tumour cells release their contents into the bloodstream), and angina in some patients. Hence, careful monitoring should be done during the entire treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Drug-Drug Interactions

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RituximabRotavirus vaccine
Critical
RituximabCladribine
Severe

Drug-Drug Interactions

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RituximabRotavirus vaccine
Critical
How does the drug interact with Mabthera 100 mg Injection:
Taking Mabthera 100 mg Injection and Rotavirus vaccine together may increase risk of side effects.

How to manage the interaction:
Taking Mabthera 100 mg Injection with Rotavirus vaccine is not recommended as it can possibly result in an interaction, it can be taken if a doctor has prescribed it. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without consulting a doctor.
RituximabCladribine
Severe
How does the drug interact with Mabthera 100 mg Injection:
Combining Mabthera 100 mg Injection with Cladribine can increase the risk of infections.

How to manage the interaction:
Co-administration of Cladribine with Mabthera 100 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience fever, chills, loose stools, sore throat, muscle aches, difficulty breathing, and pain or burning sensation while urinating. Do not stop using any medications without talking to a doctor.
RituximabDeferiprone
Severe
How does the drug interact with Mabthera 100 mg Injection:
Taking Mabthera 100 mg Injection with Deferiprone may increase the risk of infections.

How to manage the interaction:
Taking Mabthera 100 mg Injection with Deferiprone together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabAdalimumab
Severe
How does the drug interact with Mabthera 100 mg Injection:
Taking adalimumab with Mabthera 100 mg Injection may increase the risk of infections.

How to manage the interaction:
Co-administration of Mabthera 100 mg Injection with Adalimumab can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabTofacitinib
Severe
How does the drug interact with Mabthera 100 mg Injection:
Taking Mabthera 100 mg Injection and Tofacitinib may increase the risk infections.

How to manage the interaction:
Taking Tofacitinib with Mabthera 100 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabLeflunomide
Severe
How does the drug interact with Mabthera 100 mg Injection:
Taking Mabthera 100 mg Injection with Leflunomide can increase the risk of infections.

How to manage the interaction:
Taking Mabthera 100 mg Injection with Leflunomide together can result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
RituximabProcarbazine
Severe
How does the drug interact with Mabthera 100 mg Injection:
Combining Mabthera 100 mg Injection with Procarbazine can increase risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Procarbazine and Mabthera 100 mg Injection, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RituximabClozapine
Severe
How does the drug interact with Mabthera 100 mg Injection:
Taking Mabthera 100 mg Injection with Clozapine can increase the risk of infections.

How to manage the interaction:
Although taking Mabthera 100 mg Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
RituximabNatalizumab
Severe
How does the drug interact with Mabthera 100 mg Injection:
Combining Mabthera 100 mg Injection with Natalizumab may increase the risk of infections.

How to manage the interaction:
Although taking Mabthera 100 mg Injection and Natalizumab together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabBaricitinib
Severe
How does the drug interact with Mabthera 100 mg Injection:
Taking Mabthera 100 mg Injection with Baricitinib may significantly increases the risk of infections.

How to manage the interaction:
Although taking Mabthera 100 mg Injection and Baricitinib together can cause an interaction, it can be taken if A doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, breathing difficulty, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Mabthera 100 mg Injection Substitute

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Alcohol

Consult your doctor

It is not known if alcohol interacts with Mabthera 100 mg Injection. Please consult the doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Mabthera 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Mabthera 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Mabthera 100 mg Injection will be administered in the hospital setting. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Mabthera 100 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Mabthera 100 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Mabthera 100 mg Injection will be given to the children only if needed. If administered, careful monitoring of the child is needed.

FAQs

Mabthera 100 mg Injection is used to treat Non-Hodgkin’s disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris.

Mabthera 100 mg Injection contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth.

Mabthera 100 mg Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome, and angina in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Mabthera 100 mg Injection contains the active substance rituximab. This is a type of protein called a monoclonal antibody.

The common side effects of Mabthera 100 mg Injection are pale skin, painful urination, night sweats, flushing, back pain, nausea, vomiting, diarrhoea, stomach pain, mouth sores, peeling of skin, injection site reactions and pain at the site of injection. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Bayer Ag, Mã¼Llerstr. 178, 13353 Berlin
Other Info - MAB0001

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