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compositionComposition:DABIGATRAN ETEXILATE-150MG
prescription
Prescription Medicine
info
Macdaxa 150 mg Capsule 10's

Macdaxa 150 mg Capsule is an anticoagulant medicine used to prevent blood clot formation. This medicine prevents/treats conditions like deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), heart attack, and stroke. This medicine works by inhibiting the production of the clotting factor Xa, also known as thrombin. thereby preventing the conversion of fibrinogen to fibrin, a protein that helps prevent blood clot formation. Common side effects include bleeding, anaemia, nausea, stomach pain, and vomiting.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DABIGATRAN ETEXILATE-150MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macdaxa 150 mg Capsule

Macdaxa 150 mg Capsule is used to prevent and treat the risk of stroke, heart attack in patients with atrial fibrillation (irregular heart rhythm) by reducing blood clot formation. It is also used to prevent deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung).

Macdaxa 150 mg Capsule contains Dabigatran etexilate that works by inhibiting the production of clotting factor Xa, also called thrombin. This prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein), thereby preventing blood clots.

You may experience bleeding, anaemia (low number of red blood cells), nausea, stomach pain, and vomiting. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

If you are known to be allergic to Macdaxa 150 mg Capsule or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Macdaxa 150 mg Capsule . If you have a stomach ulcer, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Macdaxa 150 mg Capsule .

Uses of Macdaxa 150 mg Capsule

Macdaxa 150 mg Capsule is used in the prevention of blood clot formation, deep vein thrombosis, and pulmonary embolism. The detailed uses of Macdaxa 150 mg Capsule are as follows:

  • Stroke Prevention: Macdaxa 150 mg Capsule is used especially in patients with non-valvular atrial fibrillation.
  • Deep Vein Thrombosis (DVT): Macdaxa 150 mg Capsule treats and prevents clots in the legs.
  • Pulmonary Embolism (PE): Macdaxa 150 mg Capsule prevents clots from traveling to the lungs.
  • Post-Surgical Clot Prevention: Macdaxa 150 mg Capsule is used in clot prevention after hip or knee replacement surgery.
  • Recurrent Clot Prevention: Macdaxa 150 mg Capsule reduces risk of DVT/PE recurrence.

Key Benefits

  • Macdaxa 150 mg Capsule is primarily used to prevent and treat the risk of stroke and heart attack by reducing blood clot formation.
  • It makes the blood flow easily through the veins, making it less likely to form a serious blood clot. Thus, Macdaxa 150 mg Capsule helps prevent blood clots, thereby reducing the risk of heart attack/stroke.
  • It also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. Macdaxa 150 mg Capsule works by stopping the action of the clotting factor (thrombin).
  • Macdaxa 150 mg Capsule prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein), thereby preventing blood clots.
  • Reduces the risk of stroke in persons with atrial fibrillation (irregular heartbeat).
Side effects of Macdaxa 150 mg Capsule
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Avoid other medicines that increase the risk of bleeding.
  • Use an electric razor and a soft-bristled toothbrush.
  • Monitor for signs of bleeding like bleeding gums, unusual bruising, blood in stool, nosebleeds, or heavy menstrual bleeding.
  • If you experience severe bleeding, apply direct pressure on the wound and consult a doctor promptly.
  • If the risk of bleeding is high, discuss with your doctor about possibility of switching to different medicine with a lower bleeding risk.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Macdaxa 150 mg Capsule can be taken with or without food.
  • It is usually taken twice daily, or as prescribed by your doctor.
  • Swallow the whole Macdaxa 150 mg Capsule with a glass of water.
  • Do not break, chew, or open it.

How Macdaxa 150 mg Capsule Works

Macdaxa 150 mg Capsule contains Dabigatran etexilate that works by inhibiting the production of clotting factor Xa, also called thrombin. This prevents the conversion of fibrinogen (a soluble protein) to fibrin (an insoluble protein), thereby preventing blood clots. It facilitates the smooth flow of blood through the veins, reducing the likelihood of forming a serious blood clot. Thus, Macdaxa 150 mg Capsule helps prevent blood clots, thereby reducing the risk of heart attacks and strokes.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Macdaxa 150 mg Capsule as it may increase the risk of bleeding.

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Pregnancy

Consult your doctor

Please consult your doctor if you are planning to become pregnant or are already pregnant before starting Macdaxa 150 mg Capsule . Your doctor will prescribe Macdaxa 150 mg Capsule only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Macdaxa 150 mg Capsule . Consult your doctor if you have any concerns.

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Driving

Consult your doctor

Macdaxa 150 mg Capsule usually does not affect your ability to drive or operate machinery. Consult your doctor if you have any concerns.

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Liver

Caution

Let your doctor know if you have/had liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 150 mg Capsule . However, it is not recommended for patients with severe liver diseases.

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Kidney

Caution

Let your doctor know if you have/had kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 150 mg Capsule . However, it is not recommended for patients with severe kidney diseases.

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Children

Unsafe

Macdaxa 150 mg Capsule is not recommended for children below the age of 18 years, as the safety and efficacy of Macdaxa 150 mg Capsule have not been established in children.

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Heart

Caution

Macdaxa 150 mg Capsule should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Macdaxa 150 mg Capsule .

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Geriatrics

Caution

Macdaxa 150 mg Capsule should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Macdaxa 150 mg Capsule .

What if I have taken an overdose of Macdaxa 150 mg Capsule

Please do not exceed the recommended dose, as it might cause serious side effects. Signs and symptoms of an overdose of Macdaxa 150 mg Capsule may include an increased risk of bleeding. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Maintain healthy cholesterol and triglyceride levels.
  • Eat at regular intervals, and maintain a healthy diet that includes fresh fruits and vegetables.
  • Limit alcohol intake since it raises blood pressure and increases the risk of heart disease.
  • Monitor your weight and exercise regularly to maintain a healthy heart.

Have a query?

How Soon It Starts Working

  • The time required for Macdaxa 150 mg Capsule to start to work: Macdaxa 150 mg Capsule ideally shows its action within 0.5 to 2 hours after administration.
  • The time for which the effects of Macdaxa 150 mg Capsule last: The effect of Macdaxa 150 mg Capsule lasts for 12 to 17 hours.

What if you forget to take Macdaxa 150 mg Capsule

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep Macdaxa 150 mg Capsule out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are known to be allergic to Macdaxa 150 mg Capsule or any other medicines, please tell your doctor.
  • Do not stop taking this medicine on your own. Discontinuing Macdaxa 150 mg Capsule may worsen your condition and increase the risk of heart attack and stroke.
  • Macdaxa 150 mg Capsule is not recommended for children less than 18 years of age, as the Safety and effectiveness have not been established.
  • If you have an artificial heart valve, stomach ulcer, kidney/liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Macdaxa 150 mg Capsule .
  • Avoid consumption of alcohol while taking Macdaxa 150 mg Capsule as it may increase the risk of stomach bleeding.
  • If you are pregnant or breastfeeding, it is advised to consult a doctor before using Macdaxa 150 mg Capsule .
  • You should inform the doctor that you are taking Macdaxa 150 mg Capsule if you are due to undergo surgery.

Drug-Drug Interactions

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Drug-Drug Interactions: Macdaxa 150 mg Capsule may interact with medicines to reduce blood clotting (warfarin, phenprocoumon, acenocoumarol, heparin, clopidogrel, prasugrel, ticagrelor, rivaroxaban), medicines to treat abnormal heartbeats (amiodarone, dronedarone, quinidine, verapamil), medicines to treat fungal infections (ketoconazole, itraconazole), medicines to prevent organ rejection after transplantation (tacrolimus, cyclosporine) antiviral or HIV medicines (ritonavir, glecaprevir, pibrentasvir), antibiotics (rifampicin, clarithromycin), pain reliever (aspirin, ibuprofen, diclofenac), antiepileptic drugs (carbamazepine, phenytoin).

Drug-Food Interactions: Macdaxa 150 mg Capsule may interact with St. John’s wort, an herbal medicine for depression.

Drug-Disease Interactions: Macdaxa 150 mg Capsule should be used with caution in patients with kidney, liver, or bleeding problems, heart problems, and unstable blood pressure.

Dabigatran etexilateMifepristone
Critical
Dabigatran etexilateDronedarone
Severe

Drug-Drug Interactions

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Dabigatran etexilateMifepristone
Critical
How does the drug interact with Macdaxa 150 mg Capsule:
When Mifepristone is taken with Macdaxa 150 mg Capsule, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Mifepristone with Macdaxa 150 mg Capsule is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
Dabigatran etexilateDronedarone
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
When Macdaxa 150 mg Capsule is taken with Dronedarone, the amount of Macdaxa 150 mg Capsule in the blood can go up.

How to manage the interaction:
Taking Macdaxa 150 mg Capsule with Dronedarone together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor.
Dabigatran etexilateTirofiban
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Taking Macdaxa 150 mg Capsule with Tirofiban can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 150 mg Capsule with Tirofiban together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateRegorafenib
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Taking Macdaxa 150 mg Capsule with Regorafenib can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 150 mg Capsule with Regorafenib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateMefenamic acid
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Coadministration of Mefenamic acid with Dabigatran can increase the risk or severity of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Mefenamic acid with Macdaxa 150 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Dabigatran etexilateCarbamazepine
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Taking Macdaxa 150 mg Capsule with carbamazepine may significantly reduce the blood levels of dabigatran, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Macdaxa 150 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateNaproxen
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Coadministration of Naproxen and Macdaxa 150 mg Capsule may increase the risk or severity of unusual bleeding problems.

How to manage the interaction:
Taking Naproxen and Dabigatran together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateAcalabrutinib
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Taking Macdaxa 150 mg Capsule with Acalabrutinib can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 150 mg Capsule with Acalabrutinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateDiclofenac
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Concomitant use of diclofenac with dabigatran may increase the risk of stomach bleeding.

How to manage the interaction:
Taking diclofenac with dabigatran together possibly results in an interaction, it can be taken if your doctor has advised it. You should consult a doctor immediately if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness, light headedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateVorapaxar
Severe
How does the drug interact with Macdaxa 150 mg Capsule:
Taking Macdaxa 150 mg Capsule with Vorapaxar can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 150 mg Capsule with Vorapaxar together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DABIGATRAN ETEXILATE-150MGHerbal products/medicines

Drug-Food Interactions

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DABIGATRAN ETEXILATE-150MGHerbal products/medicines
Common Foods to Avoid:
St. John’S Wort, Garlic Pill

How to manage the interaction:
Herbs and supplements may interact with Macdaxa 150 mg Capsule. Avoid St. John's Wort, herbs including garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba during Macdaxa 150 mg Capsule treatment.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Macdaxa 150 mg Capsule is used to prevent blood clot formation, deep vein thrombosis (blood clots in deep veins), and pulmonary embolism (blood clots in the lungs).
Macdaxa 150 mg Capsule is a thrombin inhibitor. The inhibition of thrombin reduces the formation of blood-clotting material fibrin, thereby leading to fewer clots and aiding the free flow of blood.
Please consult your doctor if you are due to undergo surgery. The doctor might ask you to stop taking Macdaxa 150 mg Capsule a few days before surgery since it can cause an increased risk of bleeding during surgery.
Taking Macdaxa 150 mg Capsule during pregnancy may cause bleeding in the mother or the newborn baby. However, please consult your doctor if you are planning to become pregnant or already pregnant before starting Macdaxa 150 mg Capsule .
Macdaxa 150 mg Capsule may increase the risk of bleeding. It is advised to be cautious during your daily activities like shaving, cutting fingernails, or using sharp objects. Inform your doctor immediately if you notice any abnormal staining or bleeding.
No, you are not recommended to stop taking Macdaxa 150 mg Capsule without consulting your doctor as it may worsen the condition. Therefore, take Macdaxa 150 mg Capsule for as long as your doctor has prescribed it.
Because of the risk of bleeding, your dose of dabigatran may need to be lowered or stopped a few days before you have an operation.
You can take Macdaxa 150 mg Capsule with or without food but try to take it at the same time every day. Swallow the capsules whole with a drink of water. Do not open dabigatran capsules before taking them, as this increases the risk of side effects.
Take Macdaxa 150 mg Capsule as prescribed by your doctor. Depending on your medical conditions, you are advised to take Macdaxa 150 mg Capsule as long as your doctor has prescribed it for you.
You are recommended to avoid consumption of alcohol with Macdaxa 150 mg Capsule as it may increase the risk of bleeding.
Hair loss is not a known side effect of Macdaxa 150 mg Capsule . However, it is known to occur with anticoagulants. Consult your doctor if you observe hair loss. Your doctor will guide you on how to cope with this situation.
It varies from person to person and depends on the conditions that we treat.
Limited research available. Let your doctor know if you have/had liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 150 mg Capsule . However, it is not recommended in patients with severe liver diseases.
Store in a cool and dry place away from sunlight. Keep Macdaxa 150 mg Capsule out of the sight and reach of children.
Yes, bleeding is the main risk associated with Macdaxa 150 mg Capsule treatment; patients should be monitored for signs of bleeding.
Macdaxa 150 mg Capsule is not suitable for some people with existing medical conditions. So, to ensure safety, let your doctor know about all your medical conditions and medications. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 150 mg Capsule .
Common side effects of Macdaxa 150 mg Capsule may include bleeding, anaemia, nausea, stomach pain, and vomiting.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Dabigatran Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. National Health Service (NHS). Dabigatran - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.6229 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. U.S. Food and Drug Administration (FDA). 022512S007Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  5. Dabigatran etexilate mesylate [Prescribing Information]. 2023. [Accessed on 15 Mar. 2019] Check here
  6. Pradaxa 150 mg hard capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 27 May 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, India.
Other Info - MAC0352

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