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compositionComposition:GLIMEPIRIDE-2MG+METFORMIN-500MG+PIOGLITAZONE-15MG
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Macgil GMP-2 Tablet 10's is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-2MG+METFORMIN-500MG+PIOGLITAZONE-15MG

Manufacturer/Marketer :

Aarsh Remedies Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Macgil GMP-2 Tablet 10's

Macgil GMP-2 Tablet 10's is a prescription medication used to manage and control high blood sugar levels in adults with type 2 diabetes. It is typically prescribed when a single or double treatment medicine is no longer sufficient to keep blood sugar within a target range. By keeping blood sugar levels controlled, this medication helps prevent serious, long-term complications associated with diabetes.

For the best results, you must take Macgil GMP-2 Tablet 10's regularly and consistently exactly as prescribed by your doctor. It is highly recommended to take this tablet with food, specifically with your first main meal of the day, to reduce the chances of a stomach upset. Alongside taking this medication, adopting healthy lifestyle habits such as eating a balanced, low-sugar diet and engaging in regular physical activity is essential to achieve optimal blood sugar control.

While taking Macgil GMP-2 Tablet 10's, some people may experience mild side effects like nausea, a metallic taste in the mouth, or low blood sugar. However, if you experience sudden swelling in your legs, shortness of breath, severe stomach pain, or yellowing of your skin or eyes, you must stop taking the medication and consult your doctor immediately.

Do not take this if you have severe kidney disease, active liver damage, or severe heart failure. Before starting Macgil GMP-2 Tablet 10's, it is crucial to tell your doctor if you have a history of bladder cancer, fluid retention, or heart conditions.

This medicine can interact with alcohol, which significantly increases your risk of dangerously low blood sugar and a rare but serious condition called lactic acidosis. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you must talk to your doctor or pharmacist before using this medicine, as alternative treatments may be safer.

Uses of Macgil GMP-2 Tablet 10's

It is mainly used to manage and control high blood sugar levels in adults with type 2 diabetes.

  • Type 2 Diabetes Mellitus: Macgil GMP-2 Tablet 10's helps lower blood glucose levels in adults whose high blood sugar is not adequately controlled by diet, exercise, or other single-agent medications.

Key Benefits

Taking Macgil GMP-2 Tablet 10's consistently provides several vital health benefits that help you manage your daily life with confidence:

  • Effective Blood Sugar Control: By targeting multiple pathways in the body, it helps keep your daily blood glucose readings within a stable, healthy range.
  • Prevention of Diabetes Complications: Maintaining steady blood sugar levels reduces the long-term risk of kidney damage, nerve pain, blindness, and cardiovascular problems like heart attacks or strokes.
  • No Need for Multiple Separate Pills: Since it combines three highly effective blood-sugar-lowering agents into a single convenient tablet, it simplifies your daily medication routine.
Side effects of Macgil GMP-2 Tablet
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Frequent flossing and brushing can help remove bacteria and debris that can give your teeth a metallic taste.
  • The metallic flavor may be caused by a zinc deficiency. Eat foods like meat, chicken, and oysters that are high in zinc.
  • Reducing the intake of foods with strong aromas, like onions and garlic, as they may intensify the taste of metallic substances.
  • Avoid smoking and tobacco products as they may intensify the metallic flavor.

Directions for Use

  • Macgil GMP-2 Tablet 10's can be taken with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Macgil GMP-2 Tablet 10's as a whole with a glass of water.
  • Do not chew, crush or break it.

How Macgil GMP-2 Tablet 10's Works

Macgil GMP-2 Tablet 10's is a combination of three active ingredients that work together in different ways to control your blood sugar levels efficiently. Glimepiride works by encouraging your pancreas to release more insulin, which is the natural hormone your body uses to clear sugar from your bloodstream. Metformin focuses on reducing the amount of glucose (sugar) that your liver produces and releases into your body. It also delays the absorption of sugar from your intestines and helps your muscles use the available insulin more effectively. Pioglitazone works primarily by making your body's cells much more sensitive to insulin. This allows your muscles and fat tissues to easily take up and utilise glucose from your blood, keeping your sugar levels stable.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Macgil GMP-2 Tablet 10's as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Macgil GMP-2 Tablet 10's is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Macgil GMP-2 Tablet 10's as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Macgil GMP-2 Tablet 10's if you are breastfeeding.

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Driving

Caution

Macgil GMP-2 Tablet 10's may decrease alertness in some people. Therefore, drive only if you are alert after taking Macgil GMP-2 Tablet 10's.

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Liver

Caution

Take Macgil GMP-2 Tablet 10's with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Macgil GMP-2 Tablet 10's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Macgil GMP-2 Tablet 10's is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

Macgil GMP-2 Tablet 10's should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Macgil GMP-2 Tablet 10's.

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Geriatrics

Caution

Macgil GMP-2 Tablet 10's should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Macgil GMP-2 Tablet 10's.

What if I have taken an overdose of Macgil GMP-2 Tablet 10's

In case of an accidental overdose, seek immediate medical attention. An overdose can cause extremely low blood sugar (which may lead to confusion, fainting, or seizures) or a dangerous acid buildup in your blood. If you are conscious and suspect low blood sugar, consume a fast-acting sugar source like fruit juice or candy while waiting for medical help.

Diet & Lifestyle Advise

  • Monitor your carbohydrates: Focus on complex carbohydrates with a low glycemic index, such as whole grains, oats, vegetables, and legumes, to prevent sudden spikes in blood sugar.
  • Stay physically active: Aim for at least 150 minutes of moderate-intensity exercise, such as brisk walking or swimming, each week. Physical activity helps your body use insulin more efficiently.
  • Keep a sugar source nearby: Because this medicine can cause low blood sugar, always carry fast-acting sweets, glucose tablets, or fruit juice with you to treat sudden symptoms of hypoglycemia.
  • Check your feet daily: Diabetes can affect blood circulation and nerve sensitivity. Inspect your feet daily for any cuts, sores, or blisters, and report any non-healing wounds to your doctor.
  • Stay hydrated: Drink plenty of water throughout the day to support your kidney function and help your body flush out excess glucose.
health query

Have a query?

How Soon It Starts Working

The time required for Macgil GMP-2 Tablet 10's to start to work: Macgil GMP-2 Tablet 10's ideally shows its action within a few hours after administration.

The time for which the effects of Macgil GMP-2 Tablet 10's last: The duration of action for Macgil GMP-2 Tablet 10's is clinically unknown.

What if you forget to take Macgil GMP-2 Tablet 10's

If you miss a dose of Macgil GMP-2 Tablet 10's, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can cause your blood sugar to drop dangerously low.

Storage

• Proper storage ensures your medication remains effective and safe to use. •Keep Macgil GMP-2 Tablet 10's stored in its original packaging at room temperature, ideally below 30°C (86°F).

Drug Warnings

  • Monitor blood sugar: Check your blood sugar regularly as directed by your healthcare provider to ensure the medication is working safely.
  • Watch for swelling: Watch for sudden weight gain or swelling in your lower legs or ankles, which can indicate fluid buildup, and notify your doctor immediately.
  • Avoid alcohol: Limit or avoid alcohol consumption while taking this medication, as alcohol increases the risk of severe low blood sugar and dangerous acid buildup in the body.
  • Inform healthcare provider: Inform any doctor, dentist, or surgeon that you are taking Macgil GMP-2 Tablet 10's before undergoing any medical procedures or receiving contrast dye for imaging scans.
  • Be aware: Stress, illness, injury, or surgery can affect your blood sugar levels, and your doctor may need to temporarily adjust your treatment plan during these times.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Blood pressure medicines (such as beta-blockers or ACE inhibitors): They may hide the warning signs of low blood sugar, like a racing heart, or increase the risk of hypoglycemia.
  • Water pills (diuretics) and corticosteroids: It May raise your blood sugar levels, making Macgil GMP-2 Tablet 10's less effective.
  • Certain pain relievers (like NSAIDs): They can increase the risk of kidney strain when taken alongside this medication.
Metformin + Pioglitazone + GlimepirideMetrizamide
Critical
Metformin + Pioglitazone + GlimepirideGatifloxacin
Critical

Drug-Drug Interactions

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Metformin + Pioglitazone + GlimepirideMetrizamide
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideGatifloxacin
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Taking Glimepiride with Gatifloxacin may cause both low blood glucose and, less frequently, high blood glucose.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideIomeprol
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIodixanol
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIodamide
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIopamidol
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIopromide
Critical
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideLevofloxacin
Severe
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Glimepiride with Levofloxacin can cause both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Co-administration of Levofloxacin with Glimepiride can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideTeriflunomide
Severe
How does the drug interact with Macgil GMP-2 Tablet:
Co-administration of Teriflunomide and Pioglitazone may increase the risk of liver damage.

How to manage the interaction:
Although taking Pioglitazone and Teriflunomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Metformin + Pioglitazone + GlimepirideClopidogrel
Severe
How does the drug interact with Macgil GMP-2 Tablet:
Taking Pioglitazone with Clopidogrel can increases the blood levels of Pioglitazone, this may lead to hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Clopidogrel together with Pioglitazone may lead to interaction, but it can be taken if prescribed by a doctor. Consult a doctor immediately if you experience any symptoms like headache, dizziness, drowsiness, nervousness, weakness, shakings, nausea, hunger, sweating, and palpitation. Do not discontinue any medication without consulting the doctor.

Drug-Food Interactions

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  • Alcohol: Dramatically increases the risk of low blood sugar and can trigger a dangerous buildup of lactic acid in the blood.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Macgil GMP-2 Tablet 10's is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
Macgil GMP-2 Tablet 10's contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Macgil GMP-2 Tablet 10's helps to control blood sugar levels.
You are not recommended to take Macgil GMP-2 Tablet 10's with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Macgil GMP-2 Tablet 10's with other medicines.
In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are completely destroyed. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to it.
You are not recommended to stop taking Macgil GMP-2 Tablet 10's on your own, as discontinuing Macgil GMP-2 Tablet 10's suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Macgil GMP-2 Tablet 10's, please consult your doctor so that alternative medicine may be prescribed.
Yes, Macgil GMP-2 Tablet 10's may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.
Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.
Yes, Macgil GMP-2 Tablet 10's may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.
Store Macgil GMP-2 Tablet 10's at room temperature, in a dry place. Keep out of sight and reach of children.
Macgil GMP-2 Tablet 10's may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.
No, you should avoid or highly limit alcohol while taking this medicine. Alcohol increases your risk of developing dangerously low blood sugar and a rare but severe condition called lactic acidosis. Talk to your doctor if you have questions about alcohol use.
Yes, some individuals may experience mild weight gain while taking this medication. This can be due to improved blood sugar control or fluid retention. If you notice sudden or rapid weight gain, talk to your doctor.
If you experience symptoms of low blood sugar (shakiness, sweating, dizziness), eat or drink 15 grams of fast-acting sugar, such as half a cup of fruit juice, three to four glucose tablets, or hard candy. If symptoms persist after 15 minutes, repeat this step and talk to your doctor.
No, this medication is generally not recommended during pregnancy or breastfeeding as it may not be safe for the developing baby. If you are pregnant or planning to conceive, talk to your doctor to discuss safer alternatives for managing your blood sugar.
Taking this medicine with your main meal helps reduce common digestive side effects, such as nausea, stomach upset, or gas, and prevents your blood sugar from dropping too quickly after taking the pill. Talk to your doctor if stomach upset persists.
No, Macgil GMP-2 Tablet 10's does not cure diabetes. It helps manage and control your blood sugar levels to prevent long-term complications. You must continue taking it consistently as prescribed, along with maintaining a healthy diet and exercise routine. Talk to your doctor before making any changes.
While this medicine does not directly cause kidney damage, it is cleared from your body through your kidneys. If you already have severe kidney disease, this medicine can build up and cause serious side effects. Your doctor will monitor your kidney function regularly. Talk to your doctor if you have concerns about your kidney health.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

SIGNATURE-2, Sarkhej - Gandhinagar Hwy, Sarkhej, Ahmedabad, Sarkhej-Okaf, Gujarat 382210
Other Info - MAC0527
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