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compositionComposition:MELPHALAN-2MG
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Prescription Medicine
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Makmel 2 mg Tablet 25's is primarily used to treat various cancer conditions such as Multiple myeloma, Polycythaemia vera, advanced cancer of the ovaries and advanced breast cancer. Makmel 2 mg Tablet 25's contains Melphalan, which reduces the number of abnormal cells your body makes. Thus, it treats cancer efficiently. Common side effects of this medication include a drop in the number of blood cells and platelets, feeling sick (nausea), being sick (vomiting), diarrhoea, mouth ulcers, hair loss and high levels of urea in your blood (in people with kidney problems who are being treated for myeloma).

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MELPHALAN-2MG

Manufacturer/Marketer :

Biomak Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Makmel 2 mg Tablet 25's

Makmel 2 mg Tablet 25's is a prescription medication used to treat certain serious conditions, primarily multiple myeloma (a cancer of the plasma cells in the bone marrow) and advanced ovarian cancer. By targeting rapidly dividing cells, this medication helps control the spread of these cancers and manage disease symptoms.

You should take this medication exactly as prescribed, maintaining a consistent schedule to keep steady levels of the medicine in your body. It is important to take Makmel 2 mg Tablet 25's on an empty stomach, either 1 hour before or 2 hours after a meal, as food can interfere with how well your body absorbs it. Staying well-hydrated throughout your treatment is also highly recommended to support your kidney function.

While taking Makmel 2 mg Tablet 25's, you may experience common side effects like nausea, vomiting, or temporary hair thinning. However, you must consult your doctor immediately if you notice serious signs like a fever, sore throat, or unusual bleeding, which can indicate more severe reactions.

Before starting therapy, you must tell your doctor if you have kidney disease, a weakened immune system, or poor bone marrow function. Do not take this if you have had a severe allergic reaction to this medication in the past.

This medicine can interact with other prescription drugs, certain vaccines, and alcohol, so a complete review of your current medications is essential. Additionally, pregnant or breastfeeding women should not take Makmel 2 mg Tablet 25's due to potential harm to the baby, and elderly patients may require regular monitoring. Talk to your doctor or pharmacist if you fall into any of these groups.

Uses of Makmel 2 mg Tablet 25's

Makmel 2 mg Tablet 25's is used to treat certain serious conditions. The detailed uses of Makmel 2 mg Tablet 25's are as follows:

  • Multiple myeloma: Makmel 2 mg Tablet 25's helps control this bone marrow cancer by targeting and destroying abnormal plasma cells, which can ease bone pain and reduce complications.
  • Advanced ovarian cancer: It is used to help shrink or slow the growth of tumours in the ovaries when other treatments are not suitable.

Key Benefits

Makmel 2 mg Tablet 25's helps treat certain types of cancer by slowing the growth and spread of cancer cells. When used as prescribed, it helps control disease progression, relieve cancer-related symptoms, and offers the convenience of oral treatment.

  • Helps Control Cancer Growth: By slowing the multiplication of cancer cells, this medicine helps manage conditions such as multiple myeloma and advanced ovarian cancer, reducing the progression and spread of the disease.
  • Improves Quality of Life: Effective disease control may help reduce cancer-related symptoms such as bone pain, lower the risk of fractures in patients with bone involvement, and improve physical mobility and daily comfort.
  • Convenient Oral Treatment: As an oral tablet, this medicine can be taken at home as directed by your healthcare provider, reducing the need for frequent hospital visits associated with intravenous chemotherapy while supporting consistent long-term treatment.
Side effects of Makmel 2mg Tab
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Makmel 2 mg Tablet 25's should be taken on an empty stomach, without food to ensure optimal absorption or as directed by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Makmel 2 mg Tablet 25's as a whole with a glass of water.
  • Do not break, chew or crush Makmel 2 mg Tablet 25's.

How Makmel 2 mg Tablet 25's Works

Makmel 2 mg Tablet 25's contains melphalan, which belongs to a group of medicines called alkylating agents. It works by binding directly to the DNA inside cancer cells. By damaging the DNA, it prevents these abnormal cells from dividing and multiplying. Because cancer cells grow and divide much faster than normal cells, they are highly sensitive to this action. Over time, this damage leads to the death of the cancer cells, helping to shrink tumours and keep the disease under control.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Makmel 2 mg Tablet 25's.

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Pregnancy

Caution

Makmel 2 mg Tablet 25's should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Caution

Makmel 2 mg Tablet 25's should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

It is unknown whether Makmel 2 mg Tablet 25's alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before taking Makmel 2 mg Tablet 25's. Your doctor may titrate the dose if required based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Makmel 2 mg Tablet 25's. Your doctor may titrate the dose if required based on your condition.

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Children

Caution

Limited information is available regarding the usage of Makmel 2 mg Tablet 25's in children, so please consult a doctor if you have any concerns.

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Heart

Caution

Makmel 2 mg Tablet 25's should be used with caution if you have heart problems, as it may cause fluid retention and increase cardiac strain. Close monitoring by your doctor is essential to manage potential risks.

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Geriatrics

Caution

Geriatric patients can take Makmel 2 mg Tablet 25's, but it may be more susceptible to bone marrow suppression and kidney issues. Careful dose adjustment and regular monitoring are essential under medical supervision.

What if I have taken an overdose of Makmel 2 mg Tablet 25's

If you accidentally take more than your prescribed dose, seek emergency medical attention immediately. An overdose can cause severe damage to your blood cells and digestive tract.

Diet & Lifestyle Advise

  • Stay very well hydrated: Drink at least 8 to 10 glasses of water daily to help your kidneys flush out the waste products of cellular breakdown.
  • Avoid raw or undercooked foods: Since Makmel 2 mg Tablet 25's lowers your white blood cell count, you are at a higher risk of infection. Stick to thoroughly cooked meals and wash fruits and vegetables carefully.
  • Eat small, frequent meals: If you experience nausea, eating smaller portions throughout the day can keep your stomach settled better than three large meals.
  • Use an extra-soft toothbrush: To protect your gums from bleeding and prevent painful mouth sores, use an extra-soft toothbrush and avoid harsh mouthwashes containing alcohol.
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How Soon It Starts Working

The time required for Makmel 2 mg Tablet 25's to start to work: The onset time of Makmel 2 mg Tablet 25's has not been clinically established. The time for which the effects of Makmel 2 mg Tablet 25's last: The duration of Makmel 2 mg Tablet 25's’s effect is clinically not established.

What if you forget to take Makmel 2 mg Tablet 25's

If you miss a dose, do not take a double dose to make up for the missed one. Contact your doctor or pharmacist immediately for guidance on when to safely take your next dose.

Storage

• Store Makmel 2 mg Tablet 25's tablets in the refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). Do not freeze them.

Drug Warnings

  • Handle tablets with care: Do not break or crush the tablets. If a tablet is accidentally broken or damaged, avoid touching it directly or inhaling any powder.
  • Keep up with your blood tests: Your doctor will require frequent blood tests to monitor your kidney function and blood cell counts. Never skip these appointments.
  • Avoid live vaccines: While taking this medicine, your immune system will be weakened. Talk to your doctor before receiving any immunisations, and avoid live vaccines entirely.
  • Use reliable birth control: Both men and women should use highly effective birth control during treatment and for a specified time after stopping to prevent pregnancy.
  • Limit contact with sick individuals: Stay away from people who have active infections, colds, or the flu, as your body will find it much harder to fight off germs.

Drug-Drug Interactions

verifiedApollotooltip
  • Live Vaccines: Do not receive live vaccines while taking Makmel 2 mg Tablet 25's, as this medicine can weaken your immune system and increase the risk of developing serious, potentially life-threatening infections. Your doctor will advise you on the appropriate timing of vaccinations.
  • Kidney-Damaging Medicines: Taking Makmel 2 mg Tablet 25's together with medicines that can affect kidney function, such as cyclosporine or certain antibiotics, may increase the risk of kidney damage and other serious side effects. Your doctor may monitor your kidney function and adjust your treatment if necessary.
MelphalanYellow fever vaccine
Critical
MelphalanBCG vaccine
Critical

Drug-Drug Interactions

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MelphalanYellow fever vaccine
Critical
How does the drug interact with Makmel 2mg Tab:
Co-administration of the Yellow fever vaccine with Makmel 2mg Tab can increase the risk or severity of infection or reduces the effectiveness of the vaccine.

How to manage the interaction:
Taking Makmel 2mg Tab with the Yellow fever vaccine is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting your doctor.
MelphalanBCG vaccine
Critical
How does the drug interact with Makmel 2mg Tab:
Co-administration of the BCG vaccine with Makmel 2mg Tab together can increase the risk or severity of infection or reduces the effectiveness of the vaccine.

How to manage the interaction:
Taking Makmel 2mg Tab with the BCG vaccine is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting your doctor.
MelphalanLeflunomide
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Makmel 2mg Tab with Leflunomide together can increase the risk of infections.

How to manage the interaction:
Although taking Leflunomide and Makmel 2mg Tab together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
MelphalanNalidixic acid
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Nalidixic acid with Makmel 2mg Tab together can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Makmel 2mg Tab and Nalidixic acid together can evidently cause an interaction, it can be taken if your doctor has suggested it. However contact a doctor immediately, if you experience any symptoms such as easy bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite. Do not discontinue any medications without consulting a doctor.
MelphalanAdalimumab
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Adalimumab with Makmel 2mg Tab together can increase the risk and severity of infection.

How to manage the interaction:
Although taking Makmel 2mg Tab and Adalimumab together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
MelphalanInfliximab
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Infliximab with Makmel 2mg Tab can increase the serious infection.

How to manage the interaction:
There may be a possibility of interaction between Makmel 2mg Tab and Infliximab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
MelphalanNatalizumab
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Makmel 2mg Tab with Natalizumab can increase the risk and severity of infection.

How to manage the interaction:
Taking Makmel 2mg Tab with Natalizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. It is important to contact a doctor if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, burning during urination, weakness on one side of the body, vision problems, or confusion. Do not stop using any medications without a doctor's advice.
MelphalanThalidomide
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Thalidomide together with Makmel 2mg Tab may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Makmel 2mg Tab together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
MelphalanFingolimod
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Fingolimod and Makmel 2mg Tab can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Makmel 2mg Tab and Fingolimod, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
MelphalanBaricitinib
Severe
How does the drug interact with Makmel 2mg Tab:
Co-administration of Baricitinib and Makmel 2mg Tab together can raise the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Makmel 2mg Tab if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Always take Makmel 2 mg Tablet 25's on an empty stomach, as taking it with food can significantly reduce its absorption and make the medicine less effective. Follow your doctor's instructions regarding the timing of meals and doses.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

The duration of treatment depends on your specific condition, blood test results, and how well your cancer responds to therapy. Take Makmel 2 mg Tablet 25's exactly as prescribed and do not stop taking it on your own, even if you feel better, unless your doctor tells you to. If you have difficulty taking the medicine or experience troublesome side effects, talk to your doctor.
No, you should take Makmel 2 mg Tablet 25's on an empty stomach, either 1 hour before or 2 hours after a meal. Food can decrease how much of the medicine your body absorbs. Talk to your doctor or pharmacist if you struggle with nausea on an empty stomach.
Yes, Makmel 2 mg Tablet 25's tablets must be stored in the refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze them, and keep them away from light. Talk to your doctor or pharmacist if you need advice on transporting your medicine safely.
No, you must swallow the tablets whole. Crushing or breaking them can release harmful dust that may irritate your skin or lungs. If you have trouble swallowing tablets, talk to your doctor or pharmacist.
Some people may experience temporary hair thinning or loss while taking Makmel 2 mg Tablet 25's, though it is usually less severe than with intravenous chemotherapy. Your hair will typically grow back after treatment ends. Talk to your doctor if you have concerns about hair loss.
It is highly recommended to limit or avoid alcohol while taking Makmel 2 mg Tablet 25's, as alcohol can worsen nausea, increase the risk of dehydration, and strain your liver. Talk to your doctor about what is safe for you.
This medicine can lower your white blood cells, red blood cells, and platelets. Regular blood tests allow your doctor to monitor these levels closely and adjust your dose to keep you safe from severe infections or bleeding. Talk to your doctor about your test results.
No, Makmel 2 mg Tablet 25's can cause severe birth defects or harm an unborn baby. You must use effective birth control during treatment and for a specified period afterwards as recommended by your healthcare provider. Talk to your doctor immediately if you suspect a pregnancy.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

PLOT NO 154, SECTOR-68 IMT Faridabad, Haryana 121004 IN.
Other Info - MAK0101
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