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  3. Manigrain Er 250 Tablet 10's

Manigrain Er 250 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Manigrain Er 250 Tablet 10's is used to treat seizures. Besides this, it is also used to treat manic episodes associated with bipolar disorder and prevent migraine symptoms. It contains Valproic acid which works by reducing abnormal electrical activity in the brain. It also produces a calming effect and limits the transmission of pain signals. This medicine may sometimes cause side effects such as nausea, upset stomach, tremors, sleepiness, headache, and weight gain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

VALPROIC ACID-250MG

Manufacturer/Marketer :

Matias Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Manigrain Er 250 Tablet 10's

Manigrain Er 250 Tablet 10's belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. In addition, Manigrain Er 250 Tablet 10's also treats manic episodes associated with bipolar disorder. Besides this, it can also prevent migraine symptoms (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

Manigrain Er 250 Tablet 10's contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

Manigrain Er 250 Tablet 10's should be taken as prescribed by the doctor. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects are temporary and will go away on their own. However, if you suffer these adverse effects on a regular basis, you should consult your doctor.

Inform your doctor if you are allergic to any components present in Manigrain Er 250 Tablet 10's. If you are pregnant, do not take Manigrain Er 250 Tablet 10's because it may cause serious congenital defects. Use effective contraception if you are of childbearing age while taking Manigrain Er 250 Tablet 10's. If you are breastfeeding, inform your doctor before taking Manigrain Er 250 Tablet 10's. As Manigrain Er 250 Tablet 10's causes sleepiness and dizziness, do not drive or operate machinery. Avoid drinking alcohol with Manigrain Er 250 Tablet 10's as it may cause dizziness and tiredness. To rule out any negative effects, keep your doctor updated about your health condition and medications.

Uses of Manigrain Er 250 Tablet 10's

Manigrain Er 250 Tablet 10's is used for the treatment of Epilepsy (fits), Bipolar disorder, Migraine.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Manigrain Er 250 Tablet 10's contains Valproic acid, an anticonvulsant (or anti-epileptic) medicine that reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

How Manigrain Er 250 Tablet 10's Works

Manigrain Er 250 Tablet 10's contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

Storage

Store in a cool and dry place away from sunlight
Side effects of Manigrain Er 250 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Manigrain Er 250 Tablet 10's

Take Manigrain Er 250 Tablet 10's only as prescribed by the doctor. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sleepiness, irregular heartbeat, and coma (loss of consciousness for a period of time). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Before taking the Manigrain Er 250 Tablet 10's, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding. You should not become pregnant while you are receiving Manigrain Er 250 Tablet 10's. Consult your doctor immediately if you become pregnant while receiving a Manigrain Er 250 Tablet 10's. Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving Manigrain Er 250 Tablet 10's.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexVorinostat
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Glycerol phenylbutyrate and Manigrain Er 250 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Manigrain Er 250 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexVorinostat
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Manigrain Er 250 Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Manigrain Er 250 Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Meropenem can reduce the blood levels of Manigrain Er 250 Tablet sodium.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexSodium oxybate
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Sodium oxybate and Manigrain Er 250 Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Manigrain Er 250 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBexarotene
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Sodium phenylbutyrate and Manigrain Er 250 Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Ertapenem with Manigrain Er 250 Tablet may reduce the blood levels of Manigrain Er 250 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Manigrain Er 250 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Ketoconazole and Manigrain Er 250 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Manigrain Er 250 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexDoripenem
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Doripenem can reduce the blood levels of Manigrain Er 250 Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Adolescents and adults are advised to follow the Atkins diet (high fat, low carbohydrate).
  • Exercising on a regular basis aids with weight maintenance and general health.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can help reduce stress, reduce pain sensitivity, and increase coping abilities.
  • Have a seizure response plan in place, and make sure everyone around you knows what to do in the event of a seizure.
  • Prepare your living environment; simple changes may help reduce the risk of physical damage during a seizure.
  • Understand what causes seizures and try to reduce or avoid them.
  • Please keep your overall health in mind, as it can aid in the reduction of seizure activity.
  • Install an alarm or an emergency gadget to summon help during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Manigrain Er 250 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Do not consume alcohol while taking Manigrain Er 250 Tablet 10's as alcohol can worsen the side effects of the Manigrain Er 250 Tablet 10's, including sleepiness and dizziness.

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Pregnancy

Unsafe

Manigrain Er 250 Tablet 10's is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Manigrain Er 250 Tablet 10's.

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Breast Feeding

Caution

Manigrain Er 250 Tablet 10's passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Manigrain Er 250 Tablet 10's. Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Caution

Manigrain Er 250 Tablet 10's may cause dizziness, drowsiness or tiredness in some people. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Manigrain Er 250 Tablet 10's.

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Liver

Caution

Inform your doctor before receiving the Manigrain Er 250 Tablet 10's if you have a history of liver diseases/conditions. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Manigrain Er 250 Tablet 10's.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Consult your doctor

Use is not recommended for children less than ten years. Your doctor will decide the dose based on your child's condition if more than ten years.

Have a query?

FAQs

Manigrain Er 250 Tablet 10's is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).

Manigrain Er 250 Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Manigrain Er 250 Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Manigrain Er 250 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Manigrain Er 250 Tablet 10's. Avoid getting pregnant while taking Manigrain Er 250 Tablet 10's as it could lead to serious birth defects. Do not stop taking Manigrain Er 250 Tablet 10's and consult your doctor immediately if you become pregnant.

Manigrain Er 250 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Manigrain Er 250 Tablet 10's may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.

Manigrain Er 250 Tablet 10's contains Valproic acid as its active ingredient.

Take Manigrain Er 250 Tablet 10's with or without food as advised by your doctor.

You are recommended to avoid alcohol consumption while taking Manigrain Er 250 Tablet 10's as it may worsen the side effects of the Manigrain Er 250 Tablet 10's, including sleepiness and dizziness.

No, Manigrain Er 250 Tablet 10's does not cause addiction. However, Manigrain Er 250 Tablet 10's should be used as per dose and duration prescribed by your doctor. Do not self-medicate.

Manigrain Er 250 Tablet 10's does not cure epilepsy, it only helps to prevent the seizures. However, you have to take Manigrain Er 250 Tablet 10's for as long as it is advised by your doctor. If you face any difficulty while taking Manigrain Er 250 Tablet 10's, consult your doctor.

If you stop taking Manigrain Er 250 Tablet 10's suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to stop taking Manigrain Er 250 Tablet 10's, please consult your doctor.

Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Manigrain Er 250 Tablet 10's in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about the suitable method of contraception.

Manigrain Er 250 Tablet 10's is safe to take for long time in many patients if prescribed by a doctor. In rare cases, prolonged use of Manigrain Er 250 Tablet 10's may weaken your bones, thereby increasing their risk of breaking easily (osteopenia and osteoporosis). Get regular checkups done for bone health if you are taking Manigrain Er 250 Tablet 10's for a long time.

Manigrain Er 250 Tablet 10's may cause hair thinning, hair colour changes and even hair loss. If you have any concerns regarding this, please ask your doctor if it is possible to lower the dose of Manigrain Er 250 Tablet 10's. Your hair may regrow after either lowering your dose or changing medication.

Country of origin

India

Manufacturer/Marketer address

101-104 Gcp Business Centre Opp. Memnagar Fire Station Vijay Cross Road Memnagar Ahmedabad-380014 India
Other Info - MAN0591

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/valproic-acid.html
  2. https://www.medicines.org.uk/emc/files/pil.6102.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018081s065_018082s048lbl.pdf
  4. https://www.nhs.uk/medicines/valproic-acid/
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