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compositionComposition:DIVALPROEX SODIUM-500MG
prescription
Prescription Medicine
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Manigrain-ER 500 Tablet 10's is used to treat epilepsy, seizures or fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DIVALPROEX SODIUM-500MG

Manufacturer/Marketer :

Matias Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Manigrain-ER 500 Tablet 10's

name is a prescription medication primarily used to control and prevent various types of seizures. It is also prescribed to treat manic episodes associated with bipolar disorder and to prevent migraine headaches in adults. By balancing certain natural chemicals in the brain, it helps manage these neurological and mood-related conditions effectively.

To achieve the best results, you must take Manigrain-ER 500 Tablet 10's consistently at the exact same times every day as directed by your doctor. You can take this medication with or without food, though taking it with meals can help prevent stomach upset. Incorporating stable daily routines, such as managing stress, maintaining a regular sleep schedule, and avoiding alcohol, can significantly support your treatment progress.

While taking Manigrain-ER 500 Tablet 10's, some people may experience mild side effects, such as nausea, sleepiness, or mild dizziness. However, you must contact your doctor immediately if you experience serious symptoms, such as severe upper stomach pain, yellowing of your skin or eyes, or unusual changes in your mood or behaviour.

Before starting Manigrain-ER 500 Tablet 10's, tell your doctor if you have a history of liver problems, pancreas issues, or genetic metabolic disorders. Do not take this medication if you have active liver disease, a mitochondrial disorder, or if you are pregnant, as it can cause serious harm to an unborn baby. Talk to your doctor to find out if this medicine is safe for your specific health history.

This medication can interact with other prescription drugs, alcohol, and certain lifestyle habits, which may change how the medicine works or increase side effects. For example, drinking alcohol while taking this medicine can cause extreme sleepiness and increase the risk of liver issues. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss safer treatment options.

Uses of Manigrain-ER 500 Tablet 10's

Manigrain-ER 500 Tablet 10's is used to control and prevent various types of seizures. The detailed uses of Manigrain-ER 500 Tablet 10's are as follows:

  • Epilepsy and Seizures: Manigrain-ER 500 Tablet 10's helps reduce the frequency and intensity of seizures by calming overactive electrical activity in the brain.
  • Bipolar Mania: Manigrain-ER 500 Tablet 10's treats periods of extreme highs, irritability, or excitement by balancing chemical signals in the brain to help stabilise your mood.
  • Migraine Prevention: Manigrain-ER 500 Tablet 10's reduces the number of migraine attacks you experience when taken daily, helping prevent severe head pain before it starts.

Key Benefits

Manigrain-ER 500 Tablet 10's helps manage certain neurological conditions by stabilising electrical activity in the brain. Depending on the condition being treated, it helps control seizures, stabilise mood, or reduce the frequency of migraine attacks, supporting better daily functioning and quality of life.

  • Helps Control Seizures: By reducing abnormal electrical activity in the brain, Manigrain-ER 500 Tablet 10's helps decrease the frequency of seizures, allowing you to carry out daily activities with greater safety and confidence.
  • Supports Mood Stability: For individuals with bipolar disorder, Manigrain-ER 500 Tablet 10's helps reduce mood swings and prevent manic episodes, promoting a more balanced emotional state and improving day-to-day functioning.
  • Helps Prevent Migraine Attacks: When used for migraine prevention, Manigrain-ER 500 Tablet 10's helps reduce the frequency of migraine episodes, allowing you to enjoy your daily activities with fewer painful interruptions and less reliance on rescue pain medicines.
Side effects of Manigrain-ER 500 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Manigrain-ER 500 Tablet 10's can be taken with or without food, or as advised by the doctor.
  • It is usually taken once daily; however, your doctor may adjust the dose and frequency based on your medical condition.
  • Swallow Manigrain-ER 500 Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

How Manigrain-ER 500 Tablet 10's Works

Inside the brain, nerve cells communicate using electrical and chemical signals. Sometimes, these signals become hyperactive or unbalanced, leading to seizures, mood swings, or migraines. Manigrain-ER 500 Tablet 10's works by increasing the activity of a natural chemical messenger in the brain called gamma-aminobutyric acid (GABA). GABA acts as a natural brake system, calming down overactive nerve cells and restoring balance. This soothing effect prevents the sudden electrical rushes that cause seizures and helps stabilise your overall brain activity.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Manigrain-ER 500 Tablet 10's, as it may cause increased dizziness.

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Pregnancy

Unsafe

Manigrain-ER 500 Tablet 10's belongs to pregnancy category D. Avoid taking Manigrain-ER 500 Tablet 10's if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Consult your doctor

Manigrain-ER 500 Tablet 10's may pass into breastmilk. Consult your doctor before taking Manigrain-ER 500 Tablet 10's if you are breastfeeding.

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Driving

Unsafe

Manigrain-ER 500 Tablet 10's causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery until you are mentally alert.

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Liver

Unsafe

Manigrain-ER 500 Tablet 10's should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this. Dose adjustment may be needed in patients with kidney impairment.

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Children

Caution

Manigrain-ER 500 Tablet 10's can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below 2 years as they are at a higher risk of liver toxicity.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Caution

Manigrain-ER 500 Tablet 10's can be given in elderly patients with extreme caution due to the serious adverse effects.

What if I have taken an overdose of Manigrain-ER 500 Tablet 10's

If you take too much of this medication, seek immediate emergency medical care or contact your local poison control centre. Symptoms of an overdose may include extreme sleepiness, shallow breathing, weak muscles, or a slow heartbeat.

Diet & Lifestyle Advise

  • Keep a consistent sleep schedule of 7 to 8 hours per night, as sleep deprivation is a known trigger for seizures, manic episodes, and migraines.
  • Stay properly hydrated throughout the day, as dehydration can worsen side effects like dizziness and headaches.
  • Avoid alcohol entirely while taking this medication, as it severely interacts with Manigrain-ER 500 Tablet 10's to cause extreme sleepiness and increases the risk of liver complications.
  • Maintain a detailed symptom diary to track the frequency of your seizures, mood changes, or migraine triggers, and share this information during your medical check-ups.
health query

Have a query?

How Soon It Starts Working

  • The time required for Manigrain-ER 500 Tablet 10's to start to work: The time required for Manigrain-ER 500 Tablet 10's to show its action is unknown.
  • The time for which the effects of Manigrain-ER 500 Tablet 10's last: The duration of action for Manigrain-ER 500 Tablet 10's is unknown.

What if you forget to take Manigrain-ER 500 Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your normal routine. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.

Storage

•Store Manigrain-ER 500 Tablet 10's at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the medication in its original container with the lid tightly closed to protect it from moisture and direct light.

Drug Warnings

  • Do not stop taking Manigrain-ER 500 Tablet 10's suddenly, even if you feel completely fine, as abrupt discontinuation can trigger severe, continuous seizures.
  • If you are of childbearing age, use a highly effective form of birth control while taking this medicine to prevent unplanned pregnancies due to the risk of severe birth defects.
  • Check your body regularly for any unusual bruising, purple spots, or bleeding from the gums, and notify your doctor immediately if they occur.
  • Avoid driving, riding a bicycle, or operating machinery until you are certain how this medicine affects your alertness and coordination.
  • Keep a medical ID card in your wallet or wear an emergency alert bracelet to notify medical personnel that you are taking this medication in an emergency.

Drug-Drug Interactions

verifiedApollotooltip
  • Aspirin: Taking aspirin can increase the amount of Manigrain-ER 500 Tablet 10's in your blood, which may raise your risk of experiencing harmful side effects.
  • Other seizure medications (such as phenytoin, carbamazepine, or phenobarbital): These drugs can change how your body processes Manigrain-ER 500 Tablet 10's, which may require your doctor to adjust your doses.
  • Blood thinners (such as warfarin): Combining these with Manigrain-ER 500 Tablet 10's can increase your risk of bleeding or bruising.
DivalproexGlycerol phenylbutyrate
Critical
DivalproexKetamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Manigrain-ER 500 Tablet:
Coadministration of Glycerol phenylbutyrate and Manigrain-ER 500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Manigrain-ER 500 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexKetamine
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Co-administration of Manigrain-ER 500 Tablet and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Manigrain-ER 500 Tablet and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
DivalproexLamotrigine
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Coadministration of Manigrain-ER 500 Tablet and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Manigrain-ER 500 Tablet and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexVorinostat
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Coadministration of Manigrain-ER 500 Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Manigrain-ER 500 Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexBuprenorphine
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Co-administration of buprenorphine with Manigrain-ER 500 Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Manigrain-ER 500 Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Coadministration of Ketoconazole and Manigrain-ER 500 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Manigrain-ER 500 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexErtapenem
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Coadministration of Ertapenem with Manigrain-ER 500 Tablet may reduce the blood levels of Manigrain-ER 500 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Manigrain-ER 500 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Co-administration of Manigrain-ER 500 Tablet and Meropenem can reduce the blood levels of Manigrain-ER 500 Tablet sodium.

How to manage the interaction:
Co-administration of Manigrain-ER 500 Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Coadministration of Esketamine and Manigrain-ER 500 Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Manigrain-ER 500 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexDoripenem
Severe
How does the drug interact with Manigrain-ER 500 Tablet:
Co-administration of Manigrain-ER 500 Tablet and Doripenem can reduce the blood levels of Manigrain-ER 500 Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Manigrain-ER 500 Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol can cause severe drowsiness and dizziness and significantly increases the risk of developing liver damage.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Manigrain-ER 500 Tablet 10's belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Manigrain-ER 500 Tablet 10's is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.
Manigrain-ER 500 Tablet 10's contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. Manigrain-ER 500 Tablet 10's increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.
Manigrain-ER 500 Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.
Manigrain-ER 500 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.
Do not discontinue Manigrain-ER 500 Tablet 10's without consulting your doctor. To treat your condition effectively, continue taking Manigrain-ER 500 Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Manigrain-ER 500 Tablet 10's. Your doctor will reduce the dose gradually to avoid worsening of seizures.
Manigrain-ER 500 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Manigrain-ER 500 Tablet 10's. Avoid getting pregnant while taking Manigrain-ER 500 Tablet 10's as it could lead to serious birth defects. Do not stop taking Manigrain-ER 500 Tablet 10's and consult your doctor immediately if you become pregnant.
Manigrain-ER 500 Tablet 10's may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Manigrain-ER 500 Tablet 10's.
Topiramate (anticonvulsant) should not be taken along with Manigrain-ER 500 Tablet 10's as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It is crucial to consult with your doctor before discontinuing Manigrain-ER 500 Tablet 10's. Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
Manigrain-ER 500 Tablet 10's is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Manigrain-ER 500 Tablet 10's can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, please consult your doctor.
Yes, Manigrain-ER 500 Tablet 10's can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Manigrain-ER 500 Tablet 10's, it's essential to consult with your doctor.
Yes, Manigrain-ER 500 Tablet 10's can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Manigrain-ER 500 Tablet 10's, seeking medical attention is crucial.
Avoid consumption of alcohol while taking Manigrain-ER 500 Tablet 10's, as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Manigrain-ER 500 Tablet 10's, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
An overdose of Manigrain-ER 500 Tablet 10's can be a severe medical emergency. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you or someone you know has taken an overdose of Manigrain-ER 500 Tablet 10's, please seek immediate medical attention.
Yes, temporary hair thinning or loss can occur in some people taking Manigrain-ER 500 Tablet 10's. This effect is usually temporary and reversible once the medication is stopped or adjusted, but you should never stop taking it on your own. Talk to your doctor or pharmacist if you notice significant hair changes.
Your doctor will order regular blood tests to check the level of the medicine in your body, monitor your liver health, and measure your blood clotting cells (platelets). This helps ensure the medicine is working safely and effectively. Talk to your doctor about your testing schedule.
Yes, you can take Manigrain-ER 500 Tablet 10's with food. In fact, taking it during or immediately after a meal is highly recommended if you experience nausea or stomach upset. Talk to your doctor or pharmacist if stomach discomfort persists.
Yes, drowsiness and dizziness are common side effects of Manigrain-ER 500 Tablet 10's, especially when you first start taking it or when your dose is increased. Avoid driving or operating machinery until you know how it affects you. Talk to your doctor if the sleepiness interferes with your daily life.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and return to your regular schedule; do not double the dose. Talk to your doctor or pharmacist if you frequently miss doses.
Moderate amounts of caffeine from coffee or tea are generally fine, but excessive caffeine can trigger migraines or affect your sleep patterns, which may interfere with your treatment goals. Talk to your doctor or pharmacist for personalised dietary advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 018723S037Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. DailyMed Database. Fdadrugxsl.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Divalproex Sodium Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 April 2025]Check here
  5. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 10 April 2025]Check here
  6. Depakote Formulations. [Accessed on 02 Jun. 2026]Check here
  7. Sanofi India — Pharmaceutical Products. Sanofi.com [Internet]. [Accessed on 2026 Jan 1]Check here

Country of origin

India

Manufacturer/Marketer address

101-104 Gcp Business Centre Opp. Memnagar Fire Station Vijay Cross Road Memnagar Ahmedabad-380014 India
Other Info - MAN0589

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