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  3. Mesacol Suppository 5's

Mesacol Suppository 5's, Pack of 5 SUPPOSITORYS
Mesacol Suppository 5's, Pack of 5 SUPPOSITORYS
Mesacol Suppository 5's, Pack of 5 SUPPOSITORYS
Mesacol Suppository 5's, Pack of 5 SUPPOSITORYS
Mesacol Suppository 5's, Pack of 5 SUPPOSITORYS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Mesacol Suppository is treating ulcerative colitis and ulcerative proctitis. It contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups. Common side effects of Mesacol Suppository are diarrhoea, stomach pain, headache or nausea.

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Synonym :

MESALAZINE

Composition :

MESALAMINE-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

RECTAL

Return Policy :

Not Returnable

Expires on or after :

About Mesacol Suppository

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum).

Mesacol Suppository contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling).

Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of Mesacol Suppository do not require medical attention and typically resolve on their own over time. However, if the side effects persist or worsen, please consult your doctor.

Follow your doctor's instructions on the dosage and timing of this medication. Mesacol Suppository is for rectal use only. It is advised to wash your hands before and after applying the medicament. Ensure the rectal area is clean and dry before application.

Inform your doctor if you are allergic to any components present in Mesacol Suppository. Mesacol Suppository should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before taking Mesacol Suppository. Avoid taking Mesacol Suppository if you have severe kidney failure. If you have stomach pain, cramps, severe headache, fever or rash, after taking Mesacol Suppository, stop taking it immediately and consult a doctor.

Uses of Mesacol Suppository

Mesacol Suppository is used in the treatment of Ulcerative colitis and Ulcerative proctitis. The detailed uses of Mesacol Suppository are as follows:

  • Management of Irritable Bowel Syndrome (IBS): Mesacol Suppository helps manage IBS symptoms like bloating, gas, and abdominal discomfort.
  • Support for Ulcerative Colitis: Mesacol Suppository supports ulcerative colitis management by reducing flare-ups and promoting gut health.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use it as advised by the doctor. 
  • Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum.
  • Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture.
  • Wash your hands before and after applying the medicament. Make sure that the rectal area is clean and dry before application.
  • For rectal use only.

Medicinal Benefits

  • Mesacol Suppository contains Mesalamine, an anti-inflammatory drug used to treat ulcerative colitis and ulcerative proctitis.
  • This medicine helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.
  • Mesacol Suppository may also prevent further episodes of ulcerative colitis.

How Mesacol Suppository Works

Mesacol Suppository contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups.

Storage

• Store in a cool and dry place away from sunlight.• Keep Mesacol Suppository out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Mesacol Suppository
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.
  • If you have bowel inflammation, eat smaller quantities and more frequent meals.
  • Eat slowly and chew your food thoroughly to help digestion.
  • Eat fiber-rich foods such as fruits, whole grains, and vegetables to promote regular bowel movements.
  • Avoid gas-producing foods like cabbage, beans, broccoli and carbonated drinks.
  • Drink lots of water throughout the day to prevent dehydration and aid digestion.
  • Do regular exercise to enhance digestion and reduce bloating.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of Mesacol Suppository

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.

Drug Warnings

  • Infor your doctor if oyu are allergic to it or any other components.
  • Mesacol Suppository should be used with caution in the elderly.
  • Avoid taking Mesacol Suppository if you have severe kidney failure.
  • Do not use Mesacol Suppository if you are pregnant, planning to become pregnant, or breastfeeding without first consulting the doctor.
  • Mesacol Suppository is recommended not to be used in populations with severe renal or hepatic impairment, so inform your doctor if you have severe renal or hepatic impairment.
  • Use Mesacol Suppository in dose and duration as advised by a doctor only.
  • Mesacol Suppository is for rectal use. Do not swallow it. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.
  • $nam is not recommended for use in children.

Drug-Drug Interactions

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MesalazineCidofovir
Critical
MesalazineTenofovir alafenamide
Severe

Drug-Drug Interactions

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MesalazineCidofovir
Critical
How does the drug interact with Mesacol Suppository:
Co-administration of Mesacol Suppository with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesacol Suppository with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineTenofovir alafenamide
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Tenofovir alafenamide with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Mesacol Suppository with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineOmeprazole
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of omeprazole with Mesacol Suppository can decrease the effects of Mesacol Suppository.

How to manage the interaction:
There could be a possible interaction between Mesacol Suppository and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineDeferasirox
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Deferasirox with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Mesacol Suppository and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Metrizamide with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol Suppository with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Iomeprol with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol Suppository and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Iodamide with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineRanitidine
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Ranitidine with Mesacol Suppository can decrease the levels of Mesacol Suppository, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesacol Suppository with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Nizatidine with Mesacol Suppository can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Mesacol Suppository with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.
  • Opt for food and drinks high in Omega 3 fatty acids to relieve pain, swelling, and inflammation. Omega 3 rich acid-enriched foods include flaxseeds, walnut, soybean oil, salmon, and tuna if you prefer non-veg.
  • Eat more fibre-rich foods such as fruits and vegetables.
  • Eat smaller meals all day.
  • Drink small amounts of water throughout the day.
  • If you are intolerant to lactose, lower your intake of milk.
  • Avoid foods high in sugar, fat, and processed foods, as these, may cause inflammation.
  • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS
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Alcohol

Caution

The interaction of alcohol with Mesacol Suppository is unknown. However, avoid consuming alcohol while on treatment with this medicine.

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Pregnancy

Consult your doctor

Mesacol Suppository should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Mesacol Suppository should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother.

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Driving

Safe if prescribed

Mesacol Suppository usually does not affect your ability to drive or operate machinery.

bannner image

Liver

Caution

Inform your doctor before using Mesacol Suppository if you have a history of liver disease. It should be used cautiously in patients with mild to moderately impaired liver function. It is not recommended for use in populations with severe liver impairment.

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Kidney

Caution

Inform your doctor before using Mesacol Suppository if you have a history of kidney disease. It should be used cautiously in patients with mild to moderately impaired kidney function. It is not recommended for use in populations with severe kidney impairment.

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Children

Not applicable

Mesacol Suppository is intended for adults. Not recommended for children.

Have a query?

FAQs

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis.

Mesacol Suppository contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.

Mesacol Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Mesacol Suppository to prevent dehydration.

If you miss a dosage of mesalamine, take it as soon as you remember unless your next dose is approaching. In this situation, skip the missed dose and resume your regular schedule. Do not combine two doses to make up for a missed dosage.

You are recommended not to take Mesacol Suppository with other medications without doctor's notice, especially immunosuppressant medications such as Azathioprine.

No, you are not recommended to stop using Mesacol Suppository suddenly as it may cause recurring symptoms. Therefore, use Mesacol Suppository for as long as your doctor has prescribed it, and if you experience any difficulty while using Mesacol Suppository, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MES0001

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 11:48 AM IST

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Reference

  1. https://ciplamed-library.com/content/mesalo-foam
  2. https://www.nhs.uk/medicines/mesalazine/
  3. https://www.medicines.org.uk/emc/files/pil.914.pdf

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