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  3. Mesacol CR 500 mg Tablet 10's

Mesacol CR 500 mg Tablet 10's, Pack of 10 TabletS
Mesacol CR 500 mg Tablet 10's, Pack of 10 TabletS
Mesacol CR 500 mg Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Mesacol CR 500 mg Tablet is used to treat Ulcerative colitis and Crohn's disease. It contains Mesalazine, an anti-inflammatory drug. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. This helps reduce inflammation (redness and swelling) in the intestines and relieves stomach pain or bleeding symptoms. Also, it may prevent further episodes of ulcerative colitis.

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Composition :

MESALAZINE-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mesacol CR 500 mg Tablet

Mesacol CR 500 mg Tablet is used to treat ulcerative colitis and Crohn’s disease. Ulcerative colitis is a type of chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus.

Mesacol CR 500 mg Tablet contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling.

In some cases, you may experience diarrhoea, stomach pain, headache, nausea, vomiting or flatulence (gas). Most of these side effects of Mesacol CR 500 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Take Mesacol CR 500 mg Tablet as prescribed. You are advised to use Mesacol CR 500 mg Tablet for as long as your doctor recommends it, based on your medical condition. It should be taken one hour before food or 2 hours after food. Do not take more than the recommended dose of medicine.

Inform your doctor if you are allergic to any components present in Mesacol CR 500 mg Tablet . Mesacol CR 500 mg Tablet should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before taking Mesacol CR 500 mg Tablet . Avoid taking Mesacol CR 500 mg Tablet if you have severe kidney failure. If you have stomach pain, cramps, severe headache, fever or rash, after taking Mesacol CR 500 mg Tablet , stop taking it immediately and consult a doctor.

Uses of Mesacol CR 500 mg Tablet

Mesacol CR 500 mg Tablet is used in the treatment of Ulcerative colitis and Crohn's disease. The detailed uses of Mesacol CR 500 mg Tablet are as follows:<br/>

  • Ulcerative Colitis: Mesacol CR 500 mg Tablet treats inflammation, bleeding, and stomach pain.<br/>
  • Crohn’s Disease: Mesacol CR 500 mg Tablet helps manage symptoms and prevent recurrence.<br/>

Directions for Use

• Mesacol CR 500 mg Tablet can be taken 1 hour before or 2 hours after a meal to prevent stomach upset. • Follow your doctor's instructions on the dosage and timing of this medication, as it may differ from person to person. • Swallow the whole tablet with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

  • Mesacol CR 500 mg Tablet contains Mesalazine, an anti-inflammatory drug used to treat ulcerative colitis and Crohn’s disease.
  • This medicine helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.
  • Mesacol CR 500 mg Tablet may also prevent further episodes of ulcerative colitis.

How Mesacol CR 500 mg Tablet Works

Mesacol CR 500 mg Tablet contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby, it reduces inflammation (swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

Storage

• Store in a cool and dry place away from sunlight.• Keep Mesacol CR 500 mg Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Mesacol CR 500 mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Drug Warnings

  • Inform your doctor if you're allergic to any ingredient in the Mesacol CR 500 mg Tablet .
  • Mesacol CR 500 mg Tablet should be used with caution in the elderly.
  • Avoid taking Mesacol CR 500 mg Tablet if you have severe kidney failure.
  • Severe skin reactions such as toxic epidermal necrolysis (skin peeling and blistering) or Stevens-Johnson syndrome (a painful rash that spreads and blisters) can occur in some patients taking Mesacol CR 500 mg Tablet . Therefore, if you notice any skin reactions while taking Mesacol CR 500 mg Tablet , please consult a doctor immediately.
  • If you are pregnant or breastfeeding, inform your doctor before taking Mesacol CR 500 mg Tablet .
  • If you have stomach pain, cramps, severe headache, fever or rash, stop taking Mesacol CR 500 mg Tablet immediately and consult a doctor.
  • Avoid taking Mesacol CR 500 mg Tablet if you have had blood abnormalities or kidney problems while taking other medicines such as sulfasalazine.

Drug-Drug Interactions

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MesalazineCidofovir
Critical
MesalazineMetrizamide
Severe

Drug-Drug Interactions

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MesalazineCidofovir
Critical
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Mesacol CR 500 mg Tablet with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesacol CR 500 mg Tablet with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Metrizamide with Mesacol CR 500 mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol CR 500 mg Tablet with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Iomeprol with Mesacol CR 500 mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol CR 500 mg Tablet and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineRanitidine
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Ranitidine with Mesacol CR 500 mg Tablet can decrease the levels of Mesacol CR 500 mg Tablet, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesacol CR 500 mg Tablet with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineTenofovir alafenamide
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Tenofovir alafenamide with Mesacol CR 500 mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Mesacol CR 500 mg Tablet with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineDeferasirox
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Deferasirox with Mesacol CR 500 mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Mesacol CR 500 mg Tablet and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Iodamide with Mesacol CR 500 mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of Nizatidine with Mesacol CR 500 mg Tablet can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Mesacol CR 500 mg Tablet with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineOmeprazole
Severe
How does the drug interact with Mesacol CR 500 mg Tablet:
Co-administration of omeprazole with Mesacol CR 500 mg Tablet can decrease the effects of Mesacol CR 500 mg Tablet.

How to manage the interaction:
There could be a possible interaction between Mesacol CR 500 mg Tablet and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help in healing faster.
  • Include olive oil and omega-3 fatty acids. Eat more fibre-rich foods such as fruits and vegetables.
  • Limit dairy intake as your body may develop difficulty digesting certain dairy products when you are affected with Crohn’s disease, which leads to stomach cramps, diarrhoea or stomach upset.
  • Drink plenty of water to prevent dehydration.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Mesacol CR 500 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is unknown whether it is safe to consume alcohol with Mesacol CR 500 mg Tablet . However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Consult your doctor

Mesacol CR 500 mg Tablet should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Caution

Mesacol CR 500 mg Tablet should not be used in nursing mothers unless necessary. So, inform your doctor if you are a nursing mother.

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Driving

Safe if prescribed

Mesacol CR 500 mg Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Please consult your doctor if you have liver problems before using Mesacol CR 500 mg Tablet .

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Kidney

Caution

Inform your doctor before taking Mesacol CR 500 mg Tablet if you have a history of kidney diseases/conditions. Mesacol CR 500 mg Tablet should be used with extreme caution in patients with mild to moderate kidney impairment. It is recommended not to take Mesacol CR 500 mg Tablet if you have severe kidney impairment.

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Children

Caution

Mesacol CR 500 mg Tablet is not recommended for use in children below 6 yeras of age as the safety and efficacy for this medicine is not established. For children above 6 years, the physician will recommed it if necessary.

Have a query?

FAQs

Mesacol CR 500 mg Tablet is used to treat Ulcerative colitis and Crohn's disease.

Mesacol CR 500 mg Tablet contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helps in reducing inflammation (swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

You are not recommended to take Mesacol CR 500 mg Tablet with Ibuprofen as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Mesacol CR 500 mg Tablet with other medicines.

Yes, Mesacol CR 500 mg Tablet may cause kidney stones in some patients. It is not necessary for everyone taking Mesacol CR 500 mg Tablet to experience this side effect. However, if you notice blood in urine or pain in the sides of the stomach, please consult a doctor immediately. Drink adequate water while taking Mesacol CR 500 mg Tablet to prevent kidney stones.

Mesacol CR 500 mg Tablet should be used with caution in patients with stomach ulcers as it may increase the risk of worsening the condition. Therefore, please inform your doctor if you have a stomach ulcer before taking Mesacol CR 500 mg Tablet .

Yes, Mesacol CR 500 mg Tablet may cause diarrhoea as a common side effect. However, if the condition persists and worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while taking Mesacol CR 500 mg Tablet to prevent dehydration.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - MES0097

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 29, 2025 | 10:41 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2217.pdf
  2. https://www.medicines.org.uk/emc/files/pil.1291.pdf
  3. https://www.drugs.com/mtm/mesalamine.html

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