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Mesacol OD Tablet is used to treat ulcerative colitis and Crohn's disease. It contains Mesalamine, which works by inhibiting the production of certain chemical substances that cause pain and swelling. Thereby, it reduces inflammation (swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding. In some cases, this medicine may cause side effects like diarrhoea, stomach pain, headache, nausea, vomiting or flatulence (gas).

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MESALAMINE-1200MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mesacol OD Tablet

Mesacol OD Tablet is a prescription tablet used to treat and manage ulcerative colitis, a condition that causes swelling and sores in the lining of the colon and rectum. It helps to calm active inflammation during flare-ups and works to keep the swelling from coming back. By targeting the gut directly, it provides relief from painful symptoms and helps your bowel tissue heal.

For the best results, you must take Mesacol OD Tablet consistently every day, even when you are feeling completely well. Your doctor may advise you to take this medicine with a meal or a glass of water, depending on the specific type of tablet you are prescribed. Making dietary adjustments, such as eating smaller portions and avoiding spicy or greasy foods, can also help support your digestive recovery alongside this treatment.

While taking this medicine, you might experience mild side effects like headaches, nausea, or light stomach discomfort. However, you must contact your doctor immediately if you experience severe abdominal cramps, fever, or a sudden increase in bloody diarrhoea. These serious symptoms require prompt medical evaluation to ensure your safety.

Do not take this if you have severe kidney or liver damage, or if you are allergic to aspirin or related pain relievers. Before you start taking this medicine, tell your doctor if you have active liver issues, kidney problems, or skin conditions like eczema. Your healthcare provider will evaluate whether this treatment is safe for your specific health profile.

This medicine can interact with certain pain relievers, like ibuprofen, which can increase your risk of kidney damage. It is also important to talk to your doctor or pharmacist if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult, as your monitoring needs may differ.

Uses of Mesacol OD Tablet

Mesacol OD Tablet is used to treat and manage ulcerative colitis. The detailed uses of Mesacol OD Tablet are as follows:

  • Ulcerative Colitis (active flare-ups): Mesacol OD Tablet helps reduce swelling, pain, and bleeding in the colon and rectum when you are experiencing a sudden flare-up of symptoms.
  • Ulcerative Colitis (maintenance of remission): Mesacol OD Tablet prevents future flare-ups by keeping inflammation in check over the long term, helping you stay in remission.

Key Benefits

Mesacol OD Tablet helps manage chronic inflammatory bowel conditions by reducing inflammation in the digestive tract and relieving troublesome bowel symptoms. With regular use, it helps improve bowel function, promotes healing, and supports long-term digestive health.

  • Reduces Bowel Frequency: By controlling inflammation in the intestines, this medicine helps reduce the frequency of bowel movements, allowing you to regain better control over your daily routine.
  • Relieves Abdominal Pain and Rectal Bleeding: This medicine helps ease abdominal cramping, diarrhoea, and rectal bleeding, providing relief while allowing the intestinal lining to heal.
  • Promotes Healthy Bowel Function: By helping firm loose stools and reducing sudden bowel urgency, this medicine improves digestive comfort and daily quality of life.
  • Supports Long-Term Gut Healing: Regular use helps promote healing of the intestinal lining, improving nutrient absorption and supporting better long-term digestive health.
Side effects of Mesacol OD Tablet
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.
  • If you have bowel inflammation, eat smaller quantities and more frequent meals.
  • Eat slowly and chew your food thoroughly to help digestion.
  • Eat fiber-rich foods such as fruits, whole grains, and vegetables to promote regular bowel movements.
  • Avoid gas-producing foods like cabbage, beans, broccoli and carbonated drinks.
  • Drink lots of water throughout the day to prevent dehydration and aid digestion.
  • Do regular exercise to enhance digestion and reduce bloating.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Mesacol OD Tablet can be taken 1 hour before or 2 hours after meals.
  • It is usually taken 3-4 times a day or as prescribed by your doctor.
  • Swallow the whole Mesacol OD Tablet with a glass of water.
  • Do not crush, chew, or break it.

How Mesacol OD Tablet Works

Mesacol OD Tablet contains mesalamine, which works locally inside your digestive tract to reduce swelling and irritation. Instead of working throughout your entire body, the tablet is designed to release its active medicine directly onto the lining of your inflamed colon and rectum. It blocks the production of specific natural chemicals in your gut that trigger pain, redness, and swelling. Think of it as applying a soothing lotion to a sunburn, but on the inside of your bowel. By cooling down the inflamed tissue, it allows the lining of your gut to repair itself. This localised action helps minimise systemic side effects while focusing the treatment exactly where it is needed most.
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Alcohol

Caution

It is unknown whether it is safe to consume alcohol with Mesacol OD Tablet . However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Consult your doctor

Mesacol OD Tablet should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Mesacol OD Tablet should not be used in nursing mothers unless necessary. So, inform your doctor if you are a nursing mother.

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Driving

Safe if prescribed

Mesacol OD Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Limited information is available about using Mesacol OD Tablet in patients with liver disease. Inform your doctor before taking Mesacol OD Tablet if you have a history of liver disease

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Kidney

Caution

Inform your doctor before taking Mesacol OD Tablet if you have a history of kidney diseases/conditions. Mesacol OD Tablet should be used with extreme caution in patients with mild to moderate kidney impairment. It is recommended not to take Mesacol OD Tablet if you have severe kidney impairment.

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Children

Caution

Mesacol OD Tablet is not recommended for use in children below 6 yeras of age as the safety and efficacy for this medicine is not established. For children above 6 years, the physician will recommed it if necessary.

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Heart

Caution

Mesacol OD Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Mesacol OD Tablet .

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Geriatrics

Caution

Mesacol OD Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of Mesacol OD Tablet

If you accidentally take too many tablets, seek immediate medical care or contact, even if you do not have any symptoms of illness.

Diet & Lifestyle Advise

  • Keep a detailed food journal to track what you eat and note any foods that seem to trigger your gut irritation, such as dairy, high-fat meals, or caffeine.
  • Drink plenty of water throughout the day to stay hydrated, especially if you are dealing with watery stools or diarrhoea.
  • During active flare-ups, choose soft, low-fibre foods that are easier on your digestive tract, and switch back to high-fibre foods only when your symptoms have settled.
  • Eat smaller meals more frequently throughout the day instead of three large meals to reduce stress on your digestive system.
     
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How Soon It Starts Working

The time required for Mesacol OD Tablet to start to work: The time required for Mesacol OD Tablet to show its action is unknown. 

The time for which the effects of Mesacol OD Tablet last: Mesacol OD Tablet effect lasts for 24 hours.

What if you forget to take Mesacol OD Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Mesacol OD Tablet tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from direct sunlight and excess moisture.

Drug Warnings

  • Check your stool regularly; if you notice whole or partially intact tablets in your bowel movements, contact your doctor as the medicine may not be absorbing properly.
  • Your doctor will likely want to check your kidney health with simple blood and urine tests before and during your treatment.
  • This medicine can make your skin more sensitive to the sun, so be sure to wear high-factor sunscreen and protective clothing when outdoors.
  • Always inform any dentist or surgeon that you are taking this medication before undergoing any procedures.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Taking Mesacol OD Tablet with NSAIDs, such as ibuprofen or naproxen, may increase the risk of kidney damage. Your doctor may monitor your kidney function, especially if you require prolonged treatment.
  • Immune-Modifying Medicines: Combining Mesacol OD Tablet with immune-modifying medicines, such as azathioprine, may increase the risk of serious blood disorders, including a reduction in blood cell counts. Your doctor may recommend regular blood tests to monitor your condition.
MesalazineIomeprol
Severe

Drug-Drug Interactions

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How does the drug interact with Mesacol OD Tablet:
Co-administration of Mesacol OD Tablet with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesacol OD Tablet with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Mesacol OD Tablet:
Co-administration of Iomeprol with Mesacol OD Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol OD Tablet and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Mesacol OD Tablet:
Co-administration of Ranitidine with Mesacol OD Tablet can decrease the levels of Mesacol OD Tablet, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesacol OD Tablet with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mesacol OD Tablet:
Co-administration of omeprazole with Mesacol OD Tablet can decrease the effects of Mesacol OD Tablet.

How to manage the interaction:
There could be a possible interaction between Mesacol OD Tablet and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mesacol OD Tablet:
Co-administration of Tenofovir alafenamide with Mesacol OD Tablet may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Mesacol OD Tablet with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Mesacol OD Tablet:
Co-administration of Iodamide with Mesacol OD Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Mesacol OD Tablet:
Co-administration of Metrizamide with Mesacol OD Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol OD Tablet with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Mesacol OD Tablet:
Co-administration of Nizatidine with Mesacol OD Tablet can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Mesacol OD Tablet with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mesacol OD Tablet:
Co-administration of Deferasirox with Mesacol OD Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Mesacol OD Tablet and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no known significant food interactions with Mesacol OD Tablet when taken as directed. Follow your doctor's instructions regarding food and fluid intake during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Mesacol OD Tablet is used to treat Ulcerative colitis and Crohn's disease.
Mesacol OD Tablet works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.
You are not recommended to take Mesacol OD Tablet with Ibuprofen as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Mesacol OD Tablet with other medicines.
Yes, Mesacol OD Tablet may cause kidney stones in some patients. It is not necessary for everyone taking Mesacol OD Tablet to experience this side effect. However, if you notice blood in urine or pain in the sides of the stomach, please consult a doctor immediately. Drink adequate water while taking Mesacol OD Tablet to prevent kidney stones.
Mesacol OD Tablet should be used with caution in patients with stomach ulcers as it may increase the risk of worsening the condition. Therefore, please inform your doctor if you have a stomach ulcer before taking Mesacol OD Tablet .
Some people may develop lactose intolerance (inability to digest lactose) when affected by Crohn's disease. Therefore, it is recommended to avoid dairy products if you have Crohn's disease as it may lead to adverse effects such as diarrhoea, stomach cramps, or stomach upset.
Yes, Mesacol OD Tablet may cause diarrhoea as a common side effect. However, if the condition persists and worsens with fever, watery stools, or consistent stomach pain, please consult a doctor. Also, drink plenty of water while taking Mesacol OD Tablet to prevent dehydration.
Do not discontinue Mesacol OD Tablet without consulting your doctor. Discuss with your doctor first if you have any concerns as stopping Mesacol OD Tablet might cause your symptoms to come back.
No, Mesacol OD Tablet is not habit-forming and does not cause addiction.
It is unknown if alcohol interacts with Mesacol OD Tablet . Please consult the doctor before drinking alcohol while taking Mesacol OD Tablet .
Mesacol OD Tablet might cause joint pain. Consult the doctor if you experience severe joint pain or if the condition persists.
Take Mesacol OD Tablet 1 hour before or 2 hours after meals.
Side effects of Mesacol OD Tablet include diarrhoea, stomach pain, headache, nausea, vomiting or flatulence (gas). If the side effects persist or worsen, please consult your doctor.
No, you must swallow the tablets whole. Crushing or breaking them destroys the protective coating that ensures the medicine reaches your colon safely. Talk to your doctor or pharmacist if you have trouble swallowing tablets.
There is currently no permanent cure for ulcerative colitis, but Mesacol OD Tablet is highly effective at managing the condition, reducing flare-ups, and helping you live symptom-free. Talk to your doctor about your long-term treatment plan.
If you occasionally see what looks like an empty tablet shell, this may just be the outer coating passing through. However, if you see whole, undissolved tablets regularly, the medicine may not be absorbing properly. Talk to your doctor.
You should avoid taking aspirin or other salicylates while on this medicine unless specifically directed by your healthcare provider, as they belong to a similar family of drugs and can increase side effects. Talk to your doctor.
Hair loss is a very rare side effect reported by a small number of people taking this type of medication, though it is often linked to the underlying inflammatory bowel disease itself. Talk to your doctor if you notice unusual hair thinning.

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Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - MES0091
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