Do not take METFIRST XL 25MG TABLET if you are allergic to metoprolol succinate or any other beta-blockers. Avoid taking METFIRST XL 25MG TABLET if you have/had heart conduction, rhythm problems, uncontrolled/severe heart failure, blocked blood vessels, blood circulation problems, untreated pheochromocytoma, metabolic acidosis, low blood pressure, or prinzmetal angina. Inform your doctor if you have asthma, COPD, diabetes, blood vessel disorder, slow heart rate, pheochromocytoma, myasthenia gravis, dry eye problems, kidney or liver impairment; if you are taking anti-depressants, other blood pressure-lowering medicines, or anti-arrhythmic agents. Consult your doctor before taking METFIRST XL 25MG TABLET if you are pregnant or breastfeeding. METFIRST XL 25MG TABLET is not recommended for children as safety and efficacy have not been established. METFIRST XL 25MG TABLET may cause dizziness, so drive with caution. Let your doctor know if you are taking other prescription/non-prescription medicines or herbal supplements.

Drug-Drug Interaction: METFIRST XL 25MG TABLET may interact with antacid (cimetidine), blood pressure-lowering agents (hydralazine, clonidine, prazosin), anti-arrhythmic (amiodarone, propafenone), anaesthetics (cyclopropane), anxiolytics (temazepam, nitrazepam, diazepam), NSAID's (indomethacin, celecoxib), antibiotic (rifampicin), anti-fungal (terbinafine), corticosteroids (hydrocortisone, prednisolone), a local anaesthetic (lidocaine), anti-depressants, barbiturates, phenothiazines, and other beta-blockers.

Drug-Food Interaction: Alcohol might increase the blood pressure-lowering effect of METFIRST XL 25MG TABLET. It might also cause increased dizziness. Therefore, avoid alcohol consumption while taking METFIRST XL 25MG TABLET.

Drug-Disease Interaction: METFIRST XL 25MG TABLET may have interaction with disease conditions such as heart conduction problems, rhythm problems, uncontrolled/severe heart failure, blocked blood vessels, blood circulation problems, untreated pheochromocytoma (tumour in the adrenal gland), metabolic acidosis (excess acid in the body), low blood pressure, and prinzmetal angina.

• Do regular physical activity or exercise.
• Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.
• Limit intake of sodium chloride (table salt) in your daily diet.
• Quitting smoking is the best strategy to lower the risk of heart disease. 
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil.

• Monitor your blood pressure daily and if there is too much fluctuation then immediately contact your doctor.
• If you due to have any surgery, inform the doctor that you are taking METFIRST XL 25MG TABLET.