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compositionComposition:METHYLENE BLUE-10MG
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Methblu-10 Injection 10 ml is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy. It contains Methylene Blue, which works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body. Common side effects of this medication are mild to moderate pain at the site of injection, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METHYLENE BLUE-10MG

Manufacturer/Marketer :

Converge Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Methblu-10 Injection 10 ml

Methblu-10 Injection 10 ml is a specialised injectable prescription medicine primarily used to treat acute methemoglobinemia, a serious blood disorder where red blood cells cannot deliver oxygen effectively to the rest of your body. It is typically given in urgent situations to restore proper oxygenation to your organs and tissues. Because it is a rescue therapy, it is usually given as a single dose or a short series of injections rather than a regular daily medication.

This medicine is injected directly into a vein, so there are no restrictions regarding taking it with or without food. Because the underlying condition is often triggered by exposure to certain chemicals or drugs, your care team will recommend lifestyle adjustments such as avoiding industrial dyes, specific local anaesthetics, and high-nitrate water to prevent the condition from returning.

While receiving Methblu-10 Injection 10 ml, you may notice that your urine, stool, or skin temporarily turns a blue or green colour. While this is a normal and harmless side effect, you must contact your doctor or nurse immediately if you experience serious symptoms such as severe confusion, rapid heart rate, muscle twitching, or difficulty breathing.

Before you receive this injection, it is vital to tell your healthcare provider about your complete medical history. Do not receive this medicine if you have a genetic enzyme disorder called G6PD deficiency, as it can cause a severe blood reaction. You should also tell your doctor if you have kidney disease or a history of severe allergies.

This medication can interact dangerously with other substances, particularly prescription antidepressants such as SSRIs or MAOIs, potentially causing a life-threatening brain chemical imbalance. It is also important to tell your doctor if you are pregnant, breastfeeding, or if the patient is an elderly individual, so they can carefully weigh the risks and benefits. Talk to your doctor or pharmacist if you have any questions about these interactions.

Uses of Methblu-10 Injection 10 ml

Your doctor may prescribe Methblu-10 Injection 10 ml to treat the following conditions to help restore the blood's ability to carry oxygen and improve oxygen delivery throughout the body:

  • Methemoglobinemia: Methblu-10 Injection 10 ml helps by quickly converting abnormal methemoglobin back into functional hemoglobin, restoring your blood's capacity to transport oxygen to vital organs.
  • Drug-induced blood disorders: It reverses acute oxygen-delivery failure triggered by accidental exposure to certain toxic chemicals, nitrates, or specific medications.

Key Benefits

Using Methblu-10 Injection 10 ml as prescribed helps restore the blood's ability to carry oxygen during medical emergencies. Here are the key benefits you can expect:

  • Restores oxygen delivery quickly: Helps rapidly convert abnormal methemoglobin into functional haemoglobin, allowing oxygen to reach vital organs.
  • Provides fast symptom relief: Helps reduce symptoms such as bluish skin discolouration, shortness of breath, and extreme fatigue by improving oxygen levels.
  • Protects vital organs: By restoring normal oxygen flow, Methblu-10 Injection 10 ml helps protect the brain, heart, and kidneys from damage caused by prolonged oxygen deprivation and supports a faster recovery.
Side effects of Methblu-10 Injection 10 ml
  • Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
  • Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
  • Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
  • Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
  • Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
  • Rest and take a break from usual activities.
  • Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
  • Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
  • Avoid strenuous activities and rest the affected area.
  • Try light stretching with gentle exercises to maintain flexibility.
  • Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.
  • Talk to your doctor about identifying the cause of the discoloration, adjusting your dose, or switching to a different medication.
  • Keep an eye on your urine colour and let your doctor know if you notice any unusual changes.
  • Increase your intake of water or other liquids to dilute your urine and restore its normal colour.
  • Avoid foods that can change your urine colour, such as beets, rhubarb, and berries.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Wear loose-fitting clothes and breathable fabrics.
  • Keep your room cool by using a fan or AC.
  • Avoid or limit spicy food, alcohol and caffeine as they can trigger hot flashes.
  • Manage stress by practising relaxation techniques with yoga and meditation.
  • Quit smoking.
  • Maintain a healthy weight by including fruits and vegetables in your diet.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Methblu-10 Injection 10 ml will be administered by a healthcare professional.
  • Do not self-administer it.

How Methblu-10 Injection 10 ml Works

Methblu-10 Injection 10 ml contains methylene blue, which acts as an electron donor in the body. When you have methemoglobinemia, the iron in your red blood cells is modified, making it unable to release oxygen to your tissues. Once injected, Methblu-10 Injection 10 ml utilises a natural enzyme pathway inside your red blood cells to rapidly convert this inactive iron back to its normal state. This process restores the cells' natural ability to bind and release oxygen, allowing your tissues to breathe normally again.
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Alcohol

Caution

It is not known whether Methblu-10 Injection 10 ml interacts with alcohol. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Methblu-10 Injection 10 ml.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking Methblu-10 Injection 10 ml; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Safe if prescribed

Methblu-10 Injection 10 ml usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Limited information was available about using Methblu-10 Injection 10 ml in patients with liver disease. Inform your doctor before receiving Methblu-10 Injection 10 ml if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Use with caution in patients with kidney failure, as methylene blue is primarily excreted through the kidneys. Inform your doctor before receiving Methblu-10 Injection 10 ml if you have a history of kidney diseases. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Please consult your doctor. Your doctor will prescribe this medicine based on your child's condition.

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Heart

Consult your doctor

Methblu-10 Injection 10 ml may be used in individuals with heart conditions, but its cardiac effects depend on timing and underlying disease. Thorough cardiovascular evaluation is essential to ensure safe and appropriate administration.

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Geriatrics

Caution

Methblu-10 Injection 10 ml can be administered to geriatric patients, but careful dosing and monitoring are essential due to age-related changes in renal and hepatic function. Lower doses are typically recommended, and clinicians should assess for potential drug interactions and adverse effects such as serotonin syndrome or hypotension.

What if I have taken an overdose of Methblu-10 Injection 10 ml

Because this medication is injected under close clinical supervision, an overdose is rare. However, if too much medicine is given, it can worsen methemoglobinemia or cause breathing difficulties and chest pain. The medical team will monitor you closely and treat any symptoms immediately.

Diet & Lifestyle Advise

  • Avoid triggers: Stay away from known triggers of methemoglobinemia, such as topical benzocaine sprays, certain nitrate preservatives in foods, and well water that has not been tested for nitrates.
  • Increase fluid intake: Drink plenty of water after your treatment to help your kidneys safely flush the blue dye out of your body.
  • Avoid aniline dyes: Limit exposure to industrial chemical solvents, certain paints, and chemical dyes, as these can reactivate the blood condition.
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How Soon It Starts Working

The time required for Methblu-10 Injection 10 ml to start to work: Methblu-10 Injection 10 ml ideally shows its action within 30 minutes after administration. The time for which the effects of Methblu-10 Injection 10 ml last: The duration of action for Methblu-10 Injection 10 ml is unknown.

What if you forget to take Methblu-10 Injection 10 ml

Since this medicine is given by a healthcare professional in an emergency or hospital setting, it is highly unlikely that you will miss a dose. If your treatment plan requires multiple injections, the medical staff will maintain a strict schedule.

Storage

• Methblu-10 Injection 10 ml is usually stored and handled by healthcare professionals. Store it at 20°C to 25°C (68°F to 77°F) in its original carton. Do not freeze.

Drug Warnings

  • Inspect the solution: Ensure the solution is clear, deep blue, and free of visible particles before administration.
  • Report injection site problems: Tell your healthcare provider immediately if you feel burning, stinging, pain, or swelling around the injection site, as leakage from the vein may damage surrounding tissue.
  • Avoid driving: Do not drive or operate machinery for at least 24 hours after receiving this injection, as it may cause temporary dizziness, confusion, or blurred vision.
  • Inform your doctor about G6PD deficiency: Tell your doctor if you have a history of G6PD deficiency, as Methblu-10 Injection 10 ml may cause severe destruction of red blood cells in affected individuals.
  • Expect urine colour changes: Your urine and sweat may turn blue-green for a few days after treatment. This is a normal effect and will resolve as the medicine leaves your body.
  • Expect monitoring in hospital: Your healthcare team may check your oxygen levels continuously and repeat blood tests to ensure the medicine is working properly and that methemoglobin levels are falling.

Drug-Drug Interactions

verifiedApollotooltip

  • Antidepressants (SSRIs, SNRIs, and MAOIs): Taking these medicines with Methblu-10 Injection 10 ml can increase serotonin levels and may cause serotonin syndrome, a serious condition with symptoms such as high fever, confusion, muscle stiffness, and agitation.

Methylene blueAmitriptyline
Critical
Methylene blueFluvoxamine
Critical

Drug-Drug Interactions

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Methylene blueAmitriptyline
Critical
How does the drug interact with Methblu-10 Injection 10 ml:
Combining Methblu-10 Injection 10 ml with Amitriptyline can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Methblu-10 Injection 10 ml and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
Methylene blueFluvoxamine
Critical
How does the drug interact with Methblu-10 Injection 10 ml:
Taking Fluvoxamine with Methblu-10 Injection 10 ml can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Fluvoxamine with Methblu-10 Injection 10 ml is not recommended, but can be taken together if prescribed by a doctor. However, if you experience confusion, hallucination(seeing & hearing things that do not exist), seizure(fits), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor(shaking of hands & legs), incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medication without consulting a doctor.
Methylene blueClomipramine
Critical
How does the drug interact with Methblu-10 Injection 10 ml:
When Clomipramine is taken with Methblu-10 Injection 10 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clomipramine and Methblu-10 Injection 10 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Methylene blueEphedrine
Critical
How does the drug interact with Methblu-10 Injection 10 ml:
When Ephedrine and Methblu-10 Injection 10 ml are combined, there is an increase in the risk or severity of high blood pressure.

How to manage the interaction:
Taking Ephedrine and Methblu-10 Injection 10 ml is not recommended as it can result in an interaction, it can be taken if a doctor has prescribed it. However, if you develop a sudden, severe headache, blurred vision, disorientation, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), difficulty speaking, fever, sweating, lightheadedness, or fainting, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
Methylene blueAtomoxetine
Critical
How does the drug interact with Methblu-10 Injection 10 ml:
Using Methblu-10 Injection 10 ml together with atomoxetine can cause high blood pressure.

How to manage the interaction:
Taking Atomoxetine with Methblu-10 Injection 10 ml is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not stop using any medications without talking to a doctor.
Methylene blueNortriptyline
Severe
How does the drug interact with Methblu-10 Injection 10 ml:
Using Nortriptyline together with Methblu-10 Injection 10 ml can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although taking Nortriptyline and Methblu-10 Injection 10 ml together can cause an interaction, it can be taken if your doctor has suggested it. If you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not stop using any medications without a doctor's advice.
Methylene blueSumatriptan
Severe
How does the drug interact with Methblu-10 Injection 10 ml:
Using Methblu-10 Injection 10 ml together with Sumatriptan might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Sumatriptan and Methblu-10 Injection 10 ml, you can take these medicines together if prescribed by your doctor. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
Methylene blueSelegiline
Severe
How does the drug interact with Methblu-10 Injection 10 ml:
When Methblu-10 Injection 10 ml is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Methblu-10 Injection 10 ml and Selegiline, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach cramp, nausea, vomiting, and diarrhea, call a doctor. Do not stop using any medications without a doctor's advice.
Methylene blueEscitalopram
Severe
How does the drug interact with Methblu-10 Injection 10 ml:
Taking Escitalopram with Methblu-10 Injection 10 ml can increase the effects of serotonin(a chemical produced in the brain) in the body.

How to manage the interaction:
Taking Escitalopram with Methblu-10 Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience any symptoms like confusion, hallucinations, seizures, and increased heart rate. Do not stop using any medications without first talking to your doctor.
Methylene blueEntacapone
Severe
How does the drug interact with Methblu-10 Injection 10 ml:
Combining Entacapone with Methblu-10 Injection 10 ml can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Entacapone with Methblu-10 Injection 10 ml together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Methblu-10 Injection 10 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Methblu-10 Injection 10 ml is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy.
Methblu-10 Injection 10 ml contains Methylene Blue. Methylene blue converts methemoglobin into a more efficient type of haemoglobin to better carry oxygen throughout the body. Thus, it efficiently treats a condition called methemoglobinemia.
Injection site reactions, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm are the common side effects of Methblu-10 Injection 10 ml.
If you are currently taking anti-depressant medications such as escitalopram, notify your doctor before receiving methylene blue. Combining these medications can increase the risk of an uncommon but deadly disease known as serotonin syndrome, which can cause symptoms such as confusion, hallucination, seizure, dramatic fluctuations in blood pressure, rapid heart rate, and fever.
This is a normal and harmless side effect. The medicine is a deep blue dye, and your kidneys naturally filter it out of your body through your urine. The discolouration will disappear once the medication has fully left your system. Talk to your doctor if it persists.
No, this medicine must be injected into a vein by a trained healthcare professional in a hospital or clinical setting. This allows your medical team to monitor your blood oxygen levels and heart rate during treatment. Talk to your doctor for more information.
This medicine is generally avoided during pregnancy unless it is a life-saving emergency, as it may harm an unborn baby. If you are pregnant or think you might be, talk to your doctor about the risks and benefits.
Tell your healthcare provider immediately. Pain, redness, or swelling can mean the fluid is leaking into the tissues around your vein, which requires quick medical attention to prevent irritation. Talk to your doctor if you experience this.
It generally takes a few days for the medicine to be completely cleared from your body, mostly through your urine. You may notice blue-green urine during this time. Talk to your doctor if you have concerns about clearance.
Yes, like any medicine, it can cause an allergic reaction in some people. Inform the medical staff immediately if you develop a rash, hives, itching, or difficulty breathing during or after the injection. Talk to your doctor if you have a history of allergies.
Yes, alcohol can worsen side effects like dizziness, drowsiness, and nausea. It is best to avoid alcohol until the medicine has completely cleared from your system. Talk to your doctor or pharmacist for specific advice.
Your healthcare team may monitor your oxygen levels, heart rate, blood pressure, and repeat blood tests such as co-oximetry to measure methemoglobin levels and confirm that the treatment is working.
Yes, it may be used in certain emergency situations, including severe methemoglobinemia in newborns or infants, but dosing and monitoring are very different from adults. Treatment in babies must always be supervised by a specialist doctor.
If methemoglobin levels do not improve sufficiently, doctors may give another dose, provide additional supportive treatment, or consider other options such as exchange transfusion in severe cases. The decision depends on the cause of the methemoglobinemia, your blood test results, and your overall condition.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

7-2-1813,/5/A/1, Vasavi'S Central Court, Unit-Ii , 3rd Floor, Czech Colony, Sanath Nagar, Hyderabad - 500018., Telangana State, India.
Other Info - MET1968

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