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compositionComposition:METHYLENE BLUE-10MG
prescriptionPrescription Medicine
Methylene Blue Injection

Methylene Blue Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy. It contains Methylene Blue, which works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body. Common side effects of this medication are mild to moderate pain at the site of injection, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METHYLENE BLUE-10MG

Manufacturer/Marketer :

Vulcan Laboratories Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

Methylene Blue Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy. Methemoglobinemia is a condition that occurs when the blood cannot deliver oxygen where it is needed in the body. Vasodilatory shock is a medical emergency in which your body cannot get enough blood to your heart, brain, and kidneys.

Methylene Blue Injection contains Methylene Blue. Methylene blue works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body.

A qualified healthcare professional will administer Methylene Blue Injection. You may experience mild to moderate pain at the site of injection, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm. Most of these side effects of Methylene Blue Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

If you have a glucose-6-phosphate dehydrogenase (G6PD) deficiency, you should avoid using methylene blue. Many medicines, particularly antidepressants, can interact with methylene blue. So, before taking the Methylene Blue Injection, inform your doctor about all of your medical issues, sensitivities, and drugs. Also, let your doctor know if you are pregnant, planning to become pregnant, or are breastfeeding.

Uses of Methylene Blue Injection

Methylene Blue Injection is used in the treatment of Methemoglobinemia and Vasodilatory shock. The detailed uses of Methylene Blue Injection are as follows:

  • Treatment of Methemoglobinemia: Methylene Blue Injection is used to treat methemoglobinemia, a condition where hemoglobin is unable to carry oxygen effectively, by converting methemoglobin back to functional hemoglobin.
  • Management of Vasoplegic Syndrome Post-Surgery: Methylene Blue Injection may be administered when epinephrine is ineffective, helping increase vascular resistance during vasoplegic shock after cardiac procedures like coronary artery bypass grafting.

Key Benefits

Methylene Blue Injection contains Methylene Blue, which belongs to the class of monoamine oxidase inhibitors. It is used to treat a condition called methemoglobinemia. Methylene blue converts methemoglobin into a more efficient type of haemoglobin to better carry oxygen throughout the body.

Side effects of Methylene Blue Injection
  • Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
  • Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
  • Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
  • Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
  • Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
  • Rest and take a break from usual activities.
  • Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
  • Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
  • Avoid strenuous activities and rest the affected area.
  • Try light stretching with gentle exercises to maintain flexibility.
  • Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.
  • Talk to your doctor about identifying the cause of the discoloration, adjusting your dose, or switching to a different medication.
  • Keep an eye on your urine colour and let your doctor know if you notice any unusual changes.
  • Increase your intake of water or other liquids to dilute your urine and restore its normal colour.
  • Avoid foods that can change your urine colour, such as beets, rhubarb, and berries.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Wear loose-fitting clothes and breathable fabrics.
  • Keep your room cool by using a fan or AC.
  • Avoid or limit spicy food, alcohol and caffeine as they can trigger hot flashes.
  • Manage stress by practising relaxation techniques with yoga and meditation.
  • Quit smoking.
  • Maintain a healthy weight by including fruits and vegetables in your diet.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Methylene Blue Injection will be administered by a healthcare professional.
  • Do not self-administer it.
Methylene Blue Injection contains Methylene Blue. Methylene blue works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body.
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Alcohol

Caution

It is not known whether Methylene Blue Injection interacts with alcohol. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Methylene Blue Injection.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking Methylene Blue Injection; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Safe if prescribed

Methylene Blue Injection usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Limited information was available about using Methylene Blue Injection in patients with liver disease. Inform your doctor before receiving Methylene Blue Injection if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Use with caution in patients with kidney failure, as methylene blue is primarily excreted through the kidneys. Inform your doctor before receiving Methylene Blue Injection if you have a history of kidney diseases. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Please consult your doctor. Your doctor will prescribe this medicine based on your child's condition.

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Heart

Consult your doctor

Methylene Blue Injection may be used in individuals with heart conditions, but its cardiac effects depend on timing and underlying disease. Thorough cardiovascular evaluation is essential to ensure safe and appropriate administration.

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Geriatrics

Caution

Methylene Blue Injection can be administered to geriatric patients, but careful dosing and monitoring are essential due to age-related changes in renal and hepatic function. Lower doses are typically recommended, and clinicians should assess for potential drug interactions and adverse effects such as serotonin syndrome or hypotension.

As Methylene Blue Injection is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • Adhering to a regular meal pattern, minimizing intake of insoluble fibers, alcohol, caffeine, spicy foods, and fat, as well as engaging in regular physical activity and being hydrated, are all standard suggestions.
  • Keep a diet or food diary.
  • Make time to eat. If possible, sit down, relax, and enjoy your meal with others. Avoid eating while on the go!
  • Eat three regular meals a day, at nearly the same times and in roughly the same amounts.
  • Maintain an active lifestyle and get enough exercise. This will make you feel better.
  • Avoid high-fat meals and limit your intake of poorly absorbed carbs.
  • Maintain a balanced lifestyle and try to reduce stress as much as possible. Allow yourself time to relax and do things you enjoy. 
  • Avoid drinking alcohol and quit smoking.

Have a query?

Drug Warnings

It is recommended not to use it if you are allergic to methylene blue or other ingredients. Methylene blue should not be used to treat methemoglobinemia in people with glucose-6-phosphate deficiencies (G-6-PD). When methylene blue was delivered intravenously to patients who were concurrently taking other medications having serotonin reuptake inhibitor characteristics, serotonin toxicity/serotonin syndrome was reported. If drugs with serotonin reuptake inhibition capabilities are being used, they must be stopped before using methylene blue injectables to allow for a washout time of at least 4 - 5 half-lives. So, before taking the Methylene Blue Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using.

Drug-Drug Interactions

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Methylene blueEphedrine
Critical
Methylene blueFluvoxamine
Critical

Drug-Drug Interactions

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Methylene blueEphedrine
Critical
How does the drug interact with Methylene Blue Injection Injection:
When Ephedrine and Methylene Blue Injection are combined, there is an increase in the risk or severity of high blood pressure.

How to manage the interaction:
Taking Ephedrine and Methylene Blue Injection is not recommended as it can result in an interaction, it can be taken if a doctor has prescribed it. However, if you develop a sudden, severe headache, blurred vision, disorientation, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), difficulty speaking, fever, sweating, lightheadedness, or fainting, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
Methylene blueFluvoxamine
Critical
How does the drug interact with Methylene Blue Injection Injection:
Taking Fluvoxamine with Methylene Blue Injection can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Fluvoxamine with Methylene Blue Injection is not recommended, but can be taken together if prescribed by a doctor. However, if you experience confusion, hallucination(seeing & hearing things that do not exist), seizure(fits), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor(shaking of hands & legs), incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medication without consulting a doctor.
Methylene blueAtomoxetine
Critical
How does the drug interact with Methylene Blue Injection Injection:
Using Methylene Blue Injection together with atomoxetine can cause high blood pressure.

How to manage the interaction:
Taking Atomoxetine with Methylene Blue Injection is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not stop using any medications without talking to a doctor.
Methylene blueClomipramine
Critical
How does the drug interact with Methylene Blue Injection Injection:
When Clomipramine is taken with Methylene Blue Injection, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clomipramine and Methylene Blue Injection, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Methylene blueAmitriptyline
Critical
How does the drug interact with Methylene Blue Injection Injection:
Combining Methylene Blue Injection with Amitriptyline can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Methylene Blue Injection and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
Methylene blueEntacapone
Severe
How does the drug interact with Methylene Blue Injection Injection:
Combining Entacapone with Methylene Blue Injection can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Entacapone with Methylene Blue Injection together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Methylene blueNortriptyline
Severe
How does the drug interact with Methylene Blue Injection Injection:
Using Nortriptyline together with Methylene Blue Injection can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although taking Nortriptyline and Methylene Blue Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not stop using any medications without a doctor's advice.
Methylene blueSumatriptan
Severe
How does the drug interact with Methylene Blue Injection Injection:
Using Methylene Blue Injection together with Sumatriptan might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Sumatriptan and Methylene Blue Injection, you can take these medicines together if prescribed by your doctor. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
Methylene blueSelegiline
Severe
How does the drug interact with Methylene Blue Injection Injection:
When Methylene Blue Injection is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Methylene Blue Injection and Selegiline, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach cramp, nausea, vomiting, and diarrhea, call a doctor. Do not stop using any medications without a doctor's advice.
Methylene blueEscitalopram
Severe
How does the drug interact with Methylene Blue Injection Injection:
Taking Escitalopram with Methylene Blue Injection can increase the effects of serotonin(a chemical produced in the brain) in the body.

How to manage the interaction:
Taking Escitalopram with Methylene Blue Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience any symptoms like confusion, hallucinations, seizures, and increased heart rate. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Methylene Blue Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy.

Methylene Blue Injection contains Methylene Blue. Methylene blue converts methemoglobin into a more efficient type of haemoglobin to better carry oxygen throughout the body. Thus, it efficiently treats a condition called methemoglobinemia.

Injection site reactions, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm are the common side effects of Methylene Blue Injection.

If you are currently taking anti-depressant medications such as escitalopram, notify your doctor before receiving methylene blue. Combining these medications can increase the risk of an uncommon but deadly disease known as serotonin syndrome, which can cause symptoms such as confusion, hallucination, seizure, dramatic fluctuations in blood pressure, rapid heart rate, and fever.

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
INDIA
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Other Info - MET0183

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