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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Metrogyl O Tablet is used to treat various bacterial infections. It is also effective in treating diarrhoea due to mixed infections and dysentery caused by amoebas. It contains Ofloxacin and Metronidazole, which work by killing the bacteria and parasites responsible for the infections. In some cases, you may experience side effects such as nausea, vomiting, stomach upset, loss of appetite, dry mouth, and a metallic taste. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and any pre-existing medical conditions.

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Consume Type :

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Return Policy :

Not Returnable

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About Metrogyl O Tablet

Metrogyl O Tablet is a combination of antibacterial (ofloxacin) and anti-amoebic (metronidazole) medication used to treat various infections caused by bacteria. It is also effective in treating diarrhoea due to mixed infections and amoebic dysentery. A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. Diarrhoea is an increase in the frequency of bowel movements, resulting in loose and watery stools. Amoebic dysentery (Also Known as Amoebiasis) is an intestinal infection caused by the parasite Entamoeba histolytica.

Metrogyl O Tablet is a combination of two antibiotics that include Ofloxacin and Metronidazole. Ofloxacin prevents the division of bacterial cells and inhibits their repair mechanism, leading to the death of the bacteria. Metronidazole kills parasites and anaerobic bacteria that cause infections. It works by damaging their DNA. Both antibiotics are bactericidal in nature and work together to effectively treat the infection.

Take Metrogyl O Tablet exactly as prescribed. Your doctor will recommend how often you take Metrogyl O Tablet based on your medical condition. In some cases, you may experience common side effects, including nausea, vomiting, stomach upset, loss of appetite, dry mouth, a metallic taste, headache, dizziness, drowsiness, and confusion. Most of these side effects of Metrogyl O Tablet do not require medical attention and typically resolve on their own over time. However, if the side effects are persistent, reach out to your doctor.

It is not advisable to stop taking Metrogyl O Tablet suddenly to avoid unpleasant side effects. The full course prescribed by the doctor should be completed. Inform your doctor if you have any lung disease, epilepsy, difficulty sleeping (sleep apnoea), severe liver disease, or problems with alcohol or other prescription or recreational drugs. Metrogyl O Tablet should not be used by pregnant women (especially during the first trimester), breastfeeding mothers, and patients with liver diseases, low blood white cells (leukopenia), seizures (fits), gastrointestinal diseases (like Crohn's disease and inflammatory bowel disease), and other neurological diseases. Metrogyl O Tablet may cause dizziness and drowsiness; therefore, avoid driving and operating machinery until you are mentally alert.

Uses of Metrogyl O Tablet

Metrogyl O Tablet is used in the treatment of various bacterial and parasitic infections. Its detailed uses are as follows:<br/> • Bacterial Infections: Metrogyl O Tablet is effective in treating bacterial infections of the lungs, skin, prostate, urinary tract (kidneys and bladder), and gastrointestinal tract (stomach and intestines).<br/> • Diarrhoea Due to Mixed Infections: Metrogyl O Tablet is prescribed for the treatment of diarrhoea caused by a combination of bacterial and parasitic organisms, such as those caused by Giardia lamblia (a parasite) and Clostridium difficile (a bacteria).<br/> • Amoebic Dysentery (Amoebiasis): Metrogyl O Tablet is also effective in treating intestinal amoebiasis caused by Entamoeba histolytica, a parasite that leads to diarrhoea and dysentery.<br/> • Gynaecological Infections: Metrogyl O Tablet helps in managing pelvic inflammatory disease (caused by sexually transmitted infections like gonorrhoea and chlamydia) and vaginosis (caused by an imbalance of bacteria in the vagina).<br/> • Post-Surgical Infections: Metrogyl O Tablet may also be used to treat or prevent bacterial infections after certain abdominal or gynaecological surgeries.<br/>

Directions for Use

  • Metrogyl O Tablet may be taken with or without food (excluding dairy), but taking it with food may lessen stomach discomfort.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Metrogyl O Tablet as a whole with a glass of water.
  • Do not break, crush, or chew it.

Medicinal Benefits

Metrogyl O Tablet is used to treat various bacterial infections affecting the lungs, skin, prostate, urinary tract, and gastrointestinal tract. It is also effective in treating diarrhoea caused by mixed infections (involving both bacteria and parasites) and amoebic dysentery. It is a combination of two antibiotics: Ofloxacin and Metronidazole. Ofloxacin (an antibacterial) prevents the division of bacterial cells and inhibits their repair mechanism, leading to the death of the bacteria. Metronidazole kills parasites and anaerobic bacteria that cause infections. It works by damaging their DNA. Both antibiotics are bactericidal in nature and work together to treat the infection effectively.

How Metrogyl O Tablet Works

Metrogyl O Tablet is a combination of two antibiotics: Ofloxacin and Metronidazole. Ofloxacin works by preventing bacterial cell division and inhibiting their repair mechanisms, ultimately leading to bacterial cell death. Metronidazole is effective against parasites and anaerobic bacteria; it works by damaging their DNA, resulting in their elimination. Both antibiotics are bactericidal in nature and act synergistically to effectively treat a wide range of infections.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Metrogyl O Tablet

Do not take more than the prescribed dose of Metrogyl O Tablet . Taking extra medication will not improve your symptoms and may lead to poisoning or serious side effects. If you suspect an overdose or experience any adverse effects, seek immediate medical attention at the nearest emergency department.

Drug Warnings

If you are allergic to ofloxacin, metronidazole, or any other antibacterial or anti-amoebic agents, please inform your doctor to avoid any unwanted side effects like swallowing or breathing problems, swelling of your lips, face, throat, or tongue. Taking Metrogyl O Tablet may increase the chances of developing tendinitis (swelling of a tissue that joins a bone to a muscle) or a tendon rupture. Dairy products should be avoided along with Metrogyl O Tablet . Additionally, exposure to sunlight should be avoided while taking Metrogyl O Tablet , as it may increase phototoxicity or photosensitivity. Patients with an irregular heartbeat (QT prolongation) should tell their doctor before taking Metrogyl O Tablet . Metrogyl O Tablet should not be given to the pregnant mother (during the first trimester) and in nursing mothers as it passes into the breast milk. Please inform your doctor before taking Metrogyl O Tablet if you have a history of liver disease, low blood white cells (leukopenia), a joint or tendon disorder (such as rheumatoid arthritis), seizures (fits), gastrointestinal diseases (like Crohn's disease and Inflammatory bowel disease), or other neurological diseases. Metrogyl O Tablet may cause dizziness and drowsiness; therefore, avoid driving and operating machinery until you are mentally alert. Avoid alcohol consumption while taking Metrogyl O Tablet , as it may increase the risk of side effects like dizziness and drowsiness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Dronedarone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Metrogyl O Tablet with Dronedarone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Metrogyl O Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinQuinidine
Critical
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Quinidine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Metrogyl O Tablet with Quinidine together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinHalofantrine
Critical
How does the drug interact with Metrogyl O Tablet:
Using halofantrine together with Metrogyl O Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Metrogyl O Tablet with Halofantrine can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OfloxacinSaquinavir
Critical
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Metrogyl O Tablet with Saquinavir together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Disopyramide can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Metrogyl O Tablet with Disopyramide together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinBepridil
Critical
How does the drug interact with Metrogyl O Tablet:
Using bepridil together with Metrogyl O Tablet drugs can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Metrogyl O Tablet with Bepridil can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without consulting a doctor.
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Pimozide can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Metrogyl O Tablet with Pimozide together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Sotalol can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Metrogyl O Tablet with Sotalol together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Metrogyl O Tablet:
Coadministration of Metrogyl O Tablet with Cisapride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Metrogyl O Tablet with Cisapride together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor. Note: Cisapride is no longer available on the market. Cisapride should only be taken if prescribed by a doctor and closely monitored.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid consuming excessive amounts of caffeine-containing products, such as coffee, tea, energy drinks, cola, or chocolate. Metrogyl O Tablet may increase nervousness, sleeplessness, and anxiety caused by caffeine.
  • Probiotics should be taken after completing the full course of Metrogyl O Tablet to help restore healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods, such as yoghurt, cheese, sauerkraut, kombucha, and kimchi, can help restore the gut's beneficial bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains, such as whole-grain bread and brown rice, should be included in your diet. Make sure to drink plenty of water or other fluids every day while you are taking Metrogyl O Tablet .
  • Avoid the intake of alcoholic beverages, as they can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Metrogyl O Tablet in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Metrogyl O Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Alcohol should not be consumed while taking Metrogyl O Tablet , as it may increase the risk of side effects like dizziness and drowsiness.

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Pregnancy

Unsafe

Metrogyl O Tablet should not be taken during pregnancy, especially during the first trimester, as it may cause harm to the fetus. If you become pregnant while taking Metrogyl O Tablet , stop taking the medication, and contact your doctor immediately.

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Breast Feeding

Unsafe

Metrogyl O Tablet may pass into the breast milk, so avoid taking Metrogyl O Tablet while breastfeeding.

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Driving

Unsafe

Metrogyl O Tablet can cause dizziness, confusion, and drowsiness. Therefore, avoid driving or operating machinery unless you are mentally alert and competent.

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Liver

Consult your doctor

Metrogyl O Tablet to be taken with caution, especially if you have a history of liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

Metrogyl O Tablet to be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Metrogyl O Tablet can be given to the children if prescribed by a doctor.

Have a query?

FAQs

Metrogyl O Tablet is a combination of two antibiotics that include Ofloxacin and Metronidazole. Ofloxacin prevents the division of bacterial cells and inhibits their repair mechanism, leading to the death of the bacteria. Metronidazole kills parasites and anaerobic bacteria that cause infections. It works by damaging their DNA. Both antibiotics are bactericidal in nature and work together to treat the infection effectively.

Metrogyl O Tablet is a combination of antibacterial (ofloxacin) and anti-amoebic (metronidazole) medication used to treat various infections caused by bacteria. It is also effective in treating diarrhoea due to mixed infections and amoebic dysentery.

It is not advised to take alcohol with Metrogyl O Tablet . Taking alcohol while taking Metrogyl O Tablet can cause serious side effects such as headaches, feeling or being sick, pain in the stomach, hot flushes, a fast or irregular heartbeat, dizziness, drowsiness, etc.

Metrogyl O Tablet can make your skin sensitive to sunlight, a condition known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In the event of an emergency, always wear sunscreen before going outdoors.

If you miss a dose of Metrogyl O Tablet , take it as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for the missed one.

No. Metrogyl O Tablet is an antibacterial medicine that acts only against bacterial infections, not against viral infections. You should not take it without consulting your doctor first. Self-medication is dangerous and can lower the efficacy of Metrogyl O Tablet , leading to antibiotic resistance.

Yes, intake of Metrogyl O Tablet may cause dry mouth, and you may feel thirsty frequently. Try to drink plenty of fluids (water with electrolytes) and probiotics. You may also experience dry lips, for which you can use lip balm.

Avoid intake of Metrogyl O Tablet if you have a history of liver diseases, low blood white cells (leukopenia), seizures (fits), gastrointestinal diseases (like Crohn's disease, Inflammatory bowel disease), and other neurological diseases.

The common side effects of Metrogyl O Tablet include nausea, vomiting, stomach upset, loss of appetite, dry mouth, a metallic taste, headache, dizziness, drowsiness, and confusion. Most of these side effects of Metrogyl O Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

Cnergy It Park, 3Rd Floor Appa Saheb Marathe Marg, Prabhadevi, Mumbai 400025.
Other Info - MET2076

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