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compositionComposition:METHOTREXATE-2.5MG
prescription
Prescription Medicine
info
MEXATE 2.5MG TABLET
MEXATE 2.5MG TABLET
MEXATE 2.5MG TABLET
MEXATE 2.5MG TABLET
MEXATE 2.5MG TABLET
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

METHOTREXATE-2.5MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About MEXATE 2.5MG TABLET

MEXATE 2.5MG TABLET is a prescription medication used to manage severe autoimmune conditions like rheumatoid arthritis and severe psoriasis. It serves to calm an overactive immune system, helping to prevent joint damage and clear painful skin plaques. This medicine is typically prescribed when other standard therapies have not provided adequate relief.

To ensure your safety, MEXATE 2.5MG TABLET is typically taken only once a week on a very consistent schedule. You can take this oral medicine with or without food, but taking it with a full glass of water at the same time each week is highly recommended. Incorporating a nutrient-rich diet, staying well-hydrated, and completely avoiding alcohol are essential lifestyle adjustments that support the success of your treatment.

While using this medication, some people may experience common, mild side effects such as nausea, temporary hair thinning, or an upset stomach. However, you must consult your doctor immediately if you experience serious symptoms like a persistent cough, yellowing of the skin, or unusual bruising.

Before starting MEXATE 2.5MG TABLET, talk to your doctor if you have a history of liver disease, kidney problems, or lung conditions. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding, as it can cause severe harm to an unborn baby.

This medicine can interact with alcohol, raising the risk of liver damage, and with certain pain relievers, which can cause the drug to build up to unsafe levels. Pregnant women, breastfeeding mothers, and elderly individuals must consult their doctor or pharmacist before use, as they may require special dosing or monitoring.

Uses of MEXATE 2.5MG TABLET

Your doctor may prescribe this medicine to treat several conditions, including:

  • Severe Rheumatoid Arthritis: MEXATE 2.5MG TABLET helps reduce pain, swelling, and joint stiffness by calming the overactive immune response that attacks the joints.
  • Severe Psoriasis: It slows down the rapid growth of skin cells, helping to clear painful, scaly, and inflamed skin plaques when other therapies are ineffective.
  • Polyarticular Juvenile Idiopathic Arthritis: It helps manage joint pain and swelling in children with severe, active arthritis affecting multiple joints.
     

Key Benefits

By managing chronic inflammation, MEXATE 2.5MG TABLET helps improve daily physical function and comfort. The primary benefits of this treatment include:

  • Improved Joint Mobility: By reducing swelling and preventing joint damage, it helps you move more freely and perform everyday tasks with less pain.
  • Clearer Skin: For those dealing with severe skin plaques, it helps reduce scaling, redness, and discomfort, leading to healthier-looking skin.
  • Long-Term Disease Control: It acts as a disease-modifying treatment, meaning it doesn't just mask symptoms but actually helps slow down the progression of the condition over time.
     
Side effects of Mexate 2.5mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

Always take this medicine exactly as prescribed by your healthcare provider. Because MEXATE 2.5MG TABLET is a potent medication, improper use can lead to serious health complications.

  • Check the schedule: This medication is typically taken once a week on the exact same day, not daily. Mark your calendar or set a weekly alarm.
  • Swallow the tablet whole: Take the tablet with a full glass of water. Do not crush, chew, or break the tablet.
  • Take with or without food: You can take your weekly dose with or without food, depending on what your doctor recommends.
  • Handle with care: Wash your hands thoroughly after handling the tablets, especially if you are a caregiver.

Always follow your doctor's exact instructions regarding your weekly dosing schedule.

 

How MEXATE 2.5MG TABLET Works

MEXATE 2.5MG TABLET contains methotrexate. It belongs to a class of medications known as antimetabolites or disease-modifying antirheumatic drugs (DMARDs). In conditions like rheumatoid arthritis and psoriasis, your immune system mistakenly attacks healthy tissues, causing rapid cell division and chronic inflammation. This medicine works by blocking a specific enzyme in the body that cells need to grow and multiply. By gently slowing down this cellular process, MEXATE 2.5MG TABLET calms the overactive immune system, reduces the rapid buildup of skin cells, and prevents inflammatory chemicals from damaging your joints and tissues.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking MEXATE 2.5MG TABLET.

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Pregnancy

Unsafe

MEXATE 2.5MG TABLET may cause serious birth defects. It is not recommended to take MEXATE 2.5MG TABLET while you are pregnant.

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Breast Feeding

Unsafe

MEXATE 2.5MG TABLET passes into breast milk. Avoid breastfeeding whilst on treatment with MEXATE 2.5MG TABLET.

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Driving

Caution

MEXATE 2.5MG TABLET may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.

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Liver

Caution

Do not take MEXATE 2.5MG TABLET if you have chronic liver disease. Please consult your doctor if you have liver impairment before taking MEXATE 2.5MG TABLET.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking MEXATE 2.5MG TABLET.

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Children

Caution

MEXATE 2.5MG TABLET should be used with caution in children and only if prescribed by the doctor.

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Heart

Caution

MEXATE 2.5MG TABLET can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Safe if prescribed

MEXATE 2.5MG TABLET can be safely used in elderly patients with proper monitoring and individualised care.

What if I have taken an overdose of MEXATE 2.5MG TABLET

Do not take more than the prescribed dose of MEXATE 2.5MG TABLET as it may cause overdose leading to severe toxic reactions. The symptoms of overdose include unusual weakness, nausea, vomiting, easy bruising or bleeding, mouth sores, decreased urination, coughing up blood or vomit that looks like coffee grounds and black or bloody stools. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Take Folic Acid as Prescribed: Your doctor will likely prescribe a folic acid (vitamin B9) supplement to take on the days you do not take MEXATE 2.5MG TABLET. This helps protect healthy cells and significantly reduces common side effects like mouth sores and nausea.
  • Avoid Alcohol Completely: Because this medication is processed by the liver, drinking alcohol while taking it drastically increases your risk of severe liver damage.
  • Protect Your Skin from the Sun: This medicine can make your skin highly sensitive to sunlight. Wear protective clothing, apply a high-SPF sunscreen daily, and avoid tanning beds.
  • Stay Well-Hydrated: Drink plenty of water throughout the day, especially on the day you take your medicine. Good hydration helps your kidneys flush the medication out of your system safely.
  • Practice Good Hand Hygiene: Since this medicine can temporarily lower your body's ability to fight infections, wash your hands frequently and try to avoid close contact with people who are actively sick.
     

Have a query?

How Soon It Starts Working

The time required for MEXATE 2.5MG TABLET to start to work: MEXATE 2.5MG TABLET ideally shows its action within 1 to 2 hours after administration.

The time for which the effects of MEXATE 2.5MG TABLET last: The effect of MEXATE 2.5MG TABLET lasts for 9 to 30 hours at a low dose and 24 to 45 hours at a high dose.

What if you forget to take MEXATE 2.5MG TABLET

If you miss a dose of MEXATE 2.5MG TABLET, take it as soon as you remember the next day or the day after. If your dose is more than 2 days late, contact your doctor for advice. Do not take a double dose to make up for the missed dose.

Storage

•Store this medication at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).. •Keep the tablets in their original packaging to protect them from direct light and moisture, and do not store them in the bathroom cabinet.

Drug Warnings

  • Verify the Dose and Frequency: Always check your pill bottle to confirm you are taking the exact strength prescribed, and verify that you are taking it only once a week.
  • Avoid Daily Dosing Mistakes: Use a weekly pill planner or calendar check-off sheet to prevent accidentally taking this medication on consecutive days.
  • Monitor for Oral Ulcers: Regularly inspect your mouth and gums for painful sores, which can be an early sign of toxicity or folate deficiency.
  • Use Reliable Contraception: Ensure you are using highly effective birth control methods and confirm a negative pregnancy test before starting. Both male and female patients must maintain contraception during and for six months after treatment.
  • Keep All Lab Appointments: Never skip your scheduled blood tests, as they are your primary safety check for monitoring liver function and blood counts.
     

Drug-Drug Interactions

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • NSAIDs (such as ibuprofen or naproxen): May increase the concentration of MEXATE 2.5MG TABLET in your blood to toxic levels by delaying its clearance through the kidneys.
  • Proton Pump Inhibitors (such as omeprazole or pantoprazole): May reduce the kidney's ability to eliminate the medicine, raising the risk of severe side effects.
  • Certain Antibiotics (such as trimethoprim/sulfamethoxazole): May increase the risk of severe bone marrow suppression and low blood cell counts.

Drug-Food Interactions:

  • Alcohol: May significantly increase the risk of liver damage and severe liver scarring.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking it, as it may worsen your condition or cause complications.

  • Liver Disease: May cause severe, accelerated liver damage or liver failure in patients with pre-existing liver impairment.
  • Kidney Disease: May cause the medication to build up to dangerous, toxic levels in the body due to slower elimination.
  • Bone Marrow Suppression: May further decrease white blood cells, red blood cells, and platelets, increasing the risk of infection and bleeding.
  • Active Infections: May suppress your immune system further, making it harder for your body to fight off serious infections.
     
MethotrexateEtretinate
Critical
MethotrexateHydroxychloroquine
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Mexate 2.5mg Tablet:
Co-administration of Etretinate with Mexate 2.5mg Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Mexate 2.5mg Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateHydroxychloroquine
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Combine use of hydroxychloroquine with Mexate 2.5mg Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between hydroxychloroquine and Mexate 2.5mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateEsomeprazole
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Co-administration of Mexate 2.5mg Tablet and esomeprazole can increase the blood levels and side effects of Mexate 2.5mg Tablet.

How to manage the interaction:
Although taking Esomeprazole with Mexate 2.5mg Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
MethotrexateDexlansoprazole
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Co-administration of Mexate 2.5mg Tablet with Dexlansoprazole can increase the levels and side effects of Mexate 2.5mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Mexate 2.5mg Tablet and Dexlansoprazole, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, or body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateHuman immunoglobulin
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Taking Human immunoglobulin with Mexate 2.5mg Tablet may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Mexate 2.5mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethotrexateAspirin
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Co-administration of Mexate 2.5mg Tablet with aspirin can increase the levels and side effects of Mexate 2.5mg Tablet.

How to manage the interaction:
Although there is a possible interaction between aspirin and Mexate 2.5mg Tablet, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience symptoms such as nausea, vomiting, diarrhea, sore throat, chills, fever, rash, unusual bruising or bleeding, pale skin, dark urine, swelling of the legs and hands, breathing difficulty. Do not stop using any medications without consulting a doctor.
MethotrexateKetorolac
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Coadministration of Mexate 2.5mg Tablet with ketorolac can increase the blood levels and side effects of Mexate 2.5mg Tablet.

How to manage the interaction:
Although there is a interaction between Mexate 2.5mg Tablet and ketorolac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateEntecavir
Severe
How does the drug interact with Mexate 2.5mg Tablet:
The combined use of entecavir with Mexate 2.5mg Tablet may increase levels of Entecavir, and increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between entecavir and Mexate 2.5mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateFlucytosine
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Combine use of entecavir with Mexate 2.5mg Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Mexate 2.5mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateIndometacin
Severe
How does the drug interact with Mexate 2.5mg Tablet:
Co-administration of Mexate 2.5mg Tablet with Indomethacin can increase the levels and side effects of Mexate 2.5mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Mexate 2.5mg Tablet and Indomethacin, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms like mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), infection, as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

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METHOTREXATE-2.5MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-2.5MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Mexate 2.5mg Tablet. Avoid taking caffeine while taking Mexate 2.5mg Tablet. This can increase the risk or severity of side effects.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS, ANTIMETABOLITES]

FAQs

MEXATE 2.5MG TABLET is used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. It is also used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas (cancer that starts in the lymphatic system).

MEXATE 2.5MG TABLET acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

MEXATE 2.5MG TABLET works by suppressing the overactive immune system that is responsible for causing psoriasis. MEXATE 2.5MG TABLET interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of MEXATE 2.5MG TABLET. Stop taking MEXATE 2.5MG TABLET and consult your doctor if you have diarrhoea. Do not take anti-diarrheal medicine on your own.

MEXATE 2.5MG TABLET can affect egg and sperm production and could lead to birth defects. Women of child-bearing potential and men using MEXATE 2.5MG TABLET must use effective contraception while on treatment with MEXATE 2.5MG TABLET and for at least six months after stopping the treatment. MEXATE 2.5MG TABLET can lead to infertility. Therefore, male patients are advised to talk with their doctor regarding the possibility of sperm preservation before starting the treatment with MEXATE 2.5MG TABLET.

Yes. MEXATE 2.5MG TABLET may lower the number of white blood cells (leukopenia), making you more susceptible to infections. Contact your doctor if you develop symptoms such as fever, sore throat, breathlessness, jaundice, unusual bleeding, or unexplained bruising.

Yes. MEXATE 2.5MG TABLET may cause inflammation of the mouth lining (mucositis), leading to mouth sores or ulcers. Contact your doctor if you develop painful mouth ulcers. Folic acid supplementation may help reduce this side effect.

Before using MEXATE 2.5MG TABLET, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimise side effects.

MEXATE 2.5MG TABLET is not a painkiller. It is an anti-metabolite.

MEXATE 2.5MG TABLET is not suitable for some people. To ensure your safety, tell your doctor about all your medical conditions and medications before taking it. Based on your medical condition, your doctor will advise you whether to take it.

Common side effects of MEXATE 2.5MG TABLET may include nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. If you experience these side effects persistently, you are advised to talk to your doctor.

Yes, you can consume. However, you should avoid intake of unpasteurized milk, and soft cheeses are recommended.

It's also best to avoid too much caffeine, which is found in coffee, tea, cola, energy drinks, and chocolate. Caffeine can prevent MEXATE 2.5MG TABLET from working as it should.

Drinking alcohol is generally acceptable if you are taking MEXATE 2.5MG TABLET for the long-term treatment of an inflammatory disorder at a low weekly dose (25 mg or less). If you take large dosages of methotrexate, consult your physician and seek medical advice.

MEXATE 2.5MG TABLET may increase your risk of liver and lung problems, especially if you take a high dose. Your doctor, however, will closely monitor you while you are taking MEXATE 2.5MG TABLET. Routine check-ups will reveal any concerns or issues. If you have any concerns about taking MEXATE 2.5MG TABLET, consult your doctor.

Absolutely not. MEXATE 2.5MG TABLET is harmful to a fetus and can cause congenital mutations. Women should wait 90 days after finishing methotrexate before getting pregnant. Men should also wait 90 days before attempting to conceive because methotrexate may impair sperm (sperm formation takes 90 days).

MEXATE 2.5MG TABLET may somewhat reduce your body's response to immunizations, making them less effective than if you were not taking it. It is usually recommended that you be up to date on your immunizations before beginning MEXATE 2.5MG TABLET. If you have any concerns, please seek medical advice from your healthcare professional.

Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

MEXATE 2.5MG TABLET should be used with caution in children and only if prescribed by the doctor.

MEXATE 2.5MG TABLET may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.

This medicine is highly potent and works by slowing down cell growth. Taking it daily instead of weekly can lead to severe, life-threatening complications, including severe bone marrow suppression and organ damage. Always stick strictly to your once-weekly schedule. Talk to your doctor if you have questions about your routine.

No, you should avoid alcohol completely. Both alcohol and this medication are processed by the liver, and combining them significantly increases your risk of serious liver damage and scarring. Talk to your doctor for guidance.

MEXATE 2.5MG TABLET can cause serious birth defects and pregnancy loss. Both men and women should use effective contraception during treatment and for at least 6 months after the last dose (follow your doctor's advice regarding the exact duration). If you or your partner

Folic acid helps protect healthy cells from some of the side effects of MEXATE 2.5MG TABLET. It may reduce the risk of mouth ulcers, nausea, diarrhoea, fatigue, and other adverse effects without reducing treatment effectiveness.

MEXATE 2.5MG TABLET is a slow-acting medicine. Many people notice improvement within 6–8 weeks, but it may take 3–6 months to experience the full benefits of treatment.

You should avoid taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen without consulting your doctor first. These pain relievers can slow down the clearance of the medicine from your body, increasing the risk of serious side effects. Talk to your doctor or pharmacist for safe pain management alternatives.

Some patients experience mild, temporary hair thinning while taking this medication. Complete hair loss is rare at the low doses used for arthritis and psoriasis. Often, taking your prescribed folic acid helps reduce this side effect. Talk to your doctor if you notice significant hair changes.

Regular blood tests are essential to monitor your blood cell counts, liver function, and kidney function. Some serious side effects may occur without obvious symptoms, so routine monitoring helps ensure the medicine remains safe and effective.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 011719S117Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. National Health Service (NHS). Ibd Methotrexate Leaflet - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Methotrexate Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. MedlinePlus. A682019 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  5. Methotrexate [Prescribing Information]. 2020. [Accessed on 19 Apr. 2023] Check here
  6. Methotrexate [Prescribing Information]. 2023. [Accessed on 26 Feb. 2025] Check here
  7. Webmed.methotrexate. 2025 [Accessed on 5th Dec 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Other Info - MEX0002

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