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Reviewed By Veda Maddala , M Pharmacy

Mifeplus Tablet 10's is used in combination with Misoprostol to induce a medical abortion. It is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help. It contains Mifepristone, which works by blocking the effect of progesterone (female hormone), needed to sustain a pregnancy. In some cases, you may experience side effects such as nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

MIFEPRISTONE-25MG

Manufacturer/Marketer :

Plusplus Lifesciences Llp

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mifeplus Tablet 10's

Mifeplus Tablet 10's belongs to the class of medication called 'progestin antagonist' used in combination with Misoprostol to induce a medical abortion. Mifeplus Tablet 10's is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

Mifeplus Tablet 10's contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Mifeplus Tablet 10's to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete.

Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

Mifeplus Tablet 10's should be taken in dose and duration as advised by the doctor, preferably with food. It would be best to take it at a fixed time every day. It is a tablet and should be taken orally with a glass of water. In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Mifeplus Tablet 10's subside with time. But if your vaginal bleeding does not, please visit the doctor immediately, and it requires immediate medical attention.

Mifeplus Tablet 10's should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Mifeplus Tablet 10's if you have or ever had an ectopic pregnancy (when the fetus grows in the fallopian tube), using an intrauterine device, or if you are breastfeeding, any bleeding disorder or heart problem. Do not do strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of Mifeplus Tablet 10's

Mifeplus Tablet 10's is used for Medical abortion. The detailed uses of Mifeplus Tablet 10's are as follows:
•Medical Abortion: Mifeplus Tablet 10's is used to terminate early pregnancies by blocking progesterone, typically up to 49 days from the last menstrual period.
•Combined Therapy: Mifeplus Tablet 10's is often used in combination with misoprostol to complete the abortion process.
•Cushing’s Syndrome Treatment: Mifeplus Tablet 10's is used to treat Cushing's Syndrome by helping to manage excess cortisol levels.
•Regulation of the Menstrual Cycle: To regulate a delayed menstrual cycle, Mifeplus Tablet 10's can be used, but medical supervision is necessary to reduce the risk of side effects.
•Preventing Ovulation: Mifeplus Tablet 10's inhibits or delays ovulation which is necessary for making it an effective emergency contraceptive.

Directions for Use

Mifeplus Tablet 10's should be taken in dose and duration as prescribed by your doctor. Do not chew or crush it; swallow it as a whole.

Medicinal Benefits

Mifeplus Tablet 10's contains Mifepristone, which is taken in a regimen with Misoprostol to induce medical abortion or terminate a pregnancy before 70 days. It works by blocking the effect of progesterone (female hormone) needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Mifeplus Tablet 10's to show effect.

How Mifeplus Tablet 10's Works

Mifeplus Tablet 10's contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped.

Storage

Store in a cool and dry place away from sunlight
Side effects of Mifeplus Tablet
  • Your doctor may reduce your medication dose gradually if you have too much cortisol, while still managing your condition.
  • Try hot baths, massages, and gentle exercises like water aerobics or tai chi to ease aches and pains.
  • Limit sodium and fatty foods to reduce health risks.
  • Consume foods rich in calcium, like dairy, leafy greens, fortified plant milk, and salmon, to support bone health.
  • Include sources of vitamin D in your meals, such as cod liver oil, egg yolks, fortified milk, and fatty fish like swordfish and salmon.
  • Make time for things you enjoy and set limits to avoid getting too tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

What if I have taken an overdose of Mifeplus Tablet 10's

Do not take more than the prescribed dose of Mifeplus Tablet 10's as it may cause overdose. The symptoms of overdose include severe vaginal bleeding. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Women who have an ectopic pregnancy (a pregnancy outside of the uterus, problems with the adrenal glands (the glands near the kidneys), currently taking corticosteroid therapy (medications), have an allergic reaction to mifepristone, misoprostol or similar drugs, have bleeding problems or taking the blood-thinning drug (warfarin, clopidogrel, aspirin, heparin etc.) should not use Mifeplus Tablet 10's and contact doctor. After using Mifeplus Tablet 10's if you start feeling sleepy, do not drive or operate heavy machinery. If you use an intrauterine device (IUD), please remove it before taking the Mifeplus Tablet 10's. Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (herbal supplements to treat mild depression) and grapefruit juice should not be taken when taking Mifeplus Tablet 10's as it is known to interact. 

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Mifeplus Tablet:
When Methylprednisolone is taken with Mifeplus Tablet, it may decrease the levels of Methylprednisolone, which may be less effective in treating your condition.

How to manage the interaction:
Taking Methylprednisolone with Mifeplus Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Mifeplus Tablet:
Co-administration of Betamethasone with Mifeplus Tablet may significantly reduce the effect of Betamethasone which may be less effective as a therapy.

How to manage the interaction:
Taking betamethasone with Mifeplus Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mifeplus Tablet:
Co-administration of Mifeplus Tablet with Ticagrelor can increase the risk of vaginal bleeding in women.

How to manage the interaction:
Taking Ticagrelor with Mifeplus Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any symptoms like heavy period bleed for more than 7 days, weakness, tiredness, shortness of breath or paleness. Do not discontinue any medications without consulting a doctor.
MifepristoneFluticasone Propionate
Critical
How does the drug interact with Mifeplus Tablet:
Co-administration of Fluticasone Propionate with Mifeplus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Mifeplus Tablet and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. Do no discontinue any medications without consulting a doctor.
How does the drug interact with Mifeplus Tablet:
Using Fluticasone furoate with Mifeplus Tablet can reduce the effect of fluticasone furoate.

How to manage the interaction:
Taking Fluticasone furoate with Mifeplus Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifeplus Tablet:
Combining Mifeplus Tablet with Enoxaparin can increase the risk or severity of side effects of vaginal bleeding.

How to manage the interaction:
Taking Enoxaparin with Mifeplus Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience prolonged, excessive bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifeplus Tablet:
Using Mifeplus Tablet together with budesonide may significantly reduce the effects of budesonide.

How to manage the interaction:
Taking Budesonide with Mifeplus Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifeplus Tablet:
When Mifeplus Tablet is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Mifeplus Tablet with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifeplus Tablet:
Combining Mifeplus Tablet with Simvastatin can increase the blood levels of simvastatin, which may increase the risk of side effects.

How to manage the interaction:
Taking Simvastatin with Mifeplus Tablet is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mifeplus Tablet:
Coadministration of Sirolimus with Mifeplus Tablet can increase the levels of Sirolimus in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Sirolimus with Mifeplus Tablet is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may increase the effects of Mifeplus Tablet. Avoid consumption of grape juice while taking Mifeplus Tablet. However, if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, swelling, and high blood pressure, consult the doctor.

Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.

  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.

  • Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.

  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.

  • Get an ultrasound to check if the abortion is done completely to avoid unwanted complications.

  • Try to include heart-healthy omega-3 fatty acid-containing foods or drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTIPROGESTERONE
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Alcohol

Unsafe

Alcohol is known to cause excessive drowsiness if taken along with Mifeplus Tablet 10's and increase uterine bleeding.

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Pregnancy

Unsafe

Mifeplus Tablet 10's is used for medical abortion. If taken in pregnancy, it can lead to abortion.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before prescribing Mifeplus Tablet 10's; your doctor will decide whether Mifeplus Tablet 10's can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Mifeplus Tablet 10's may reduce alertness or induce sleep and dizziness. If you experience these symptoms, don't drive or operate machinery.

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Liver

Caution

Mifeplus Tablet 10's to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Mifeplus Tablet 10's to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Mifeplus Tablet 10's is not recommended for children below the age of 12. The safety and effectiveness of Mifeplus Tablet 10's have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Mifeplus Tablet 10's or not.

Have a query?

FAQs

Mifeplus Tablet 10's is used in combination with Misoprostol to induce a medical abortion. Mifeplus Tablet 10's is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

No, Mifeplus Tablet 10's should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine bleeding.

No, the Mifeplus Tablet 10's is not known to affect any future chances of fertility. Mifeplus Tablet 10's is used for medical abortion.

If you miss a dose of Mifeplus Tablet 10's, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

After taking Mifeplus Tablet 10's, you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

No, the Mifeplus Tablet 10's does not affect fertility. Use contraception during sexual intercourse as it may lead to unwanted pregnancy if you are not planning it.

Some of the common side effects of Mifeplus Tablet 10's are nausea, weakness, fever/chills, vomiting, headache, diarrhoea, and dizziness.

Mifeplus Tablet 10's contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the development of the pregnancy is stopped.

No, taking more than the prescribed dose of Mifeplus Tablet 10's will not make it more effective and could be dangerous. Please follow the dosage as prescribed by your doctor to avoid potential side effects or complications.

Please inform your doctor if you have a history of liver disease before using Mifeplus Tablet 10's. The dosage may need to be adjusted by your doctor, as liver impairment can affect how the drug is metabolized.

Swallow Mifeplus Tablet 10's as a whole with water; do not crush or chew it. The doctor will determine the dose based on your condition.

After taking Mifeplus Tablet 10's, you may experience cramping or bleeding in the uterus as the medication works to block the hormone progesterone and prepare your body for the next step in the abortion process. Typically, bleeding begins within 24-48 hours after taking Mifeplus Tablet 10's. It is common to experience other side effects such as nausea, vomiting, diarrhoea, dizziness, or infection following the abortion. Follow-up with your doctor is essential to ensure that the process is complete.

Country of origin

India

Manufacturer/Marketer address

A-2, Sector 59, Noida, Uttar Pradesh 201 309, India
Other Info - MIF0049

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