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compositionComposition:NALBUPHINE-10MG
prescription
Prescription Medicine
info
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Nacphin Injection 1 ml contains nalbuphine which is an opiod analgesic. It is mainly used to relieve severe pain caused due to various reasons This medicine works by reducing the production of prostaglandins, thus, reducing pain. You may experience certain common side effects such as drowsiness, dry mouth, nausea, vomiting, and constipation.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NALBUPHINE-10MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nacphin Injection 1 ml

Nacphin Injection 1 ml is a prescription injectable medicine used to relieve moderate to severe pain. It belongs to a group of medicines called opioid analgesics, which work by altering the way the brain and nervous system perceive pain signals. Nacphin Injection 1 ml is commonly used for short-term pain management, including pain after surgery, during labor, or before and after certain medical procedures, and is administered under the supervision of a healthcare professional.

Because Nacphin Injection 1 ml is given as an injection, healthcare professionals typically manage how often and when you receive it. It is used consistently under medical supervision for as long as needed to control your pain, but for the shortest duration possible. It can be injected regardless of whether you have eaten, as food does not affect how this injection works. Making simple changes, such as drinking plenty of fluids and resting, can help support your body during treatment.

While Nacphin Injection 1 ml helps manage pain, it can cause some common side effects like sleepiness, dizziness, or a dry mouth. Most of these effects are mild, but you must talk to your doctor immediately if you experience severe drowsiness, slow or shallow breathing, or signs of an allergic reaction.

Before starting Nacphin Injection 1 ml, tell your doctor if you have breathing problems, a history of head injuries, or kidney disease. Do not take this if you have a severe lung disease, a blockage in your bowels, or a known allergy to this injection.

This injection can interact with other medicines that cause sleepiness, such as sleeping pills, anxiety medications, or alcohol, which can lead to dangerous breathing issues. If you are pregnant, breastfeeding, or an older adult, consult your doctor to ensure Nacphin Injection 1 ml is safe for your specific situation.

Uses of Nacphin Injection 1 ml

Nacphin Injection 1 ml is used in the treatment of Pain. The detailed uses of Nacphin Injection 1 ml are as follows:

  • Moderate to severe pain: Helps manage significant pain, especially during and after surgical procedures or childbirth.
  • Preoperative and postoperative pain: Keeps you comfortable and controls pain before surgery begins and during your recovery.
  • Obstetrical analgesia: Provides pain relief for mothers during labor and delivery under close medical supervision.

Key Benefits

Nacphin Injection 1 ml helps provide rapid relief from moderate to severe pain, supporting greater comfort and recovery in patients who require strong pain management. Controlling pain effectively helps improve overall well-being and daily functioning.
Benefits may include:

  • Provides fast-acting relief from moderate to severe pain.
  • Helps improve comfort following surgery, injury, or other painful medical conditions.
  • Supports rest and recovery by reducing pain-related discomfort.
  • May allow earlier participation in rehabilitation and recovery activities after surgery.
  • Provides effective pain control under appropriate medical supervision.
  • Supports overall quality of life by helping patients remain more comfortable during treatment and recovery.
Side effects of Nacphin Injection 1 ml
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • To assist control body temperature and avoid dehydration, drink a lot of water.
  • To lessen tension and anxiety, engage in deep breathing exercises, mindfulness meditation, or other relaxation methods.
  • Put on clothes that are breathable and moisture-wicking to help keep your skin dry.
  • Steer clear of hot, muggy conditions that can make clamminess worse.
  • Wash the afflicted areas frequently with soap and water.
  • Limit your intake of things that make you perspire, like alcohol, coffee, and spicy foods
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of Nacphin Injection 1 ml. Typically, it is administered every 3 to 6 hours.
  • Nacphin Injection 1 ml will be administered by a doctor or nurse in a hospital setting. It can be given intravenously, subcutaneously, or intramuscularly.
  • Do not self-administer this medication.

How Nacphin Injection 1 ml Works

Nacphin Injection 1 ml works by acting on specific receptors in your brain and spinal cord, known as opioid receptors. It has a unique dual action: it stimulates certain receptors (kappa receptors) to block pain signals, while simultaneously blocking or limiting other receptors (mu receptors) that are associated with some of the more severe side effects of traditional opioids. Changing the way your central nervous system perceives and responds to pain helps you feel comfortable and reduces the intensity of the pain signals reaching your brain.
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Alcohol

Unsafe

You are advised not to take alcohol with Nacphin Injection 1 ml as it might cause increased sedation and respiratory depression.

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Pregnancy

Caution

Nacphin Injection 1 ml is not recommended for use during pregnancy unless absolutely indicated. Please consult your doctor if you have any concerns.

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Breast Feeding

Caution

Nacphin Injection 1 ml should be used with caution during breastfeeding. Please consult your doctor if you have any concerns.

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Driving

Unsafe

Nacphin Injection 1 ml may cause dizziness and drowsiness, which may affect your ability to drive.

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Liver

Caution

Exercise caution before using Nacphin Injection 1 ml in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Nacphin Injection 1 ml in case of kidney problems. Please consult your doctor to address any concerns.

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Children

Unsafe

Nacphin Injection 1 ml is not recommended for use in children below 12 years of age. Please consult your physician if you have any concerns.

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Heart

Caution

Nacphin Injection 1 ml should be administered with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before receiving Nacphin Injection 1 ml.

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Geriatrics

Caution

Nacphin Injection 1 ml should be administered with caution in older adults. please seek medical advice before receiving it.

What if I have taken an overdose of Nacphin Injection 1 ml

If you suspect an overdose, seek immediate emergency medical attention or call a poison control center. Symptoms of an overdose may include extreme sleepiness, very slow or shallow breathing, cold and clammy skin, pinpoint pupils, or loss of consciousness.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water throughout the day to help prevent constipation, which is a common effect of strong pain relievers.
  • Eat high-fiber foods: Include plenty of fruits, vegetables, and whole grains in your diet to support regular bowel movements while using Nacphin Injection 1 ml.
  • Avoid sudden movements: To prevent dizziness or falls, stand up slowly from a sitting or lying position.
  • Rest as needed: Since Nacphin Injection 1 ml can make you feel sleepy or lightheaded, avoid driving, operating machinery, or performing tasks that require mental alertness until you know how it affects you.
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How Soon It Starts Working

The time required for Nacphin Injection 1 ml to start to work: Nacphin Injection 1 ml ideally shows its action within 2 to 3 minutes after intravenous administration and 15 minutes after subcutaneous administration. The time for which the effects of Nacphin Injection 1 ml last: The effect of Nacphin Injection 1 ml lasts for 3 to 6 hours.

What if you forget to take Nacphin Injection 1 ml

Because Nacphin Injection 1 ml is typically injected in a clinical setting or as needed for pain, a strict schedule may not always apply. If you are using it on a regular schedule at home and miss a dose, inject it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and return to your regular schedule. Do not inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store Nacphin Injection 1 ml at controlled room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the medication in its original carton to protect it from direct light

Drug Warnings

  • Check the solution: Always inspect the liquid before injecting. It must be completely clear and colorless. If you notice any particles, cloudiness, or a change in color, do not use it.
  • Rotate injection sites: If you are injecting Nacphin Injection 1 ml into your muscles or under your skin, use a different spot for each injection to prevent tissue damage, soreness, or scarring.
  • Do not share needles: Never share needles or syringes with anyone else. This is critical to prevent the spread of serious blood-borne infections.
  • Avoid alcohol: Do not drink alcohol while using Nacphin Injection 1 ml, as the combination can lead to dangerous breathing problems, severe sleepiness, or a coma.
  • Watch for withdrawal: If you have been taking other strong opioid pain relievers regularly, Nacphin Injection 1 ml may cause sudden withdrawal symptoms because of how it works in the brain. Talk to your doctor before switching.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that cause drowsiness (e.g., sleeping pills, anti-anxiety medicines, muscle relaxants, other opioid pain relievers): Taking these medicines alongside Nacphin Injection 1 ml may increase the risk of severe drowsiness, slow breathing, and life-threatening side effects.
  • Full opioid medicines (e.g., morphine, oxycodone): Nacphin Injection 1 ml may trigger withdrawal symptoms in people who are physically dependent on full opioid medicines.
  • Monoamine oxidase inhibitors (MAOIs): Do not use Nacphin Injection 1 ml if you have taken an MAOI within the past 14 days, as serious interactions may occur.
NalbuphineDiazepam
Severe
NalbuphinePentazocine
Severe

Drug-Drug Interactions

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NalbuphineDiazepam
Severe
How does the drug interact with Nacphin Injection 1 ml:
Co-administration of Nacphin Injection 1 ml with Diazepam can make the side effects worse or more dangerous.

How to manage the interaction:
Although there is a possible interaction between Diazepam and Nacphin Injection 1 ml, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
NalbuphinePentazocine
Severe
How does the drug interact with Nacphin Injection 1 ml:
Taking Nacphin Injection 1 ml with Pentazocine can increase the risk of serious side effects.

How to manage the interaction:
Although taking Pentazocine and Nacphin Injection 1 ml together can evidently cause an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
NalbuphineCariprazine
Severe
How does the drug interact with Nacphin Injection 1 ml:
Taking Nacphin Injection 1 ml with Cariprazine can increase the risk of serious side effects.

How to manage the interaction:
Although taking Cariprazine and Nacphin Injection 1 ml together can evidently cause an interaction, but can be taken together if prescribed by a doctor. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NalbuphineClobazam
Severe
How does the drug interact with Nacphin Injection 1 ml:
Co-administration of Clobazam with Nacphin Injection 1 ml can increase the risk of breathing problems.

How to manage the interaction:
Taking Clobazam with Nacphin Injection 1 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you experience symptoms such as difficulty breathing, dizziness, or drowsiness, it is important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
NalbuphineClozapine
Severe
How does the drug interact with Nacphin Injection 1 ml:
Co-administration of Clozapine with Nacphin Injection 1 ml can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Nacphin Injection 1 ml, but it can be taken if prescribed by a doctor. If you experience symptoms like dizziness, constipation, or abdominal pain, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NalbuphineChlordiazepoxide
Severe
How does the drug interact with Nacphin Injection 1 ml:
Co-administration of Nacphin Injection 1 ml with chlordiazepoxide can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Nacphin Injection 1 ml and chlordiazepoxide together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as dizziness, shortness of breath, numbness in hands and feet, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
NalbuphineLurasidone
Severe
How does the drug interact with Nacphin Injection 1 ml:
Using Lurasidone together with Nacphin Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Despite the fact that Nacphin Injection 1 ml and Lurasidone interact, it can be taken if prescribed by a doctor. Consult a doctor if you develop dizziness, drowsiness, difficulty concentrating, or problems in judgment, reaction speed, or movement control. Do not discontinue any medications without consulting a doctor.
NalbuphineBaclofen
Severe
How does the drug interact with Nacphin Injection 1 ml:
Co-administration of Baclofen can enhance the effects of Nacphin Injection 1 ml, which depresses the central nervous system and can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Baclofen and Nacphin Injection 1 ml, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
NalbuphineHydroxyzine
Severe
How does the drug interact with Nacphin Injection 1 ml:
Using Hydroxyzine together with Nacphin Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydroxyzine and Nacphin Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. Consult a doctor if you experience dizziness, sleepiness, trouble focusing, and impairment in judgment, response speed, and motor coordination, you should avoid driving or operating dangerous machinery until you know how they affect you. Do not discontinue any medications without consulting a doctor.
NalbuphineAripiprazole
Severe
How does the drug interact with Nacphin Injection 1 ml:
Using Aripiprazole together with Nacphin Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Aripiprazole with Nacphin Injection 1 ml can result in an interaction, but it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Furthermore, because these medications may induce dizziness, sleepiness, trouble focusing, and impairment in judgement, response speed, and motor coordination, you should avoid driving or operating dangerous machinery. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid consuming alcohol while taking Nacphin Injection 1 ml, as it may greatly increase the risk of severe drowsiness, breathing difficulties, and overdose.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANALGESICS]

FAQs

Nacphin Injection 1 ml belongs to the group of opioid analgesics used to relieve severe pain. It may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery.
Nacphin Injection 1 ml works by blocking the impulses of pain and increasing the threshold of pain in the body.
Nacphin Injection 1 ml is not indicated to treat headaches due to migraines. It is best to get your headache checked by a professional. Please consult your doctor in case of any concerns.
No, Nacphin Injection 1 ml should not be taken with other opioid analgesics, CNS depressant drugs, or benzodiazepines as it might lead to life-threatening respiratory depression.
While on therapy with Nacphin Injection 1 ml, avoid it if you are allergic to any of its active substances. Be cautious if you experience drowsiness and dizziness, or if you have breathing problems, and avoid driving or operating heavy machinery. Be aware of the potential for dependence or withdrawal symptoms with prolonged use of Nacphin Injection 1 ml. Inform your doctor if you have a history of liver, kidney or heart diseases, gastrointestinal high blood pressure, and breathing problems (asthma, chronic obstructive pulmonary disease-COPD) before starting Nacphin Injection 1 ml.
Nacphin Injection 1 ml cause side effects such as drowsiness, nausea, constipation, vomiting and dry mouth. Most of these side effects are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.
No, you should not drive or operate machinery after receiving Nacphin Injection 1 ml. Nacphin Injection 1 ml can make you feel very sleepy, dizzy, or lightheaded, which can impair your ability to react quickly and safely. Talk to your doctor about when it is safe to resume driving.
As a strong pain reliever, Nacphin Injection 1 ml carries a risk of physical dependence and abuse, though it may have a lower risk compared to some other strong opioids. Always use it exactly as prescribed by your doctor to minimize these risks.
Nacphin Injection 1 ml is sometimes used for pain relief during labor, but regular use during pregnancy is not recommended as it may cause withdrawal symptoms in the newborn baby. Talk to your doctor to understand the benefits and risks.
Yes, Nacphin Injection 1 ml can cause constipation, although it may be less severe than with some other opioid pain medicines. To manage this, drink plenty of water and eat high-fiber foods. Talk to your doctor if constipation becomes a problem.
Nausea is a common side effect of Nacphin Injection 1 ml. Lying down quietly for a short period after receiving the injection can sometimes help reduce this feeling. If the nausea is severe or does not go away, talk to your doctor.
You must exercise extreme caution if you have asthma or other breathing disorders, as Nacphin Injection 1 ml can slow down your breathing. Always tell your doctor about your complete medical history before receiving Nacphin Injection 1 ml.
Taking Nacphin Injection 1 ml while using other strong opioid pain relievers can trigger sudden withdrawal symptoms or increase the risk of severe drowsiness. Always tell your doctor about all the medications you are currently taking.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NAC0059

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