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  3. Rubuphine 10 mg Injection 1 ml

Rubuphine 10 mg Injection 1 ml, Pack of 1 Injection
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Composition :

NALBUPHINE-10MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Rubuphine 10 mg Injection 1 ml

Rubuphine 10 mg Injection 1 ml belongs to the group of opioid analgesics used to relieve severe pain. It may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery. Pain is defined as an unpleasant sensation produced in the body in response to external changes, stress, or trauma.

Rubuphine 10 mg Injection 1 ml contains 'Nalbuphine' that works by reducing the production of inflammatory substances (prostaglandins) and thus, relieves the body of swelling and subsequent pain. Rubuphine 10 mg Injection 1 ml also blocks pain-producing nerve transmitters, leading to a reduced sensation of pain and offering massive pain relief.

Rubuphine 10 mg Injection 1 ml will be administered by a qualified health care professional. Do not self-inject. Rubuphine 10 mg Injection 1 ml may cause certain common side effects such as drowsiness, dry mouth, nausea, vomiting, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform the doctor if you are allergic to any of the components of Rubuphine 10 mg Injection 1 ml. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding as Rubuphine 10 mg Injection 1 ml should be used with caution in these states. Rubuphine 10 mg Injection 1 ml may cause drowsiness, so avoid driving or operating machinery.

Uses of Rubuphine 10 mg Injection 1 ml

Treatment of Pain

Directions for Use

• Follow your doctor's instructions on the dosage and timing of Rubuphine 10 mg Injection 1 ml. Typically, it is administered every 3 to 6 hours.• Rubuphine 10 mg Injection 1 ml will be administered by a doctor or nurse in a hospital setting. It can be given intravenously, subcutaneously, or intramuscularly.• Do not self-administer this medication.

Medicinal Benefits

Rubuphine 10 mg Injection 1 ml is an analgesic that is used as a painkiller for short-term management of severe pain. Rubuphine 10 mg Injection 1 ml blocks pain signals, so the brain doesn't perceive the severity of pain, hence increasing the body's threshold for pain. Rubuphine 10 mg Injection 1 ml may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery.

How Rubuphine 10 mg Injection 1 ml Works

Rubuphine 10 mg Injection 1 ml contains 'Nalbuphine' that works by reducing the production of inflammatory substances (prostaglandins) and thus, relieves the body of swelling and subsequent pain. Rubuphine 10 mg Injection 1 ml also blocks pain-producing nerve transmitters, leading to a reduced sensation of pain and offering massive pain relief.

Storage

Store in a cool and dry place away from sunlight
Side effects of Rubuphine 10 mg Injection 1 ml
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • To assist control body temperature and avoid dehydration, drink a lot of water.
  • To lessen tension and anxiety, engage in deep breathing exercises, mindfulness meditation, or other relaxation methods.
  • Put on clothes that are breathable and moisture-wicking to help keep your skin dry.
  • Steer clear of hot, muggy conditions that can make clamminess worse.
  • Wash the afflicted areas frequently with soap and water.
  • Limit your intake of things that make you perspire, like alcohol, coffee, and spicy foods
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Rubuphine 10 mg Injection 1 ml

Since Rubuphine 10 mg Injection 1 ml is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe drowsiness, slow heart rate and breathing, muscle weakness, pinpoint pupils, cold/clammy skin, and fainting.

Drug Warnings

Do not take Rubuphine 10 mg Injection 1 ml if you are allergic to any of the contents; if you have acute or severe asthma, respiratory depression, gastrointestinal obstruction, or paralytic ileus. Rubuphine 10 mg Injection 1 ml should not be taken with other opioid analgesics, CNS depressant drugs, or benzodiazepines as it might lead to life-threatening respiratory depression. Inform your doctor if you have asthma, COPD, adrenal insufficiency, severe hypotension, increased intracranial pressure, brain problems, head injury, gastrointestinal problems, seizures, kidney or liver problems. Avoid driving or operating machinery as Rubuphine 10 mg Injection 1 ml may impair your mental and physical ability. You are advised not to take alcohol with Rubuphine 10 mg Injection 1 ml as it might cause increased sedation and respiratory depression. Keep your doctor informed if you or anyone in your family have a history of substance abuse as Rubuphine 10 mg Injection 1 ml may cause addiction, abuse, and misuse.

Drug-Drug Interactions

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NalbuphineAripiprazole
Severe
NalbuphineClozapine
Severe

Drug-Drug Interactions

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NalbuphineAripiprazole
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Using Aripiprazole together with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Aripiprazole with Rubuphine 10 mg Injection 1 ml can result in an interaction, but it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Furthermore, because these medications may induce dizziness, sleepiness, trouble focusing, and impairment in judgement, response speed, and motor coordination, you should avoid driving or operating dangerous machinery. Do not stop using any medications without a doctor's advice.
NalbuphineClozapine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Co-administration of Clozapine with Rubuphine 10 mg Injection 1 ml can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Rubuphine 10 mg Injection 1 ml, but it can be taken if prescribed by a doctor. If you experience symptoms like dizziness, constipation, or abdominal pain, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NalbuphineOlanzapine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Combining Olanzapine with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression such as Olanzapine can lead to serious side effects including respiratory distress, intestinal obstruction, fecal impaction.

How to manage the interaction:
Although taking Olanzapine and Rubuphine 10 mg Injection 1 ml together can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms like feeling tired, having trouble breathing, feeling dizzy or drowsy, difficulty focusing, taking pain or cough medications, constipation, blockage in your intestines, difficulty passing stool, hard or dry stool, less frequent bowel movements, stomach problems, feeling sick, feeling bloated, having stomach pain, or swelling contact the doctor immediately. you should avoid driving or operating hazardous machinery until you know how they affect you and do not discontinue any medications without consulting your doctor.
NalbuphineClonazepam
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Co-administration of Rubuphine 10 mg Injection 1 ml with Clonazepam can make the side effects worse.

How to manage the interaction:
Although there is a possible interaction between Clonazepam and Rubuphine 10 mg Injection 1 ml, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
NalbuphineHydroxyzine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Using Hydroxyzine together with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydroxyzine and Rubuphine 10 mg Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. Consult a doctor if you experience dizziness, sleepiness, trouble focusing, and impairment in judgment, response speed, and motor coordination, you should avoid driving or operating dangerous machinery until you know how they affect you. Do not discontinue any medications without consulting a doctor.
NalbuphinePentazocine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Taking Rubuphine 10 mg Injection 1 ml with Pentazocine can increase the risk of serious side effects.

How to manage the interaction:
Although taking Pentazocine and Rubuphine 10 mg Injection 1 ml together can evidently cause an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
NalbuphineBaclofen
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Co-administration of Baclofen can enhance the effects of Rubuphine 10 mg Injection 1 ml, which depresses the central nervous system and can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Baclofen and Rubuphine 10 mg Injection 1 ml, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
NalbuphineCariprazine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Taking Rubuphine 10 mg Injection 1 ml with Cariprazine can increase the risk of serious side effects.

How to manage the interaction:
Although taking Cariprazine and Rubuphine 10 mg Injection 1 ml together can evidently cause an interaction, but can be taken together if prescribed by a doctor. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NalbuphineOxazepam
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
The risk or severity of adverse effects can be increased when Rubuphine 10 mg Injection 1 ml is combined with Oxazepam.

How to manage the interaction:
Although taking Oxazepam and Rubuphine 10 mg Injection 1 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like dizziness, drowsiness, difficulty concentrating, impairment in judgment, reduced reaction speed, and motor coordination, make sure to contact your doctor immediately. Avoid driving or operating hazardous machinery. Do not discontinue any medications without first consulting your doctor.
NalbuphineChlordiazepoxide
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Co-administration of Rubuphine 10 mg Injection 1 ml with chlordiazepoxide can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Rubuphine 10 mg Injection 1 ml and chlordiazepoxide together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as dizziness, shortness of breath, numbness in hands and feet, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Stay hydrated by drinking plenty of water.
  • Invest in a balanced diet. Load up on lean meats, fruits, green leafy vegetables, nuts, oily fish etc. Limit your intake of sweets and sugars as these can worsen inflammation. 
  • Cut back on alcohol as this can have an adverse effect on pain states as well as the quality of your sleep.
  • Try meditation and deep breathing to reduce overall stress and pain. 
  • Stop smoking as smoking is known to worsen pain conditions. 
  • Engage in mild physical exercise daily and keep your body active.

Habit Forming

Yes

Therapeutic Class

ANALGESICS

Rubuphine 10 mg Injection 1 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are advised not to take alcohol with Rubuphine 10 mg Injection 1 ml as it might cause increased sedation and respiratory depression.

bannner image

Pregnancy

Caution

Rubuphine 10 mg Injection 1 ml is not recommended for use during pregnancy unless absolutely indicated. Please consult your doctor if you have any concerns.

bannner image

Breast Feeding

Caution

Rubuphine 10 mg Injection 1 ml should be used with caution during breastfeeding. Please consult your doctor if you have any concerns.

bannner image

Driving

Unsafe

Rubuphine 10 mg Injection 1 ml may cause dizziness and drowsiness, which may affect your ability to drive.

bannner image

Liver

Caution

Exercise caution before using Rubuphine 10 mg Injection 1 ml in case of established liver disease. Please consult your doctor to address any concerns.

bannner image

Kidney

Caution

Exercise caution before using Rubuphine 10 mg Injection 1 ml in case of kidney problems. Please consult your doctor to address any concerns.

bannner image

Children

Unsafe

Rubuphine 10 mg Injection 1 ml is not recommended for use in children below 12 years of age. Please consult your physician if you have any concerns.

Have a query?

FAQs

Rubuphine 10 mg Injection 1 ml belongs to the group of opioid analgesics used to relieve severe pain. It may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery.

Rubuphine 10 mg Injection 1 ml works by blocking the impulses of pain and increasing the threshold of pain in the body.

Rubuphine 10 mg Injection 1 ml is not recommended in those suffering from asthma as there may be a reaction. Consult your doctor before use.

Rubuphine 10 mg Injection 1 ml is not indicated to treat headaches due to migraines. It is best to get your headache checked by a professional. Please consult your doctor in case of any concerns.

No, Rubuphine 10 mg Injection 1 ml should not be taken with other opioid analgesics, CNS depressant drugs, or benzodiazepines as it might lead to life-threatening respiratory depression.

While on therapy with Rubuphine 10 mg Injection 1 ml, avoid it if you are allergic to any of its active substances. Be cautious if you experience drowsiness and dizziness, or if you have breathing problems, and avoid driving or operating heavy machinery. Be aware of the potential for dependence or withdrawal symptoms with prolonged use of Rubuphine 10 mg Injection 1 ml. Inform your doctor if you have a history of liver, kidney or heart diseases, gastrointestinal high blood pressure, and breathing problems (asthma, chronic obstructive pulmonary disease-COPD) before starting Rubuphine 10 mg Injection 1 ml.

Rubuphine 10 mg Injection 1 ml cause side effects such as drowsiness, nausea, constipation, vomiting and dry mouth. Most of these side effects are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

58-D, Government Industrial Estate, Charkop, Kandivli (W), Mumbai 400 067 (India).
Other Info - RUB0163

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:55 AM IST

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Reference

  1. https://www.ncbi.nlm.nih.gov/books/NBK534283/
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018024s041lbl.pdf
  3. https://pubchem.ncbi.nlm.nih.gov/compound/Nalbuphine
  4. https://www.sandoz.ca/sites/www.sandoz.ca/files/Nubain%20Consumer%20Information.pdf
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