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compositionComposition:DOMPERIDONE-10MG+NAPROXEN-500MG
prescription
Prescription Medicine
info
Napblis-D Tablet 10's

Napblis-D Tablet is used to treat migraine headaches. Additionally, it can also be used to alleviate pain associated with rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain). It contains Naproxen and Domperidone, which work by reducing certain chemical substances (prostaglandins) that cause pain and swelling. Also, it prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre in the brain. It may cause common side effects, such as dry mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

DOMPERIDONE-10MG+NAPROXEN-500MG

Manufacturer/Marketer :

Anax Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Napblis-D Tablet

Napblis-D Tablet is a prescription medication primarily used to relieve acute migraine headaches, especially when they are accompanied by nausea and vomiting. It combines two active ingredients to target both the throbbing head pain and the stomach upset at the same time. By addressing both symptoms, it helps restore comfort and allows you to return to your daily activities more quickly.

This medicine is typically taken at the very first sign of a migraine attack rather than on a regular daily basis. For the fastest relief, it is best to take it on an empty stomach, though you can take it with food if it causes mild stomach upset. Making lifestyle adjustments, such as keeping a consistent sleep schedule and identifying personal headache triggers, can also significantly improve your treatment outcomes.

While taking Napblis-D Tablet , some people may experience mild side effects like dry mouth or drowsiness. However, you should seek immediate medical help if you experience severe symptoms, such as sharp stomach pain, black stools, or an irregular heartbeat. Always consult your doctor if you notice any unusual changes in your health while using this medication.

Before starting this treatment, tell your doctor if you have a history of high blood pressure, asthma, kidney issues, or stomach ulcers. Do not take this if you have active bleeding in your stomach, severe heart failure, or a history of allergic reactions to pain relievers. Your doctor will help determine if this medication is safe for your specific health profile.

Napblis-D Tablet is generally intended for use in adolescents and adults when prescribed by a healthcare professional for acute migraine attacks. It should not be used in children unless specifically prescribed and supervised by a specialist with experience in managing paediatric headache disorders.

This medicine can interact with blood thinners, other pain medications, and alcohol, which can increase your risk of stomach bleeding. Pregnant or breastfeeding women, as well as elderly individuals, should consult their doctor before using Napblis-D Tablet to ensure it is safe for them.

Uses of Napblis-D Tablet

Napblis-D Tablet is used to relieve acute migraine headaches. The detailed uses of Napblis-D Tablet are as follows:

  • Migraine headaches: Napblis-D Tablet helps relieve intense, throbbing pain, sensitivity to light and sound, and other debilitating symptoms of a migraine attack.
  • Nausea and vomiting: It helps control the feelings of sickness and active vomiting that frequently occur alongside severe headaches.

Key Benefits

Napblis-D Tablet provides comprehensive relief by addressing the dual challenges of a migraine attack. Because pain and nausea often occur together, treating them with a single medication simplifies your recovery process.

  • Dual-action relief: It stops both head pain and stomach discomfort simultaneously, preventing the need for multiple separate treatments.
  • Faster absorption: By reducing nausea and encouraging stomach movement, it helps your body absorb the pain-relieving component more efficiently.
  • Improved daily functioning: It reduces the severity and duration of migraine symptoms, helping you get back to your normal routine with less downtime.
     

Directions for Use

To get the most benefit from Napblis-D Tablet , follow these steps and your doctor's exact instructions:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can interfere with how the medicine is absorbed.
  • Take the medication at the first sign of a migraine attack for maximum effectiveness.
  • While it can be taken with or without food, taking it before meals may help it work faster. If you have a sensitive stomach, taking it with a small meal can help prevent irritation.
  • Always consult your doctor or pharmacist if you are unsure about how or when to take this medication.

How Napblis-D Tablet Works

Napblis-D Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen works by inhibiting the cyclooxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins that induce pain and swelling. Domperidone is an antiemetic that blocks specific receptors, such as dopamine and serotonin receptors, that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).
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Alcohol

Unsafe

It is advised not to take alcohol as Napblis-D Tablet can cause dizziness or drowsiness.

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Pregnancy

Consult your doctor

Napblis-D Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Napblis-D Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Napblis-D Tablet can cause dizziness or drowsiness. Drive only if you are alert.

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Liver

Consult your doctor

Limited information was available for the use of Napblis-D Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Napblis-D Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Limited information was available regarding the use of Napblis-D Tablet in patients with kidney impairment. Please consult your doctor if you have any concerns regarding using Napblis-D Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Napblis-D Tablet should be used in children below 12 years of age only when prescribed by a child specialist.

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Heart

Unsafe

Napblis-D Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Unsafe

Napblis-D Tablet should be avoided in geriatric patients, as it can cause serious adverse effects.

What if I have taken an overdose of Napblis-D Tablet

Do not take more than the prescribed dose of Napblis-D Tablet as it may cause serious side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Making simple lifestyle adjustments can help reduce the frequency of your migraines and support the safe use of Napblis-D Tablet :

  • Identify triggers: Keep a headache diary to track potential triggers, such as specific foods (like aged cheese or chocolate), caffeine, or high stress levels.
  • Eat regular meals: Skipping meals can cause blood sugar levels to drop, which is a common trigger for migraines.
  • Stay hydrated: Drink plenty of water throughout the day, as dehydration can quickly bring on a headache.
  • Limit alcohol: Avoid or significantly limit alcohol consumption, as it can trigger migraines and increase the risk of stomach irritation when taking this medication.
  • Establish a sleep routine: Aim for consistent sleep and wake times, even on weekends, to keep your body's rhythms stable.

Have a query?

How Soon It Starts Working

  • The time required for Napblis-D Tablet to start to work: Napblis-D Tablet ideally shows its action within 30 to 60 minutes after administration.
  • The time for which the effects of Napblis-D Tablet last: The duration of action for Napblis-D Tablet is unknown.

What if you forget to take Napblis-D Tablet

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue back to your regular dosage routine. Avoid taking two doses at once.

Storage

•Store the tablets at room temperature, ideally between 15°C and 30°C (59°F and 86°F). •Keep the medication in its original packaging to protect it from direct sunlight, moisture, and heat. Do not store it in damp areas like the bathroom cabinet.

Drug Warnings

Before using Napblis-D Tablet , it is important to understand how it may interact with other substances or health conditions.

Drug-Drug Interactions

  • Blood thinners: Taking this medicine with blood-thinning medications (like warfarin) may increase the risk of serious stomach bleeding.
  • Heart rhythm medicines: Combining this with drugs that affect your heart rhythm can increase the risk of serious cardiac side effects.
  • Other pain relievers: Avoid taking other NSAIDs concurrently, as this can damage your stomach lining.
  • SSRIs (Selective Serotonin Reuptake Inhibitors): Concomitant use may increase the risk of gastrointestinal bleeding, particularly because naproxen is a non-steroidal anti-inflammatory drug (NSAID). Patients should be monitored for signs of bleeding.
  • Lithium: Naproxen may reduce the clearance of lithium from the body, potentially increasing lithium levels and the risk of lithium toxicity. Monitoring and dose adjustments may be required.

Drug-Food Interactions

  • High-fat meals: Eating heavy, high-fat food right before taking this medicine may delay how quickly it is absorbed, meaning it might take longer to relieve your headache.

Drug-Disease Interactions

  • Stomach ulcers or bleeding: Do not take this medicine if you have a history of bleeding or active ulcers in your stomach or intestines.
  • Heart conditions: Avoid use if you have severe heart failure or a history of heart rhythm disorders.
  • Liver or kidney issues: This medicine should be used with extreme caution or avoided if you have moderate-to-severe kidney or liver damage.

Drug-Drug Interactions

verifiedApollotooltip

Drug-drug interactions: Napblis-D Tablet may interact with other NSAIDs (such as ketorolac), anticoagulants (such as warfarin), corticosteroids (such as prednisolone), anti-hypertensive medications (such as ramipril and amlodipine), antibiotics (such as amikacin), lipid-lowering drugs (such as atorvastatin), and antidepressants (such as citalopram and fluoxetine).

Drug-food interactions: No interactions found.

Drug-disease interactions: Patients with peptic ulcers, inflammatory bowel disease (inflammation of the digestive tract), liver diseases, kidney diseases, heart problems, and respiratory diseases should take the Napblis-D Tablet only when prescribed by a doctor.

Naproxen + DomperidoneKetorolac
Critical
Naproxen + DomperidoneMeloxicam
Critical

Drug-Drug Interactions

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Naproxen + DomperidoneKetorolac
Critical
How does the drug interact with Napblis-D Tablet:
Co-administration of Ketorolac with Napblis-D Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Ketorolac with Napblis-D Tablet together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without first talking to your doctor.
Naproxen + DomperidoneMeloxicam
Critical
How does the drug interact with Napblis-D Tablet:
Co-administration of Napblis-D Tablet with Meloxicam can increase the risk or severity of side effects (gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss).

How to manage the interaction:
Taking Meloxicam with Napblis-D Tablet is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not discontinue the medications without consulting a doctor.
Naproxen + DomperidoneCidofovir
Critical
How does the drug interact with Napblis-D Tablet:
Taking Cidofovir with Napblis-D Tablet may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Cidofovir with Napblis-D Tablet is generally avoided as it can result in an interaction. If you experience symptoms such as vomiting, loss of hunger, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, or dizziness. Do not discontinue the medication without consulting a doctor.
Naproxen + DomperidonePonatinib
Severe
How does the drug interact with Napblis-D Tablet:
Co-administration of Napblis-D Tablet and Ponatinib may increase the risk or severity of bleeding problems.

How to manage the interaction:
There may be a possible interaction between Napblis-D Tablet and Ponatinib, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.
Naproxen + DomperidoneMefenamic acid
Severe
How does the drug interact with Napblis-D Tablet:
Co-administration of Mefenamic acid with Napblis-D Tablet can increase the risk or severity of stomach bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefenamic acid with Napblis-D Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Naproxen + DomperidoneIndometacin
Severe
How does the drug interact with Napblis-D Tablet:
Co-administration of Indometacin with Napblis-D Tablet can increase the risk or severity of gastric bleeding, ulceration, and perforation leading to serious blood loss.

How to manage the interaction:
Taking Indometacin with Napblis-D Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
Naproxen + DomperidoneDeferasirox
Severe
How does the drug interact with Napblis-D Tablet:
Using Deferasirox with Naproxen and Domperidone may increase the risk of stomach inflammation and ulcers.

How to manage the interaction:
Co-administration of Deferasirox with Naproxen and Domperidone can result in an interaction, but it can be taken if a doctor has advised it. If you have symptoms like severe stomach pain, vomiting (especially with blood), loss of appetite, or tarry stools. to consult a doctor. Do not stop using any medications without a doctor's advice.
Naproxen + DomperidoneIbuprofen
Severe
How does the drug interact with Napblis-D Tablet:
Co-administration of Napblis-D Tablet and Ibuprofen can increase the risk or severity of bleeding, ulceration, and rarely leading to serious blood loss.

How to manage the interaction:
Taking Napblis-D Tablet and Ibuprofen together can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Naproxen + DomperidoneIopamidol
Severe
How does the drug interact with Napblis-D Tablet:
Co-administration of Napblis-D Tablet and Iopamidol may increase the effectiveness of Iopamidol.

How to manage the interaction:
There may be a possible interaction between Napblis-D Tablet and Iopamidol , but they can be taken together if they are prescribed by doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm and weakness consult the doctor. Do not discontinue any medication without a doctor's advice.
Naproxen + DomperidoneIrbesartan
Severe
How does the drug interact with Napblis-D Tablet:
Co-administration of Irbesartan along with Napblis-D Tablet may result in side effects including low blood pressure, impaired kidney function.

How to manage the interaction:
There may be a possible interaction between Napblis-D Tablet and Irbesartan, but they can be taken together if they are prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, decreased hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pains, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Napblis-D Tablet is used to treat migraine headaches, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). It also controls nausea and vomiting associated with migraines.
Napblis-D Tablet contains Naproxen and Domperidone. Naproxen works by inhibiting the cyclooxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins that induce pain and swelling. Domperidone is an antiemetic that blocks specific receptors, such as dopamine and serotonin receptors, that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).
Napblis-D Tablet cannot permanently cure migraine. It can provide relief from pain and headache.
Napblis-D Tablet on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be used only for a duration as prescribed by the doctor.
Arthritis is a chronic condition affecting the joints, characterised by pain and inflammation. Napblis-D Tablet does not cure arthritis, but it relieves symptoms of arthritis-like joint pain, swelling, and stiffness.
Yes, Napblis-D Tablet may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Napblis-D Tablet .
Dry mouth may be caused by Domperidone in Napblis-D Tablet . Chew a sugar-free sweet or sugar-free gum.
Yes, Napblis-D Tablet is a painkiller. It contains Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation, while Domperidone helps manage nausea, which is common in migraines. Additionally, it can also be used to alleviate pain associated with gout, rheumatoid arthritis, and dysmenorrhea (menstrual pain).
To ensure safe and effective treatment, it's helpful to know that Napblis-D Tablet may have a potential impact on blood pressure, but with proper monitoring, you can minimise risks. By working closely with your healthcare provider, you can enjoy the benefits of Napblis-D Tablet while maintaining healthy blood pressure. Open communication with your doctor is key to a successful treatment plan.
The side effects of Napblis-D Tablet include dry mouth, constipation, abdominal pain, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Most of these side effects do not require medical attention and typically resolve on their own over time. However, please consult your doctor if any symptoms persist or worsen.
You should consult your doctor before stopping Napblis-D Tablet , even if your migraine is relieved. It is generally used as needed for migraine attacks, but stopping suddenly without medical advice may not be ideal. Follow the dosage instructions provided by your doctor and complete the entire treatment course to effectively treat your medical condition.
Yes, Napblis-D Tablet may cause diarrhoea, a common side effect. If you experience this symptom, drink plenty of water to stay hydrated, take probiotics, avoid spicy, fatty, or dairy foods, and limit caffeine intake to manage diarrhoea.
To ensure a safe and effective treatment experience with Napblis-D Tablet , it's essential to be aware of certain contraindications. By knowing these guidelines, you can minimise risks and maximise benefits. Napblis-D Tablet is not recommended for individuals with NSAID hypersensitivity, NSAID-induced asthma, or severe allergic reactions, as well as during pregnancy, especially after 30 weeks, and in cases of severe liver impairment, heart conditions, or significant electrolyte disturbances. Additionally, caution is advised for patients with gastrointestinal bleeding, obstruction, or prolactin-releasing pituitary tumours and when taking QT-prolonging drugs or potent CYP3A4 inhibitors. By working closely with your healthcare provider, you can navigate these guidelines and enjoy a successful treatment outcome.
Yes, prolonged or frequent use of Napblis-D Tablet may cause kidney damage as it contains Naproxen, an NSAID, which can affect kidney function, especially with long-term use. Therefore, it should only be used as a doctor prescribes to minimize the risk.
No, you should not take a higher than the recommended dose of Napblis-D Tablet , as it may cause serious side effects like irregular heartbeat, drowsiness, extreme tiredness, nausea, stomach pain, and breathing difficulties. If you accidentally take more than the prescribed dose, seek immediate medical attention.
Napblis-D Tablet should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.
Yes, taking Napblis-D Tablet on an empty stomach is often recommended because it helps the medication absorb faster to relieve your migraine quickly. However, if you experience stomach irritation, you can take it with a small meal. Talk to your doctor for personalised advice.
Most people begin to feel relief within 30 to 60 minutes after taking the tablet. The exact time can vary depending on whether you took it with food. Talk to your doctor if your symptoms do not improve.
This medication is generally not recommended during pregnancy, especially in the third trimester, as it may harm the unborn baby or cause complications during delivery. Talk to your doctor to discuss safer alternatives.
Yes, drowsiness or sleepiness is a known side effect for some people taking this medicine. Avoid driving or operating machinery until you know how this medication affects you. Talk to your doctor if this side effect becomes troublesome.
It is highly advised to avoid alcohol while taking this medicine. Alcohol can increase the risk of severe stomach bleeding and can also act as a direct trigger for migraine attacks. Talk to your doctor if you have concerns.
No, Napblis-D Tablet is specifically formulated to treat migraine attacks accompanied by nausea and should not be used as a routine treatment for everyday tension headaches. Talk to your doctor for appropriate treatments for other headache types.
If your migraine symptoms persist or worsen after taking the medication, do not take additional doses beyond what was prescribed. Talk to your doctor to explore alternative treatment options.
In rare cases, one of the active ingredients in Napblis-D Tablet can affect the electrical signals in your heart, leading to an irregular heart rhythm. This risk is higher if you have pre-existing heart conditions or take certain other medicines. Talk to your doctor to make sure this medication is safe for your heart.
Medication-overuse headache is a condition in which frequent use of medicines intended for acute headache relief can lead to more frequent or persistent headaches over time. Using acute migraine treatments more than 10–15 days per month may increase this risk, depending on the medication and individual circumstances. If you are needing migraine treatment frequently, talk to your doctor about strategies to reduce headache frequency and the possible need for preventive therapy.

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Reference

  1. MedlinePlus. A681029 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Domperidone 10Mg Film Coateds Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. National Health Service (NHS). Naproxen - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  4. National Health Service (NHS). Domperidone - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Naproxen [Prescribing Information]. [Accessed on 22 Apr. 2019] Check here
  6. Motilium Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 21 December 2021] Check here
  7. Naproxen Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 21 December 2021]Check here

Country of origin

India

Manufacturer/Marketer address

551, 1st Floor, 14th main, 10th Cross, Padmanabh Nagar, Bangaluru-560070
Other Info - NAP0130

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