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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Nebipure-AM 5 mg/5 mg Tablet is used to treat high blood pressure. It contains Amlodipine and Nebivolol, which relaxes and widens the blood vessels making it easier for the heart to pump blood to all parts of the body. This lowers blood pressure and helps in reducing the risk of stroke, heart attack, other heart problems, or kidney problems in the future. It may cause side effects such as headaches, feeling exhausted, cold extremities, ankle swelling, slow heart rate, constipation, tiredness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Risemarker Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nebipure-AM 5 mg/5 mg Tablet

Nebipure-AM 5 mg/5 mg Tablet is a combination of blood pressure-lowering medicine, primarily used to treat high blood pressure. Nebipure-AM 5 mg/5 mg Tablet contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker) which collectively lower blood pressure. Hypertension or high blood pressure is a chronic condition in which the force exerted by the blood against the artery wall is high. As a result, it leads to heart diseases, irregular heartbeat, and other complications.

Nebipure-AM 5 mg/5 mg Tablet contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker),  primarily used to treat high blood pressure. Amlodipine works by relaxing the blood vessels. Nebivolol acts by relaxing and widening the blood vessels making it easier for the heart to pump blood to all parts of the body. This lowers your blood pressure and helps in reducing your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future. This medicine needs to be taken regularly to be effective.

Take Nebipure-AM 5 mg/5 mg Tablet as prescribed by your doctor. You are advised to take Nebipure-AM 5 mg/5 mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. Preferably take it after a meal to avoid an upset stomach. In some cases, you may experience headaches, feeling exhausted, cold extremities, ankle swelling, slow heart rate, constipation, tiredness. Most of these side effects of Nebipure-AM 5 mg/5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.  

It is advisable to drink plenty of fluids while taking this medicine to overcome muscle weakness, dry mouth, and extreme thirst. Do not take grapefruit or grapefruit juices with Nebipure-AM 5 mg/5 mg Tablet as it can increase the concentration of Nebipure-AM 5 mg/5 mg Tablet and worsen its side effects. Please inform your doctor if you have had an allergic reaction to Nebipure-AM 5 mg/5 mg Tablet , are pregnant or planning to get pregnant, are breastfeeding, have liver disease or kidney disease, heart failure, diabetes, a heart valve problem, or heart attack. Reducing the amount of table salt (sodium chloride) in your food often relieves the swelling of the body. Nebipure-AM 5 mg/5 mg Tablet is prescribed to adults and children more than six years of age.

Uses of Nebipure-AM 5 mg/5 mg Tablet

Treatment of Hypertension (high blood pressure).

Directions for Use

• Take Nebipure-AM 5 mg/5 mg Tablet with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Nebipure-AM 5 mg/5 mg Tablet is a combination of blood pressure-lowering medicine, contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker), primarily used to treat high blood pressure. Amlodipine works by relaxing the blood vessels. Nebivolol acts by relaxing and widening the blood vessels, making it easier for the heart to pump blood to all parts of the body. This lowers your blood pressure and reduces your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future. This medicine needs to be taken regularly to be effective.

How Nebipure-AM 5 mg/5 mg Tablet Works

Nebipure-AM 5 mg/5 mg Tablet contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker),  primarily used to treat high blood pressure. Amlodipine works by relaxing the blood vessels. Nebivolol acts by relaxing and widening the blood vessels making it easier for the heart to pump blood to all parts of the body. This lowers your blood pressure and helps in reducing your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future.

Storage

Keep Nebipure-AM 5 mg/5 mg Tablet out of the sight and reach of children.

What if I have taken an overdose of Nebipure-AM 5 mg/5 mg Tablet

Do not take more than the prescribed dose of Nebipure-AM 5 mg/5 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Don't stop taking Nebipure-AM 5 mg/5 mg Tablet without talking to your doctor first. Stopping Nebipure-AM 5 mg/5 mg Tablet abruptly may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. You should not use Nebipure-AM 5 mg/5 mg Tablet if you have a very slow heartbeat, asthma, serious heart condition (sick sinus syndrome), or any heart blockage. It should not be given to children less than 12 years of age. Before taking Nebipure-AM 5 mg/5 mg Tablet you should tell the doctor if you have any muscle disorder (myasthenia gravis, rhabdomyolysis), breathing problem (COPD, bronchitis, emphysema), low blood sugar level (hypoglycemia), low blood pressure (hypotension), depression, previous heart failure, liver/kidney disease, thyroid hormone disorder, adrenal gland cancer, or problems with circulation (Raynaud’s syndrome).

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Using Nebipure-AM 5 mg/5 mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Nebipure-AM 5 mg/5 mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Taking simvastatin with Nebipure-AM 5 mg/5 mg Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Nebipure-AM 5 mg/5 mg Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineFosphenytoin
Severe
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
When Nebipure-AM 5 mg/5 mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Nebipure-AM 5 mg/5 mg Tablet, which may make Nebipure-AM 5 mg/5 mg Tablet less effective.

How to manage the interaction:
Although taking Nebipure-AM 5 mg/5 mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Using Nebipure-AM 5 mg/5 mg Tablet and phenytoin together may drastically lower Nebipure-AM 5 mg/5 mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although Nebipure-AM 5 mg/5 mg Tablet with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Coadministration of Ceritinib together with Nebipure-AM 5 mg/5 mg Tablet can slow heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Nebipure-AM 5 mg/5 mg Tablet with Ceritinib, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, or an irregular heartbeat, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Coadministration of Nebipure-AM 5 mg/5 mg Tablet and rifampicin together may lower Nebipure-AM 5 mg/5 mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Nebipure-AM 5 mg/5 mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Using Nebipure-AM 5 mg/5 mg Tablet and rifabutin together may lower Nebipure-AM 5 mg/5 mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Nebipure-AM 5 mg/5 mg Tablet with rifabutin, but it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Coadministration of lemborexant and Nebipure-AM 5 mg/5 mg Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Nebipure-AM 5 mg/5 mg Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Coadministration of Nebipure-AM 5 mg/5 mg Tablet with itraconazole may significantly raise the blood levels and effects of Nebipure-AM 5 mg/5 mg Tablet.

How to manage the interaction:
Nebipure-AM 5 mg/5 mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Nebipure-AM 5 mg/5 mg Tablet:
Coadministration of Nebipure-AM 5 mg/5 mg Tablet and carbamazepine together may significantly reduce Nebipure-AM 5 mg/5 mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Nebipure-AM 5 mg/5 mg Tablet with carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+NEBIVOLOL-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+NEBIVOLOL-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consumption of grapefruit and grapefruit juice with Nebipure-AM 5 mg/5 mg Tablet the levels of Nebipure-AM 5 mg/5 mg Tablet in your bloodstream may drop. Avoid consuming a lot of grapefruit juice and grapefruit when using Nebipure-AM 5 mg/5 mg Tablet, instead, take it with water. As a result, your body will absorb the drug more easily.

Diet & Lifestyle Advise

  • Keep your weight under control with BMI (Body Mass Index) 19.5-24.9.

  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • If you are taking alcohol, then only one serving for women and two servings is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Try to include heart-healthy omega-3 fatty acids containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil can help in lowering your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES
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Alcohol

Caution

You are recommended not to consume alcohol along with Nebipure-AM 5 mg/5 mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

It is advised to consult your doctor if you plan to conceive or are already pregnant before starting Nebipure-AM 5 mg/5 mg Tablet .

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Breast Feeding

Caution

Please consult your doctor before taking Nebipure-AM 5 mg/5 mg Tablet if you are breastfeeding; your doctor will prescribe you Nebipure-AM 5 mg/5 mg Tablet only if the benefits outweigh the risks.

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Driving

Caution

Nebipure-AM 5 mg/5 mg Tablet may cause dizziness and weakness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Nebipure-AM 5 mg/5 mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Nebipure-AM 5 mg/5 mg Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Nebipure-AM 5 mg/5 mg Tablet should not be used by children, as the efficacy and safety have not been established.

Have a query?

FAQs

Nebipure-AM 5 mg/5 mg Tablet is used to treat hypertension (high blood pressure).

Nebipure-AM 5 mg/5 mg Tablet contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker); primarily used to treat high blood pressure. Amlodipine works by relaxing the blood vessels. Nebivolol acts by relaxing and widening the blood vessels making it easier for the heart to pump blood to all parts of the body. This lowers your blood pressure and helps in reducing your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future.

Your doctor may probably tell you to stop taking Nebipure-AM 5 mg/5 mg Tablet as it lowers blood pressure (hypotension) when combined with general anaesthesia before surgery. So, please inform your doctor before surgery if you are taking Nebipure-AM 5 mg/5 mg Tablet .

Yes, Nebipure-AM 5 mg/5 mg Tablet is known to cause ankle swelling. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.

If you have diabetes, you should monitor your blood glucose levels often as Nebipure-AM 5 mg/5 mg Tablet might mask hypoglycemia symptoms (low glucose levels). However, please consult your doctor before taking Nebipure-AM 5 mg/5 mg Tablet if you have diabetes.

If you have hyperthyroidism (overactive thyroid), you should monitor your condition regularly as Nebipure-AM 5 mg/5 mg Tablet might mask hyperthyroidism symptoms such as abnormally fast heart rate. However, please consult your doctor before taking Nebipure-AM 5 mg/5 mg Tablet if you have hyperthyroidism.

Do not overdose on Nebipure-AM 5 mg/5 mg Tablet or any medicine, which could lead to very unpleasant side effects. Take Nebipure-AM 5 mg/5 mg Tablet only as prescribed by your doctor. An overdose of Nebipure-AM 5 mg/5 mg Tablet can cause a very slow heartbeat, low blood pressure, breathlessness, and acute heart failure. Rush to your nearest doctor as early as possible if you have overdosed on Nebipure-AM 5 mg/5 mg Tablet .

You should take Nebipure-AM 5 mg/5 mg Tablet as advised by your doctor. But take it at the same time every day for consistency. Swallow it as whole with a glass of water. Do not break, crush or chew it.

If you miss a dose of Nebipure-AM 5 mg/5 mg Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

Nebipure-AM 5 mg/5 mg Tablet may cause side effects such as headache, ankle swelling, slow heart rate, tiredness, constipation or cold extremities (cold hands and feet). If these side effects persist or worsen, please consult your doctor.

You are recommended to take your doctor’s advice before taking Nebipure-AM 5 mg/5 mg Tablet if you are pregnant or breastfeeding.

No, do not stop taking Nebipure-AM 5 mg/5 mg Tablet even if you feel better as discontinuing Nebipure-AM 5 mg/5 mg Tablet suddenly may raise your blood pressure. Therefore, please consult your doctor before making any changes to your dosage schedule.

Country of origin

India

Manufacturer/Marketer address

Sakthi Nagar, Guru Colony Housing Board, Sivakasi – 626 124, TAMIL NADU.
Other Info - NEB0283

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