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Nefrosave Forte Tablet is a combination medication used to treat chronic kidney disease (CKD). It contains acetylcysteine and pyridoxamine, which help the body metabolism of fats, carbohydrates, and proteins, thereby assisting in maintaining energy balance in kidney disease patients. Common side effects include nausea, vomiting, diarrhoea, and abdominal pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ACETYLCYSTEINE-300MG+PYRIDOXAMINE DIHYDROCHLORIDE-50MG

Manufacturer/Marketer :

Fourrts India Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nefrosave Forte Tablet

Nefrosave Forte Tablet is a prescription medication primarily used to support kidney function in individuals with diabetic kidney disease. It may help slow the progression of kidney damage by reducing oxidative stress and limiting harmful chemical processes in the kidneys. Your doctor may prescribe this medicine to help keep your kidneys working efficiently over the long term. However, clinical evidence for pyridoxamine in people with diabetic kidney disease remains limited, and its long-term benefits have not yet been conclusively established.

To get the best results, you must take Nefrosave Forte Tablet regularly and exactly as prescribed, typically once or twice a day. You can take this medicine with or without food, but keeping a consistent daily routine helps maintain steady levels of the medicine in your body. Combining this medication with a kidney-friendly diet and proper blood sugar control will significantly enhance its beneficial effects.

While taking Nefrosave Forte Tablet , you might experience mild side effects like an upset stomach, mild nausea, or diarrhoea. Most of these symptoms are temporary and go away as your body adjusts, but you should contact your doctor immediately if you develop a severe skin rash, yellowing of your skin or eyes, or severe stomach pain.

Talk to your doctor before starting Nefrosave Forte Tablet if you have a history of stomach ulcers, asthma, or severe allergies. Do not take this if you are allergic to any of the ingredients in this medicine or if you have been told by a healthcare provider that your body cannot tolerate oral antioxidant supplements.

This medication may interact with certain blood pressure drugs, chest pain medications, and activated charcoal, so tell your healthcare provider about everything you take. You should avoid heavy alcohol use and smoking while on this therapy, as they can worsen kidney strain and reduce the treatment's success. 

Talk to your doctor if you are pregnant, breastfeeding, or managing multiple health conditions as an older adult.
 

Uses of Nefrosave Forte Tablet

A doctor may prescribe Nefrosave Forte Tablet for:

  • Diabetic kidney disease (diabetic nephropathy): It helps slow down kidney damage in people with diabetes by reducing oxidative stress and harmful protein build-up in the kidney tissue.
     

Key Benefits

Nefrosave Forte Tablet may support kidney health and may help slow the progression of kidney damage in appropriate patients.

  • Supports Kidney Function: May help protect the kidneys from ongoing damage and supports their ability to filter waste products effectively.
  • Helps Slow Kidney Disease Progression: May help delay the worsening of kidney damage, supporting long-term kidney health.
  • Protects Kidney Cells: May help reduce oxidative stress and cellular damage that can contribute to declining kidney function.
  • Supports Overall Well-Being: Maintaining healthy kidney function may help reduce symptoms associated with impaired kidney health and improve overall quality of life.
  • Complements Long-Term Kidney Care: Works best when used alongside a healthy lifestyle, regular monitoring, and other treatments recommended by your doctor.
     
Side effects of Nefrosave Forte Tablet
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Drink lots of water to thin mucus and make it easier to cough up.
  • Take hot lemon and honey drink to soothe the cough.
  • Rest to get enough sleep and Rest your voice and speak in a low voice.
  • Use a cool mist vaporizer or humidifier.
  • Take hot water in the shower for 10 to 15 minutes.
  • Use saline nasal spray and a bulb syringe to help with congestion.
  • Sore throat can be treated by gargling with hot salt water.
  • Take a vitamin C by eating citrus fruits and fresh vegetables.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Nefrosave Forte Tablet can be taken with or without food, as advised by your doctor.
  • Follow the recommended dosage and duration advised by the doctor to achieve optimal results.
  • Swallow Nefrosave Forte Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Nefrosave Forte Tablet Works

Nefrosave Forte Tablet contains acetylcysteine and pyridoxamine dihydrochloride. It works through a dual-action mechanism to help protect the kidneys from progressive damage. The first active component, acetylcysteine, acts as a powerful antioxidant. It neutralises harmful molecules called free radicals, which can damage the delicate filtering units of the kidneys and contribute to declining kidney function. The second active component, pyridoxamine dihydrochloride, helps reduce the formation of advanced glycation end-products (AGEs). When blood sugar remains high for long periods, it can react with proteins in the body to form these harmful compounds, which may contribute to kidney damage. By helping slow the formation of AGEs, pyridoxamine may reduce sugar-related damage and inflammation in the kidneys. Working together, these two active components help protect the delicate filtering units and blood vessels in the kidneys from ongoing damage, supporting healthy kidney function over time.
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Alcohol

Caution

It is not known if alcohol interacts with Nefrosave Forte Tablet . However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Consult your doctor

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor as there is no substantial research yet on the use of Nefrosave Forte Tablet in breastfeeding/nursing mothers.

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Driving

Safe if prescribed

Nefrosave Forte Tablet may not affect your ability to drive or use machinery.

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Liver

Consult your doctor

Limited information was available about the use of Nefrosave Forte Tablet in patients suffering from liver impairment. Please consult your doctor.

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Kidney

Safe if prescribed

Nefrosave Forte Tablet can be taken safely when prescribed. Usually, it does not affect the kidney.

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Children

Consult your doctor

Limited information is available regarding the usage of Nefrosave Forte Tablet in children, so please consult a doctor if you have any concerns.

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Heart

Consult your doctor

Limited information was available regarding the use of Nefrosave Forte Tablet in patients with heart problems. Please consult your doctor.

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Geriatrics

Consult your doctor

Limited information is available regarding the usage of Nefrosave Forte Tablet in elders, so please consult a doctor if you have any concerns.

What if I have taken an overdose of Nefrosave Forte Tablet

If you accidentally take more than your prescribed dose, seek immediate medical attention or call an emergency health services clinic right away. Look out for severe symptoms like severe vomiting, intense stomach pain, or difficulty breathing.

Diet & Lifestyle Advise

  • Limit sodium intake: Reduce the amount of salt in your meals to help manage your blood pressure and decrease the workload on your kidneys.
  • Control blood sugar: Monitor your blood sugar levels closely, as keeping sugar in check prevents further damage to the delicate filters in your kidneys.
  • Stay moderately hydrated: Drink water consistently throughout the day, but discuss your daily fluid limits with your doctor, especially if you have advanced kidney issues.
  • Watch your protein intake: High-protein diets can put extra strain on the kidneys. Talk to a dietitian about the right amount of protein for your specific condition.
  • Avoid smoking and limit alcohol: Smoking damages blood vessels throughout the body, including those in the kidneys, while alcohol can disrupt fluid balance and affect blood pressure.
     

Health Queries

Is it safe for me to get the COVID-19 vaccine while taking my daily high blood pressure and other medicationsspecifically Altron 40mg, Amlodipine 10mg, Nefrosave forte, Anxit 0.25, Reblet L, and Pan MPSand can I continue taking these same medicines after I am vaccinated?

Veda Maddala

Veda Maddala

M Pharmacy

It is safe and highly recommended for you to receive the COVID-19 vaccine. You should continue taking all your daily medicationsincluding Altron, Amlodipine, Nefrosave forte, Anxit, Reblet L, and Pan MPSas scheduled, both before and after your vaccination. Keeping your blood pressure and health stable is essential. There are no known interactions between the vaccine and these medications. You may experience common, mild side effects like a sore arm or low fever, which are normal signs of your body building immunity. Please do not stop your daily treatments, and discuss any personal concerns with your doctor.
health query

Have a query?

How Soon It Starts Working

  • The time required for Nefrosave Forte Tablet to start to work: The time required for Nefrosave Forte Tablet to show its action is unknown.
  • The time for which the effects of Nefrosave Forte Tablet last: The duration of action for Nefrosave Forte Tablet is clinically unknown.

What if you forget to take Nefrosave Forte Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Nefrosave Forte Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Take It Regularly: Take this medicine exactly as prescribed and at the same time each day. Do not stop treatment or change your dose without consulting your doctor.
  • Inform Your Healthcare Provider About Other Medicines: Tell your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking before starting Nefrosave Forte Tablet .
  • Avoid Taking Activated Charcoal Together: Activated charcoal may reduce the absorption of this medicine. Take it only if advised by your doctor and maintain an appropriate time gap if both are required.
  • Keep Up with Regular Monitoring: Your doctor may monitor your kidney function during treatment using tests such as serum creatinine, estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio (UACR). If you have diabetes, regular blood sugar monitoring may also be recommended.
  • Discuss Changes in Your Test Results: If your kidney function tests show worsening results or increasing protein in your urine despite treatment, do not stop the medicine on your own. Consult your doctor promptly so your treatment plan can be reviewed and adjusted if needed.
     

Drug-Drug Interactions

verifiedApollotooltip

Nefrosave Forte Tablet may interact with certain medicines, affecting its effectiveness or increasing the risk of side effects.

  • Nitroglycerin: May interact with Nefrosave Forte Tablet , potentially causing abnormally low blood pressure and severe headaches.
  • Activated charcoal: Can bind to this medication in the digestive tract, significantly reducing how much medicine is absorbed into your body.
  • Medicines that lower blood pressure or widen blood vessels: Taking these medicines together may increase the risk of low blood pressure in some people, so your doctor may monitor you more closely. 
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Nefrosave Forte Tablet is used to treat chronic kidney disease (CKD). Chronic kidney disease is characterised by a progressive loss of kidney function over time.
Nefrosave Forte Tablet contains Pyridoxamine dihydrochloride and Acetylcysteine, which help prevent kidney damage or injury in various ways. As a result, it improves kidney function and reduces complications in patients with chronic kidney disease.
To treat your condition effectually, continue taking Nefrosave Forte Tablet for as long as your doctor has prescribed. Please do not stop taking Nefrosave Forte Tablet without consulting your doctor.
CKD is typically caused by illnesses such as high blood pressure, diabetes, high cholesterol, kidney infections, renal inflammation, recurring kidney stones, an enlarged prostate, and long-term, regular use of certain medications such as lithium and nonsteroidal anti-inflammatory drugs (NSAIDs).
You cannot always avoid chronic kidney disease (CKD), but you can reduce your chances of developing it by managing underlying conditions like diabetes or high blood pressure.
Chronic kidney disease can be caused by taking too many non-steroidal anti-inflammatory medications or taking them for longer than recommended.
Smoking raises your risk of cardiovascular illness, such as heart attacks or strokes, which is linked to an increased risk of chronic kidney disease (CKD).
It is recommended that you minimise the intake of potassium and phosphate-rich foods.
Blood and urine tests can be used to detect chronic kidney disease (CKD). Other tests may be used to determine the extent of kidney injury. These may include an ultrasound, MRI, or CT scan, as well as a kidney biopsy.
Nefrosave Forte Tablet contains Pyridoxamine dihydrochloride and Acetylcysteine.
It is crucial to exercise caution and consult with a healthcare professional before combining medications.
If you miss a dose of your prescription, take it as soon as you recall and then resume your regular routine. If you are near the next dose, skip the missing dose and resume your regular schedule.
Nefrosave Forte Tablet is primarily used to protect kidney function and slow down the progression of kidney damage in patients living with diabetic kidney disease. Talk to your doctor to see if this treatment is suitable for your condition.
Yes, you can take Nefrosave Forte Tablet with or without food. However, taking it with a meal can help reduce the chances of experiencing a mild upset stomach. Talk to your doctor or pharmacist if you struggle with nausea.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your normal schedule. Do not double the dose. Talk to your doctor if you frequently miss doses.
It is highly recommended to limit or avoid alcohol while taking this medicine. Alcohol can put extra stress on your kidneys and liver, making it harder for the medication to protect your organs. Talk to your doctor for personalised advice.
The safety of this medication during pregnancy is not fully established. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before starting this medication to weigh the risks and benefits.
Some people may experience mild stomach upset, nausea, or diarrhoea when first starting Nefrosave Forte Tablet . These symptoms usually improve as your body adjusts, but if they persist or worsen, talk to your doctor.
You should exercise caution. One of the active properties of this medicine can occasionally trigger breathing issues in sensitive individuals. Talk to your doctor about your asthma history before starting treatment.
Kidney protection is a long-term process, meaning you will likely need to take Nefrosave Forte Tablet consistently for a long period. Do not stop taking it without consulting your healthcare provider first. Talk to your doctor to understand your overall treatment plan.
The safety and effectiveness of this medicine in children and adolescents have not been well established. It should only be used if specifically prescribed and closely supervised by a specialist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

#1, Fourrts Avenue, Annai Indira Nagar, Okkiyam Thoraipakkam, Chennai, India.
Other Info - NEF0077
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