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Composition:SACUBITRIL-24MG+VALSARTAN-26MG

Prescription Medicine

Neptaz 50 Tablet is used to treat heart failure. It helps reduce the risk of hospitalisation and death in adults with chronic heart failure. It works by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. In some cases, this medicine may cause side effects such as cough, dizziness, nausea, diarrhoea, and weakness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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More about the Product

Composition :

SACUBITRIL-24MG+VALSARTAN-26MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

Quick Overview

Understanding Neptaz 50 Tablet 14's

Usage & Safety

About Neptaz 50 Tablet

Neptaz 50 Tablet is used in the treatment of heart failure in adults and children above one year age. It helps to reduce the risk of death and hospitalisation in adults with chronic heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.

Neptaz 50 Tablet is a combination of medicines: valsartan and sacubitril. Valsartan blocks the effect of angiotensin II receptors, which constrict the blood vessels. Sacubitril works by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. Together, Neptaz 50 Tablet helps in the treatment of heart failure.

Not everyone who is taking Neptaz 50 Tablet will get these side effects. In some cases, you may experience specific common side effects, such as cough, dizziness, nausea, diarrhoea, and weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Take Neptaz 50 Tablet as advised. Your physician will decide the dosage based on your medical condition. You can take Neptaz 50 Tablet with or without food. It is recommended not to exceed the recommended dose of Neptaz 50 Tablet . Do not chew, crush, or break the medicine. Swallow it as a whole with a glass of water. You are advised to take Neptaz 50 Tablet for as long as your doctor has prescribed it.

Inform your physician if you are allergic to Neptaz 50 Tablet . Do not take Neptaz 50 Tablet with ACE inhibitors (such as captopril or enalapril) since the risk of side effects may increase. Do not take Neptaz 50 Tablet for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking Neptaz 50 Tablet if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid edema or swelling beneath the area of skin).

Do not to stop taking it on your own, as it may cause a sudden increase in blood pressure, chest pain, or a heart attack. Do not hesitate to consult your doctor if you experience any difficulties while taking Neptaz 50 Tablet .

Uses of Neptaz 50 Tablet

Neptaz 50 Tablet used to treat heart failure. The detailed uses of Neptaz 50 Tablet are as follows:

Heart Failure Treatment: Neptaz 50 Tablet serves as a part of the treatment plan for specific types of heart failure, helping the heart function more efficiently.
Hypertension Management: Neptaz 50 Tablet is used to manage hypertension (high blood pressure), by reducing the risk of heart-related issues and complications.
Cardiovascular Protection: Neptaz 50 Tablet provides cardiovascular protection by lowering blood pressure, reducing the risk of heart attacks and strokes.

Key Benefits

Neptaz 50 Tablet is a combination of two medicines, valsartan and sacubitril, which helps the heart to pump blood to all body parts by relaxing and widening the blood vessels.
Neptaz 50 Tablet helps treat certain types of heart failure.
It may also help you to live longer and lower the frequency of hospitalizations for heart failure.
Neptaz 50 Tablet helps in slowing down the heart rate, making it easier for the heart to pump blood throughout the body.

Side effects of Neptaz 50 Tablet

Low Blood Pressure

Managing Low Blood Pressure Triggered by Medication: Expert Advice:

If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
Take regular breaks to sit or lie down if you need to stand for long periods.
When lying down, elevate your head with extra pillows to help improve blood flow.
Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

High Potassium Levels In Blood

Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
Limit dairy products to 200g of yoghurt or 300ml of milk per day.

Decreased Kidney Function

Changes in kidney function need immediate medical attention.
Always monitor your blood pressure and inform your healthcare team if there are any sudden changes.
Take medicines as prescribed and eat a balanced diet suggested by your dietician for healthy kidney function.
Physical activity and exercise must be included in your daily routine to have proper kidney functioning and to maintain a healthy weight.
Get enough sleep to reduce the stress levels that have a direct impact on your kidney functioning.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

Low Potassium Levels In Blood

Low Blood Sugar

If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
Make medication adjustments as recommended by your doctor to prevent future episodes.
Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
Monitor your blood sugar levels closely for patterns and changes.
Track your progress by recording your blood sugar levels, food intake, and physical activity.
Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.

Directions for Use

Neptaz 50 Tablet can be taken with or without food as advised by the doctor.
Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
Swallow Neptaz 50 Tablet as a whole with a glass of water.
Do not chew, crush or break it.

How Neptaz 50 Tablet Works

Neptaz 50 Tablet is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors, which work by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. Together, Neptaz 50 Tablet helps in the treatment of heart failure.

Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Neptaz 50 Tablet to avoid unpleasant side-effects.

Pregnancy

Consult your doctor

It is not recommended to take Neptaz 50 Tablet while you are pregnant. Please consult your doctor. Your doctor will decide whether Neptaz 50 Tablet can be given to pregnant women or not.

Breast Feeding

Consult your doctor

It is not recommended to take Neptaz 50 Tablet while you are breast-feeding. Please consult your doctor. Your doctor will decide whether Neptaz 50 Tablet can be given to breast-feeding mothers or not.

Driving

Unsafe

Neptaz 50 Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

Liver

Caution

Dose adjustment may be needed. Neptaz 50 Tablet should be used with caution in patients with liver disease.

Kidney

Caution

Dose adjustment may be needed. Neptaz 50 Tablet should be used with caution in patients with kidney disease.

Children

Unsafe

Neptaz 50 Tablet can be used to treat heart failure in children who are at least 1 year old when prescribed by a child specialist

Heart

Caution

Neptaz 50 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Neptaz 50 Tablet .

Geriatrics

Caution

Neptaz 50 Tablet should be given with caution to elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Neptaz 50 Tablet

Take Neptaz 50 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include dizziness, fainting, and hypotension (low blood pressure). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

You are advised to consume low salt and low-fat diet while taking Neptaz 50 Tablet .
Regular exercise is also recommended to complement treatment with Neptaz 50 Tablet .
Eat a diet rich in whole grains, vegetables, fruits.
Avoid smoking and alcohol consumption.
Maintain a healthy weight with proper diet and exercise.
Managing stress with meditation, yoga, massage would also help in treating high blood pressure.

Have a query?

How Soon It Starts Working

The time required for Neptaz 50 Tablet to start to work: The time required for Neptaz 50 Tablet to show its action is unknown. The time for which the effects of Neptaz 50 Tablet last: The duration of action for Neptaz 50 Tablet is clinically unknown.

What if you forget to take Neptaz 50 Tablet

If you miss a dose of Neptaz 50 Tablet , take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Neptaz 50 Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Avoid taking Neptaz 50 Tablet if you are allergic to it.
Keep your doctor informed if you have kidney or liver diseases.
Orthostatic hypotension (sudden lowering of blood pressure when standing) may occur, so patients using Neptaz 50 Tablet should get up slowly and carefully.
Speak to your doctor if you have diabetes before taking Neptaz 50 Tablet .
Inform your doctor about all the medications you are currently taking, including aliskiren (a medication used to treat high blood pressure), any other heart or blood pressure medications, lithium, and mineral supplements that contain potassium.
Inform your doctor if you feel light-headed or have little or no urination, rapid weight gain, or swelling in your hands, feet, or ankles after taking Neptaz 50 Tablet .
A prolonged intake of Neptaz 50 Tablet can cause an altered potassium level; therefore, regular monitoring of potassium levels is required. Neptaz 50 Tablet is not recommended for use in infants below one year of age.
It is always essential to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

Drug-Drug Interactions: Pain medication (aspirin), a medicine used to lower cholesterol (rosuvastatin, atorvastatin), medicine to treat both type 1 and type 2 diabetes (insulin detemir), blood pressure medication (metoprolol), a medication used in the management of asthma (budesonide/formoterol).

Drug-Food Interactions: Maintain low salt and low-fat diet while taking Neptaz 50 Tablet . Avoid consuming food rich in potassium, such as potassium-containing salt substitutes or over-the-counter potassium supplements. Avoid smoking and alcohol consumption.

Drug-Disease Interactions: Hypotension (low blood pressure), diabetes, angioedema (rapid edema or swelling beneath the skin), hyperkalemia (high potassium in the blood), renal artery stenosis, renal/liver disease, renal impairment.

Sacubitril + ValsartanAliskiren

Critical

Sacubitril + ValsartanCaptopril

Severe

Drug-Drug Interactions

Sacubitril + ValsartanAliskiren

Critical

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Aliskiren together with Neptaz 50 Tablet may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Neptaz 50 Tablet with Aliskiren is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.

Sacubitril + ValsartanCaptopril

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Captopril and Neptaz 50 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Neptaz 50 Tablet and Captopril, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.

Sacubitril + ValsartanPotassium citrate

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Potassium citrate with Neptaz 50 Tablet may increase the risk of side effects such as low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Potassium citrate together with Neptaz 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.

Sacubitril + ValsartanPotassium acetate

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Potassium acetate with Neptaz 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Potassium acetate together with Neptaz 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.

Sacubitril + ValsartanLisinopril

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Lisinopril and Neptaz 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Lisinopril together with Neptaz 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.

Sacubitril + ValsartanAmiloride

Severe

How does the drug interact with Neptaz 50 Tablet:
Taking Amiloride with Neptaz 50 Tablet may increase potassium levels in the blood. (High levels of potassium can cause hyperkalemia - high levels of potassium in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythms).

How to manage the interaction:
Although taking Amiloride and Neptaz 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.

Sacubitril + ValsartanTriamterene

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Triamterene and Neptaz 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Triamterene together with Neptaz 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medication without consulting a doctor.

Sacubitril + ValsartanEnalapril

Severe

How does the drug interact with Neptaz 50 Tablet:
Taking Enalapril together with Neptaz 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and a condition called hyperkalemia -high blood potassium).

How to manage the interaction:
Taking Neptaz 50 Tablet and Enalapril together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Sacubitril + ValsartanSpironolactone

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Spironolactone together with Neptaz 50 Tablet may increase potassium levels in the blood.

How to manage the interaction:
Although taking Spironolactone and Neptaz 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without consulting a doctor.

Sacubitril + ValsartanBenazepril

Severe

How does the drug interact with Neptaz 50 Tablet:
Co-administration of Benazepril and Neptaz 50 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Neptaz 50 Tablet and Benazepril, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods

Moderate

Drug-Food Interactions

SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods

Moderate

Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Co-administration of Neptaz 50 Tablet along with moderate-to-high dietary potassium intake, especially salt substitutes may lead to high potassium levels in the blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements along with Neptaz 50 Tablet as this can lead to high potassium levels in blood. However, if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs, consult a doctor.

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Author Details

Written By

Veda Maddala
M Pharmacy

Reviewed By

Dr Aneela Siddabathuni
MPharma., PhD

Last Updated

Jun 26, 2026 | 8:32 AM IST

We provide you with authentic, trustworthy and relevant information.

See our editorial policy

Reference

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase 3, New Delhi - 110020.

Other Info - NEP0209

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Neptaz 50 Tablet 14's

Delivery Information

More about the Product

Composition :

Manufacturer/Marketer :

Consume Type :

Expires on or after :

Return Policy :

NPPA :

About Neptaz 50 Tablet

Uses of Neptaz 50 Tablet

Key Benefits

Low Blood Pressure

High Potassium Levels In Blood

Decreased Kidney Function

Dizziness

Anemia

Low Potassium Levels In Blood

Low Blood Sugar

Directions for Use

How Neptaz 50 Tablet Works

Alcohol

Pregnancy

Breast Feeding

Driving

Liver

Kidney

Children

Heart

Geriatrics

What if I have taken an overdose of Neptaz 50 Tablet

Diet & Lifestyle Advise

How Soon It Starts Working

What if you forget to take Neptaz 50 Tablet

Storage

Drug Warnings

Drug-Drug Interactions

Drug-Drug Interactions

Drug-Food Interactions

Drug-Food Interactions

All Substitutes & Brand Comparisons

Sacutan 50 Tablet 14's

Mymarda 50 mg Tablet 10's

Sacurise 50 Tablet 14's

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FAQs

What is the use of Neptaz 50 Tablet ?

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Can I stop taking Neptaz 50 Tablet if I feel better?

Does Neptaz 50 Tablet cause orthostatic hypotension?

What happens when the blood pressure is high?

Can I take potassium supplements with Neptaz 50 Tablet ?

Does Neptaz 50 Tablet cause headache?

Is Neptaz 50 Tablet safe for patients with hypotension?

Can I take Neptaz 50 Tablet with ramipril?

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Does Neptaz 50 Tablet cause muscle weakness?

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Can I take Neptaz 50 Tablet if I have kidney disease or liver disease?

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