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compositionComposition:NEVIRAPINE-400MG
prescription
Prescription Medicine
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Nevir-ER Tablet is used to treat Human Immunodeficiency Virus (HIV) Infection. It contains Neviparine, which belongs to the non-nucleoside reverse transcriptase inhibitors (NNRTI) class. It works by inhibiting the HIV reverse transcriptase enzymes necessary for the virus's DNA reproduction. This inhibits DNA replication and thereby prevents the further spread of infection.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NEVIRAPINE-400MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nevir-ER Tablet

Nevir-ER Tablet is a prescription medicine used to manage Human Immunodeficiency Virus type 1 (HIV-1) infection. It belongs to a group of medicines that help control the virus, keeping it from multiplying in your body. It is always prescribed in combination with other antiretroviral medications to ensure the treatment is highly effective.

To get the best results, you must take this medicine consistently at the exact same times every day without missing any doses. You can take this medicine with or without food, which makes it easy to fit into your daily routine. Adopting a nutritious diet and staying physically active are also excellent lifestyle changes that support your immune system while taking this medicine.

While taking Nevir-ER Tablet , some people may experience mild side effects like a light skin rash, nausea, or headaches. However, it is crucial to consult your doctor immediately if you experience severe symptoms, such as a painful, blistering skin rash, or signs of liver damage like yellowing of your skin or eyes.

Before you begin taking this medicine, talk to your doctor if you have a history of liver or kidney problems. Do not take this if you have moderate to severe liver damage, as this medicine can worsen your liver health. Your healthcare provider will evaluate your medical history to ensure this is the safest treatment option for you.

This medicine can interact with other treatments, including herbal supplements like St. John's wort, which can make Nevir-ER Tablet less effective. It is also important to avoid alcohol as it can increase the risk of liver damage. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you should consult your doctor before starting this medicine to discuss potential risks.

Uses of Nevir-ER Tablet

Nevir-ER Tablet is used to manage Human Immunodeficiency Virus type 1 (HIV-1) infection. The detailed uses of Nevir-ER Tablet are as follows: 

  • HIV-1 Infection: Nevir-ER Tablet is used in combination with other antiretroviral medicines to control HIV-1 infection. It helps lower the viral count in your body so your immune system can work better.
  • Prevention of Mother-to-Child Transmission: In specific clinical settings, this medicine is prescribed to help reduce the risk of passing the virus from a pregnant person to their unborn child.

Key Benefits

Nevir-ER Tablet provides vital, real-world health support by keeping the virus under control and helping you maintain your long-term health. Below are the key benefits of this treatment:

  • Suppresses the Virus: It significantly lowers the level of the virus in your blood, making it harder for the infection to progress.
  • Restores Immune Health: By keeping the virus in check, it allows your immune system to rebuild its strength, helping your body defend itself against other everyday infections.
  • Reduces Hospital Visits: Consistent use of this medicine reduces the likelihood of developing serious, life-threatening complications associated with advanced viral infections.
Side effects of Nevir-ER Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Maintain good oral hygiene.
  • Rinsing with salt water may also help relieve mouth ulcers.
  • Avoid foods that cause inflammation like spicy, salty or sugary foods.
  • Eat soft foods like yoghurt, apple sauce, and mashed potatoes.
  • Drink enough fluids.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Nevir-ER Tablet can be taken with or without food because food does not impact its effectiveness.
  • It is usually taken once or twice a day; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, chew or crush Nevir-ER Tablet .

How Nevir-ER Tablet Works

Nevir-ER Tablet contains nevirapine, which belongs to a class of medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs). To multiply and spread, the virus needs a specific tool inside your body called an enzyme. This medicine works by directly binding to this enzyme and blocking its action. Without this enzyme, the virus cannot make copies of itself, which effectively halts its spread and protects your immune system from further damage.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Nevir-ER Tablet . Alcohol intake might increase the risk of stomach or intestine bleeding.

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Pregnancy

Consult your doctor

If you are pregnant or suspect you may be pregnant, inform your doctor before taking Nevir-ER Tablet . Your doctor will prescribe a suitable dose of this medicine to prevent maternal-fetal HIV transmission.

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Breast Feeding

Unsafe

Nevir-ER Tablet is excreted in milk. If you have HIV or are taking Nevir-ER Tablet , you should not breastfeed your baby.

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Driving

Unsafe

Avoid driving vehicles after taking Nevir-ER Tablet as it may cause fatigue.

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Liver

Caution

Nevir-ER Tablet can result in serious, sometimes fatal, liver damage. Inform your doctor if you have or have had a liver illness, particularly hepatitis B or C. Your doctor will most likely advise you not to take Nevir-ER Tablet .

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Kidney

Caution

Before using Nevir-ER Tablet , inform your doctor if you have or have ever had kidney disease, particularly if you are on dialysis treatment.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

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Heart

Consult your doctor

Please consult your doctor before receiving Nevir-ER Tablet if you have pre-existing heart problems. Your doctor will prescribe Nevir-ER Tablet if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Nevir-ER Tablet is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Nevir-ER Tablet

If you suspect you or someone else has taken too much of this medicine, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Eat cooked and safe foods: Since your immune system is recovering, avoid raw seafood, raw eggs, or undercooked meats to reduce your risk of severe food poisoning.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out metabolic waste and keep your body functioning optimally.
  • Avoid alcohol: Alcohol places a heavy burden on your liver. Avoiding it helps protect your liver from additional stress while processing this medication.
  • Maintain a balanced diet: Focus on whole foods, lean proteins, and plenty of well-washed, cooked vegetables to give your body the nutrients it needs to rebuild its immune defences.
health query

Have a query?

How Soon It Starts Working

The time required for Nevir-ER Tablet to start to work: Nevir-ER Tablet ideally shows its action within 4 hours after administration. The time for which the effects of Nevir-ER Tablet last: The effect of Nevir-ER Tablet lasts for 24 hours.

What if you forget to take Nevir-ER Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your normal schedule. Do not take a double dose to make up for a missed one. If you stop taking this medicine for more than a few days, consult your doctor before starting again, as you may need to restart with a gradually increasing dose.

Storage

• Store Nevir-ER Tablet tablets and oral suspension at room temperature, ideally between 20°C to 25°C (68°F to 77°F). 

Drug Warnings

  • Watch your skin closely, especially during the first 18 weeks of starting this medicine. Any rash, even a mild one, should be reported to your doctor immediately.
  • Your doctor will start you on a lower dose for the first 14 days before moving you to a gradually increasing dose. This lead-in period is critical because it significantly lowers your risk of developing a severe, dangerous rash.
  • Keep all your scheduled appointments for blood tests. Your doctor must monitor your liver function regularly to catch any early signs of liver strain.
  • If you use the liquid form, always use the marked syringe or cup provided with the medicine to ensure you receive the correct amount.
  • Do not skip doses or stop taking this medicine suddenly, as this can cause the virus to rapidly become resistant to this treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Hormonal Contraceptives: This medicine can lower the effectiveness of birth control pills, patches, or implants. You should use a reliable barrier method (such as condoms) to prevent pregnancy.
  • Rifampicin and St. John's Wort: Taking these substances alongside Nevir-ER Tablet can drastically lower the amount of this medicine in your blood, making your HIV treatment less effective.
  • Antifungal Medications: Certain antifungals, like ketoconazole, may interact with this medicine, requiring your doctor to adjust your therapy.
NevirapineAtazanavir
Critical
NevirapineRanolazine
Critical

Drug-Drug Interactions

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NevirapineAtazanavir
Critical
How does the drug interact with Nevir-ER Tablet:
When Atazanavir is taken with Nevir-ER Tablet, it can reduce the levels and side effects of atazanavir & increase the blood levels and effects of Nevir-ER Tablet.

How to manage the interaction:
Taking Nevir-ER Tablet with Atazanavir is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, loss of appetite, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), dark-coloured urine, pale-coloured stools, or pain or ache in the right abdominal area below your ribs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NevirapineRanolazine
Critical
How does the drug interact with Nevir-ER Tablet:
Co-administration of Nevir-ER Tablet with Ranolazine may significantly reduce the blood levels of Ranolazine. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Nevir-ER Tablet with Ranolazine is generally avoided as it can lead to an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
NevirapineEtravirine
Severe
How does the drug interact with Nevir-ER Tablet:
when Nevir-ER Tablet is used in conjunction with etravirine, the effects of etravirine may be reduced.

How to manage the interaction:
Co-administration of Nevir-ER Tablet with Etravirine can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
NevirapineMipomersen
Severe
How does the drug interact with Nevir-ER Tablet:
Coadministration of Nevir-ER Tablet and Mipomersen can increase the risk and severity of liver problems.

How to manage the interaction:
Although taking Nevir-ER Tablet and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding make sure to contact your doctor immediately. Do not stop using any medications without a doctor's advice.
NevirapineTeriflunomide
Severe
How does the drug interact with Nevir-ER Tablet:
Coadministration of Nevir-ER Tablet and Teriflunomide can increase the risk and severity of liver problems.

How to manage the interaction:
Although taking Nevir-ER Tablet and Teriflunomide together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, or bleeding make sure to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NevirapineCariprazine
Severe
How does the drug interact with Nevir-ER Tablet:
Taking Cariprazine with Nevir-ER Tablet may reduce the blood levels of cariprazine, which may make the medication less effective.

How to manage the interaction:
Taking Cariprazine with Nevir-ER Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without consulting a doctor.
NevirapineButorphanol
Severe
How does the drug interact with Nevir-ER Tablet:
When Butorphanol is taken with Nevir-ER Tablet may reduce the blood levels of Butorphanol. This can lead to low treatment outcomes.

How to manage the interaction:
Although taking Nevir-ER Tablet and Butorphanol together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heartbeat, body aches, involuntary twitching and kicking, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss call a doctor right away. Do not discontinue any medications without consulting a doctor.
NevirapineApremilast
Severe
How does the drug interact with Nevir-ER Tablet:
Coadministration of Nevir-ER Tablet with Apremilast may decrease the blood levels of Apremilast, which may make the medication less effective.

How to manage the interaction:
Although there is a possible interaction between Apremilast and Nevir-ER Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
NevirapineLomitapide
Severe
How does the drug interact with Nevir-ER Tablet:
Coadministration of Nevir-ER Tablet and Lomitapide may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Nevir-ER Tablet and Lomitapide together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes call a doctor right away. Do not discontinue any medications without consulting a doctor.
NevirapineRifampicin
Severe
How does the drug interact with Nevir-ER Tablet:
Taking Nevir-ER Tablet with rifampicin can decrease the blood levels of Nevir-ER Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Nevir-ER Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Nevir-ER Tablet when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Nevir-ER Tablet is used to treat HIV infection.
Nevir-ER Tablet contains Neviparine, which works by inhibiting the HIV reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of viral replication and thereby prevents further spread of infection.
No, completing the entire treatment course prescribed by the doctor is always recommended. Sudden discontinuation of the medicine can lead to serious side effects. Your doctor will decide whether to stop the medication or not.
Nevir-ER Tablet does not cure HIV infection. However, it helps to control the disease and prevent opportunistic infections. Nevir-ER Tablet is used in combination with other anti-retroviral medicines.
Nevir-ER Tablet is an antiretroviral medicine. It contains Neviparine, which belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTI) used to treat HIV infection.
Yes, Nevir-ER Tablet is safe if taken in the dose and duration prescribed by the doctor.
Nevir-ER Tablet can be taken with or without food. Swallow it as a whole with a glass of water. Do not chew, crush, or break the medicine.
Yes, Nevir-ER Tablet is an effective antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) infection.
If you miss a dose of Nevir-ER Tablet , take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Nevir-ER Tablet may cause side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, fatigue, diarrhoea, myalgia (muscle pain), skin rash and other allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
Yes, you can take Nevir-ER Tablet with or without food. It does not change how your body absorbs the medicine. Talk to your doctor or pharmacist if you experience stomach discomfort.
You should contact your doctor right away if you get any rash. While mild rashes are common, they can quickly turn into a serious medical emergency if not monitored. Talk to your doctor for advice.
It is best to avoid alcohol entirely. Both alcohol and this medicine can strain your liver, and combining them raises your risk of severe liver damage. Talk to your doctor or pharmacist about safe lifestyle habits.
Starting with a lower dose and gradually increasing the dose helps your body adapt. This approach is highly effective at reducing your risk of a severe allergic skin reaction. Talk to your doctor if you have questions about your dosing schedule.
This medicine can make hormonal birth control pills less effective. It is highly recommended that you use a barrier method, like condoms, to prevent pregnancy. Talk to your doctor or pharmacist about the best contraceptive options for you.
You should never let your medicine run out, as stopping treatment can make the virus resistant to the medication. If you have missed doses for several days, do not restart on your own; talk to your doctor or pharmacist immediately for instructions.
Breastfeeding is generally not recommended for individuals with HIV because the virus can be passed to the baby through breast milk. Talk to your doctor or pharmacist to discuss the safest feeding options for your child.

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Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - NEV0080
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