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compositionComposition:LURASIDONE
prescription
Prescription Medicine
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NEWDON 40MG TABLET is used to treat schizophrenia and bipolar disorder. It contains Lurasidone which works by blocking neurotransmitters and helps regulate mood, thoughts and behaviour. In some cases, this medicine may cause side effects such as nausea, vomiting, sleepiness, weight gain, indigestion, dry mouth, and restlessness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LURASIDONE

Manufacturer/Marketer :

Crescent Pharmaceuticals

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About NEWDON 40MG TABLET

NEWDON 40MG TABLET is a prescription medicine used to treat schizophrenia in adults and teenagers, as well as depressive episodes associated with bipolar disorder. It belongs to a class of medications called atypical antipsychotics, which work to help restore the balance of natural chemical signals in the brain. This medication is designed to improve your thinking, mood, and daily behaviours.

For this medicine to work effectively, you need to take it consistently every single day at the same time. You must always take NEWDON 40MG TABLET with food, specifically, a meal or snack containing at least 350 calories to ensure your body absorbs it properly. Incorporating a structured daily routine, regular sleep schedules, and stress-reduction techniques can greatly support the benefits of your treatment.

While taking this medicine, you may experience some mild side effects like drowsiness or mild nausea. However, you should contact your doctor immediately if you experience more serious issues, such as uncontrollable muscle movements, severe muscle stiffness, or extreme restlessness.

Do not take this if you have had a severe allergic reaction to it in the past. Talk to your doctor before starting NEWDON 40MG TABLET if you have a history of liver damage, kidney problems, heart disease, high cholesterol, or diabetes. It is also important to tell your doctor if you have a history of seizures or Parkinson's disease.

Certain medicines can interfere with how this medicine works, so share your full prescription list with your healthcare provider. Avoid drinking alcohol while on this medication, as it can dangerously increase sleepiness and dizziness. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor to ensure this treatment is safe for your specific situation.

Uses of NEWDON 40MG TABLET

Your doctor may prescribe this medicine to treat several conditions, including:

  • Schizophrenia: NEWDON 40MG TABLET helps manage severe mental health symptoms by reducing hallucinations, delusions, and disorganised thinking, allowing you to engage more fully in daily life.
  • Bipolar depression: It helps relieve the intense feelings of sadness, loss of interest, and low energy that occur during depressive episodes associated with bipolar I disorder.

Key Benefits

NEWDON 40MG TABLET helps manage symptoms of certain mental health conditions by helping restore the balance of brain chemicals involved in mood, thinking, and behaviour. Key benefits include:

  • Helps Stabilise Mood and Thinking: By regulating brain activity, NEWDON 40MG TABLET helps reduce symptoms such as mood changes, disturbed thinking, and behavioural disturbances, supporting improved daily functioning.
  • Provides Relief from Bipolar Depression: In people with bipolar disorder, NEWDON 40MG TABLET helps reduce symptoms of depressive episodes, such as persistent sadness, low energy, and loss of interest in daily activities.
  • Supports Overall Quality of Life: By improving mood stability and reducing symptoms, NEWDON 40MG TABLET helps individuals manage daily responsibilities, maintain social relationships, and participate more comfortably in everyday activities.
Side effects of Newdon 40mg Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Focus on eating nutrient-rich foods such as citrus fruits, spinach, ginger, garlic, turmeric, and fermented foods to improve immunity and general health.
  • Drink plenty of water to stay hydrated, and think about taking probiotics, zinc, vitamin C, and vitamin D supplements.
  • Adopt healthful practices such as leading a balanced lifestyle and remaining at home when necessary.

Directions for Use

  • NEWDON 40MG TABLET can be taken with or without food as advised by a doctor.
  • It is advised to take NEWDON 40MG TABLET exactly as prescribed by your doctor, following the recommended dosage and duration for your specific medical condition to achieve optimal results
  • Swallow NEWDON 40MG TABLET as a whole with a glass of water.
  • Do not crush, chew, or break it.

How NEWDON 40MG TABLET Works

NEWDON 40MG TABLET contains lurasidone, which works by acting on specific natural chemicals in your brain called neurotransmitters. These chemicals, primarily dopamine and serotonin, play a vital role in regulating your mood, thoughts, and behaviours. When there is an imbalance of these chemicals, it can lead to symptoms of schizophrenia or depression. By attaching to and balancing the activity of dopamine and serotonin receptors, NEWDON 40MG TABLET helps smooth out these chemical signals. This targeted action reduces unusual perceptions, calms chaotic thoughts, and lifts depressive moods.
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Alcohol

Unsafe

Avoid consuming alcohol while on treatment with NEWDON 40MG TABLET as it may increase the risk of side effects.

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Pregnancy

Caution

NEWDON 40MG TABLET is not recommended for use in pregnancy. Hence, if you are pregnant, inform your doctor before taking NEWDON 40MG TABLET . Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known if NEWDON 40MG TABLET passes into the breastmilk. If you are breastfeeding, consult your doctor before taking NEWDON 40MG TABLET , your doctor will prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

NEWDON 40MG TABLET may cause dizziness. So, it is not recommended to drive or operate heavy machinery after taking NEWDON 40MG TABLET .

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Liver

Caution

NEWDON 40MG TABLET should be used with caution in patients with liver disease. If you have liver disease, inform your doctor before taking NEWDON 40MG TABLET . Your doctor may adjust the dose based on your condition.

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Kidney

Caution

NEWDON 40MG TABLET should be used with caution in patients with kidney disease. If you have kidney disease, inform your doctor before taking NEWDON 40MG TABLET . Your doctor may adjust the dose based on your condition.

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Children

Unsafe

NEWDON 40MG TABLET is not recommended for use in children under 13 years.

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Heart

Consult your doctor

It is unknown whether NEWDON 40MG TABLET is safe for use in cardiac patients. Please consult your physician.

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Geriatrics

Caution

NEWDON 40MG TABLET should be used under extreme caution in elderly patients. This medicine contains a black box warning - increased risk of death, stroke, or mini-stroke in patients with dementia-related psycosis.

What if I have taken an overdose of NEWDON 40MG TABLET

If you suspect an overdose, seek emergency medical care or call a poison control centre immediately. Symptoms of an overdose may include extreme drowsiness, rapid heartbeat, or unusual muscle movements.

Diet & Lifestyle Advise

  • The 350-calorie rule: Plan your doses around a substantial meal, such as breakfast or dinner. A light snack like a piece of fruit is not enough; aim for a balanced meal containing proteins, fats, and carbohydrates to ensure proper medication absorption.
  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit contains compounds that can increase the amount of the medication in your body, raising your risk of side effects.
  • Stay hydrated: This medication can interfere with your body's ability to regulate its temperature. Drink plenty of water and be careful during vigorous exercise or in hot weather to avoid overheating.
  • Monitor your weight and blood sugar: Antipsychotic medicines can sometimes cause changes in your weight, cholesterol, or blood sugar levels. Keep a regular log of your weight and focus on a diet rich in vegetables, lean proteins, and whole grains.
health query

Have a query?

How Soon It Starts Working

The time required for NEWDON 40MG TABLET to start to work: NEWDON 40MG TABLET ideally shows its action within 1 to 3 hours after administration. The time for which the effects of NEWDON 40MG TABLET last: The effect of NEWDON 40MG TABLET lasts for 24 hours.

What if you forget to take NEWDON 40MG TABLET

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store NEWDON 40MG TABLET tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •

Drug Warnings

  • Avoid alcohol: Do not drink alcohol while taking NEWDON 40MG TABLET , as it may increase drowsiness, dizziness, and other nervous system side effects.
  • Be cautious with activities requiring alertness: Do not drive, operate machinery, or perform tasks requiring concentration until you know how NEWDON 40MG TABLET affects you, as it may cause sleepiness, dizziness, or impaired alertness.
  • Stand up slowly: Rise gradually from a sitting or lying position to reduce the risk of dizziness, light-headedness, or falls, especially when you first start treatment or after a dose increase.
  • Do not stop treatment abruptly: Never stop taking NEWDON 40MG TABLET without consulting your doctor. Stopping the medicine suddenly may worsen your condition or cause withdrawal symptoms. Your doctor will advise you on how to reduce the dose gradually if treatment needs to be discontinued.
  • Inform healthcare providers: Tell your doctor, dentist, or other healthcare professionals that you are taking NEWDON 40MG TABLET before any surgery, dental procedure, or before starting any new prescription, over-the-counter, or herbal medicines.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Strong CYP3A4 inhibitors: Medicines like ketoconazole (an antifungal) or clarithromycin (an antibiotic) can significantly increase the levels of NEWDON 40MG TABLET in your blood, raising the risk of severe side effects.
  • Strong CYP3A4 inducers: Medicines like rifampin (an antibiotic) or carbamazepine (a seizure medication) can drastically lower the amount of NEWDON 40MG TABLET in your body, making it less effective.
  • Central nervous system depressants: Combining this medicine with sleep aids, anxiety medications, or opioid pain relievers can lead to severe drowsiness and slow breathing.
LurasidonePrimidone
Critical
LurasidoneIndinavir
Critical

Drug-Drug Interactions

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LurasidonePrimidone
Critical
How does the drug interact with Newdon 40mg Tablet:
Co-administration of Newdon 40mg Tablet with primidone may result in significantly lower blood levels of Newdon 40mg Tablet, making the medication less effective or ineffective in treating your illness.

How to manage the interaction:
There is an interaction between Newdon 40mg Tablet and Primidone, so it is not recommended; it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LurasidoneIndinavir
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with Indinavir may result in significantly higher Newdon 40mg Tablet blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Newdon 40mg Tablet and Indinavir may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneKetoconazole
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with ketoconazole may increase the risk of side effects like Parkinson's disease(It is a brain disorder that produces uncontrollable movements).

How to manage the interaction:
While Newdon 40mg Tablet and ketoconazole is not recommended as it may lead to an interaction, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, fits, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneClarithromycin
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with Clarithromycin may result in significantly higher Newdon 40mg Tablet blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Newdon 40mg Tablet and Clarithromycin may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneCeritinib
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with Ceritinib may result in significantly increase the blood levels of Newdon 40mg Tablet.

How to manage the interaction:
Newdon 40mg Tablet and Ceritinib together are not recommended as they can lead to an interaction. They can be used if prescribed by a doctor. However, consult a doctor if you experience low blood pressure, such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneDarunavir
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with Darunavir may result in significantly higher Newdon 40mg Tablet blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Newdon 40mg Tablet and Darunavir may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneRifabutin
Critical
How does the drug interact with Newdon 40mg Tablet:
Newdon 40mg Tablet administration with Rifabutin may result in significantly lower blood levels of Newdon 40mg Tablet.

How to manage the interaction:
There is an interaction between Newdon 40mg Tablet and Rifabutin, so it is not recommended that you take it unless a doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidonePhenytoin
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with phenytoin may significantly decrease the blood levels of Newdon 40mg Tablet.

How to manage the interaction:
Using Newdon 40mg Tablet with phenytoin is not recommended, it can be taken if a doctor has prescribed it. Consult a doctor, if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneVoriconazole
Critical
How does the drug interact with Newdon 40mg Tablet:
Using Newdon 40mg Tablet together with Voriconazole may result in significantly higher Newdon 40mg Tablet blood levels.

How to manage the interaction:
While Newdon 40mg Tablet and Voriconazole may interact, it is not recommended that they be used unless prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, dizziness, headache, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneRifamycin
Critical
How does the drug interact with Newdon 40mg Tablet:
Coadministration of Newdon 40mg Tablet with Rifamycin can increase the metabolism of Newdon 40mg Tablet.

How to manage the interaction:
Although there is an interaction between Newdon 40mg Tablet and Rifamycin, you can take it if your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: These can block enzymes that break down the medication, leading to dangerously high levels of the medicine in your system.
  • Calorie intake: Taking this medicine without at least 350 calories of food will reduce its absorption by half, making it much less effective.
LURASIDONEGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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LURASIDONEGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking grapefruit juice with Newdon 40mg Tablet treatment can increase the levels of Newdon 40mg Tablet which can increase the risk or severity of side effects. Taking grapefruit juice with Newdon 40mg Tablet should be avoided as it can result in an interaction. Contact a doctor immediately if you experience symptoms like abnormal muscle movements, seizures, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not stop using any medications without talking to a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

It may take several weeks before you notice the full benefits of NEWDON 40MG TABLET , although some symptoms may begin to improve within the first week or two. It is crucial to keep taking the medicine daily even if you do not feel immediate changes. Talk to your doctor if you have concerns about your progress.
Take the missed dose with food as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently forget your doses.
Some people may experience weight gain while taking NEWDON 40MG TABLET , though it generally has a lower risk of causing significant weight gain compared to some other medicines in its class. Regular exercise and a balanced diet can help manage your weight. Talk to your doctor or pharmacist for personalised lifestyle advice.
You should avoid alcohol while taking NEWDON 40MG TABLET . Alcohol can increase the medicine's sedative effects, making you more drowsy, dizzy, or less alert, which increases the risk of falls and accidents. You should also avoid grapefruit or grapefruit juice because it may affect how the medicine is processed in your body. Talk to your doctor if you have questions about food or drink interactions.
Yes, NEWDON 40MG TABLET can make it harder for your body to cool down, increasing the risk of dehydration or heatstroke. Avoid staying in hot environments for too long, drink plenty of fluids, and wear light clothing during hot weather. Talk to your doctor if you experience signs of overheating like extreme thirst or dizziness.
You must never stop taking NEWDON 40MG TABLET suddenly without consulting your healthcare provider. Stopping this medicine abruptly can cause your symptoms to return or worsen. If you need to stop, your doctor will guide you on gradually decreasing your dose to safely discontinue the medication. Talk to your doctor before making any changes.
NEWDON 40MG TABLET should only be used during pregnancy if your doctor determines that the potential benefits outweigh the risks. Taking this medicine during the third trimester may cause withdrawal symptoms or movement disorders (extrapyramidal symptoms) in newborn babies, including muscle stiffness, tremors, sleepiness, breathing difficulties, or feeding problems. If you are pregnant, planning a pregnancy, or become pregnant during treatment, consult your doctor promptly.
No. You must take NEWDON 40MG TABLET with food containing at least 350 calories, as taking it without enough food can significantly reduce how much of the medicine your body absorbs. Swallow the tablet whole with a glass of water and do not crush or chew it. If you have difficulty planning your doses around meals, speak with your doctor or pharmacist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Lurasidone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 200603S015Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020]Check here
  4. Lurasidone Lurasidone. 2014. [Accessed on 25 Mar. 2019]Check here
  5. Lurasidone hydrochloride [Prescribing Information]. 2013. [Accessed on 25 Jul. 2024]Check here
  6. Yusra Azhar; Kamleh Shaban. Lurasidone. NIH National Library of Medicine. National Center for Biotechnology Information. [Revised in June 2021] [Accessed on 10th June 2022]Check here
  7. Sunovion Pharmaceuticals Inc. DailyMed. NIH National Library of Medicine. [Revised in July 2022] [Accessed on 10th June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

SCO-58, 59, Sector-17D Chandigarh-160017
Other Info - NEW0161

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