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compositionComposition:CEFUROXIME-500MG
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Nexen 500mg Tablet is used to treat bacterial infections. It contains Cefuroxime, which works by killing infection-causing bacteria. It may cause common side effects like headache, dizziness, stomach upset, and unpleasant taste in the mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

CEFUROXIME-500MG

Manufacturer/Marketer :

Zee Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nexen 500mg Tablet

Nexen 500mg Tablet is an antibiotic prescribed to treat a variety of bacterial infections, including middle ear infections, throat infections, sinus infections, and urinary tract infections. It works by stopping the growth of bacteria, helping your body clear the infection and preventing it from spreading further. This medication is only effective against bacterial infections and will not work for viral illnesses such as the common cold or flu.

To get the best results, you must take Nexen 500mg Tablet consistently at evenly spaced intervals throughout the day as directed by your doctor. This oral medication should be taken with food, as this helps your body absorb the medicine much better and reduces the risk of an upset stomach. Drinking plenty of fluids, getting adequate rest, and eating a balanced diet will also support your body’s recovery during treatment.

While taking this medicine, you may experience mild side effects like nausea, mild diarrhoea, or a temporary, unusual taste in your mouth. Most of these symptoms are mild and go away on their own, but you should contact your doctor immediately if you develop severe, watery diarrhoea, a high fever, or stomach cramps. Always consult your doctor if you experience any unusual or persistent symptoms.

Talk to your doctor before starting Nexen 500mg Tablet if you have a history of kidney disease, liver disease, or severe stomach disorders such as colitis (inflammation of the large intestine). Kidney disease may affect how cefuroxime is removed from the body and could require dose adjustments. Do not take this medicine if you have a known severe allergy to cephalosporin antibiotics or if you have had a severe allergic reaction to penicillin. Your doctor will help determine if this medication is safe for your specific health history.

Certain medications, such as antacids or drugs that reduce stomach acid, can interfere with how your body absorbs Nexen 500mg Tablet, making it less effective. Limit or avoid alcohol during treatment to prevent stomach irritation, and consult your doctor if you are pregnant, breastfeeding, or managing health conditions at an older age.

Uses of Nexen 500mg Tablet

Nexen 500mg Tablet may be prescribed for the following bacterial infections:

  • Pharyngitis and tonsillitis: Nexen 500mg Tablet helps clear bacterial infections of the throat and tonsils, relieving painful swallowing and reducing swelling.
  • Acute middle ear infections: It targets the bacteria causing painful fluid buildup behind the eardrum, resolving ear pain and pressure.
  • Acute bacterial sinusitis: It eliminates bacterial infections in the nasal passages, relieving facial pain, congestion, and headaches.
  • Urinary tract infections: It treats bacterial infections in the bladder or kidneys, easing symptoms like burning urination and frequent urges.
  • Skin and soft tissue infections: It clears bacterial infections on the skin, reducing redness, warmth, swelling, and pain.
  • Chronic bronchitis flare-ups: It helps treat bacterial flare-ups in patients with ongoing bacterial lung airway irritation, improving breathing.

Key Benefits

Nexen 500mg Tablet may provide the following benefits when used as prescribed.

  • Relieves Infection Symptoms: By eliminating the bacteria causing the infection, Nexen 500mg Tablet may help reduce symptoms such as fever, pain, swelling, congestion, burning during urination, or discomfort associated with bacterial infections.
  • Helps Clear Bacterial Infections: Nexen 500mg Tablet works against a wide range of susceptible bacteria, helping the body overcome infections affecting the ears, throat, sinuses, urinary tract, skin, and respiratory system.
  • Reduces the Risk of Complications: Prompt and appropriate treatment with Nexen 500mg Tablet may help prevent bacterial infections from worsening, spreading to other parts of the body, or causing more serious health problems.
  • Supports Faster Recovery: By controlling the infection effectively, Nexen 500mg Tablet may help improve overall well-being and allow patients to return to normal daily activities sooner.
  • Provides Targeted Antibacterial Action: Nexen 500mg Tablet specifically targets bacteria responsible for the infection and is designed to treat bacterial illnesses without affecting viral infections such as the common cold or flu.
Side effects of Nexen 500mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Inflammation of Vagina needs immediate attention and cannot be ignored.
  • Get a physical examination and prevent wearing clothes that can hold heat and moisture.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Follow your doctor's instructions, and rest well with proper medication.
  • Take a balanced diet and get regular screenings to reduce inflammation.

Directions for Use

  • Nexen 500mg Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Nexen 500mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Nexen 500mg Tablet Works

Cefuroxime, the active ingredient in Nexen 500mg Tablet, belongs to a class of antibiotics known as cephalosporins. It works by interfering with the formation of the bacterial cell wall, a protective outer layer that bacteria need to survive and multiply. Cefuroxime binds to specific proteins called penicillin-binding proteins (PBPs), which bacteria use to build and strengthen this protective outer layer. By blocking these proteins, cefuroxime prevents the bacteria from forming a proper cell wall. As a result, the bacterial cell wall becomes weak and unstable, causing the bacteria to break down and die. Since human cells do not have cell walls, cefuroxime specifically targets the bacteria causing the infection without affecting the body's own cells.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Nexen 500mg Tablet.

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Pregnancy

Safe if prescribed

Nexen 500mg Tablet is a pregnancy category B drug. So, Nexen 500mg Tablet can be safely taken by pregnant women if prescribed by the doctor.

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Breast Feeding

Caution

Nexen 500mg Tablet is excreted in human milk; caution should be exercised. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Driving

Caution

No studies on the effects on the ability to drive and use machines have been performed. However, as this medicine may cause dizziness, patients should be warned to be cautious when driving or operating machinery.

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Liver

Caution

Consult your doctor; there is no substantial research yet on the use of Nexen 500mg Tablet in patients with liver problems.

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Kidney

Caution

Consult your doctor, as there is no substantial research yet on the use of Nexen 500mg Tablet in people with kidney problems.

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Children

Safe if prescribed

Nexen 500mg Tablet can be given safely to children provided the dose has been prescribed by a child specialist. However, there is no clinical evidence of using Nexen 500mg Tablet in children under the age of 3 months.

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Heart

Consult your doctor

Please consult your doctor before using Nexen 500mg Tablet if you have pre-existing heart problems. Your doctor will prescribe Nexen 500mg Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Nexen 500mg Tablet to geriatric patients. Your doctor will prescribe Nexen 500mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Nexen 500mg Tablet

Taking too much of this medicine may cause nausea, vomiting, diarrhoea, dizziness, or stomach discomfort. In severe overdose situations, particularly in people with significant kidney impairment or very high drug levels, serious effects on the nervous system, including seizures, may occur. If you suspect an overdose, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Take probiotics: Consider consuming probiotic-rich foods like yoghurt or taking a probiotic supplement a few hours after your antibiotic dose to help maintain a healthy balance of gut bacteria.
  • Stay hydrated: Drink plenty of water throughout the day, especially if you experience mild diarrhoea, to keep your body well-hydrated and flush out toxins.
  • Complete the full course: Always finish the entire prescription, even if your symptoms disappear. Stopping early can allow the remaining bacteria to multiply and become resistant to the medication.
  • Rest and recover: Give your body ample time to rest while fighting off the infection, as physical exertion can slow down your recovery process.
health query

Have a query?

How Soon It Starts Working

The time required for Nexen 500mg Tablet to start to work: Nexen 500mg Tablet ideally shows its action within 2 to 3 hours after administration. The time for which the effects of Nexen 500mg Tablet last: The effect of Nexen 500mg Tablet lasts for 8 hours.

What if you forget to take Nexen 500mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store the tablet form of Nexen 500mg Tablet at room temperature, between 15°C and 30°C (59°F to 86°F), in a dry place away from direct heat and moisture. Do not store them in the bathroom.

Drug Warnings

  • Check the medication: Before taking, inspect the tablets or liquid. Do not use the liquid suspension if it has changed colour significantly or contains unusual clumps.
  • Do not treat viruses: Remember that Nexen 500mg Tablet is only for bacterial infections; using it for colds or flu will not cure the illness and can lead to antibiotic resistance.
  • Watch for severe diarrhoea: If you develop severe, watery diarrhoea during or up to several weeks after stopping treatment, contact your doctor immediately before taking any anti-diarrhoea medications, as these can make the condition worse.
  • Monitor kidney function: If you are taking this medicine for a prolonged period, your doctor may occasionally order blood tests to check how well your kidneys are working.
  • Inform other healthcare providers: Let your dentist, surgeon, or any other doctor know that you are currently taking Nexen 500mg Tablet, as it can occasionally interfere with certain medical or lab tests (like urine sugar tests).

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Stomach acid reducers (antacids, H2 blockers, proton pump inhibitors): Certain oral formulations of cefuroxime may be absorbed less effectively when taken with medicines that reduce stomach acid. Your doctor or pharmacist can advise you on appropriate timing if these medicines are needed together.
  • Oral contraceptives (birth control pills): Cefuroxime is not known to significantly reduce the effectiveness of hormonal contraceptives. However, if you experience severe vomiting or diarrhoea while taking the antibiotic, contraceptive absorption may be affected. Consult your doctor or pharmacist if you have concerns about contraception during treatment.
  • Gout medications (probenecid): Probenecid can slow down how quickly your kidneys remove Nexen 500mg Tablet from your system, leading to higher levels of the antibiotic in your blood and increasing the risk of side effects.
CefuroximeBCG vaccine
Severe
CefuroximeLepirudin
Severe

Drug-Drug Interactions

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CefuroximeBCG vaccine
Severe
How does the drug interact with Nexen 500mg Tablet:
Co-administration of Nexen 500mg Tablet may reduce the anti-tumor activity of BCG in the bladder.

How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Nexen 500mg Tablet. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
CefuroximeLepirudin
Severe
How does the drug interact with Nexen 500mg Tablet:
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Nexen 500mg Tablet.

How to manage the interaction:
Although taking Nexen 500mg Tablet and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
CefuroximeDalteparin
Severe
How does the drug interact with Nexen 500mg Tablet:
Co-administration of Dalteparin and Nexen 500mg Tablet can increase the blood levels and effects of Dlateparin.

How to manage the interaction:
Taking Nexen 500mg Tablet with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Taking Nexen 500mg Tablet with food significantly increases its absorption rate in your body. Avoid taking it on an empty stomach to ensure it works at its best.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Nexen 500mg Tablet is used to treat a wide range of bacterial infections. It helps in the treatment of urinary tract infections (UTI), mild to moderate lower respiratory tract infections (bronchitis), severe lower respiratory tract infections (pneumonia), pyelonephritis (kidney inflammation due to the bacterial infection), uncomplicated gonorrhoea (sexually transmitted infection), and Lyme disease (caused due to biting of infected black-legged tick insect).
Nexen 500mg Tablet is a broad-spectrum antibiotic that kills a wide range of bacteria (bactericidal). It kills the bacterial cell by binding to the outer layer of the bacteria and blocking the activity of the enzyme that makes peptidoglycan (a vital component of the bacterial cell wall). As a result, the bacterial cell cannot grow and multiply and finally gets killed.
No, it is a prescribed drug, given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.
You should avoid taking Nexen 500mg Tablet with oral birth control pills, medicines that reduce gastric acidity (like antacids, omeprazole), immunosuppressing drugs (mycophenolate or mycophenolic), medicines used for reducing uric acid (probenecid), and some urinary glucose tests. Besides this, it also interacts with typhoid and BCG vaccines.
Depending upon the severity of your medical condition, your doctor may prescribe it to you daily for a specific duration. The usual dose of Nexen 500mg Tablet is 5-10 days, but depending on your current infection state, your doctor may extend your dose intake for more days.
Try to stay well hydrated by drinking at least six glasses of water or other fluids per day. Keep your underwear clean and try to use cotton underwear to avoid the spread of infection. Always keep your bladder empty as much as possible by peeing regularly. Your doctor may prescribe cranberry juice with antibiotics to treat a urinary tract infection.
After taking an antibiotic, you may need to wait for up to three hours before eating or drinking any dairy products, including milk, butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.
If you have taken an accidental overdose of Nexen 500mg Tablet, you may have diarrhoea, nausea or vomiting. In rare cases, it can also cause convulsions or seizures (fits). Try to reach out to the doctor in this case.
No. Nexen 500mg Tablet treats only bacterial infection. Cough, flu or cold are usually caused by viruses. So, you should consult a doctor for these conditions.
Yes. Nexen 500mg Tablet may interact with birth control pills and lower their efficiency. So, you should tell your doctor if you are using any birth control pills.
No. You should complete the full course of Nexen 500mg Tablet as your doctor prescribes. You must take Nexen 500mg Tablet at the right dose, times, and for the right number of days.
Nexen 500mg Tablet might be a safer alternative if you are allergic to amoxicillin. However, please consult the doctor before starting Nexen 500mg Tablet.
Nexen 500mg Tablet helps treat respiratory tract infections, ear infections, skin infections, genitourinary infections, and bone infections.
Nexen 500mg Tablet may cause dizziness in some cases. Therefore, drive or operate machinery only if you are alert.
Do not discontinue Nexen 500mg Tablet without consulting the doctor. To treat your infection effectively, continue taking Nexen 500mg Tablet for the prescribed duration even though you feel better.
If you miss a dose of Nexen 500mg Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Nexen 500mg Tablet may interact with other medications. Consult the doctor if you are taking oral birth control pills, antacids, immuno-suppressing drugs, or medicines used for reducing uric acid.
Avoid alcohol consumption as it might lower the effectiveness of Nexen 500mg Tablet.
Nexen 500mg Tablet can be taken by pregnant or breastfeeding women if prescribed by the doctor. Please consult the doctor if you are pregnant, think you are pregnant, planning for pregnancy or breastfeeding.
Side effects of Nexen 500mg Tablet include headache, dizziness, stomach upset, overgrowth of candida (fungal skin infection), and an unpleasant taste in the mouth. Consult the doctor if the side effects persist or worsen.
It is best to avoid alcohol while taking Nexen 500mg Tablet. Alcohol can irritate your stomach, increase the risk of side effects like dizziness and nausea, and dehydrate your body, which can slow down your recovery from the infection. Talk to your doctor or pharmacist if you have concerns.
Taking Nexen 500mg Tablet with a meal or snack helps your body absorb the active ingredients much more effectively, ensuring the infection is treated properly. It also helps protect your stomach lining, reducing the chances of mild side effects like nausea or stomach upset. Talk to your doctor if you struggle to take it with food.
Mild diarrhoea is a common side effect of Nexen 500mg Tablet as it temporarily affects your gut bacteria. However, if you experience severe, watery, or bloody diarrhoea accompanied by stomach cramps, do not take any over-the-counter anti-diarrhoea medicines. This could be a sign of a serious gut infection, and you should talk to your doctor immediately.
Antacids and other stomach acid-reducing medications can significantly lower the absorption and effectiveness of Nexen 500mg Tablet. If you need to take an antacid, it is recommended to space them out by taking the antacid at least two hours before or after your dose of this medication. Talk to your doctor or pharmacist for a safe schedule.
Nexen 500mg Tablet is generally considered safe during pregnancy and breastfeeding, but it should only be used when clearly needed and prescribed by a healthcare provider. The medicine can pass into breast milk in small amounts, so monitor your infant for signs of diaper rash or thrush. Talk to your doctor to weigh the benefits and risks.
Nexen 500mg Tablet is not known to significantly reduce the effectiveness of hormonal contraceptive pills. However, if you experience severe vomiting or diarrhoea while taking the antibiotic, your body may not absorb your contraceptive properly. If this occurs, follow the instructions provided with your contraceptive and consult your doctor or pharmacist for additional guidance.

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Reference

  1. U.S. Food and Drug Administration (FDA). 050605S048,050672S034Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.3810 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Cefuroxime Patient Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Cefuroxime [EMC SmpC]. 2025. [Accessed on 29 Oct. 2025]Check here
  6. Cefuroxime Cefuroxime. 2025. [Accessed on Feb 2 2026]Check here
  7. Zinnat Tablets 125mg - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 27 Oct 2025]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Uchani, G.T. Road, Karnal-132001 Haryana (INDIA).
Other Info - NEX0292
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