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Nidalox 250mg/300mg Tablet is used to treat diarrhoea and amoebic dysentery. It contains Diloxanide and Tinidazole which work by killing the infection-causing organisms. In some cases, this medicine may cause side effects such as nausea, headache, dryness in the mouth, metallic taste, and flatulence. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Nidalox 250mg/300mg Tablet

Nidalox 250mg/300mg Tablet is a prescription medicine used to treat amoebic infections in the gut and other parts of the body. It targets and eliminates the parasites responsible for causing severe diarrhoea, dysentery, and stomach cramps. This treatment helps clear the infection completely by acting on the parasites at different stages of their life cycle.

To get the best results, you must take this medicine exactly as prescribed, completing the full course even if you start feeling better. It is usually taken with or after food to help prevent stomach upset. Staying well-hydrated and eating easily digestible, bland foods can support your recovery during treatment.

While taking Nidalox 250mg/300mg Tablet, you may experience mild side effects like a metallic taste, nausea, or an upset stomach. These symptoms usually go away once the treatment is finished, but you should contact your doctor immediately if you notice severe dizziness, numbness, tingling in your hands or feet, or skin rashes.

Talk to your doctor before starting this medicine if you have a history of liver disease, kidney problems, or nerve disorders. Do not take this if you have a history of neurological conditions or if you have had allergic reactions to similar anti-parasitic treatments.

Do not drink alcohol while taking Nidalox 250mg/300mg Tablet and for at least 3 days after finishing the course, as this can cause severe flushing, nausea, and a rapid heartbeat. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before starting this medication.

Uses of Nidalox 250mg/300mg Tablet

Here are the common parasitic infections that Nidalox 250mg/300mg Tablet is used to treat:

  • Amoebic Dysentery: Nidalox 250mg/300mg Tablet helps treat severe intestinal infections characterised by painful stomach cramps, bloody stools, and diarrhoea by destroying the disease-causing parasites in the gut.
  • Hepatic Amebiasis: Nidalox 250mg/300mg Tablet treats parasitic infections that have spread from the intestines to the liver, preventing liver abscesses and further complications.
  • Mixed Intestinal Parasitic Infections: Nidalox 250mg/300mg Tablet is effective against multiple stages of parasites in the digestive tract, ensuring both the active and dormant forms are cleared from your body.
     

Key Benefits

Nidalox 250mg/300mg Tablet offers several benefits by eliminating parasitic infections and supporting digestive recovery:

  • Provides Fast Symptom Relief: It helps relieve abdominal cramps, bloating, diarrhoea, and other symptoms associated with amoebic infections.
  • Clears Both Active and Dormant Parasites: Its dual-action formula helps eliminate different stages of the parasite, reducing the risk of recurrence.
  • Supports Recovery of Digestive Health: By clearing the infection, it allows the intestines to heal and improves the absorption of nutrients.
  • Helps Prevent Serious Complications: Early and complete treatment reduces the risk of the infection spreading beyond the intestines, including to the liver.
     

Directions for Use

  • Nidalox 250mg/300mg Tablet can be taken with food or as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication for effective results.
  • Swallow Nidalox 250mg/300mg Tablet as a whole with a glass of water.
  • Do not break, chew or crush Nidalox 250mg/300mg Tablet.

How Nidalox 250mg/300mg Tablet Works

Nidalox 250mg/300mg Tablet contains two active medicines that work together to treat amoebic infections by eliminating both active parasites and their dormant cyst forms. Diloxanide is an amoebicide that works mainly inside the intestines. It targets and destroys the cyst form of Entamoeba histolytica, helping eliminate the parasite from the gut and reducing the risk of the infection spreading or recurring. Tinidazole is an antiprotozoal and antibacterial medicine that works by entering the parasite's cells and damaging its DNA. This prevents the parasite from growing and multiplying, helping clear active infections in the intestines as well as in tissues such as the liver. Together, these medicines help eliminate both active parasites and dormant cysts, providing effective treatment for amoebic infections and reducing the risk of relapse.
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Alcohol

Unsafe

Consuming alcohol while taking Nidalox 250mg/300mg Tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure. So please consult your doctor before taking Nidalox 250mg/300mg Tablet.

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Pregnancy

Caution

Nidalox 250mg/300mg Tablet may be unsafe to use during pregnancy. Please consult your doctor before taking Nidalox 250mg/300mg Tablet if you are pregnant. Your doctor will weigh the benefits and any potential risks before prescribing it.

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Breast Feeding

Caution

Nidalox 250mg/300mg Tablet may be unsafe to use during breastfeeding. Please consult your doctor before taking Nidalox 250mg/300mg Tablet if you are breastfeeding. Your doctor will weigh the benefits and any potential risks before prescribing it.

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Driving

Caution

Nidalox 250mg/300mg Tablet should be used with caution in driving. It may cause drowsiness or dizziness; please do not drive a car or operate machinery while taking Nidalox 250mg/300mg Tablet if you experience such side effects.

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Liver

Caution

Nidalox 250mg/300mg Tablet should be used with caution in liver disease. Please inform your doctor before taking Nidalox 250mg/300mg Tablet if you have liver impairment.

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Kidney

Caution

Nidalox 250mg/300mg Tablet should be used with caution in kidney disease. Please inform your doctor before taking Nidalox 250mg/300mg Tablet if you have kidney impairment.

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Children

Caution

Nidalox 250mg/300mg Tablet should be taken as advised by your doctor. Because dose adjustment is made according to age, weight and severity of the infection by your doctor.

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Heart

Caution

Nidalox 250mg/300mg Tablet should be taken with caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Nidalox 250mg/300mg Tablet should be used under caution in geriatric patients due to the risk of side effects. Please consult your physician.

What if I have taken an overdose of Nidalox 250mg/300mg Tablet

Take Nidalox 250mg/300mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Drink plenty of safe, filtered, or boiled water and oral rehydration fluids to replace fluids lost through diarrhoea.
  • Eat Safe, Hygienic Food: Avoid raw or undercooked foods, unpeeled fruits, and street food to reduce the risk of reinfection.
  • Choose Easily Digestible Foods: Eat bland foods such as bananas, rice, applesauce, toast, or plain khichdi while your digestive system recovers. Avoid spicy, oily, or heavily seasoned meals.
  • Maintain Good Hand Hygiene: Wash your hands thoroughly with soap and water after using the toilet and before preparing or eating food to prevent spreading the infection.
     
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How Soon It Starts Working

The time required for Nidalox 250mg/300mg Tablet to start to work: Nidalox 250mg/300mg Tablet ideally shows its action within 30 to 60 minutes of administration. The time for which the effects of Nidalox 250mg/300mg Tablet last: Nidalox 250mg/300mg Tablet effect lasts for 4 to 5 hours.

What if you forget to take Nidalox 250mg/300mg Tablet

If you accidentally take more than the prescribed amount, seek immediate medical attention or contact a local poison control centre. Look out for symptoms such as severe nausea, vomiting, dizziness, or confusion.

Storage

•Store Nidalox 250mg/300mg Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medication in its original packaging to protect it from direct sunlight, heat, and moisture.

Drug Warnings

  • Avoid Alcohol Completely: Do not consume alcohol during treatment and for at least 72 hours after your last dose, as it may cause severe nausea, vomiting, headache, flushing, and a rapid heartbeat.
  • Use Caution While Driving: Avoid driving or operating machinery if you experience dizziness, drowsiness, or reduced alertness.
  • Complete the Full Course: Continue taking the medicine for the full prescribed duration, even if your symptoms improve before treatment is finished.
  • Report Nerve-Related Symptoms Promptly: Contact your doctor immediately if you develop numbness, tingling, weakness, or unusual sensations in your hands or feet.
  • Lithium: Tinidazole (like metronidazole) can increase serum lithium concentrations and increase the risk of lithium toxicity. 
     

verifiedApollotooltip
  • Blood Thinners (such as Warfarin): May increase the risk of bleeding when combined with blood thinners like warfarin.
  • Anti-Seizure Medicines: Taking this medication alongside certain seizure medicines may affect how those drugs work in your body.
     

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  • Alcohol: Interacts severely with alcohol, causing a reaction that leads to flushing, severe headache, nausea, and vomiting.
     

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Habit Forming

No

Therapeutic Class

[ANTIPROTOZOAL AGENTS, AMEBICIDES]

FAQs

Nidalox 250mg/300mg Tablet is used to treat diarrhoea and amoebic dysentery.
Nidalox 250mg/300mg Tablet is a combination of two medicines, namely: Diloxanide and Tinidazole. Diloxanide (amoebicide) works inside the large intestine to kill the infection-causing amoeba (parasites). Tinidazole (antibiotic) works by damaging the DNA (genetic material) of bacteria and protozoa and inhibits the formation of new DNA essential for bacteria's survival. Thereby, it kills microorganisms and prevents the spread of infection. .
Nidalox 250mg/300mg Tablet causes common side effects like nausea, headache, dryness in the mouth, metallic taste, and flatulence in some cases. Most of these side effects of Nidalox 250mg/300mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Nidalox 250mg/300mg Tablet should be used with caution in kidney diseases, liver diseases, peripheral neuropathy, epilepsy, blood disorders, G-6 phosphate dehydrogenase deficiency, and sexually transmitted diseases.
Take Nidalox 250mg/300mg Tablet as soon as you remember it. However, do not take it if it's almost time for your next dose. Also, do not take an extra dose to make up for your missed dose.
Do not stop taking Nidalox 250mg/300mg Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.
No, you must completely avoid alcohol while taking Nidalox 250mg/300mg Tablet and for at least three days after completing your treatment. Mixing the two can cause a severe reaction with symptoms like headache, hot flushes, nausea, vomiting, and a racing heart. Talk to your doctor or pharmacist if you have concerns.
If you vomit within 30 minutes of taking your dose, talk to your doctor or pharmacist to find out if you need to take another dose. Do not take an extra tablet without professional medical advice.
You should avoid taking Nidalox 250mg/300mg Tablet during pregnancy, especially during the first trimester, unless your doctor decides it is absolutely necessary. Always talk to your doctor or pharmacist before starting any new medication if you are pregnant or planning to conceive.
A metallic taste is a very common and temporary side effect of this medicine. It is harmless and will go away once you finish your treatment course. Sucking on sugar-free hard candy or chewing sugar-free gum can help manage this taste.
Some people may notice darker urine while taking this medicine. Although this can occasionally occur during treatment, dark urine should not be ignored, particularly if it is accompanied by yellowing of the skin or eyes, severe tiredness, abdominal pain, or persistent nausea. Contact your doctor promptly if these symptoms occur, as they may indicate a liver problem.
No, Nidalox 250mg/300mg Tablet is specifically formulated to treat parasitic infections like amebiasis. It is not effective against viral infections (like the typical stomach flu) or standard bacterial food poisoning. Talk to your doctor for an accurate diagnosis if you have severe stomach issues.

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Country of origin

India

Manufacturer/Marketer address

A-50, G. T. Karnal Road, Industrial Area Near Azadpur, Opposite Hans Cinema, Delhi- 110033, Delhi, India
Other Info - NI99314
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