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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Nirglim-M 2 Tablet is used to treat type 2 diabetes. It contains Glimepiride and Metformin, which work by decreasing the amount of glucose absorbed from the food and the amount of glucose made by the liver. It helps the pancreas produce insulin and enables the body to use it efficiently. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache or a metallic taste. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Whats That

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Synonym :

GLIMEPIRIDE+METFORMIN HYDROCHLORIDE

Manufacturer/Marketer :

Nirvana India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nirglim-M 2 Tablet

Nirglim-M 2 Tablet belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Nirglim-M 2 Tablet contains Glimepiride and Metformin. Glimepiride helps the pancreas release more insulin, thereby lowering blood sugar levels. Metformin reduces the amount of sugar produced by the liver, slows down sugar absorption from food, and helps the body use insulin more effectively.

In some cases, Nirglim-M 2 Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Nirglim-M 2 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Nirglim-M 2 Tablet if you are allergic to any of its components. Nirglim-M 2 Tablet is not recommended during pregnancy, breastfeeding and in children. Avoid alcohol consumption with Nirglim-M 2 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Nirglim-M 2 Tablet

Nirglim-M 2 Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Nirglim-M 2 Tablet are as follows:
• Management of Type 2 Diabetes: Nirglim-M 2 Tablet helps lower blood sugar levels in individuals diagnosed with type 2 diabetes.
• Improvement of Insulin Sensitivity: Nirglim-M 2 Tablet enhances the action of insulin, making the body's tissues more responsive to it.
• Reduction of Cardiovascular Risks: Regular use of Nirglim-M 2 Tablet can help reduce the risk of cardiovascular diseases in diabetic patients.
• Control of Blood Sugar Levels Post Meals: Nirglim-M 2 Tablet assists in lowering postprandial blood sugar spikes, which is beneficial for overall diabetes management.

Directions for Use

  • Nirglim-M 2 Tablet can be taken with meals or as prescribed by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Nirglim-M 2 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

Medicinal Benefits

  • Nirglim-M 2 Tablet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients with type 2 diabetes.
  • It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.
  • Nirglim-M 2 Tablet contains Glimepiride and Metformin, which work together to offer a dual-action approach for effectively managing type 2 diabetes.
  • Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood.
  • Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Additionally, it enhances the sensitivity of muscle cells to insulin, allowing these cells to remove sugar more effectively from the bloodstream.

How Nirglim-M 2 Tablet Works

Nirglim-M 2 Tablet is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Nirglim-M 2 Tablet

Take Nirglim-M 2 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include hypoglycaemia (low blood sugar) and lactic acidosis (buildup of lactic acid in the blood). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Nirglim-M 2 Tablet if you are allergic to any of its components, if you have type 1 diabetes mellitus, diabetic ketoacidosis or diabetic coma. Inform the doctor if you have liver or kidney problems, low blood sugar, or circulation problems.

Nirglim-M 2 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning to become pregnant. The safety and effectiveness of Nirglim-M 2 Tablet in children have not been established. This medicine may pass into breastmilk; hence, it should be avoided in nursing mothers. 

Nirglim-M 2 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Nirglim-M 2 Tablet . Avoid alcohol consumption with Nirglim-M 2 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Beware of symptoms of hypoglycemia (low blood sugar), which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume candies, glucose biscuits, or honey/sugar. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interactions

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MetforminMetrizamide
Critical
MetforminIodamide
Critical

Drug-Drug Interactions

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MetforminMetrizamide
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Nirglim-M 2 Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIodamide
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Nirglim-M 2 Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Iopamidol with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopromide
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Iopromide with Nirglim-M 2 Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Nirglim-M 2 Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIomeprol
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Iomeprol with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoversol
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Ioversol with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Iopentol with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Iohexol with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Iopanoic acid with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with Nirglim-M 2 Tablet:
Co-administration of Ioglycamic acid with Nirglim-M 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nirglim-M 2 Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits, and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid the consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Nirglim-M 2 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Nirglim-M 2 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Nirglim-M 2 Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Nirglim-M 2 Tablet if you are breastfeeding.

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Driving

Caution

Nirglim-M 2 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Nirglim-M 2 Tablet .

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Liver

Caution

Take Nirglim-M 2 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Nirglim-M 2 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Nirglim-M 2 Tablet is not recommended for children as the safety and effectiveness were not established.

Have a query?

FAQs

Nirglim-M 2 Tablet is indicated in the treatment of type 2 diabetes mellitus.

Nirglim-M 2 Tablet works by decreasing the amount of glucose absorbed from the food and the amount of glucose made by the liver. It helps the pancreas to produce insulin and helps the body use insulin efficiently.

Nirglim-M 2 Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure, such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completely. In type 2 diabetes, though islet cells are working, the body doesn't respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Nirglim-M 2 Tablet on your own as discontinuing Nirglim-M 2 Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Nirglim-M 2 Tablet , please consult your doctor so that alternative medicine may be prescribed.

You are not recommended to take Nirglim-M 2 Tablet with phenytoin as it may reduce the effect of Nirglim-M 2 Tablet and increase blood sugar levels. However, please consult a doctor before using Nirglim-M 2 Tablet with other medicines.

Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.

Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.

You are advised to take Nirglim-M 2 Tablet for the duration recommended by the doctor.

Store Nirglim-M 2 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Nirglim-M 2 Tablet may cause lactic acidosis (builds up of lactic acid in the blood). Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.

Nirglim-M 2 Tablet is an anti-diabetic medicine used to treat type 2 diabetes mellitus, also known as noninsulin-dependent diabetes mellitus.

Side effects of Nirglim-M 2 Tablet are stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Long-term use of Nirglim-M 2 Tablet may lead to vitamin B12 deficiency. Regular monitoring of vitamin B12 levels is recommended.

You are recommended to avoid consumption of alcohol with Nirglim-M 2 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Nirglim-M 2 Tablet should be swallowed as a whole with water; do not crush, break or chew it.

Regularly monitor blood glucose levels. Have your meals regularly and never miss a meal. Always carry a source of sugar and consume it if you experience low blood sugar. If you are due to undergo any tests or surgery, inform the doctor that you are taking Nirglim-M 2 Tablet . Avoid drinking alcohol.

Other medicines should be taken with Nirglim-M 2 Tablet only if prescribed by the doctor. To prevent any interactions it is advised to consult the doctor before taking other medicines during treatment with Nirglim-M 2 Tablet .

Country of origin

India

Manufacturer/Marketer address

Nirvana India Pvt Ltd, B1 Extn., A41 Mohan Cooperative Estate First Floor, New Delhi-110044
Other Info - NIR0091

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