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compositionComposition:NITROGLYCERIN-5MG
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Prescription Medicine
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Nitroplus Injection 5 ml belongs to the class of anti-anginal drugs, which is used in the treatment of angina pectoris, heart attack (myocardial infarction) and perioperative hypertension. It works by relaxing the blood vessels and thus helps boost blood supply to the heart. Some of the common side effects include headache, hypotension, dizziness, light-headedness, and blurred vision. Let your doctor know if you are taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

NITROGLYCERIN-5MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nitroplus Injection 5 ml

Nitroplus Injection 5 ml is a prescription medicine given as an injection or infusion into a vein to treat sudden, severe chest pain when other treatments have not worked. It is also used to control high blood pressure during surgeries and to manage heart failure after a heart attack. This medicine works quickly to relax your blood vessels and improve blood flow to the heart muscle.

Because Nitroplus Injection 5 ml is given through a vein, it is used continuously or as needed by healthcare professionals in a hospital setting. It is not taken at home or with meals, as your dose will be adjusted slowly based on your body's immediate needs. To help support your treatment, your doctor may suggest following a low-salt diet and resting quietly during the infusion.

While receiving this medicine, you may experience mild side effects like headaches, dizziness, or a warm, flushed feeling. Tell your healthcare provider right away if you experience serious symptoms, such as severe dizziness, a pounding heartbeat, or extreme weakness, which may point to a sudden drop in blood pressure.

Before you receive Nitroplus Injection 5 ml, tell your doctor if you have any existing health issues. Do not take this if you have severe anaemia, high pressure inside your head, a recent head injury, or if you are already experiencing very low blood pressure. It should also be avoided if you have certain heart conditions where the heart cannot pump blood properly.

This medicine can interact dangerously with other drugs, especially medications used to treat erectile dysfunction, as well as alcohol. Always talk to your doctor or pharmacist if you are pregnant, breastfeeding, or if the patient is an elderly individual, as these groups require careful monitoring during treatment.

Uses of Nitroplus Injection 5 ml

Your doctor may prescribe Nitroplus Injection 5 ml to help manage the following conditions:

  • Severe chest pain (angina): Nitroplus Injection 5 ml helps by rapidly widening the blood vessels that supply the heart, which relieves intense chest pain when other treatments have failed.
  • High blood pressure during surgery: Nitroplus Injection 5 ml helps control sudden and dangerous spikes in blood pressure before, during, or after surgical procedures.
  • Congestive heart failure after a heart attack: Nitroplus Injection 5 ml helps reduce the workload on a weakened heart, allowing it to pump blood more easily and reducing fluid backup in the lungs.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Rapid pain relief: Because Nitroplus Injection 5 ml is injected directly into a vein, it begins working almost instantly to relieve severe, crushing chest pain, providing immediate comfort when time is critical.
  • Precise control over blood pressure: Healthcare providers can easily adjust the infusion rate of Nitroplus Injection 5 ml to keep your blood pressure within a safe and stable range during delicate surgeries.
  • Reduced strain on the heart: By relaxing the body's blood vessels, this medicine reduces the effort your heart needs to pump blood, which helps protect the heart muscle from further damage during a cardiac event.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Nitroplus Injection 5 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Nitroplus Injection 5 ml Works

Nitroplus Injection 5 ml contains nitroglycerine, which works by relaxing the smooth muscles surrounding your blood vessels. This relaxation causes your veins and arteries to widen, a process known as vasodilation. When these vessels widen, it becomes much easier for blood to flow through them. This reduces the amount of blood returning to the heart, lowering the pressure inside the heart chambers. It also dilates the arteries on the surface of the heart, which directly increases the supply of oxygen-rich blood to the heart muscle. By lowering the heart's workload and increasing its oxygen supply, the medicine quickly relieves chest pain and helps stabilise your cardiovascular system.
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Alcohol

Unsafe

Concomitant use of nitrates and alcohol may cause hypotension. So intake of Nitroplus Injection 5 ml should be avoided with Nitroplus Injection 5 ml.

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Pregnancy

Caution

Nitroplus Injection 5 ml should not be used during pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Nitroplus Injection 5 ml.

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Breast Feeding

Caution

The safety of Nitroplus Injection 5 ml is not known in breastfeeding women. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Nitroplus Injection 5 ml.

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Driving

Unsafe

Nitroplus Injection 5 ml can cause dizziness. So, operating machinery and driving, which require concentration, should be avoided.

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Liver

Caution

Tell your doctor before receiving Nitroplus Injection 5 ml if you have a history of liver impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Tell your doctor before receiving Nitroplus Injection 5 ml if you have a history of kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

The safety of Nitroplus Injection 5 ml is not known in children below the age of 18 years.

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Heart

Caution

Nitroplus Injection 5 ml is commonly used to treat heart conditions like angina and heart failure by relaxing blood vessels and improving blood flow. It should be administered under medical supervision, especially if you have low blood pressure or recent cardiac events.

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Geriatrics

Caution

Geriatric patients can receive Nitroplus Injection 5 ml, but it may be more sensitive to its effects like dizziness, low blood pressure, or fainting. Close monitoring and careful dose adjustments are essential to ensure safe use.

What if I have taken an overdose of Nitroplus Injection 5 ml

Since this medicine is given under close medical supervision, an overdose is rare. If an overdose does occur, symptoms may include a severe throbbing headache, confusion, fever, rapid heartbeat, and a dangerous drop in blood pressure. The healthcare team is trained to recognise these signs and will immediately stop the infusion or adjust the rate to treat the symptoms.

Diet & Lifestyle Advise

  • Bed Rest During Treatment: While receiving this treatment in the hospital, you must remain resting in bed as instructed by your healthcare team to prevent sudden falls or fainting caused by low blood pressure.
  • Rise Slowly: Avoid sudden movements, such as sitting up or standing up too quickly from a lying position, as this can cause sudden dizziness.
  • Follow a Low-Sodium Diet: If your doctor advises, maintain a low-sodium (low-salt) diet to help manage your blood pressure and reduce the fluid load on your heart.
  • Stay Hydrated: Stay hydrated by drinking water as recommended by your doctor, which helps maintain stable blood circulation.
  • Adopt a Heart-Healthy Lifestyle: Once you are discharged, work with your care provider to develop a safe, gradual exercise routine and quit smoking to protect your cardiovascular health.
  • Continue Long-Term Heart Treatment: Your doctor may switch you from intravenous Nitroplus Injection 5 ml to oral or sublingual nitrates, or prescribe other heart medicines to help prevent future episodes of chest pain.
  • Keep Follow-Up Appointments: Attend all scheduled follow-up appointments with your cardiologist or healthcare provider so your treatment plan can be reviewed and adjusted if needed.
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Have a query?

How Soon It Starts Working

The time required for Nitroplus Injection 5 ml to start to work: Nitroplus Injection 5 ml ideally shows its action within 1 to 3 minutes after administration.

The time for which the effects of Nitroplus Injection 5 ml last: The duration of action for Nitroplus Injection 5 ml is unknown.

What if you forget to take Nitroplus Injection 5 ml

Because Nitroplus Injection 5 ml is given by healthcare professionals in a controlled clinical setting, it is highly unlikely that you will miss a dose. If you have any concerns about your infusion schedule, talk to your doctor or nurse.

Storage

•Nitroplus Injection 5 ml is stored at controlled room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Do not freeze the medication.

Drug Warnings

  • Check the solution: Before the infusion begins, ensure the medical staff inspects the vial. The solution should be clear and colourless; do not use it if it is discoloured or contains particles.
  • Use special tubing: This medicine can bind to standard plastic PVC (polyvinyl chloride) tubing, which reduces the amount of medicine you receive. Ensure your healthcare team uses the recommended non-PVC infusion sets.
  • Monitor blood pressure: Your blood pressure and heart rate must be monitored continuously during the entire time you are receiving this infusion.
  • Report site pain: If you feel burning, swelling, or pain at the injection site where the needle or tube enters your vein, tell your nurse immediately.
  • Avoid alcohol: Do not drink alcohol shortly before or after receiving this medicine, as it can dangerously increase the blood-pressure-lowering effects of Nitroplus Injection 5 ml.

Drug-Drug Interactions

verifiedApollotooltip
  • Medications for erectile dysfunction: Taking these medicines while receiving Nitroplus Injection 5 ml can cause a severe, life-threatening drop in blood pressure.
  • Blood pressure-lowering drugs: Combining Nitroplus Injection 5 ml with other blood pressure medicines, water pills (diuretics), or certain heart medications can cause your blood pressure to drop too low.
  • Tricyclic antidepressants: Using these medications alongside Nitroplus Injection 5 ml may increase the risk of low blood pressure when standing up.
Glyceryl trinitrateVardenafil
Critical
Glyceryl trinitrateAvanafil
Critical

Drug-Drug Interactions

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Glyceryl trinitrateVardenafil
Critical
How does the drug interact with Nitroplus Injection 5 ml:
Taking Vardenafil and Nitroplus Injection 5 ml together can increase the risk or severity of low blood pressure.

How to manage the interaction:
Combining Vardenafil and Nitroplus Injection 5 ml is generally avoided as it can lead to an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateAvanafil
Critical
How does the drug interact with Nitroplus Injection 5 ml:
Taking Avanafil and Nitroplus Injection 5 ml together can increase the risk or severity of low blood pressure.

How to manage the interaction:
Combining Avanafil and Nitroplus Injection 5 ml is generally avoided as it can lead to an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateMethylergometrine
Critical
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Methylergometrine with Nitroplus Injection 5 ml can increase the levels and side effects of Methylergometrine.

How to manage the interaction:
Taking Methylergometrine with Nitroplus Injection 5 ml is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, headache, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateChloroprocaine
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Chloroprocaine and Nitroplus Injection 5 ml can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Chloroprocaine and Nitroplus Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateLevobupivacaine
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Levobupivacaine and Nitroplus Injection 5 ml can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levobupivacaine and Nitroplus Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateSodium nitrite
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Sodium nitrite and Nitroplus Injection 5 ml has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Sodium nitrite and Nitroplus Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateEtidocaine
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Etidocaine and Nitroplus Injection 5 ml can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Etidocaine and Nitroplus Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateProcaine
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Procaine and Nitroplus Injection 5 ml has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking procaine and Nitroplus Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitratePrilocaine
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of Prilocaine and Nitroplus Injection 5 ml has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking prilocaine and Nitroplus Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateBupivacaine
Severe
How does the drug interact with Nitroplus Injection 5 ml:
Coadministration of bupivacaine and Nitroplus Injection 5 ml can increase the risk and severity of developing methemoglobinemia, (Red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking bupivacaine and Nitroplus Injection 5 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Nitroplus Injection 5 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

Nitroplus Injection 5 ml belongs to the class of anti-anginal medication, primarily used for treating angina pectoris and myocardial infarction. Nitroplus Injection 5 ml can also be used to control intraoperative blood pressure.
Nitroplus Injection 5 ml contains Nitroglycerin, a natural vasodilator that relaxes the muscles surrounding blood vessels, making the heart's job easier.
Nitroplus Injection 5 ml may result in hypotension (low blood pressure). Therefore, regular blood pressure monitoring is recommended while on Nitroplus Injection 5 ml therapy.
Nitroplus Injection 5 ml is prescribed when a quick response is needed or individuals cannot take tablets.
No, you should not take Nitroplus Injection 5 ml with the erectile dysfunction medication, such as sildenafil, vardenafil, or tadalafil, as the simultaneous administration of Nitroplus Injection 5 ml and these drugs can drop the blood pressure dangerously.
Yes, Nitroplus Injection 5 ml can cause a headache. Please increase fluid intake to cope with the headache. If the problem persists, consult your doctor and do as advised.
Caution should be exercised while using Nitroplus Injection 5 ml, especially if you have hyperthyroidism (overactive thyroid); inform your doctor before taking Nitroplus Injection 5 ml because it may mask your symptoms or make it difficult to recognise the signs of excess thyroid hormone in the body.
Nitroplus Injection 5 ml is given as an intravenous (IV) infusion or injection directly into a vein. This must be done by a trained healthcare professional in a hospital or clinical setting. Talk to your doctor if you have questions about the procedure.
Yes, headache is a very common side effect of Nitroplus Injection 5 ml. It happens because the medicine widens the blood vessels in your head. Your healthcare team can usually manage this with simple pain relievers. Talk to your doctor if the headache becomes severe.
You should generally remain in bed or resting while receiving Nitroplus Injection 5 ml. This is because the medicine can cause a rapid drop in blood pressure, making you feel dizzy or faint when you stand up. Talk to your doctor about when it is safe for you to move around.
You must avoid taking erectile dysfunction medications, as the combination can cause a dangerous drop in blood pressure. You should also avoid alcohol and any sudden physical movements. Talk to your doctor or pharmacist about other substances to avoid.
Nitroplus Injection 5 ml is usually used for short-term treatment in a hospital. If it is given continuously for a long time, your body may gradually become less responsive to the medicine, a process known as nitrate tolerance. To help reduce this, your doctor may plan nitrate-free intervals or switch you to another medicine when appropriate. Never stop or change your treatment on your own. Your healthcare team will decide the safest approach based on your condition.

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Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NIT0052
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