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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Nizoclin 200 mg Tablet is an antifungal medicine used in the treatment of fungal infections such as blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and histoplasmosis (lung infection caused by Histoplasma fungus). This medicine works by inhibiting the growth and multiplication of fungal cells that are responsible for the growth of infection-causing fungi.
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Composition :

KETOCONAZOLE-200MG

Manufacturer/Marketer :

Canixa Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nizoclin 200 mg Tablet

Nizoclin 200 mg Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus). It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks.

Nizoclin 200 mg Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Take Nizoclin 200 mg Tablet as prescribed. Your doctor will advise you on how often you need to take Nizoclin 200 mg Tablet based on your medical condition. Some people may experience headache, nausea, stomach pain, and diarrhoea. Most of these side effects of Nizoclin 200 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

If you are allergic to Ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Nizoclin 200 mg Tablet . Avoid breastfeeding while taking Nizoclin 200 mg Tablet as it may be excreted in breast milk. You are recommended to avoid alcohol consumption whilst on treatment with Nizoclin 200 mg Tablet . Nizoclin 200 mg Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that the benefits outweigh the risks.

Uses of Nizoclin 200 mg Tablet

Treatment of Systemic fungal infections

Directions for Use

Take Nizoclin 200 mg Tablet with food to avoid stomach upset or take it as advised by the doctor. Swallow the whole tablet/capsule with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

Nizoclin 200 mg Tablet is an antifungal used to treat severe fungal infections. It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks. It destroys fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

How Nizoclin 200 mg Tablet Works

Nizoclin 200 mg Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nizoclin 200 mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Nizoclin 200 mg Tablet

Never take more than the prescribed dose. When Nizoclin 200 mg Tablet is used at high doses, it may, though unlikely, result in decreased testosterone levels, sperm production, and an issue with the adrenal glands (adrenal insufficiency). Seek emergency medical help if an overdose is suspected.

Drug Warnings

If you are allergic to Ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Nizoclin 200 mg Tablet . Avoid breastfeeding while taking Nizoclin 200 mg Tablet as it may be excreted in breast milk. You are recommended to avoid alcohol consumption with Nizoclin 200 mg Tablet . If you have a loss of appetite, tiredness, stomach pain, vomiting, yellowing of skin or eyes, dark urine, or light-coloured stools, inform your doctor immediately as they might be symptoms of hepatotoxicity (liver damage). 

Drug-Drug Interactions

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KetoconazoleDofetilide
Critical

Drug-Drug Interactions

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How does the drug interact with Nizoclin 200 mg Tablet:
Coadministration of Nizoclin 200 mg Tablet with Eplerenone can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Eplerenone is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
KetoconazoleDofetilide
Critical
How does the drug interact with Nizoclin 200 mg Tablet:
When Dofetilide is taken with Nizoclin 200 mg Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Dofetilide is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Nizoclin 200 mg Tablet:
When Dronedarone is taken with Nizoclin 200 mg Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Dronedarone is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleConivaptan
Critical
How does the drug interact with Nizoclin 200 mg Tablet:
Using conivaptan together with Nizoclin 200 mg Tablet may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Nizoclin 200 mg Tablet:
Using irinotecan together with Nizoclin 200 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Irinotecan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
KetoconazoleTriazolam
Critical
How does the drug interact with Nizoclin 200 mg Tablet:
When Triazolam is taken with Nizoclin 200 mg Tablet, it can increase the risk of drowsiness and slowed breathing.

How to manage the interaction:
Taking Triazolam with Nizoclin 200 mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleEliglustat
Critical
How does the drug interact with Nizoclin 200 mg Tablet:
When Eliglustat is taken with Nizoclin 200 mg Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Eliglustat is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or slow heart rate, weak pulse, or heart palpitations, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Nizoclin 200 mg Tablet:
Co-administration of Nizoclin 200 mg Tablet and Isavuconazole can significantly increase the blood levels of Isavuconazole, which may increase the risk of side effects.

How to manage the interaction:
Taking Isavuconazole with Nizoclin 200 mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Nizoclin 200 mg Tablet:
Coadministration of Ivabradine with Nizoclin 200 mg Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Nizoclin 200 mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
KetoconazoleMethadone
Critical
How does the drug interact with Nizoclin 200 mg Tablet:
When Methadone is taken with Nizoclin 200 mg Tablet, it can increase the risk of serious side effects such as respiratory problems, low blood pressure, irregular heart rhythm.

How to manage the interaction:
Taking Nizoclin 200 mg Tablet with Methadone is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience breathing difficulty, fainting, heart palpitations, consult the doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Nizoclin 200 mg Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Nizoclin 200 mg Tablet.

Diet & Lifestyle Advise

  • Avoid high-risk areas such as renovated buildings, construction sites, pigeon or chick coops, and caves.
  • Wear a respiratory mask when there is a risk of exposure to spores.
  • People with a weak immune system are advised to avoid activities that involve close contact with dust or dirt including digging, yard work, and gardening.
  • Close windows and stay inside during dust storms.
  • Clean skin injuries well with soap and water to reduce the risk of developing a skin infection.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS - ORAL
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nizoclin 200 mg Tablet as it may increase the risk of liver damage and cause adverse effects.

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Pregnancy

Caution

Nizoclin 200 mg Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Nizoclin 200 mg Tablet may be excreted in breast milk. Therefore, it is recommended to avoid breastfeeding while taking Nizoclin 200 mg Tablet .

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Driving

Caution

Nizoclin 200 mg Tablet may cause dizziness or drowsiness. Therefore, drive only if you alert after taking Nizoclin 200 mg Tablet .

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Liver

Unsafe

Nizoclin 200 mg Tablet is contraindicated in patients with chronic or acute liver disease. Therefore, inform your doctor if you have any Liver diseases/conditions.

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Kidney

Caution

If you have any concerns regarding the use of Nizoclin 200 mg Tablet in patients with kiver diseases/conditions, consult a doctor.

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Children

Caution

Nizoclin 200 mg Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that benefits outweigh risks.

Have a query?

FAQs

Nizoclin 200 mg Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).

Nizoclin 200 mg Tablet works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Nizoclin 200 mg Tablet is not recommended to treat fungal meningitis (fungal infection spreads to the brain and spinal cord) as it poorly penetrates into the cerebrospinal fluid. Therefore, inform your doctor if you have fungal meningitis so that appropriate medication may be prescribed.

You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola and energy drinks while taking Nizoclin 200 mg Tablet as it may increase the adverse effects of caffeine such as drowsiness, nervousness or nausea.

You are not recommended to take Nizoclin 200 mg Tablet with simvastatin (lipid-lowering drug) as co-administration of these medicines may cause muscle problems. Therefore, please consult a doctor before taking Nizoclin 200 mg Tablet with other medicines.

No, you are not recommended to stop taking Nizoclin 200 mg Tablet without consulting your doctor as it may cause recurring infection. Therefore, take Nizoclin 200 mg Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Nizoclin 200 mg Tablet , please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Lg Floor, Block No. 2, , Attalika Warehouse (South), , 12 Km Mysore Road, R.V.C.E. Post, , Bangalore 560059.
Other Info - NIZ0053

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