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  1. Home
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  3. NOBEL MR 2MG TABLET

Prescription drug
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NOBEL MR 2MG TABLET, Pack of 10 TabletS
NOBEL MR 2MG TABLET, Pack of 10 TabletS
NOBEL MR 2MG TABLET, Pack of 10 TabletS
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Extra 15% Off with Bank Offers

Composition :

NIMESULIDE-100MG + PARACETAMOL-325MG + TIZANIDINE-2MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About NOBEL MR 2MG TABLET

NOBEL MR 2MG TABLET is a combination medicine used to relieve pain due to muscle spasms such as arthritis, muscle pain, tooth pain, bone and joint pain, headache, and period pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
 
NOBEL MR 2MG TABLET contains Nimesulide (analgesic), Paracetamol (mild analgesic and fever reducer), and Tizanidine (muscle relaxant). Nimesulide and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Tizanidine works on the centres of the spinal cord and brain, which helps relieve muscle stiffness, thereby improving muscle movements. Together, NOBEL MR 2MG TABLET helps in reducing pain due to muscle spasms.
 
You are advised to take NOBEL MR 2MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as nausea, vomiting, dizziness, dry mouth, and diarrhoea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. NOBEL MR 2MG TABLET may cause dizziness, so drive with caution. NOBEL MR 2MG TABLET should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with NOBEL MR 2MG TABLET as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects. 

Uses of NOBEL MR 2MG TABLET

Treatment of Musculoskeletal pain, Muscle spasms, Arthritis.

Have a query?

Directions for Use

• Take NOBEL MR 2MG TABLET with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

NOBEL MR 2MG TABLET is a combination of three drugs, namely: Tizanidine, Nimesulide, and Paracetamol. NOBEL MR 2MG TABLET is a combination medicine used to relieve pain and inflammation associated with osteoarthritis,  muscle pain, tooth pain, bone and joint pain, headache, and period pain. Tizanidine is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Nimesulide and Paracetamol are analgesics that work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Together, NOBEL MR 2MG TABLET helps in relieving pain due to muscle spasms. 

How NOBEL MR 2MG TABLET Works

NOBEL MR 2MG TABLET contains Nimesulide (analgesic), Paracetamol (mild analgesic and fever reducer), and Tizanidine (muscle relaxant). Nimesulide and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Tizanidine works on the centres of the spinal cord and brain, which helps relieve muscle stiffness, thereby improving muscle movements. Together, NOBEL MR 2MG TABLET helps in reducing pain due to muscle spasms.

Storage

• Store in a cool and dry place away from sunlight.• Keep NOBEL MR 2MG TABLET out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Nobel Mr 2mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.

What if I have taken an overdose of NOBEL MR 2MG TABLET

Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take NOBEL MR 2MG TABLET if you are allergic to any of its contents, if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine, or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. NOBEL MR 2MG TABLET may cause dizziness, so drive only if you are alert. NOBEL MR 2MG TABLET is not recommended for children as safety and effectiveness have not been established. Stop taking NOBEL MR 2MG TABLET and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other analgesic for pain relief along with NOBEL MR 2MG TABLET unless prescribed.  

Drug-Drug Interactions

verifiedApollotooltip
TizanidineZiprasidone
Critical
TizanidineCisapride
Critical

Drug-Drug Interactions

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TizanidineZiprasidone
Critical
How does the drug interact with Nobel Mr 2mg Tablet:
Co-administration of Nobel Mr 2mg Tablet with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Nobel Mr 2mg Tablet with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
TizanidineCisapride
Critical
How does the drug interact with Nobel Mr 2mg Tablet:
Coadministration of Nobel Mr 2mg Tablet with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Nobel Mr 2mg Tablet with Cisapride is avoided as it can result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
TizanidineDronedarone
Critical
How does the drug interact with Nobel Mr 2mg Tablet:
Coadministration of Nobel Mr 2mg Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Nobel Mr 2mg Tablet with Dronedarone is generally avoided as it can result in an interaction, it can be taken when prescribed by a doctor. If you experience sudden dizziness, shortness of breath, palpitations, or chest pain, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TizanidineCiprofloxacin
Critical
How does the drug interact with Nobel Mr 2mg Tablet:
Coadministration of Ciprofloxacin and Nobel Mr 2mg Tablet together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin and Nobel Mr 2mg Tablet together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
TizanidineSaquinavir
Critical
How does the drug interact with Nobel Mr 2mg Tablet:
Combining Nobel Mr 2mg Tablet with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Nobel Mr 2mg Tablet with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TizanidineFluvoxamine
Critical
How does the drug interact with Nobel Mr 2mg Tablet:
Taking Fluvoxamine with Nobel Mr 2mg Tablet it can increases the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Nobel Mr 2mg Tablet is not recommended, but can be taken together if prescribed by a doctor. However, if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness, contact your doctor immediately. Do not stop using any medications without consulting a doctor.
TizanidineMetolazone
Severe
How does the drug interact with Nobel Mr 2mg Tablet:
Coadministration of Nobel Mr 2mg Tablet and metolazone may cause low blood pressure.

How to manage the interaction:
Taking Nobel Mr 2mg Tablet with Metolazone together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not stop using any medications without talking to a doctor.
TizanidineMorphine
Severe
How does the drug interact with Nobel Mr 2mg Tablet:
Using Morphine together with Nobel Mr 2mg Tablet can increase the risk of central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Nobel Mr 2mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
TizanidineIrbesartan
Severe
How does the drug interact with Nobel Mr 2mg Tablet:
Combining Nobel Mr 2mg Tablet with Irbesartan can increase the risk of low blood pressure.

How to manage the interaction:
Taking Irbesartan with Nobel Mr 2mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
TizanidineIsosorbide mononitrate
Severe
How does the drug interact with Nobel Mr 2mg Tablet:
Taking isosorbide mononitrate with Nobel Mr 2mg Tablet will have an additive effect and may lower blood pressure.

How to manage the interaction:
Although taking isosorbide mononitrate and Nobel Mr 2mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, dizziness, lightheadedness, fainting, and/or pulse or heart rate changes. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes, instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • To avoid developing pressure sores, change your position every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

NOBEL MR 2MG TABLET Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking NOBEL MR 2MG TABLET as it may cause increased drowsiness. It can also increase the risk of stomach bleeding.

bannner image

Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks. NOBEL MR 2MG TABLET should not be taken during the last three months of pregnancy.

bannner image

Breast Feeding

Caution

Consult your doctor before taking NOBEL MR 2MG TABLET, your doctor will decide whether NOBEL MR 2MG TABLET can be taken by breastfeeding mothers or not.

bannner image

Driving

Caution

NOBEL MR 2MG TABLET may cause dizziness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

NOBEL MR 2MG TABLET should not be given to children as safety and effectiveness were not established.

FAQs

NOBEL MR 2MG TABLET is used to relieve pain due to muscle spasms such as arthritis, muscle pain, tooth pain, bone and joint pain, headache, and period pain.

NOBEL MR 2MG TABLET contains Nimesulide, Paracetamol, and Tizanidine. Nimesulide and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Tizanidine works on the centres of the spinal cord and brain, which helps relieve muscle stiffness, thereby improving muscle movements. Together, NOBEL MR 2MG TABLET helps in reducing pain due to muscle spasms.

NOBEL MR 2MG TABLET is used to reduce and relieve pain and inflammation associated with osteoarthritis. Arthritis is tenderness and swelling in the joints.

Diarrhoea might be a side-effect of NOBEL MR 2MG TABLET. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if the condition persists or worsens.

NOBEL MR 2MG TABLET should not be taken for longer durations unless prescribed by the doctor. Use the minimum effective dose for the shortest duration.

Dry mouth could be a side-effect of NOBEL MR 2MG TABLET. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevents drying of the mouth.

Taking NOBEL MR 2MG TABLET can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking NOBEL MR 2MG TABLET if you have gastrointestinal bleeding or other bleeding problems like haemophilia before using NOBEL MR 2MG TABLET.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase III, New Delhi - 110020
Other Info - NOB0020

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:29 PM IST

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Reference

  1. https://www.ema.europa.eu/en/documents/referral/nimesulide-article-107-procedures-annex-iii_en.pdf
  2. https://www.drugs.com/paracetamol.html
  3. https://www.drugs.com/tizanidine.html

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