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compositionComposition:EPTACOG ALFA-1MG
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Novoseven 1 mg Injection is used to treat bleeding disorders and to prevent bleeding after surgery or other essential treatments. It may also be given to treat heavy bleeding after delivery of the baby, even if the mother does not have a bleeding disorder. Novoseven 1 mg Injection contains Eptacog alfa, a blood coagulation factor that works by making the blood clot at the site of bleeding when the body’s own clotting factors are not working.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EPTACOG ALFA-1MG

Manufacturer/Marketer :

Novo Nordisk India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Novoseven 1 mg Injection

Novoseven 1 mg Injection is a prescription injection used to control and prevent bleeding episodes in patients with rare blood clotting disorders, such as haemophilia with inhibitors or specific clotting factor deficiencies. It works by restoring the body's natural ability to form blood clots during active bleeds or surgical procedures. This specialised therapy helps manage severe bleeds and protects patients from dangerous blood loss.

You will typically inject this medication as needed during a bleeding event or on a regular schedule prescribed by your doctor to prevent bleeding. Because it is given as an intravenous injection, food intake does not affect how this medicine works in your body. To support your treatment, incorporating low-impact joint-strengthening exercises and avoiding high-risk physical activities can help reduce the frequency of spontaneous bleeding episodes.

Some individuals may experience mild side effects while using Novoseven 1 mg Injection, such as redness at the injection site, mild fever, or headache. However, you must contact your doctor immediately if you experience signs of a serious blood clot, such as sudden chest pain, shortness of breath, or leg swelling. Always monitor your body closely after each injection and report any unusual symptoms to your medical team.

Do not take this if you have a known severe allergy to this medication or to mouse, hamster, or bovine proteins, which are used during the manufacturing process. Talk to your doctor before starting treatment if you have a history of heart disease, a recent stroke, or active blood clots, as these conditions may increase your risk of complications.

Avoid using other clotting factor medicines alongside Novoseven 1 mg Injection unless specifically directed by your specialist, as combining these treatments can dangerously increase your risk of unwanted blood clots. It is also important to consult your doctor before using this medication if you are pregnant, breastfeeding, or an elderly patient, as these specific groups may require customised monitoring.
 

Uses of Novoseven 1 mg Injection

Your doctor may prescribe this medicine to help manage the following conditions:
 

  • Haemophilia A or B with inhibitors: Novoseven 1 mg Injection helps control and prevent bleeding episodes in patients who have developed inhibitors (antibodies) against clotting factors VIII or IX by bypassing the blocked clotting pathway.
  • Congenital factor VII deficiency: It replaces the missing activated clotting factor VII, helping restore normal blood clot formation and control bleeding episodes.
  • Glanzmann's thrombasthenia: This medicine is used to treat bleeding episodes and to prevent bleeding during surgical or dental procedures in patients withGlanzmann's thrombasthenia, particularly when platelet transfusions are ineffective or unsuitable.
  • Prevention of surgical bleeding: Novoseven 1 mg Injection is administered before, during, or after surgery and other invasive procedures to reduce the risk of excessive bleeding in patients with eligible bleeding disorders.
     

Key Benefits

Novoseven 1 mg Injection is used to treat bleeding and to prevent bleeding after surgery or other important treatments. It is used in people who were born with haemophilia (inherited bleeding disorder) and did not normally respond to factors VIII or IX treatment, has acquired haemophilia, Factor VII deficiency, or Glanzmann’s thrombasthenia (a bleeding disorder), and the condition cannot be treated effectively with platelet transfusion, or if platelets are not readily available. Novoseven 1 mg Injection may also be given to treat heavy bleeding after delivery of the baby, even if the mother does not have a bleeding disorder. Novoseven 1 mg Injection contains Eptacog alfa, a blood coagulation factor that works by making the blood clot at the site of bleeding when the body’s own clotting factors are not working. Early treatment with Novoseven 1 mg Injection reduces the amount and duration of bleeding. Novoseven 1 mg Injection works in all types of bleeds, including joint bleeds.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Novoseven 1 mg Injection will be administered by a healthcare professional. In some cases, it may be given to use at home. Follow your doctor’s instructions if you use this injection at home.
  • Do not use if the solution is cloudy, contains particles, or if the vial is damaged.

How Novoseven 1 mg Injection Works

Novoseven 1 mg Injection works by stepping in to jump-start the body's natural blood-clotting process at the site of a blood vessel injury. When a blood vessel is damaged, the body normally relies on a chain reaction of proteins called clotting factors to form a plug and stop the leak. In people with certain bleeding disorders, this chain reaction is broken because of missing or blocked factors. Novoseven 1 mg Injection bypasses the missing or blocked steps in the clotting chain. It binds directly to substances exposed at the injury site, triggering a rapid 'thrombin burst.' Thrombin is the key enzyme that converts liquid blood into a solid, stable clot, effectively sealing the injured vessel and stopping the bleeding quickly.
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Alcohol

Caution

It is not known if alcohol affects Novoseven 1 mg Injection. However, limit or avoid consumption of alcohol while on treatment with Novoseven 1 mg Injection.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Novoseven 1 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Novoseven 1 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

It is not known whether Novoseven 1 mg Injection can affect the driving ability. Drive or operate machinery only if you are alert after taking this medicine.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Novoseven 1 mg Injection.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Novoseven 1 mg Injection.

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Children

Consult your doctor

Limited information is available. Please consult your doctor for more information.

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Heart

Caution

If you have a pre-existing or a history of heart disease, inform your doctor before receiving Novoseven 1 mg Injection.

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Geriatrics

Consult your doctor

Limited information available about the use of Novoseven 1 mg Injection in geriatric patients. Please consult your physician.

What if I have taken an overdose of Novoseven 1 mg Injection

If you inject more than the prescribed dose of Novoseven 1 mg Injection, you may be at an increased risk of forming dangerous blood clots in your blood vessels. Seek immediate emergency medical attention if you suspect an overdose.

Diet & Lifestyle Advise

  • Stay physically active: Engage in low-impact exercises such as walking, swimming, or cycling to strengthen the muscles around your joints and help reduce the risk of bleeding. Avoid high-impact or contact sports unless approved by your doctor.
  • Maintain a healthy body weight: Keeping your weight within a healthy range reduces stress on your joints and may help decrease the frequency of joint bleeding episodes.
  • Practice good oral hygiene: Brush your teeth with a soft-bristled toothbrush and floss gently to maintain healthy gums and reduce the risk of oral bleeding.
  • Schedule regular dental check-ups and inform your dentist about your bleeding disorder.
  • Avoid medicines that increase bleeding risk: Unless specifically prescribed by your doctor, avoid aspirin, ibuprofen, naproxen, and other NSAIDs, as they can interfere with normal clotting. Speak with your healthcare provider about safer alternatives for pain relief.
  • Protect yourself from injuries: Use appropriate protective equipment during physical activities, avoid situations that increase your risk of trauma, and seek medical advice promptly if you experience signs of internal bleeding or joint swelling.
     
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How Soon It Starts Working

The time required for Novoseven 1 mg Injection to start to work: Novoseven 1 mg Injection ideally shows its action within few minutes after administration. The time for which the effects of Novoseven 1 mg Injection last: The duration of action for Novoseven 1 mg Injection is clinically unknown.

What if you forget to take Novoseven 1 mg Injection

Because Novoseven 1 mg Injection is often used on an as-needed basis to treat active bleeding, missing a dose can delay clot formation and allow bleeding to continue. If you are on a regular prevention schedule and miss a dose, inject it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store unopened vials of Novoseven 1 mg Injection in a refrigerator between 2°C and 8°C
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution before administration: After reconstitution, the solution should be clear and colourless. Do not use it if it appears cloudy, discoloured, or contains visible particles.
  • Use proper injection technique: Rotate injection sites whenever possible to reduce the risk of vein irritation, scarring, or local injection-site reactions.
  • Use sterile equipment every time: Never reuse needles, syringes, infusion sets, or transfer devices. Always use new sterile equipment for each administration to minimise the risk of infection.
  • Maintain a treatment record: Keep a log of each infusion, including the date, dose, batch (lot) number, and reason for treatment (such as a bleeding episode or routine prophylaxis), and share it with your healthcare provider during follow-up visits.
  • Carry medical identification: Always carry a medical alert card or bracelet stating that you have a bleeding disorder and are receiving Novoseven 1 mg Injection so appropriate treatment can be provided in an emergency.
     

verifiedApollotooltip
  • Coagulation factor concentrates (such as Factor VIII or IX complexes): Combining these with Novoseven 1 mg Injection may significantly increase the risk of forming dangerous, life-threatening blood clots.
  • Antifibrinolytics (such as tranexamic acid or aminocaproic acid): Using these medicines close to the time of injecting Novoseven 1 mg Injection can enhance clot stability but may also increase the risk of unwanted blood clots in the blood vessels.

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  • No clinically significant food/disease/drug interactions are known with Novoseven 1 mg Injection when used as directed.
     

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Novoseven 1 mg Injection is used to treat bleeding disorders.
Novoseven 1 mg Injection works by making the blood clot at the site of bleeding when the body’s own clotting factors are not working.
Do not use Novoseven 1 mg Injection at the same time as prothrombin complex concentrates or rFXIII (recombinant factor XIII). Talk to your doctor before using Novoseven 1 mg Injection if you also use Factor VIII or IX products.
Novoseven 1 mg Injection may cause blood clots at the site of injection or in the blood vessels of the kidney, liver, lungs or limbs. Consult your doctor if you experience any signs of a blood clot, such as red and painful swelling in the leg, abdominal pain, and difficulty breathing.
In case of mild or moderate bleeding episodes, Novoseven 1 mg Injection may be prescribed for use at home if required. Do not stop using Novoseven 1 mg Injection or adjust the dose without checking with your doctor. You should not continue home treatment for longer than 24 hours without consulting your doctor. Contact your doctor immediately if the bleeding is not controlled within 24 hours.
Novoseven 1 mg Injection is used to control and prevent bleeding episodes, especially during surgeries, in patients with bleeding disorders such as hemophilia with inhibitors, congenital factor VII deficiency, or Glanzmann's thrombasthenia. Talk to your doctor to see if this treatment is right for your condition.
Novoseven 1 mg Injection is injected directly into a vein (intravenously). A healthcare provider can give this injection, or you can learn to administer it at home after receiving proper training. Talk to your doctor or pharmacist to learn the correct injection technique.
Yes, unopened vials of Novoseven 1 mg Injection can often be stored at room temperature (up to 25°C) for a limited time, but they must not be frozen. Always check the package insert for specific temperature limits, and talk to your doctor or pharmacist for guidance on safe storage.
Swelling, warmth, or pain in a leg can be a sign of a deep vein blood clot, which is a serious potential side effect. You must seek immediate emergency medical care if you notice these symptoms. Talk to your doctor as soon as possible about any unusual changes after injection.
The safety of Novoseven 1 mg Injection during pregnancy has not been fully established. It should only be used during pregnancy if the potential benefits outweigh the risks. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
Some patients with haemophilia develop "inhibitors," which are antibodies that block standard factor treatments from working. Novoseven 1 mg Injection bypasses these blocked pathways to help the blood clot directly. Talk to your doctor to understand why this specific treatment was chosen for you.
No, you should avoid taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen while using Novoseven 1 mg Injection, as these medicines can thin your blood and increase the risk of bleeding. Talk to your doctor or pharmacist for safe pain relief options.
Do not inject the medicine if the solution appears cloudy, discoloured, or contains visible particles. It should be completely clear and colourless. Discard the vial safely and prepare a new one. Talk to your doctor or pharmacist if you experience issues with reconstitution.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Plot No.32, 47-50, EPIP Area, Whitefield, Bangalore - 560 066
Other Info - NOV0077
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