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compositionComposition:ADEMETIONINE-400MG
prescription
Prescription Medicine
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Nusam 400 Tablet is used to treat liver disease, depression, and osteoarthritis. It works by protecting the liver from toxins, regulating mood and stimulating the production of cartilage. In some cases, this medicine may cause side effects such as headache, vomiting, diarrhoea, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ADEMETIONINE-400MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nusam 400 Tablet

Nusam 400 Tablet is a prescription medicine used to treat intrahepatic cholestasis, a condition where bile flow from the liver is reduced. This medicine is commonly prescribed for adults living with chronic liver disease to help support and restore normal liver function. It provides essential support to compromised liver cells, enabling them to process toxins and bile more effectively.

To get the most benefit, you should take Nusam 400 Tablet regularly and consistently, exactly as prescribed by your doctor. It is best taken on an empty stomach, either one hour before or two hours after a meal, to ensure proper absorption into your system. Making specific dietary adjustments, such as reducing unhealthy fat intake and staying hydrated, can also help improve your overall treatment results.

While taking this medicine, some people may experience mild side effects like nausea, stomach discomfort, or mild diarrhoea. If you notice any serious issues, such as severe abdominal pain, persistent vomiting, or signs of an allergic reaction, contact your healthcare provider right away. Your doctor can help determine if these symptoms require a change in your treatment plan.

Talk to your doctor before starting Nusam 400 Tablet if you have a history of mood disorders, particularly bipolar disorder, as this medicine can affect your emotional state. Do not take this if you have been diagnosed with certain rare genetic metabolic disorders that affect how your body processes amino acids. Additionally, anyone with a known allergy to any of the ingredients in this medication should not take it.

This medicine can interact with certain other treatments, such as specific classes of antidepressants, which can cause an unsafe buildup of active chemicals in your brain. Avoid drinking alcohol while on this medication, as alcohol causes direct liver damage and reduces the effectiveness of your treatment. If you are pregnant, breastfeeding, or an elderly individual, always consult your doctor or pharmacist before starting this medicine.

Uses of Nusam 400 Tablet

Nusam 400 Tablet is used to treat intrahepatic cholestasis. The detailed uses of Nusam 400 Tablet are as follows:

  • Intrahepatic cholestasis: Nusam 400 Tablet helps improve the flow of bile through the liver, preventing harmful bile buildup and relieving related symptoms like intense skin itching.
  • Chronic liver disease: This medicine supports long-term liver health in conditions such as hepatitis or cirrhosis by protecting liver cells from permanent damage.
  • Fatty liver support: It aids the liver in maintaining normal fat metabolism, reducing cellular inflammation, and helping prevent fat accumulation in liver tissue.

Key Benefits

Nusam 400 Tablet provides targeted clinical relief that directly improves how you feel day-to-day by restoring key processes within your liver cells.

  • Relief from severe itching: By promoting healthy bile flow, this medicine significantly reduces the painful, persistent itching that often accompanies bile blockage.
  • Cellular protection and recovery: It helps rebuild and strengthen the outer membranes of your liver cells, defending them against daily toxins and supporting natural tissue recovery.
  • Reduction in fatigue: Restoring healthy liver function helps your body process nutrients and eliminate waste more efficiently, which can reduce the heavy, daily exhaustion caused by liver issues.

Directions for Use

  • Nusam 400 Tablet should be taken before a meal, as food may affect its absorption.
  • It is recommended to take Nusam 400 Tablet once daily or as advised by your doctor.
  • Swallow the whole Nusam 400 Tablet with a glass of water.
  • Do not crush, chew, or break it.

How Nusam 400 Tablet Works

Nusam 400 Tablet contains ademetionine, which works by delivering a vital compound that your liver naturally produces but lacks during times of chronic illness. When your liver is damaged or inflamed, its natural stores of protective substances drop, leaving liver cells vulnerable to further injury. Once you take the medicine, it aids your liver in two major ways. First, it helps produce glutathione, a natural antioxidant that acts as a shield to neutralise toxic molecules inside liver cells. Second, it improves the physical flexibility of your liver cell membranes, which allows bile to be pumped smoothly out of the liver and into the digestive tract, preventing congestion and cell damage.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nusam 400 Tablet as it may cause increased dizziness and liver damage.

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Pregnancy

Consult your doctor

Avoid taking Nusam 400 Tablet if you are pregnant unless advised by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will recommend only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Nusam 400 Tablet , your doctor will decide whether Nusam 400 Tablet can be taken by breastfeeding mothers or not.

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Driving

Safe if prescribed

Nusam 400 Tablet does not affect your ability to drive. However, you are advised to be cautious while driving if you experience dizziness.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Nusam 400 Tablet can be given to children with caution only if recommended by the doctor.

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Heart

Caution

Limited data is available regarding the use of Nusam 400 Tablet in patients with heart problems. Please consult your doctor if you have any concerns regarding this.

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Geriatrics

Caution

Nusam 400 Tablet should be given to elderly patients only if prescribed by a doctor. If you have any concerns, please consult a healthcare professional.

What if I have taken an overdose of Nusam 400 Tablet

If you accidentally take too much of this medicine, seek immediate medical attention. Always bring the original medication packaging with you so the healthcare providers know exactly what you took.

Diet & Lifestyle Advise

  • Eat a liver-friendly diet: Focus on meals rich in fresh vegetables, fruits, whole grains, and lean proteins while avoiding processed foods, trans fats, and excess sugar to minimise stress on your liver.
  • Eliminate alcohol completely: Alcohol is a major liver toxin that can counteract the benefits of Nusam 400 Tablet and accelerate liver damage.
  • Drink plenty of fluids: Stay well-hydrated throughout the day by drinking water, which helps your kidneys and liver process and eliminate bodily waste safely.
  • Maintain a moderate exercise routine: Engaging in daily physical activity like walking helps improve your body’s metabolism and reduces fat buildup in the liver.
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How Soon It Starts Working

The time required for Nusam 400 Tablet to start to work: Nusam 400 Tablet starts to show its action within 2 to 6 hours of administration. The time for which the effects of Nusam 400 Tablet last: The duration of action for Nusam 400 Tablet is clinically unknown.

What if you forget to take Nusam 400 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your normal routine. Do not take a double dose to make up for a missed one.

Storage

•Store Nusam 400 Tablet tablets in their original blister packaging in a dry place at room temperature, ideally between 15°C and 25°C (59°F to 77°F). •This medicine is highly sensitive to moisture and humidity, so do not store it in bathroom cabinets.

Drug Warnings

  • Inspect the blister pack: Never take a tablet if the foil packaging is torn, punctured, or shows signs of moisture leakage.
  • Monitor your mental health: Pay close attention to your mood and behaviour, and notify your doctor immediately if you experience sudden restlessness, severe insomnia, or extreme irritability.
  • Do not share this medicine: This treatment is prescribed specifically for your personal medical history and should never be given to anyone else, even if they have similar liver symptoms.
  • Keep up with blood tests: Attend all laboratory appointments scheduled by your doctor so they can regularly check your liver enzymes and adjust your treatment safely.

verifiedApollotooltip
  • Antidepressants (such as SSRIs or MAOIs): Combining Nusam 400 Tablet with these medicines can cause dangerously high levels of serotonin to accumulate in your body, leading to a serious medical emergency.
  • Levodopa: This medicine may reduce the effectiveness of levodopa, which is used to manage Parkinson's disease.

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verifiedApollotooltip
  • High-protein meals: Eating high-protein foods at the same time you take this medicine can significantly reduce how much of the drug your body absorbs. Always take it on an empty stomach.

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FAQs

Nusam 400 Tablet is used to treat various medical conditions, including depression, osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), and excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. It is also used to treat liver disease during pregnancy, improve symptoms in people with fibromyalgia, and treat nerve problems in people with AIDS or sexual dysfunction in men with depression.
Nusam 400 Tablet contains Ademetionine is used in the treatment of liver disease, depression, and osteoarthritis. It is used in liver conditions associated with reduced bile formation (intrahepatic cholestasis). It restores the balance of serotonin, a natural chemical present in the brain. It also blocks the production of certain inflammatory chemical substances that cause pain and swelling in osteoarthritis.
If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.
Do not take Nusam 400 Tablet if you have used MAO inhibitors (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others) in the last 14 days as the co-administration of Nusam 400 Tablet and MAO inhibitor cause serious drug interaction. Let know doctor know about this.
No, the Nusam 400 Tablet does not cure arthritis. Nusam 400 Tablet is only used to relieve symptoms of arthritis, such as joint pain, swelling and stiffness.
Yes, Nusam 400 Tablet is good for the liver. It aids liver function, minimises liver damage and treats liver disease.
Nusam 400 Tablet contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid).
Do not take Nusam 400 Tablet if you are allergic to any of its components, if you have used an MAO inhibitor in the past 14 days, or if you have inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.
Nusam 400 Tablet may cause side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Talk to your doctor if you experience these side effects persistently.
It is not known if Nusam 400 Tablet is safe to use for the long term. Take Nusam 400 Tablet for the duration prescribed by the doctor.
No, you should take Nusam 400 Tablet on an empty stomach, either one hour before or two hours after eating. Taking it with food can significantly lower how much medicine your body absorbs. Talk to your doctor or pharmacist if you are having trouble scheduling your doses.
You should completely avoid alcohol during your treatment. Alcohol causes direct liver damage and impairs the ability of this medicine to protect and heal your liver cells. Talk to your doctor if you need support in stopping alcohol use.
This medicine is sometimes used during the later stages of pregnancy for specific liver conditions, but it must only be taken under strict medical supervision. Talk to your doctor to weigh the potential benefits and risks before starting this treatment.
Yes, in some individuals, particularly those with a history of depression or bipolar disorder, this medicine can cause anxiety, restlessness, or manic episodes. If you experience sudden mood shifts, stop taking the medication and talk to your doctor immediately.
The tablets are highly sensitive to moisture and light. If you notice any cracks, discolouration, or softening of the tablets inside their pack, do not take them. Talk to your pharmacist to check if your medicine needs to be replaced.
No, you should never stop taking your medication abruptly, even if your laboratory tests look normal or your symptoms disappear. Stopping early can cause your liver issues to return. Talk to your doctor before making any changes.
This medicine works closely with specific B vitamins, such as vitamin B12 and folate, which help your body process the active ingredients. However, you should still talk to your doctor or pharmacist before starting any new vitamin supplements alongside this medicine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - NUS0052

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